Clinical trials: Suicide and Self-harm
Medication Adherence, Accidental Overdose
Blister Packaging Medication to Increase Treatment Adherence and Clinical Response
This quantitative, interview-based study will determine if increased prescription medication adherence via blister pack administration will reduce suicide related behavior among the high risk population of patients discharged…
- Conditions
- Medication Adherence, Accidental Overdose, Deliberate Overdose, Suicide, Attempted
- Trial name
- BP (NCT01118208)
- Testing
- Blister packaging medications, Dispense as usual
- Where
- United States
- Volunteers
- 303 people
- Sponsor
- VA Eastern Colorado Health Care System
Posttraumatic Stress Disorder, Borderline Personality Disorder
Cognitive Processing Therapy (CPT) for Posttraumatic Stress Disorder and Borderline Personality Disorder (PTSD-BPD)
Posttraumatic Stress Disorder (PTSD) with co-occurring Borderline Personality Disorder (BPD) (i.e., PTSD-BPD) is common (as high as 58%), debilitating, costly, and limited treatment options available for this population.
- Trial name
- NCT04230668
- Testing
- Cognitive Processing Therapy with Suicide Risk Management, Treatment as Usual with Suicide Rick Management
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- Palo Alto University
Anxiety Disorder, Mood Disorder
Does Spiritual/Religious Commitment Mediate the Relationship Between Mood Variability and Suicidal Ideation.
The purpose of this study is to determine whether or not spiritual and/or religious commitment affects mood variability and thoughts of suicide.
- Trial name
- NCT00225459
- Where
- Canada
- Volunteers
- 200 people
- Sponsor
- University of Saskatchewan
Depression
A Clinical Study of Trazodone Hydrochloride Prolonged-Release Tablets for Treatment of Depression
This is a multicenter, randomized, double-blind, parallel-group, placebo-controlled study to evaluate the efficacy and safety of trazodone hydrochloride prolonged-release tablets for treatment of depression in Chinese population.
- Trial name
- NCT01524497
- Testing
- Trazodone
- Where
- China
- Volunteers
- 382 people
- Sponsor
- Lee's Pharmaceutical Limited
Suicide Prevention
Adapting a Brief Suicide Intervention for Pediatric Primary Care: Enhancing Uptake and Impact
Suicide is a leading cause of death among adolescents in the United States and improving access to high quality just-in-time suicide interventions to reduce risk has important public health implications.
- Trial name
- NCT06499740
- Testing
- Pilot Intervention, Treatment as Usual
- Where
- 3 sites in United States
- Volunteers
- 48 people
- Sponsor
- University of Washington
Bipolar Disorder, Bipolar Depression
Efficacy of Convulsive Therapies for Bipolar Depression
This trial aims to assess the efficacy and tolerability of Magnetic Seizure Therapy (MST) as an alternative to electroconvulsive therapy (ECT) for Bipolar Disorder (BD).
- Conditions
- Bipolar Disorder, Bipolar Depression, Bipolar I Disorder, Bipolar II Disorder
- Trial name
- CORRECT-BD (NCT03641300)
- Testing
- Magnetic Seizure Therapy (MST), Electroconvulsive Therapy (ECT)
- Where
- 3 sites in Canada
- Volunteers
- 76 people
- Sponsor
- Centre for Addiction and Mental Health
Suicidal Behavior
Brief Intervention and Contact Program Main Trial
Suicide is a significant public health concern and causes approximately 1.5% of all deaths in the general population in Canada. Research shows that for individuals with comorbid psychiatric illness and suicidal behaviour, the…
- Trial name
- BIC (NCT05656781)
- Testing
- Brief Intervention and Contact (BIC) based on Word Health Organization (WHO)
- Where
- Canada
- Volunteers
- 132 people
- Sponsor
- St. Joseph's Healthcare Hamilton
Suicide
Culturally Centered CBT for Latinx Youth
The primary aim of the proposed research is to test the effect of a culturally centered treatment protocol, the Socio-cognitive behavioral therapy (SCBT), versus Treatment as Usual on suicidal thoughts and attempts, and…
- Trial name
- NCT04278157
- Testing
- Socio-Cognitive Behavioral Therapy for Suicidal Behavior (SCBT-SB), Treatment as Usual
- Where
- 2 sites in United States
- Volunteers
- 114 people
- Sponsor
- Bradley Hospital
Adverse Mental/Physical Effects of Low Dose S. Tortuosum.
Safety Study of the Effect of Scelectium Tortuosum (as Zembrin®)in Aged Normals
Phosphodiesterase is a candidate for the Rx \& prevention of cognitive and psychotic disorders. Since caffeine targets primarily PDE4(Phosphodiesterase subtype 4), caffeine analogs have been developed to mimic the actions of…
- Trial name
- NCT01805518
- Testing
- Scelectium Tortuosum
- Where
- Puerto Rico
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Woodbury, Michel, M.D.
Suicide and Self-harm
The Effect of a Brief Psychological Intervention on Reducing Self-harm Repetition: Feasibility Study
Recent research has focused on examining brief interventions for reducing self-harm, such as the volitional help sheet (VHS). The VHS is a theory-based psychological intervention.
