Clinical trials: Suicide
Suicide
Scaling Out S.A.F.E. Firearm Across Two Health Systems as a Universal Suicide Prevention Strategy (SCALE ASPIRE)
In this randomized controlled trial, researchers will assess the expansion of the S.A.F.E. Firearm program into adult primary care and women's health at two health systems in Michigan and Colorado that have previously implemented…
- Trial name
- NCT07009314
- Testing
- Implementation package (training, facilitation, electronic health record nudge)
- Where
- 2 sites in United States
- Volunteers
- 5,442 people
- Sponsor
- Northwestern University
Suicidal Ideation, Suicide, Attempted
iTBS+D-Cycloserine for Youth Suicide
Background and Rationale: Suicide is the second leading cause of death in Canadian Emerging Adults (EAs; 18-24yrs). Current treatments for suicidal thoughts and behaviors are limited and novel treatments are required to save…
- Conditions
- Suicidal Ideation, Suicide, Attempted, Depression, Anxiety
- Trial name
- NCT06121284
- Testing
- D-Cycloserine, intermittent Theta-Burst-repetitive Transcranial Magnetic Stimulation
- Where
- Canada
- Volunteers
- 54 people
- Sponsor
- University of Calgary
Major Depressive Disorder
Long-Term Maintenance With Ketamine and Esketamine for Reduction of Suicide in High-Risk Patients With Depression
The study will consist of a 24-week-long trial examining outcomes in patients with Major Depressive Disorder and suicidal ideation who will receive intravenous (IV) ketamine and intranasal (IN) esketamine, compared to a large…
- Trial name
- NCT05450432
- Testing
- Ketamine, Esketamine
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Massachusetts General Hospital
Suicide, Mental Health Disorder
A Digitally Assisted Risk Reduction Platform for Youth at High Risk for Suicide
Despite efforts to prevent suicide, US rates are climbing, and suicide is the second leading cause of death among youth. Digital tools, especially personal smartphones, are promising avenues to address these issues and can be…
- Conditions
- Suicide, Mental Health Disorder, Anhedonia
- Trial name
- NCT05920252
- Testing
- Vira, Treatment as Usual (TAU)
- Where
- United States
- Volunteers
- 78 people
- Sponsor
- Ksana Health
Suicide Attempt, Suicidal and Self-injurious Behavior
Suicide Preventive Psychosocial Treatment for Youths
Suicide is the leading cause of death amongst 10-18-year-olds in Sweden. Suicide attempts are the strongest predictor of subsequent death by suicide, often lead to inpatient care, and are associated with substantial societal…
- Conditions
- Suicide Attempt, Suicidal and Self-injurious Behavior, Suicide Attempted, Suicide, Attempted
- Trial name
- NCT06931639
- Testing
- Safe Alternatives for Teens and Youth (SAFETY), Enhanced Treatment As Usual
- Where
- 5 sites in Sweden
- Volunteers
- 282 people
- Sponsor
- Karolinska Institutet
Suicide Attempt, Suicide Ideation
Electronic, Self-Guided Safety Plan in Adolescents: Project SAFER
Suicide is a leading cause of death for youth 10-24, and nearly ¼ of adolescents report nonfatal suicidal thoughts and behaviors (STB).
- Trial name
- Project SAFER (NCT06868407)
- Testing
- Psychoeducation about Suicide Crisis Resources (Control Intervention), Experimental: Self-Guided Electronic Safety Plan Intervention
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- University of Denver
Distress; Maternal, Self-Efficacy
Integrated Intervention for Caregivers--Open Trial
Adolescents who have been hospitalized for suicidal behavior are at risk for engaging in additional suicidal behavior. After hospitalization, parents or guardians are typically asked to be responsible for helping to prevent…
- Conditions
- Distress; Maternal, Self-Efficacy, Parenting, Suicide
- Trial name
- NCT03487575
- Testing
- Open trial
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Wake Forest University Health Sciences
Suicidal Ideation
Correlation of Campbell Score With Suicidal Ideation
The Campbell Score is a blood based means of assessing molecules believed to be associated with suicidal ideation and in some cases successful suicide.
