Clinical trials: Supportive Therapy
Acute Lung Injury
Evaluation of Variable Pressure Support Ventilation in the Therapy of Acute Lung Injury
Variable pressure support during assisted spontaneous breathing (noisy PSV) has been shown to improve the respiratory function in experimental acute lung injury (ALI).
- Trial name
- EVA (NCT00786292)
- Testing
- Assisted mechanical ventilation
- Where
- Germany
- Sponsor
- Technische Universität Dresden
Fibromyalgia
MDMA-assisted Therapy for Fibromyalgia
Fibromyalgia is a debilitating chronic pain disorder. Based on prior research with MDMA, it can be hypothesized MDMA-assisted therapy in fibromyalgia patients may increase the range of positive emotions, interpersonal trust, and…
- Trial name
- NCT06066853
- Testing
- MDMA
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Spaulding Rehabilitation Hospital
Dexmedetomidine, Ketamine
Safety and Efficacy of Esketamine - Dexmedetomidine Combination Versus Dexmedetomidine Monotherapy for Hyperactive Delirium in ICU Patients on Non-Invasive Respiratory Support (SEED-NIRS Trial): Study Protocol of a Randomized Controlled Trial
This investigator-initiated, randomized, controlled, single-blind, superiority trial aims to assess the efficacy and safety of esketamine combined with dexmedetomidine for the management of agitation or delirium in intensive care…
- Conditions
- Dexmedetomidine, Ketamine, Analgesia, Respiratory Therapy
- Trial name
- SEED-NIRS (NCT07377981)
- Testing
- Esketamine combined with dexmedetomidine, Dexmedetomidine
- Where
- China
- Volunteers
- 356 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
TTR Cardiac Amyloidosis
A Study of Doxycycline and Tauroursodeoxycholic Acid (Doxy/TUDCA) Plus Standard Supportive Therapy Versus Standard Supportive Therapy Alone in Cardiac Amyloidosis Caused by Transthyretin
Cardiac amyloidosis caused by transthyretin either mutated (in ATTRm amyloidosis) or wildtype (in ATTRwt, formerly senile, amyloidosis) is a rare disease but is diagnosed with increasing frequency thanks to the availability of…
- Trial name
- NCT03481972
- Testing
- Doxycycline and tauroursodeoxycholic acid, Standard of care
- Where
- Italy
- Volunteers
- 102 people
- Sponsor
- Fondazione IRCCS Policlinico San Matteo di Pavia
Chemotherapy-induced Neutropenia
Balugrastim (Neugranin) in Breast Cancer Participants Receiving Doxorubicin/Docetaxel
Determination of the effect of balugrastim on the duration and severity of severe neutropenia.
- Trial name
- NEUGR-002 (NCT00837265)
- Testing
- Balugrastim, Pegfilgrastim, Chemotherapy Regimen
- Volunteers
- 334 people
- Sponsor
- Teva Branded Pharmaceutical Products R&D, Inc.
HIV/AIDS
Motivation Matters Study
The study aims to develop and evaluate the efficacy and causal mechanisms of an interactive SMS intervention to optimize individual health and secondary HIV prevention benefits of ART in HIV-positive FSWs.
- Trial name
- MM (NCT02627365)
- Testing
- Individualized, interactive short messaging intervention
- Where
- Kenya
- Volunteers
- 119 people
- Sponsor
- University of Washington
Mindfulness, Meditation
Mindfulness to Enhance Quality of Life and Support Advance Care Planning
The MEANING trial is a randomized controlled mixed methods pilot designed to compare a novel mindfulness meditation-based intervention (MEANING) to usual care for adults with advanced-stage solid malignancies and their family…
- Conditions
- Mindfulness, Meditation, Metastatic Cancer, Quality of Life
- Trial name
- MEANING (NCT03257007)
- Testing
- Mindfulness
- Where
- United States
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- Indiana University
Vulvar Cancer, Quality of Life
Quality of Life, Unmet Needs and Satisfaction With Care After Vulvar Cancer
The aim of this prospective, longitudinal Swedish multi-center study is to assess the quality of life, treatment-related morbidity, unmet needs and satisfaction with care after treatment for vulvar cancer, evaluated by a…
- Trial name
- PROVE (NCT04152512)
- Testing
- Questionnaire administration
- Where
- 4 sites in Sweden
- Volunteers
- 153 people
- Sponsor
- Karolinska University Hospital
Postoperative Nausea and Vomiting
Implementation Study of the PostOperative Nausea and Vomiting Prediction Rule
This study evaluates whether the implementation of a prediction rule for postoperative nausea and vomiting changes physician behaviour, improves patient outcome and improves cost-effectiveness of treatment of postoperative nausea…
- Trial name
- NCT00293618
- Testing
- Automatic Risk Presentation in the operating room, Education, Feedback
- Where
- Netherlands
- Volunteers
- 11,970 people
- Sponsor
- UMC Utrecht
Bone Sarcoma, Osteosarcoma
Efficacy of Regorafenib Combined With Best Supportive Care as Maintenance Treatment in High Grade Bone Sarcomas Patients
This is a multicenter phase II study concerning patients with high-grade bone sarcoma (HGBS) without complete remission after standard treatment at diagnosis or at relapse.
