Clinical trials: Suicide and Self-harm
Borderline Personality Disorder
Hope for the Chronically Suicidal Patient
The aim of this study is to evaluate the clinical and cost effectiveness of Dialectical Behavior Therapy (DBT) for chronically suicidal behavior in individuals diagnosed with borderline personality disorder (BPD).
- Trial name
- NCT00154154
- Testing
- General Psychiatric Management, Dialectical Behaviour Therapy
- Where
- 2 sites in Canada
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Centre for Addiction and Mental Health
Suicide, Trauma
Integrated Suicide & Trauma Therapy for Suicide Risk
The investigators have developed a novel suicide intervention, Integrated Suicide and Trauma Therapy (ISTT). ISTT combines Brief-Skills for Safer Living (Brief-SfSL)-a promising method to enhance coping skills and reduce…
- Conditions
- Suicide, Trauma, Major Depressive Disorder
- Trial name
- ISTT (NCT05613972)
- Testing
- Integrated Suicide and Trauma Therapy
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- Unity Health Toronto
Alcohol Use, Suicidal Ideation/Behavior
Examining the Relationship Between Ongoing Alcohol Use, Suicidal Thoughts and Behaviors and Related Constructs, and Behavioral Economic Decision-Making
The purpose of this single groups trial is to (Aim 1) determine relationships between alcohol use, suicidal thoughts and behaviors (STBs), and behavioral economic decision-making in a community sample (N = 100) of alcohol using…
- Trial name
- NCT06845761
- Testing
- Self-Guided Cognitive Behavioral Therapy
- Where
- United States
- Volunteers
- 102 people
- Sponsor
- Mark J Rzeszutek, PhD
Suicide, Attempted, Suicidal Ideation
Biomarkers as Predictors of Suicidal Risk in Adolescents
Suicide is one of the most devastating events in society at all levels. The primary goal of this study is to predict suicide in adolescents at risk.
- Conditions
- Suicide, Attempted, Suicidal Ideation, Suicidal Intention, Suicide
- Trial name
- NCT03014518
- Testing
- Clinical assessments and blood samples; follow-up for 12 mos, Clinical assessments and blood samples; no 12mo follow-up
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- The Cleveland Clinic
Suicidal Ideation and Behavior, Impulsivity
Title: "Intervention Based on Didactic Model for Suicidal Behavior in the Framework of Impulsivity and Ideations."
Suicide has become a major public health problem among young people around the world. This study will examine the effects of higher secondary school-based suicide prevention (HSSSP) program on youth suicidal thoughts and…
- Trial name
- NCT05324670
- Testing
- Didactic model for suicidal behavior in the framework of impulsivity and ideations
- Where
- Pakistan
- Volunteers
- 150 people
- Sponsor
- International Islamic University, Islamabad
Suicidal Ideation and Behavior, Suicide
RomSi: Mobile Health Intervention to Enhance Suicide Prevention by Reducing Stigma and Increasing Literacy
Suicide is one of the leading causes of death in Spain, representing a public health crisis that requires urgent and effective solutions.
- Trial name
- NCT06759129
- Testing
- Immediate-use of a mobile health application until completion, Delayed use of a mobile health application until completion
- Where
- Spain
- Volunteers
- 214 people, healthy volunteers welcome
- Sponsor
- University of Valencia
Sleep Initiation and Maintenance Disorders, Suicidal Ideation
Addressing Nocturnal Sleep/Wake Effects on Risk of Suicide in Older Adults
Suicide is a leading cause of death in the US, and insomnia is a risk factor for suicidal thoughts and behaviors. In older adults, suicide is associated with impaired cognitive functioning, and insomnia, which is more prevalent…
- Trial name
- ANSWERS-OA (NCT04986007)
- Testing
- Digital Cognitive Behavioral Therapy for Insomnia
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- MICHAEL A GRANDNER
Posttraumatic Stress Disorder (PTSD), Suicidal Ideation
Augmenting Massed Cognitive Processing Therapy (CPT) to Prevent Suicide Risk Among Patients With PTSD
The purpose of this research is to see if Crisis Response Planning (CRP), a brief strategy designed to help people cope effectively with emotional crises, combined with Cognitive Processing Therapy (CPT), a talk treatment for…
- Conditions
- Posttraumatic Stress Disorder (PTSD), Suicidal Ideation, Suicide Attempt
- Trial name
- mCPT+CRP (NCT07238192)
- Testing
- Cognitive Processing Therapy
- Where
- United States
- Volunteers
- 190 people
- Sponsor
- Ohio State University
Mild Traumatic Brain Injury, Suicide Prevention
Crisis Response Planning in Military Personnel With Mild Traumatic Brain Injury
The study purpose is to test the effect of Crisis Response Planning (CRP) when used as the second method of suicide prevention in military service members who are at risk for suicide due to mild traumatic brain injury (mTBI).
- Conditions
- Mild Traumatic Brain Injury, Suicide Prevention, Suicide Risk | Patient, Suicide Risk
- Trial name
- NCT07327567
- Testing
- Crisis Response Planning
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center at San Antonio
Suicide Ideation, Suicidal Behaviors
A New Clinical Model for the Engagement of Latinx Youth With Suicidal Behavior
This study will test a model of providing treatment to Latinx/Hispanic youth, who experience suicidal thoughts and behavior, and their caregivers.