- Trial name
- NCT03376113
- Testing
- the volitional help sheet
- Where
- Taiwan
- Volunteers
- 68 people
- Sponsor
- National Taiwan University Hospital
Lethal Means Safety
Leveraging Video Vignettes and Social Media to Promote Safe Firearm Storage Among Veterans
Family and friends are trusted by Veterans, and can play a vital role in supporting Veteran suicide prevention. Veterans are more likely to adopt secure firearm storage if their loved ones discuss firearm safety with them and if…
- Trial name
- WAV (NCT07756697)
- Testing
- WAV videos, VA News videos, VA LMS brochure
- Where
- United States
- Volunteers
- 654 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Suicidal Behaviors
AN EXTENDED COHORT STUDY TO INVESTIGATE SUICIDAL BEHAVIOR IN SPAIN (THE SURVIVE 2 STUDY)
The goal of this observational study is to learn more about people who come to emergency departments in Spain after a suicide attempt and to find ways to prevent another attempt.
- Trial name
- SURVIVE 2 (NCT07554729)
- Where
- 2 sites in Spain
- Volunteers
- 3,600 people
- Sponsor
- Parc de Salut Mar
Suicidal Ideation, Major Depressive Disorder
Low Amplitude Pulse Seizure Therapy Versus Standard Ultra-Brief Right Unilateral Electroconvulsive Therapy
This protocol proposes an initial randomized clinical trial that includes all patients with suicidal ideation (SI) at baseline, and with SI as the primary outcome measure to examine whether Right Unilateral Low-Amplitude Pulse …
- Conditions
- Suicidal Ideation, Major Depressive Disorder, Schizo Affective Disorder, Bipolar Disorder
- Trial name
- LAP-ST vs ECT (NCT06529029)
- Testing
- Sigma-Stim, RUL LAP-ST (Low-Amplitude Pulse Seizure Therapy - Right Unilateral)
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Michigan State University
Suicide Attempt, Suicide Ideation
A One-Arm Open Trial of a Smartphone Delivered Treatment for Suicidal Thoughts and Behavior
This study aims to evaluate the acceptability, safety, and preliminary efficacy of a smartphone-delivered intervention called Therapeutic Evaluative Conditioning for Suicide (TEC-S) in reducing suicidal thoughts and behaviors…
- Trial name
- NCT06967545
- Testing
- Smartphone-delivered Therapeutic Evaluative Conditioning for Suicide (TEC-S)
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Massachusetts General Hospital
Self Harm, Depression
Computer Assisted Family Intervention to Treat Self-Harm Disparities in Latinas and Sexual/Gender Minority Youth
This study is designed to refine and test the efficacy of a computer assisted culturally informed and flexible/adaptive intervention for Latino adolescents for whom self-harm behaviors are a health disparity-specifically, Latinas…
- Conditions
- Self Harm, Depression, Emotion Dysregulation, Suicidal Ideation
- Trial name
- NCT03709472
- Testing
- Computer Assisted CIFFTA, Behavioral: Traditional face-to-face treatment-no technology
- Where
- United States
- Volunteers
- 172 people, healthy volunteers welcome
- Sponsor
- University of Miami
Suicidal Ideation, Depression
Trial of the Rapid Antisuicidal Effects of Intranasal Ketamine in Comorbid Depression and Alcohol Abuse
This project aims to evaluate the potential rapid and sustained antisuicidal and antidepressant effects of a single intranasal dose of ketamine in inpatients during a mood episode in Major Depressive Disorder (MDD) or Bipolar…
- Conditions
- Suicidal Ideation, Depression, Alcohol Abuse
- Trial name
- NCT03539887
- Testing
- Intranasal ketamine
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- The University of Texas Health Science Center, Houston
Depression, Anxiety, Post Traumatic Stress Disorder
Adaptation and Evaluation of the KEEP Model
This study capitalizes on an opportunity to formally evaluate local adaptations of "Keeping Foster and Kinship Parents Supported and Trained" (KEEP), an evidence-based foster parent intervention, to reduce mental health…
- Conditions
- Depression, Anxiety, Post Traumatic Stress Disorder, Suicide and Self-harm, Externalizing Behavior
- Trial name
- NCT05816421
- Testing
- KEEP, Non-Affinity KEEP
- Where
- United States
- Volunteers
- 283 people
- Sponsor
- Oregon Social Learning Center
Bipolar Disorder, Suicidal Ideation
An fMRI Study on Temporal Discounting in Bipolar Disorder
The investigators propose to explore the link between bipolar disorder, anxiety, and suicide by investigating intertemporal discounting in depressed, suicidal patients with bipolar I and II disorder who have various levels of…
- Conditions
- Bipolar Disorder, Suicidal Ideation, Depression
- Trial name
- NCT02323763
- Testing
- fMRI Scanning
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- Massachusetts General Hospital
Suicide Attempt
Treating Suicidality Remotely
Background: Practical and psychological barriers make it difficult for people with Suicidal Thoughts and Behaviors (STBs) to get professional help.
- Trial name
- TREASURE (NCT06370104)
- Testing
- Brief Cognitive Behavioral Therapy for Suicide Prevention, Living under control
- Where
- Netherlands
- Volunteers
- 364 people
- Sponsor
- 113 Suicide Prevention
Self-harm
Suicide Prevention by Empowering Adolescents in Pakistan (SEPAK)
Self-harm is now seen as an epidemic affecting young people across the world and particularly in low and middle-income countries (LMIC) such as Pakistan.
- Trial name
- SEPAK (NCT04969718)
- Testing
- LEADS Plus educational posters, Question, Persuade, and Refer (Teachers) Plus educational posters, Screening by Professionals programme plus educational posters
- Where
- 8 sites in Pakistan
- Volunteers
- 1,350 people, healthy volunteers welcome
- Sponsor
- Pakistan Institute of Living and Learning