Clinical trials: Suicide and Self-harm
Borderline Personality Disorder, Suicide
Treatment of Suicidal Women With Borderline Personality Disorder
This study is a component analysis of dialectical behavior therapy (DBT) to determine the importance of DBT skills training and DBT individual therapy in treating suicidal women with borderline personality disorder.
- Trial name
- NCT00183651
- Testing
- Standard dialectical behavior therapy (SDBT), Individual DBT with no DBT group sessions (DBT-I), Group Skills DBT with no DBT individual sessions (DBT-S)
- Where
- United States
- Volunteers
- 99 people
- Sponsor
- University of Washington
Depression - Major Depressive Disorder, Anxiety
Deaf CBT-TS to Reduce Suicide Risk
The goal of this clinical trial is to learn if a short, Zoom-based intervention, Cognitive Behavioral Therapy for Treatment-Seeking for Deaf Individuals (Deaf CBT-TS) can change beliefs about mental health treatment and increase…
- Conditions
- Depression - Major Depressive Disorder, Anxiety, PTSD - Post Traumatic Stress Disorder, Insomnia
- Trial name
- NCT07279363
- Testing
- Deaf CBT-TS
- Where
- United States
- Volunteers
- 110 people
- Sponsor
- University of Rochester
Suicidal Thoughts and Behaviors
Developing and Testing a Brief, Personalized Intervention for Suicidal Thoughts and Behaviors
Suicide is a leading cause of death in the United States and around the world. Individuals at high-risk for suicide are heterogenous.
- Trial name
- AFSP_PRECISE (NCT07749391)
- Testing
- PRECISE
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- University of California, San Diego
Suicide, Suicidal Ideation
Safety Planning Intervention Telehealth Service Model in Emergency Departments
The purpose of this study is to evaluate the effectiveness and implementation of a suicide prevention strategy delivered via telehealth in Emergency Departments.
- Trial name
- NCT05307432
- Testing
- SPI+ Delivered by ED Staff, SPI+ Delivered by SPCC Clinicians
- Where
- United States
- Volunteers
- 2,814 people
- Sponsor
- University of Pennsylvania
Bipolar Depression, Suicidal Ideas
Sequential Therapy for the Treatment of Severe Bipolar Depression.
NeuroRx is developing NRX-101, a fixed-dose combination oral capsule composed of d-cycloserine (DCS) and lurasidone for the maintenance of remission from Severe Bipolar Depression with Acute Suicidal Ideation (C-SSRS level 4 or…
- Conditions
- Bipolar Depression, Suicidal Ideas, Suicidal Ideation, Suicide, Attempted
- Trial name
- STABIL-B (NCT02974010)
- Testing
- NRX-101 Oral Capsule, Lurasidone Oral Capsule, Ketamine Intravenous Infusion
- Where
- 4 sites in United States
- Volunteers
- 22 people
- Sponsor
- NeuroRx, Inc.
Treatment Resistant Depression (TRD), Depression - Major Depressive Disorder
2-Year Study of Vagus Nerve Stimulation for Higher-Grade Treatment-Resistant Depression: Clinical Outcomes and Policy Recommendation
The goal of this observational study is to evaluate whether vagus nerve stimulation (VNS) intervention can reduce depressive symptoms and suicidality in adults with higher-grade treatment-resistant depression (HG-TRD)-individuals…
- Conditions
- Treatment Resistant Depression (TRD), Depression - Major Depressive Disorder, Bipolar Depression
- Trial name
- VNS TRD HG-TRD (NCT07097025)
- Testing
- vagus nerve stimulation
- Where
- 2 sites in Israel
- Volunteers
- 19 people
- Sponsor
- Dr.Yoav Domany
Postnatal Depression
A Problem-Solving Intervention for Women With Suicidal Ideation During Postnatal Period in Pakistan
The aim of this study is to determine the feasibility and acceptability of culturally adapted CMAP for suicidal Ideation for women in postnatal period. Objectives 1.
- Trial name
- NCT05852314
- Testing
- Culturally Adapted Manual Assisted Therapy (CMAP-SI)
- Where
- Pakistan
- Volunteers
- 90 people
- Sponsor
- Pakistan Institute of Living and Learning
Suicidal and Self-injurious Behavior
Suicide Prevention in Rural Veterans During High-risk Care Transition Scenarios
In the United States (U.S.), suicide is a major public health concern. U.S. Veterans who live in rural areas may be at even higher risk for suicide than their urban counterparts.
- Trial name
- NCT04054947
- Testing
- Suicide Prevention Program
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- White River Junction Veterans Affairs Medical Center
Suicide, Attempted
AID-trial Assertive Intervention After Deliberate Self-harm
Background Previous suicide attempts is a high-risk factor with a repetition rate between 12-30 percent. Compliance with after treatment is often poor.
- Trial name
- AID (NCT00700089)
- Testing
- Assertive intervention, Standard treatment
- Where
- Denmark
- Volunteers
- 243 people
- Sponsor
- University of Copenhagen
Current Major Depressive Disorder
Evolution of Dark Ideas When Introducing or Switching an Antidepressant
Depression is a frequent disease and a serious public health problem, of which suicide is the most severe complication. Its treatment is based on the introduction of antidepressant which not only proposes a significant delay in…
- Trial name
- DEPASSE (NCT03327974)
- Testing
- DEPASSE Apllication
- Where
- France
- Volunteers
- 38 people
- Sponsor
- University Hospital, Montpellier
Suicide Prevention, Suicidal Ideation
Co-creation of Tools for Men With Suicidal Thoughts and/or Behavior
The primary objective of this project is to co-create suicide prevention tools for men with suicidal thoughts ensuring these tools are supported by their future users.