- Conditions
- Suicide Ideation, Suicidal Behaviors, Depressive Symptoms
- Trial name
- NCT06882798
- Testing
- Socio-Cognitive Behavioral Therapy for Suicidal Behavior (SCBT-SB), SCBT-SB + CHW
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Bradley Hospital
Suicide and Depression, Adolescent Behavior
Clinical Trial for Integrated Care to Help At Risk Teens (iCHART) Intervention
This protocol will test the effectiveness of an intervention, iCHART (integrated Care to Help At-Risk Teens) and facilitate recruitment for other studies in the larger ETUDES Center grant, which are focused on treatment…
- Trial name
- NCT05748730
- Testing
- iCHART, Treatment As Usual
- Where
- 13 sites in United States
- Volunteers
- 765 people
- Sponsor
- University of Pittsburgh
Major Depressive Episode, Suicidal Behavior
Neuroinflammation, Serotonin, Impulsivity and Suicide
Suicide is a major health problem that causes annually a million death worlwide. In the stress-vulnerability model, suicidal behavior (SB) results from the interaction between an individual's predisposition (personality, family…
- Trial name
- NISIS (NCT02824081)
- Testing
- Blood sample
- Where
- France
- Volunteers
- 280 people
- Sponsor
- University Hospital, Montpellier
Suicidal Ideation, Suicide, Attempted
Reducing Suicide Ideation Among Young People
It is Cluster Randomized Control Trial research to examine feasibility and relevance of the modified tool Nae Disha for Life, which will incorporate suicide prevention and resilience to reduce suicide ideation among young people…
- Trial name
- NCT06474312
- Testing
- Nae Disha
- Where
- India
- Volunteers
- 363 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Bipolar II Disorder, Depression, Bipolar
Acceptability & Safety of Two Sequential Doses of Psilocybin in Bipolar Disorder II Depression and Suicidality
The purpose of the study is to assess the safety and acceptability of up to two sequential administrations of 25 mg psilocybin with additional therapeutic support in decreasing suicidality in patients with Bipolar Disorder (BD…
- Conditions
- Bipolar II Disorder, Depression, Bipolar, Suicidality
- Trial name
- NCT06706232
- Testing
- Psilocybin, Therapeutic Support
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- The University of Texas Health Science Center, Houston
Suicide
High Risk Suicidal Behavior in Veterans
Suicide is a pressing problem in the US military, with evidence of increased risk for suicide particularly among soldiers serving in Iraq and Afghanistan.
- Trial name
- NCT02462694
- Testing
- Dialectical Behavior Therapy, Treatment As Usual
- Volunteers
- 91 people
- Sponsor
- Bronx Veterans Medical Research Foundation, Inc
Suicide and Self-harm
CAMS-G Group Therapy for Suicidal Veterans
The primary aim of this pilot study is to determine the feasibility and acceptability of CAMS-G. Our aim is to determine if CAMS-G is an effective treatment and whether it has the potential to be tested in a large-scale setting.
- Trial name
- NCT03682406
- Testing
- CAMS-G
- Where
- United States
- Volunteers
- 41 people
- Sponsor
- Louisville VA Medical Center
Suicidal Ideation, Depression
Trial of the Rapid Antisuicidal Effects of Intranasal Ketamine in Comorbid Depression and Alcohol Abuse
This project aims to evaluate the potential rapid and sustained antisuicidal and antidepressant effects of a single intranasal dose of ketamine in inpatients during a mood episode in Major Depressive Disorder (MDD) or Bipolar…
- Conditions
- Suicidal Ideation, Depression, Alcohol Abuse
- Trial name
- NCT03539887
- Testing
- Intranasal ketamine
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- The University of Texas Health Science Center, Houston
Suicide
Emergency Department Safety Assessment and Follow-up Evaluation 2
Many patients at risk for suicide are discharged from the ED with little or no intervention. Evidence-based suicide prevention interventions, like universal screening and safety planning should be adopted in clinical practice to…
- Trial name
- ED-SAFE-2 (NCT02453243)
- Testing
- Safety Planning, A Lean Implementation Strategy
- Where
- 8 sites in United States
- Volunteers
- 14,250 people
- Sponsor
- University of Massachusetts, Worcester
Suicide Prevention
Native-RISE (Risk Identification for Suicide and Enhanced Care)
The goal of this research is to test a systems-level suicide prevention strategy, Native-RISE (Risk Identification for Suicide and Enhanced care), that combines predictive analytics and brief contact interventions (BCIs) to…
- Trial name
- NCT06782516
- Testing
- System of Care - combination of algorithm and Brief Contact Intervention, Active Comparator - Provider notification of risk status
- Where
- 3 sites in United States
- Volunteers
- 1,687 people
- Sponsor
- Johns Hopkins Bloomberg School of Public Health
Bipolar Depression, Suicidal Ideation
NRX101 Glx Biomarker Validation Study
Subnormal level of Glutamate+Glutamine (Glx) in the Anterior Cingulate Cortex (ACC) of the brain has been associated with depression and PTSD.
- Trial name
- NRX-GLX (NCT03402152)
- Testing
- NRX-101, Lurasidone HCl
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- NeuroRx, Inc.