Clinical trials: Suicide and Self-harm
Depression, Suicide
Integrating Ketamine Effects on Neuronal Molecular Signatures and the Brain Functional and Structural Connectome
Subanesthetic dose of intravenous ketamine (KET) has been found to be highly effective in rapid treatment depression and associated suicidality but its exact mechanism of remains uncertain.
- Trial name
- NCT06698848
- Testing
- ketamin
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Self-Harm, Depression
Signatures of N-Ac for Non-Suicidal Self-Injury in Adolescents
To measure NAC-induced changes to concentrations of glutathione (GSH) in the anterior cingulate cortex (ACC) as measured by magnetic resonance spectroscopy (MRS) in 36 adolescents and young adults with NSSI (12 in each group…
- Conditions
- Self-Harm, Depression, Suicide
- Trial name
- NCT04005053
- Testing
- N-acetyl cysteine
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- University of Minnesota
Behavioral Symptoms, Suicide
Natural History of Depression, Bipolar Disorder and Suicide Risk
Mood disorders, such as depression and bipolar disorder, are difficult to treat. One reason is that there are no objective ways to measure how these disorders affect the body and respond to different treatments.
- Conditions
- Behavioral Symptoms, Suicide, Self-Injurious Behavior, Sensory System Agents
- Trial name
- NCT06462196
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- National Institute of Mental Health (NIMH)
Alcohol Use Disorder (AUD), Suicidal Ideation
Examining the Relationship Between Ongoing Alcohol Use, Suicidal Thoughts and Behaviors and Related Constructs, and Behavioral Economic Decision-Making.
This study will evaluate the relationship between alcohol use, suicidal thoughts and behaviors, and behavioral economic decision-making.
- Trial name
- NCT07842588
- Testing
- CBT4CBT
- Volunteers
- 180 people
- Sponsor
- Mark J Rzeszutek, PhD
Suicide, Attempted, Suicide
The Catalonia Suicide Risk Code Epidemiology Study: an Epidemiological Study of Suicide Attempts in Catalonia, Spain
Suicide attempts (SA) constitute a major public health issue worldwide. Research suggests that 2.7% of adult people ever attempt suicide; among children and adolescents this is estimated to be 6.0%.
- Conditions
- Suicide, Attempted, Suicide, Suicide and Self-harm
- Trial name
- CSRC-Epi (NCT04235127)
- Testing
- sociodemographic variables, somatic conditions, mental disorders, treatment and drug use
- Volunteers
- 186,000 people
- Sponsor
- Hospital del Mar Research Institute (IMIM)
HIV, Suicide
Suicide Assessment and Feasible Evidence-based Treatments for Youth Living With HIV in Lilongwe
The overall aim of this study is to determine the feasibility, fidelity, acceptability, and preliminary effectiveness of the Friendship Bench +Safety Planning intervention in reducing suicidal ideation and behaviors (SIBs) and…
- Trial name
- NCT06770101
- Testing
- Behavioral: Enhanced Friendship Bench + Safety Planning, Augmented usual care
- Where
- 4 sites in Malawi
- Volunteers
- 60 people
- Sponsor
- University of Pennsylvania
Depressive Disorder, Major, Adult Attention Deficit Hyperactivity Disorder
Clinical and Suicidal Features of Urban, Turkish Middle Age Depressive Patients With Comorbid ADHD
In the presence of attention deficit hyperactivity disorder (ADHD) together with additional psychiatric diseases, the treatment process and prognosis of both ADHD and psychiatric comorbidity are adversely affected.
- Conditions
- Depressive Disorder, Major, Adult Attention Deficit Hyperactivity Disorder, Suicide
- Trial name
- NCT03721588
- Testing
- Clinical interviews, psychometric scales were applied.
- Volunteers
- 96 people
- Sponsor
- Bozyaka Training and Research Hospital
Suicide
Cognitive Inhibition, Psychosocial Interactions and Suicide Attempt in Elderly
The study aims to determine the correlation between the cognitive inhibition impairment and the history of suicide attempt in elderly depressed patients.
- Trial name
- OBSUIVAL (NCT02858427)
- Testing
- eye tracking, neuropsychological assessement, psychiatric assessment
- Where
- 2 sites in France
- Volunteers
- 36 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Chronic Pain, Suicidal Ideation
Mindfulness for Pain and Suicide
The proposed study will assess the feasibility and acceptability of a mindfulness-based intervention to reduce functional impairment from chronic pain and risk of suicide.
