Clinical trials: Suicide and Self-harm
Suicidal Ideation, Suicide, Attempted
Establishing Efficacy of an Inpatient Intervention and Phone App to Reduce Suicidal Risk
In this 2-site study, University of Texas Southwestern Medical Center (UTSW) and Western Psychiatric Institute and Clinic (WPIC), the investigators will conduct a randomized clinical trial (RCT) in 240 psychiatrically…
- Trial name
- ASAP+BRITE (NCT03825588)
- Testing
- ASAP (As Safe As Possible), BRITE smart phone app, TAU (treatment as usual)
- Where
- 2 sites in United States
- Volunteers
- 241 people
- Sponsor
- University of Texas Southwestern Medical Center
Suicide, Mental Health Stigma
Reducing Stigma - A Treatment for Early Psychosis to Prevent Suicide
A mental health program, called RESTEPS, will be developed for patients with early psychosis being treated in outpatient mental health centers, focusing on reducing suicide risk by targeting mental health stigma and social…
- Trial name
- AFSP RESTEPS (NCT07898631)
- Testing
- RESTEPS
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- Butler Hospital
Suicidal Ideation, Major Depressive Disorder
The Effect of Ketamine on Mechanises Underlying Suicidal Ideation and Drug-resistant Major Depression
Suicide attempts are a serious concern worldwide. Currently, existing drugs take about three weeks to show effect on suicidal thoughts and drives.
- Conditions
- Suicidal Ideation, Major Depressive Disorder, Healthy Participants
- Trial name
- NCT02037503
- Testing
- Ketamine, Saline
- Where
- Israel
- Volunteers
- 100 people
- Sponsor
- Tel-Aviv Sourasky Medical Center
Major Depressive Disorder With Suicidal Ideation With Intent
Study of Efficacy and Safety of MIJ821 in Addition to Comprehensive Standard of Care on the Rapid Reduction of Symptoms of Major Depressive Disorder in Subjects Who Have Suicidal Ideation With Intent
Study of efficacy and safety of MIJ821 in addition to comprehensive standard of care on the rapid reduction of symptoms of Major Depressive Disorder (MDD) in subjects who have suicidal ideation with intent
- Trial name
- NCT04722666
- Testing
- MIJ821 Intravenous Injection
- Where
- 39 sites in United States, Argentina and 12 more
- Volunteers
- 199 people
- Sponsor
- Novartis Pharmaceuticals
Suicide Prevention, Social Media Users
Exploring The Effect of TikTok Trigger Warnings in a Clinical Sample of Youth at Risk of Suicide
Rates of suicide among Canadian youth have risen steadily over the past two decades, alongside rapid growth in social media use-especially TikTok.
- Trial name
- NCT07913854
- Testing
- Trigger Warning
- Where
- Canada
- Volunteers
- 82 people
- Sponsor
- Sunnybrook Health Sciences Centre
Suicide, Depression
Reducing Suicide Risk Among Aging Caregivers of Persons With AD/ADRD
This project aims to adapt, implement, and evaluate a Dialectical Behavior Therapy skills training group intervention for aging adult family caregivers of person with Alzheimer's Disease and Alzheimer's Disease Related Dementias…
- Conditions
- Suicide, Depression, Caregiver Burden, Physical Health
- Trial name
- NCT06055322
- Testing
- Adapted Dialectical Behavior Therapy
- Where
- United States
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- Texas Tech University
Unipolar Depression, Impulsive Behavior
How to Reduce Suicidal Thoughts and Impulsivity in Depression
The study aims at investigating if tDCS applied to left DLPFC or to right OFC to treatment as usual is effective in reducing severe suicidal ideas in major depressive episode.
- Conditions
- Unipolar Depression, Impulsive Behavior, Suicidal Ideation
- Trial name
- DEPIMPULSE (NCT05894980)
- Testing
- active tDCS stimulating left DLPFC, active tDCS stimulating right OFC
- Where
- 4 sites in France
- Volunteers
- 100 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Traumatic Brain Injury, Hopelessness
Window to Hope-Evaluating a Psychological Treatment for Hopelessness Among Veterans With Traumatic Brain Injury
The purpose of this project is to provide further evidence regarding a groundbreaking psychological treatment for suicide prevention in individuals with moderate to severe traumatic brain injury (TBI), Window to Hope (WtoH).
- Conditions
- Traumatic Brain Injury, Hopelessness, Suicide
- Trial name
- WtoH (NCT01691378)
- Testing
- Window to Hope, Waitlist Control
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- Lisa Brenner
Suicidal Ideation and Behaviors, Suicide Attempt
Video Conference-Based Brief Cognitive Behavioral Therapy for Suicidal High-Risk Outpatients With Mood Disorders
This pilot randomized controlled trial aims to evaluate the feasibility, acceptability, and preliminary effectiveness of videoconference-based brief cognitive behavioral therapy (V-BCBT) for adult outpatients with mood disorders…
- Conditions
- Suicidal Ideation and Behaviors, Suicide Attempt, Cognitive Behavioral Therapy
- Trial name
- V-BCBT (NCT07395817)
- Testing
- Videoconference-Based Brief Cognitive Behavioral Therapy (V-BCBT), Treatment as Usual (TAU)
- Where
- South Korea
- Volunteers
- 40 people
- Sponsor
- Hyung Keun Park
Bipolar Depression, Suicidal Ideation
NRX-101 for Maintenance of Remission From Severe Bipolar Depression in Patients With Suicidal Ideation
NMDA antagonist drugs have increasingly been demonstrated to reduce symptoms of depression and suicidal ideation. NeuroRx has developed a sequential therapy consisting of IV NRX-100 (ketamine HCL) for rapid stabilization of…
- Trial name
- SBD-ASIB (NCT03396068)
- Testing
- NRX-101, Lurasidone HCl
- Where
- 4 sites in United States
- Volunteers
- 72 people
- Sponsor
- NeuroRx, Inc.
