Clinical trials: Supportive Therapy
Delirium, Neurocognitive Disorders
Evaluating Novel Healthcare Approaches to Nurturing and Caring for Hospitalized Elders
The goal of this clinical trial is to compare the Hospital Elder Life Program (HELP) with a family-augmented version of HELP (FAM-HELP), that includes family members and care partners, for the prevention of delirium in older…
- Conditions
- Delirium, Neurocognitive Disorders, Mild Cognitive Impairment, Alzheimer Disease
- Trial name
- ENHANCE (NCT05929703)
- Testing
- HELP, FAM-HELP
- Where
- 7 sites in United States
- Volunteers
- 1,900 people
- Sponsor
- University of Michigan
Oral Mucositis, Stomatitis
A Phase II Controlled Trial of Velafermin for Prevention of Oral Mucositis
CG53135-05 (velafermin), a recombinant human fibroblast growth factor-20 (rhFGF-20) protein, is under investigation for the prevention of oral mucositis.
- Trial name
- NCT00323518
- Testing
- velafermin
- Where
- 33 sites in United States
- Volunteers
- 390 people
- Sponsor
- CuraGen Corporation
Low Female Sexual Desire
Randomized Comparison of Mindfulness Versus Group Support for Treatment of Low Sexual Desire in Women
The purpose of this study is to determine whether an 8-session mindfulness-based intervention (MBCT group) is effective for women with low sexual interest/desire in reducing sexual distress, improving their sexual response, and…
- Trial name
- DESIRE (NCT01690897)
- Testing
- Mindfulness-based treatment, Sex therapy, education, and support treatment
- Where
- Canada
- Volunteers
- 149 people
- Sponsor
- University of British Columbia
Liver Failure, Critical Care
Oxidative Stress and Microcirculation in Patient With Hepatic Failure Undergoing Liver Support Treatment
Background: In patients undergoing hemodialysis or hemofiltration will suffer from the injury of reactive oxidative species. Oxidative stress will affect cell membrane, protein, and DNA.
- Trial name
- NCT00772252
- Testing
- liver support treatment
- Where
- Taiwan
- Volunteers
- 80 people
- Sponsor
- National Taiwan University Hospital
Patient Compliance, Patient Adherence
Motivational Interviewing to Support Oral AntiCoagulation Adherence in Patients With Non-valvular Atrial Fibrillation (MISOAC-AF)
The purpose of the study is to investigate the impact of motivational interviewing in the adherence of patients with AF to oral anticoagulation (OAC) regimens.
- Trial name
- MISOAC-AF (NCT02941978)
- Testing
- Motivational interview, Control
- Where
- Greece
- Volunteers
- 1,140 people
- Sponsor
- AHEPA University Hospital
Psychological Distress, Depression - Major Depressive Disorder
Internet-based Support for Adjustment to Prostate Cancer
The study aims to study the efficacy of internet-based cognitive behavior therapy (ICBT) in reducing subjective distress and comorbid psychiatric symptoms in men diagnosed with prostate cancer.
- Conditions
- Psychological Distress, Depression - Major Depressive Disorder, Insomnia, Anxiety
- Trial name
- ISAC (NCT06766526)
- Testing
- Internet-based cognitive behavioral therapy, Non-directive support
- Where
- Sweden
- Volunteers
- 180 people
- Sponsor
- Linkoeping University
Liver Cirrhosis, Kidney Failure, Acute
Intermittent ADVOS vs. Hemodialysis in Non-intensive Care Patients With Liver Dysfunction
In the planned randomized controlled prospective pilot study, we aim to evaluate ADVOS compared with conventional hemodialysis regarding the elimination of protein-bound toxins in patients with therapy-refractory hepatorenal…
- Conditions
- Liver Cirrhosis, Kidney Failure, Acute, Kidney Replacement, Multi Organ Failure
- Trial name
- ADVOMITTENT (NCT06129617)
- Testing
- Hemodialysis, ADVOS
- Where
- Germany
- Volunteers
- 14 people
- Sponsor
- University Medical Center Mainz
Breast Cancer, Colorectal Cancer
AI-Assisted Chemotherapy Side Effect Management
This two-stage adaptive randomized controlled trial evaluates the feasibility and preliminary efficacy of large language model (LLM)-assisted intervention for managing chemotherapy side effects in patients with solid tumors.
- Trial name
- ALLIANCE (NCT07198581)
- Testing
- LLM-assisted chemotherapy side effect management
- Where
- South Korea
- Volunteers
- 174 people
- Sponsor
- Incheon St.Mary's Hospital
Insomnia Type; Sleep Disorder, Cognitive Impairment
Digital Sleep Therapy for Older Adults With Cognitive Impairment
This study aims to determine the efficacy of digital Behavioural Therapy for Insomnia (dBTi) compared to online sleep health education (control) at reducing insomnia symptom severity (Insomnia Severity Index: ISI) in older adults…
- Trial name
- ExCEED (NCT05173844)
- Testing
- SleepFix mobile application
- Where
- Australia
- Volunteers
- 128 people
- Sponsor
- Woolcock Institute of Medical Research
Hepatitis C, HIV Coinfection
Supporting Treatment Outcomes Among PWID
The goal of this study is to improve HCV care continuum outcomes for people who inject drugs (PWID), reduce potential onward transmission to others and improve HIV outcomes among those who are HIV/HCV coinfected.