- Trial name
- NCT04606875
- Testing
- Campbell Score
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Therapeutic Solutions International
Suicide Prevention
Safety Planning and Cognitive Behavioral Therapy for Adolescent Suicide Prevention in Mozambique
This implementation research project aims to test the effectiveness and implementation outcomes of suicide safety planning along and a transdiagnostic cognitive behavioral intervention for suicide prevention on decreasing…
- Trial name
- NCT06465381
- Testing
- Safety Planning Intervention, Enhanced Usual Care, Transdiagnostic Cognitive Behavioral Therapy for Suicide Prevention
- Where
- 7 sites in Mozambique
- Volunteers
- 2,100 people
- Sponsor
- University of Washington
Suicide, Suicide and Self-harm
Feasibility, Acceptability, and Preliminary Efficacy of a Novel Personalized Mobile Intervention for Suicide - Open Trial
The primary aim of this grant is to conduct pilot testing on a novel personalized mobile intervention for suicide - Mobile Application to Prevent Suicide (MAPS) - and to establish feasibility, acceptability, safety, and primary…
- Conditions
- Suicide, Suicide and Self-harm, Suicide, Attempted, Suicidal Ideation
- Trial name
- NCT05180331
- Testing
- Mobile Application to Prevent Suicide (MAPS)
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Butler Hospital
Depression, Suicide
Reaching Out to Distressed Medical Residents, Fellows and Faculty
The purpose of this study is to study whether distressed medical residents, fellows, and faculty health professionals benefit from completing online an anonymous and interactive screening of stress, depression, substance use, and…
- Trial name
- NCT02010866
- Testing
- counseling
- Where
- United States
- Volunteers
- 4,000 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Ovarian Cancer
A Study of an Infectivity Enhanced Suicide Gene Expressing Adenovirus for Ovarian Cancer in Patients With Recurrent Ovarian and Other Selected Gynecologic Cancers
In spite of surgical and chemotherapeutic advances, long term survival for advanced and recurrent gynecologic cancers remains dismal and no curative treatment for recurrent disease exists. Novel treatment strategies are needed.
- Trial name
- NCT00964756
- Testing
- Ad5.SSTR/TK.RGD, Ganciclovir (GCV)
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- University of Alabama at Birmingham
Suicide, Depressive Disorder, Major
Promote Access to Stop Suicide: Comparison of Follow up Services for Youth at Risk for Suicide
This research study is designed to answer specific questions about new ways to provide services for youth at-risk of suicide.
- Conditions
- Suicide, Depressive Disorder, Major, Anxiety Disorders, Suicidal Ideation
- Trial name
- PASS (NCT03016572)
- Testing
- Standard of Care, Crisis Intervention, Wraparound Services
- Where
- United States
- Volunteers
- 65 people
- Sponsor
- The Cleveland Clinic
Suicide, Psychiatric Hospitalization
Development of a Video-based Intervention for Suicide Prevention
The investigators will develop a brief video-based intervention for suicide prevention, called LifePlans. LifePlans will be tested in an initial open trial (n = 10) to examine its feasibility and acceptability.
- Trial name
- NCT04307394
- Testing
- LifePlans
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Butler Hospital
Suicidal Ideation
INternet-based Programmes FOR the Prevention of Suicidal Ideation in MEDical Students
Two programmes have been built to prevent suicidal ideation; one focuses on stress management based on cognitive and behavioural principles and the other on health promotion.
- Trial name
- InforMed (NCT03949556)
- Testing
- Videos and/or SMS
- Where
- France
- Volunteers
- 2,544 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Charles Perrens, Bordeaux
Suicide Prevention
Increasing Help-Seeking Behavior Among Transitioning Veterans at Risk for Suicide With Online Gatekeeper Training
The purpose of this study is to evaluate the feasibility and acceptability of a gatekeeper training called VA S.A.V.E. which was developed through a partnership between the VA and the PsychArmor Training Institute.
- Trial name
- NCT04565951
- Testing
- VA S.A.V.E.
- Where
- United States
- Volunteers
- 281 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Suicidal Ideation, Regulation, Emotion
Effect of Morning Light Exposure on Mood
Mood dysregulation and suicidal ideation are closely associated with disruption of sleep and circadian rhythms. Moreover, sleep problems and circadian disruption are commonplace features of military life.
- Trial name
- NCT05616819
- Testing
- Active light exposure
- Where
- United States
- Volunteers
- 480 people, healthy volunteers welcome
- Sponsor
- University of Arizona
Major Depressive Disorder
Opiate Suicide Study in Patients With Major Depression
To explore whether intravenous ketamine followed by buprenorphine produces more rapid and sustained anti-suicidal effects than ketamine followed by placebo, investigators will conduct a single study that will take approximately…
- Trial name
- AFSP (NCT04116528)
- Testing
- Buprenorphine
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Stanford University
Suicide
Comprehensive Adaptive Multisite Prevention of University Student Suicide
Suicide is the 2nd leading cause of death among college students and suicidal ideation and suicide-related behaviors are a frequent presenting problem at college counseling centers (CCCs), which are overburdened.
- Trial name
- CAMPUS (NCT04707066)
- Testing
- Treatment As Usual (TAU), Collaborative Assessment and Management of Suicidality (CAMS) - Phase 1, Dialectical Behavior Therapy (DBT) - Phase 2
- Where
- 4 sites in United States
- Volunteers
- 253 people
- Sponsor
- Duke University
Suicide, Suicide, Attempted
Improving Firearm Storage in Alaska Native Villages
Rates of suicide among young Alaska Native males are over ten-fold higher than among a similar age cohort in the rest of the United States. A high proportion of these deaths are associated with firearms.
- Conditions
- Suicide, Suicide, Attempted, Wounds and Injuries
- Trial name
- NCT00643812
- Testing
- Installation of gun locker in household
- Where
- United States
- Volunteers
- 266 people, healthy volunteers welcome
- Sponsor
- University of Washington