Older Adults (50-90 Years), Mental Health
Project HOPEFUL: A PN-RCT With Implementation Science
This PN-RCT replicates and evaluates an 8-week warm calling treatment (i.e. caring contacts) delivered to older adults receiving home and community-based services (HCBS; classified as "homebound") in 20-30 minute call "dosages"…
- Conditions
- Older Adults (50-90 Years), Mental Health, Depression and Suicide Ideation, Social Functioning
- Trial name
- NCT07475039
- Testing
- Standardized and manualized warm calls from providers trained in the BE training, Standardized and manualized warm calls from providers trained in the BE training + ASIST training
- Where
- United States
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- University of Florida
Depression, Suicidal Ideation
Brain Changes During Social Reward Psychotherapy for Mid- and Late-Life Suicidality
The investigators hypothesized that during the 9-week course of Engage \& Connect treatment there will be an increase in brain functions of the Positive Valence System which in turn will lead to reduction in suicidality.
- Conditions
- Depression, Suicidal Ideation, Major Depressive Disorder, Depressive Disorder
- Trial name
- NCT05925322
- Testing
- "Engage & Connect" Psychotherapy, Symptom Review and Psychoeducation (SRP)
- Where
- United States
- Volunteers
- 128 people
- Sponsor
- Weill Medical College of Cornell University
Suicide, Depressive Disorder, Major
Promote Access to Stop Suicide: Comparison of Follow up Services for Youth at Risk for Suicide
This research study is designed to answer specific questions about new ways to provide services for youth at-risk of suicide.
- Conditions
- Suicide, Depressive Disorder, Major, Anxiety Disorders, Suicidal Ideation
- Trial name
- PASS (NCT03016572)
- Testing
- Standard of Care, Crisis Intervention, Wraparound Services
- Where
- United States
- Volunteers
- 65 people
- Sponsor
- The Cleveland Clinic
Suicide and Self-harm
Combined Dialectical Behavior Therapy and Digital Cognitive Behavioral Therapy for Insomnia for Adolescents at High Risk for Suicide
The proposed research addresses the urgent need to reduce suicide rates among teens. This will be the first study that the investigators know of that will examine the feasibility and preliminary effectiveness of augmenting a…
- Trial name
- NCT05842863
- Testing
- Dialectical Behavior Therapy, Cognitive Behavioral Therapy for Insomnia
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Stanford University
Depression, Suicidal Ideation
BRITEPath- Phase 2
BRITEPath (BP) aims to support co-located mental health clinicians in the development of a high quality, effective, and personalized safety plan for referred patients who screen positive for depression and/or suicidal ideation.
- Trial name
- NCT04672798
- Testing
- BRITEPath, Treatment As Usual (TAU)
- Where
- 6 sites in United States
- Volunteers
- 101 people
- Sponsor
- University of Pittsburgh
Self Inflicted Injury, Suicide and Self Inflicted Injury
Effects of Community-based Caring Contact on Post-discharge Young Adults With Self-harm
The study will determine whether community-based caring contact via a mobile app connection with or without volunteer support in addition to treatment as usual (psychiatric and psychosocial treatments) has an effect on suicidal…
- Trial name
- NCT03081078
- Testing
- Volunteer support, Mobile app
- Where
- 4 sites in Hong Kong
- Volunteers
- 108 people
- Sponsor
- The University of Hong Kong
Suicide Risk Assessment
The Effectiveness of Interactive Discussion Group Intervention About Suicide Risk Identification and Assessment for Clinical Nurses
Suicide attempters or people with self-harm have a high percentage in seeking medical services before and after their suicidal or self-harm behaviour compared to general population.
- Trial name
- NCT02033915
- Testing
- Interactive discussion group
- Where
- Taiwan
- Volunteers
- 111 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Suicide
Suicide Prevention for Sexual and Gender Minority Youth (Case Series)
The overarching goal of this study is to develop a suicide prevention program for sexual-and-gender-minority youth and emerging adults.
- Trial name
- NCT04757649
- Testing
- Safety Planning Intervention with Navigation Services
- Where
- United States
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- San Diego State University
Suicide
Operation Enduring Freedom/Operation Iraqi Freedom Veterans' Experiences of Habituation to Pain, Perceived Burdensomeness, and Failed Belongingness
Veterans possess significant risk factors for self-directed violence (SDV). For example, depressed Veterans are at a greater risk for SDV than the general population.
- Trial name
- NCT01334385
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- VA Eastern Colorado Health Care System
Suicidal Ideation, Major Depressive Disorder
Low Amplitude Pulse Seizure Therapy Versus Standard Ultra-Brief Right Unilateral Electroconvulsive Therapy
This protocol proposes an initial randomized clinical trial that includes all patients with suicidal ideation (SI) at baseline, and with SI as the primary outcome measure to examine whether Right Unilateral Low-Amplitude Pulse …
- Conditions
- Suicidal Ideation, Major Depressive Disorder, Schizo Affective Disorder, Bipolar Disorder
- Trial name
- LAP-ST vs ECT (NCT06529029)
- Testing
- Sigma-Stim, RUL LAP-ST (Low-Amplitude Pulse Seizure Therapy - Right Unilateral)
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Michigan State University