- Conditions
- Chronic Pain, Suicidal Ideation, Suicide, Attempted, Opioid Use
- Trial name
- NCT05286112
- Testing
- Mindfulness-Based Cognitive Therapy (MBCT), Health Education
- Where
- United States
- Volunteers
- 76 people
- Sponsor
- Canandaigua VA Medical Center
Suicidal Ideation, Suicidal Behavior
Integrated Suicide Supports and Safety Planning for Youth
The goal of this clinical trial is to evaluate an app to help keep teens and young adults with suicidal thoughts safe. The app includes a safety plan created by adolescents and healthcare providers, and videos to encourage…
- Trial name
- ISSP (NCT06701006)
- Testing
- Integrated skills and safety planning app
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Washington
Vitiligo, Depressive Episode
Mental Health Associations With Vitiligo
This cohort study is a large population-based study in the UK to determine the risks of comorbid mental health conditions (including depression, anxiety and other potential psychological complications of vitiligo) in adults with…
- Conditions
- Vitiligo, Depressive Episode, Recurrent Depressive Disorder, Anxiety Disorders
- Trial name
- NCT04953338
- Testing
- Exposure of mental health condtion of interest
- Where
- United Kingdom
- Volunteers
- 36,104 people, healthy volunteers welcome
- Sponsor
- Momentum Data
Suicide
Adolescent and Child Suicide Prevention in Routine Clinical Encounters
The objective of this study is to compare two approaches to implement an evidence-based firearm safety promotion program, S.A.F.E. Firearm, in pediatric primary care as a universal suicide prevention strategy.
- Trial name
- ASPIRE (NCT04844021)
- Testing
- Nudge, Nudge+
- Where
- 2 sites in United States
- Volunteers
- 47,307 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Suicidal Ideation, Trauma, Psychological
CMAP Plus Trauma-focused Cognitive Behavior Therapy for Suicidal Ideation Among Burn Survivors
The study aims to determine whether CMAP Plus TFBCT is feasible and acceptable for burn survivors with suicidal ideations. To identify any barriers to the recruitment of participants.
- Trial name
- NCT05453864
- Testing
- CMAP Plus TFCBT
- Volunteers
- 80 people
- Sponsor
- Pakistan Institute of Living and Learning
Mental Disorders, Suicide, Attempted
Ideation Trajectories and Suicide Attempts in Adolescents With Psychiatric Disorders in Chile
This project seeks to evaluate the trajectories of suicidal ideation and attempts in adolescent patients with psychiatric disorders in secondary care controls in the Maule region, in relation to clinical factors (depressive…
- Trial name
- NCT04635163
- Testing
- None intervention
- Where
- Chile
- Volunteers
- 388 people
- Sponsor
- Universidad Católica del Maule
Help-Seeking Behavior, Suicide
Online Suicide Prevention Campaign Aimed at Men
This study aims to examine whether the online suicide prevention campaign for men could increase openness about emotions and help-seeking behavior, and decrease hopelessness and adherence to traditional gender norms concerning…
- Trial name
- NCT05530941
- Testing
- Online suicide prevention campaign
- Where
- Belgium
- Volunteers
- 205 people, healthy volunteers welcome
- Sponsor
- University Ghent
Suicide Attempt
Patients Admitted to ICU After a Suicide Attempt
The goal of this study is to increase the knowledge on the experience and symptom profile to suicide attempters admitted to an ICU.
- Trial name
- SA_ICU (NCT06966505)
- Where
- Norway
- Volunteers
- 86 people
- Sponsor
- Oslo University Hospital
Suicide, Attempted, Suicide Threat
Written Exposure Therapy for Suicide Prevention
Military service members admitted to inpatient psychiatry for self-injurious thoughts and behaviors (SITBs) represent an at-risk group for continued SITBs and rehospitalizations in the post-discharge period.
- Trial name
- NCT05878795
- Testing
- WET-SP, TAU
- Where
- United States
- Volunteers
- 160 people
- Sponsor
- Boston University
Post Traumatic Stress Disorder, Cannabis Use
Warrior CARE: Naturalistic Observation and Harm Reduction
This study is looking at therapeutic potential of reducing Tetrahydrocannabinol (THC) levels in regular cannabis smokers using contingency management (CM) intervention in a U.S.
- Conditions
- Post Traumatic Stress Disorder, Cannabis Use, Suicide
- Trial name
- NOC (NCT05386862)
- Testing
- Reduce THC Use
- Where
- United States
- Sponsor
- Wayne State University
Recreational Drug Use, Sexual Violence
Evaluation of Teen Connection Project for Trans and Gender Minority Youth
The purpose of this project is to develop and evaluate an online mentoring and skill-building program for transgender and/or gender minority youth (TGMY) ages 14 to 18, the Teen Connection Project (TCP).
- Conditions
- Recreational Drug Use, Sexual Violence, Victimisation, Depressive Symptoms
- Trial name
- TCP (NCT06587139)
- Testing
- Teen Connection Project (TCP)
- Where
- United States
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Bipolar Depression, Suicidal Ideation and Behavior
NRX-101 for Bipolar Depression With Subacute Suicidal Ideation
NMDA antagonist drugs have shown to reduce symptoms of depression and suicidal ideation. NeuroRx has developed NRX-101 (fixed dose combination of D-cycloserine and lurasidone) for oral use in the treatment of bipolar depression…
- Trial name
- NCT03395392
- Testing
- NRX-101, Lurasidone HCl
- Where
- 14 sites in United States
- Volunteers
- 74 people
- Sponsor
- NeuroRx, Inc.