- Trial name
- REGOMAIN (NCT04698785)
- Testing
- Treatment by regorafenib and best supportive care
- Where
- 16 sites in France
- Volunteers
- 36 people
- Sponsor
- Centre Leon Berard
Deep Vein Thrombosis, Superficial Thrombophlebitis
DOACT Algorithm Versus AI-Based Decision Models in Oral Anticoagulant Therapy for Vascular Patients
Study using a decision algorithm for the application of an oral anticoagulant calculator in vascular diseases, aimed at validating a clinical decision-support tool for conditions such as deep vein thrombosis, superficial…
- Conditions
- Deep Vein Thrombosis, Superficial Thrombophlebitis, Pulmonary Thromboembolisms, Clinical Decision Support Systems
- Trial name
- DOACT (NCT07290608)
- Testing
- DOACT algorithm, No algorithm, LLM-based tools
- Where
- Brazil
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- ITALO EUGENIO SOUZA GADELHA DE ABREU
Quality of Life
Effect of Nurse-led Supportive Care on Quality of Life
Breast cancer is the most common type of cancer in women with a high mortality rate in the world. The several methods are used in the treatment of breast cancer.
- Trial name
- NCT05399160
- Testing
- Nurse-led Supportive Care
- Where
- Turkey (Türkiye)
- Volunteers
- 42 people
- Sponsor
- Izmir Bakircay University
Hand, Hand Therapy
Early Functional Response as a Predictor of Clinical Outcomes in Hand Rehabilitation: A Prospective Feasibility Study Using a Digital Monitoring System
This study investigates whether early changes observed during the first weeks of hand and upper extremity rehabilitation can predict patient outcomes months later.
- Conditions
- Hand, Hand Therapy, Upper Extremity, Prediction Models
- Trial name
- HANDREHPREDICT (NCT07522060)
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Hacettepe University
Squamous Cell Carcinoma of Hypopharynx, Squamous Cell Carcinoma of Larynx
Scheduled IV Fluids in the Supportive Management of Patients Undergoing Chemo-radiotherapy for Head and Neck Cancer
Patients undergoing concurrent chemoradiotherapy (CCRT) for head and neck squamous cell carcinoma frequently experience treatment-related toxicities including mucositis, dysphagia, acute kidney injury, pain, constipation…
- Conditions
- Squamous Cell Carcinoma of Hypopharynx, Squamous Cell Carcinoma of Larynx, Squamous Cell Carcinoma of Oropharynx, Squamous Cell Carcinoma of Oral Cavity
- Trial name
- NCT07784855
- Testing
- Scheduled IV Hydration, Clinician Assessment-Based IV Hydration
- Where
- 6 sites in United States
- Volunteers
- 180 people
- Sponsor
- West Virginia University
Eating Disorders
Comparing Two Group Therapy Treatments for Binge Eating Disorder
This study will compare two different approaches for the treatment for Binge Eating Disorder.
- Trial name
- NCT00071578
- Testing
- Group Psychotherapy-Negative Emotion Focus, Group Psychotherapy- Self-Esteem Focus
- Where
- United States
- Volunteers
- 101 people
- Sponsor
- Stanford University
Functional Somatic Disorder, Somatic Symptom Disorder
Internet Based Emotional Awareness and Expression Therapy for Functional Somatic Disorder With and Without Therapist Support
Functional somatic syndromes (e.g. irritable bowel syndrome, fibromyalgia) and medically unexplained symptoms (e.g. chronic primary pain) are very common in primary care.
- Conditions
- Functional Somatic Disorder, Somatic Symptom Disorder, Functional Somatic Syndromes
- Trial name
- NCT06301360
- Testing
- Internet based Emotional Awareness and Expression Therapy (I-EAET)
- Where
- 2 sites in Sweden
- Volunteers
- 150 people
- Sponsor
- Daniel Maroti
Inappropriate Prescribing
The Study in Outpatient Medicine Using Nudges to Improve Sleep
The goal of this clinical trial is to learn if electronic health record (EHR) nudges (changes to the EHR that do not restrict freedom of choice or alter incentives) can reduce Z-drug prescribing in primary care clinics for…
- Trial name
- SOMNUS (NCT06640023)
- Testing
- Z-drug Default Quantity, Redirection + Accountable Justification
- Where
- United States
- Volunteers
- 444 people
- Sponsor
- University of Southern California
Endometrial Cancer
Social Interventions for Support During Treatment for Endometrial Cancer and Recurrence
The SISTER study is a randomized trial, looking at various modalities of social support for Black patients undergoing treatment for endometrial cancer.
- Trial name
- SISTER (NCT04930159)
- Testing
- Facilitated group support, 1:1 Peer Support
- Where
- 11 sites in United States
- Volunteers
- 252 people
- Sponsor
- University of Washington
Head and Neck Cancer
Medical Cannabis During Chemoradiation for Head and Neck Cancer
The primary purpose of the study is to observe the adherence and health seeking behavior of patients with Head and Neck cancer (HNC) certified to obtain medically certified cannabis as part of their supportive care regimen…
- Trial name
- NCT03431363
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Albert Einstein College of Medicine
Atrial Fibrillation, Prescribing Practices
Supporting Use of AC Through Provider Profiling of Oral AC Therapy for AF
The SUPPORT-AF study aims to improve rates of anticoagulation (AC) in atrial fibrillation (AF) patients by developing and delivering supportive tools and educational materials to providers treating patients with AF.
- Conditions
- Atrial Fibrillation, Prescribing Practices, Anticoagulants
- Trial name
- SUPPORT-AF (NCT03583008)
- Testing
- Anticoagulation (AC) Intervention--Academic Detailing, Anticoagulation (AC) Intervention--Prescribing Practices
- Where
- United States
- Volunteers
- 112 people, healthy volunteers welcome
- Sponsor
- University of Massachusetts, Worcester
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