- Trial name
- STOP-C (NCT04652804)
- Testing
- Low intensity HCV treatment adherence support, Medium intensity HCV treatment adherence support, High intensity HCV treatment adherence support
- Where
- India
- Volunteers
- 3,000 people
- Sponsor
- Johns Hopkins University
Generalized Anxiety Disorder (GAD), Major Depressive Disorder (MDD)
AI-Supported Therapy for Depression and Anxiety Compared With Standard CBT
This study is a pivotal, randomised, controlled, non-inferiority trial evaluating "Nook," an AI-delivered, neurosymbolic, clinician-supervised digital psychological intervention for depression and anxiety, compared with standard…
- Trial name
- NCT07620340
- Testing
- AI-Digital CBT, Cognitive Behavioural Therapy
- Volunteers
- 400 people
- Sponsor
- PsyScale
Periodontal Diseases
Evaluation of a Herbal Antiseptic Gel as a Supportive Treatment for Teeth Cleaning in Patients With Periodontal Disease
The goal of this clinical trial is to learn if the herbal gel is more effective as compared to placebo in reducing periodontal inflammation in patients with periodontal disease.
- Trial name
- NCT07135674
- Testing
- herbal drug
- Where
- India
- Volunteers
- 50 people
- Sponsor
- Rungta College of Dental Sciences and Research
Supportive Care, Childhood Cancer
Home Chemotherapy Intervention for Children With Cancer - a Feasibility Study
Children with cancer undergo intensive treatment with many serious side effects and frequent in- and outpatient visits. Studies show that the frequent hospitalizations are very disruptive to children and their families, who…
- Trial name
- INTACTatHome (NCT05372536)
- Testing
- parent-led home-administered low-dose Cytarabine
- Where
- Denmark
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Depression, Diabetes
Training Doctors to Support Patient Self-Care of Depression
This study will determine whether practicing primary care providers (PCPs) can be trained to support patient self-care of depression and co-existing diabetes during office visits, and begin to explore whether this might improve…
- Trial name
- NCT01618552
- Testing
- SEE IT training, Knowledge enhancement
- Where
- 2 sites in United States
- Volunteers
- 182 people
- Sponsor
- University of California, Davis
Breast Neoplasms, Alopecia
Effect of Cryotherapy in the Prevention of Madarosis Produced by Chemotherapy in Breast Cancer Patients
Chemotherapy-induced alopecia (CIA) significantly compromises body image in breast cancer patients, particularly when involving eyebrow and eyelash loss (madarosis).
- Conditions
- Breast Neoplasms, Alopecia, Madarosis, Eyebrow Diseases
- Trial name
- NCT06955702
- Testing
- cryotherapy for chemotherapy-induced madarosis
- Where
- 2 sites in Spain
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Salamanca
Oral Mucositis, Head and Neck Neoplasms
Laser vs Ozone Therapy for Oral Mucositis in Cancer Patients
This randomized clinical trial aims to compare the efficacy of laser therapy and ozone therapy in the treatment of oral mucositis in adult cancer patients undergoing chemotherapy or radiotherapy, particularly those with head and…
- Conditions
- Oral Mucositis, Head and Neck Neoplasms, Hematologic Neoplasms
- Trial name
- LOMUC (NCT07069153)
- Testing
- Laser Therapy, Ozone therapy
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- University of Pavia
Sleep Apnea, Obstructive
Group-based Peer Support Versus Individual Education for Patients Undergoing CPAP Treatment
The investigators will compare two alternatives designed to maximize adherence to continuous positive airway pressure (CPAP) therapy for obstructive sleep apnea (OSA) - peer-support administered in groups, versus individual…
- Trial name
- NCT02538419
- Testing
- CPAP + Peer Support, CPAP + Individual Education
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Brigham and Women's Hospital
Coronary Artery Disease
Heart tEam Decision-making Assisted by Revaz AI Trial
Coronary artery disease, the narrowing of the blood vessels that supply the heart, is the leading cause of death worldwide. About 2.4 million Canadian adults live with it.
- Trial name
- HEART-AI (NCT07837765)
- Testing
- Revaz AI
- Where
- 2 sites in Canada
- Volunteers
- 712 people
- Sponsor
- University of Calgary
Brain and Central Nervous System Tumors
Chemotherapy, Radiation Therapy, and Peripheral Stem Cell Transplantation in Treating Children With Newly Diagnosed Medulloblastoma or Supratentorial Primitive Neuroectodermal Tumor
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining chemotherapy and radiation therapy with peripheral stem cell transplantation may allow the doctor…
- Trial name
- NCT00003211
- Testing
- filgrastim, amifostine trihydrate, cisplatin
- Where
- 4 sites in United States, Australia
- Volunteers
- 94 people
- Sponsor
- St. Jude Children's Research Hospital
Autistic Disorder, Autism Spectrum Disorder
Cognitive Enhancement Therapy for Adult Autism Spectrum Disorder
This study will investigate and contrast the effects of two psychological treatments for adults with autism spectrum disorder. Cognitive Enhancement Therapy (CET) is a cognitive remediation intervention that aims to help adults…
- Conditions
- Autistic Disorder, Autism Spectrum Disorder, Asperger's Syndrome, Pervasive Developmental Disorder
- Trial name
- Perspectives (NCT00902798)
- Testing
- Cognitive Enhancement Therapy, Enriched Supportive Therapy
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- University of Pittsburgh