- Conditions
- Suicide Prevention, Suicidal Ideation, Suicidal Behaviour
- Trial name
- NCT06629220
- Testing
- Tools
- Where
- Belgium
- Volunteers
- 13 people
- Sponsor
- University Ghent
Suicide Attempt
Preventing Suicide With Digital Phenotyping and Pharmacogenetics-Based Interventions
The goal of this protocol for an observational retrospective multi-site cohort study is to develop a predictive algorithm for suicidal behavior integrating genetic risk markers, digital phenotypes, and exposomic data in people…
- Trial name
- SMARTomicS-R (NCT07422090)
- Testing
- No Intervention: Observational Cohort
- Where
- Spain
- Volunteers
- 5,000 people
- Sponsor
- Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz
Suicidal Ideation, Suicide, Attempted
Establishing Efficacy of an Inpatient Intervention and Phone App to Reduce Suicidal Risk
In this 2-site study, University of Texas Southwestern Medical Center (UTSW) and Western Psychiatric Institute and Clinic (WPIC), the investigators will conduct a randomized clinical trial (RCT) in 240 psychiatrically…
- Trial name
- ASAP+BRITE (NCT03825588)
- Testing
- ASAP (As Safe As Possible), BRITE smart phone app, TAU (treatment as usual)
- Where
- 2 sites in United States
- Volunteers
- 241 people
- Sponsor
- University of Texas Southwestern Medical Center
Feasibility, Acceptability
Caring Cards to and From Veterans: A Peer Approach to Suicide Prevention
Veteran suicide is a national problem; social disconnection is an important contributor to suicide risk. This pilot study will recruit Veterans to take part in a peer-centered intervention called Caring Cards (CC).
- Conditions
- Feasibility, Acceptability, Thwarted Belongingness, Perceived Burdensomeness
- Trial name
- NCT04486677
- Testing
- Caring Cards Group, Caring Cards Recipients
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- VA Office of Research and Development
Suicidal Ideation, Suicidal Behavior
The "AIM Study": Investigating Whether Actigraphy and Ideation Measures Can Promote Patient Safety
This is a research project looking at whether measuring movements or responses to certain questions can help predict suicidal thoughts or actions.
- Conditions
- Suicidal Ideation, Suicidal Behavior, Mental Health Symptoms, Mental Health Hospitalizations
- Trial name
- AIM (NCT03080168)
- Testing
- Actigraph
- Where
- United States
- Volunteers
- 220 people
- Sponsor
- VA Office of Research and Development
Suicide, Suicide, Attempted
Health Professionals Perspective on Suicide
The aim is to investigate how health professionals view/respond towards suicidal patients, what was their attitude, experiences and difficulties/challenges they faced while dealing with suicidal patients (whether successful or…
- Conditions
- Suicide, Suicide, Attempted, Completed Suicide, Suicide Prevention
- Trial name
- NCT05067686
- Where
- Pakistan
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Syeda AYAT E ZAINAB Ali
Depression
Risperidone and Suicidality in Major Depressive Disorder
The purpose of this trial is to investigate the efficacy of risperidone as an adjunct to an antidepressant treatment in the acute management of suicidality during an episode of major depressive disorder.
- Trial name
- NCT00167154
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Alabama at Birmingham
Physician-Assisted Suicide
Physician-assisted Dying in Mentally Ill Patients - Which Criteria Are Decisive?
Physician-assisted dying (PAD) is currently a highly controversial topic in medical ethics and public debates worldwide. It poses a moral conflict between the ethical principle of respect for patient autonomy and the ethical…
- Trial name
- NCT05492461
- Volunteers
- 20,000 people
- Sponsor
- Psychiatric Hospital of the University of Basel
Sleep Disturbance, Sleep
Sleep and Circadian Interventions for College Students at High Risk of Suicide
The purpose of this study is to examine the extent to which delivering sleep and circadian focused interventions in addition to evidenced based psychiatric care for depression and suicide risk may contribute to decreasing suicide…
- Conditions
- Sleep Disturbance, Sleep, Depression, Suicide
- Trial name
- REST-UP (NCT07346014)
- Testing
- Sleep Feedback + Psychoeducation, Transdiagnostic Sleep and Circadian Intervention + Bright Light (TSC+), Triple Chronotherapy (TCT+)
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- University of Pittsburgh
Death, Assisted, Tissue and Organ Procurement
Experience of Relatives and Intensive Care Units Caregivers of Controlled Donation After Circulatory Death
Controlled donation after circulatory death (cDCD) refers to organ donation (OD) from patients whose death is defined using circulatory criteria and from whom circulatory death occurs after a planned withdrawal of life-sustaining…
- Conditions
- Death, Assisted, Tissue and Organ Procurement, Life Support Care
- Trial name
- CARE-M3 (NCT05041023)
- Testing
- Relative section, Caregiver section
- Where
- France
- Volunteers
- 367 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris