Clinical trials: Supportive Therapy
Depression
A Study to Assess Feasibility of Using Clinician-directed and Digital Application Supported Cognitive Behavior Therapy (CBT) in Conjunction With Esketamine in Participants With Treatment-resistant Depression
The purpose of this study is to explore feasibility of combining clinician-directed cognitive behavioral therapy (CBT) supplemented with the Mindset app with esketamine therapy in participants with Treatment-resistant Depression.
- Trial name
- NCT05268497
- Testing
- Esketamine, Cognitive Behavioral Therapy (CBT), Antidepressant
- Where
- 5 sites in United States
- Sponsor
- Janssen Research & Development, LLC
Frailty Syndrome, Exercise
Frailty Syndrome of Post-cancer Treatment Eldery Patients
Decrease the prevalence of frailty syndrome in individuals with complete response of cancer.
- Conditions
- Frailty Syndrome, Exercise, Nutritional Support, Cancer
- Trial name
- PANACEE (NCT04746768)
- Testing
- exercise and nutritional support
- Where
- France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Grenoble
Distalization, Class II Malocclusion
Comparison of Distalization of Maxillary First and Second Molars Between a Miniscrew Implant Supported Device and Clear Aligners.
The goal of this randomized clinical trial is to compare distalization of maxillary first and second molars achieved with a device supported with mini screw implants in the palate (Advanced Molar Distalization Appliance, AMDA®)…
- Conditions
- Distalization, Class II Malocclusion, Aligner Therapy, Distalization by Miniscrews
- Trial name
- NCT07040176
- Testing
- Upper molar distalization
- Where
- Greece
- Volunteers
- 40 people
- Sponsor
- Aristotle University Of Thessaloniki
Prostate Cancer
Multidisciplinary Care After Prostatectomy
This is a pilot, prostective, comparative, randomized, monocentric open-label study whose main objective is to determine whether appropriate psychological, nutritional and physical activity support can improve the quality of life…
- Trial name
- MCAP (NCT05644197)
- Testing
- Multidisciplinary program
- Volunteers
- 100 people
- Sponsor
- Provence Private hospital
Breast Neoplasms
Mobile Application Support for Women With Breast Cancer Undergoing Chemotherapy
Mobile phones have become an essential tool for everyday life. The convenience and easy accessibility of the data and information received through mobile phones have made mobile applications as the latest trend to provide…
- Trial name
- NCT05072197
- Testing
- Mobile device as a support tool for the treatment of women with breast cancer undergoing chemotherapy
- Where
- Taiwan
- Volunteers
- 70 people
- Sponsor
- Cheng-Hsin General Hospital
Obstructive Sleep Apnea
PAP Adherence After Diet/Lifestyle Intervention in OSA Patients
The aim of this study is to explore the role of diet/lifestyle intervention on Positive airway pressure (PAP) treatment adherence in patients with obstructive sleep apnea (OSA).Specifically, we evaluated the effects of a…
- Trial name
- NCT05881824
- Testing
- MDG intervention
- Where
- Greece
- Volunteers
- 74 people
- Sponsor
- University of Crete
Patient Empowerment, Low Anterior Resection Syndrome
Interactive Online Informational and Peer Support App for Patients with Low Anterior Resection Syndrome
After surgery for rectal cancer, many people undergo changes in bowel habits, which may include the need to empty their bowels more often, accidental leakage of stool or gas, the sudden urge to go to the bathroom, and more.
- Conditions
- Patient Empowerment, Low Anterior Resection Syndrome, Colo-rectal Cancer, Peer Group
- Trial name
- NCT04469426
- Testing
- Interactive online informational and peer support app
- Where
- 5 sites in Canada
- Volunteers
- 101 people, healthy volunteers welcome
- Sponsor
- Jewish General Hospital
Diabetes Mellitus, Chronic Disease
Patient Activation Through Community Empowerment/Engagement for Diabetes Management (PACE-D)
The study is a non-randomised controlled trial involving an intervention group and a control group. It aims to evaluate the effects of a patient engagement and empowerment model of collaborative care support planning on clinical…
- Conditions
- Diabetes Mellitus, Chronic Disease, Patient Care Planning, Patient Participation
- Trial name
- PACE-D (NCT04288362)
- Testing
- Intervention Group, Control Group
- Where
- Singapore
- Volunteers
- 1,620 people
- Sponsor
- National University Health System, Singapore
Class III Malocclusion, Skeletal Malocclusion
Comparison of Skeletal Anchorage Versus Conventional Tooth-Borne Face Mask Therapy Following the Alt-RAMEC Protocol
This study investigated two different methods of maxillary protraction in growing patients with skeletal Class III malocclusion characterized by maxillary deficiency.
- Conditions
- Class III Malocclusion, Skeletal Malocclusion, Maxillary Deficiency
- Trial name
- MiniFM (NCT07279662)
- Testing
- Skeletal Anchorage Supported Maxillary Protraction, Tooth-Borne Maxillary Protraction Appliance
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Murat Kaan Erdem
Tobacco Use Disorder, Nicotine Dependence
TUBSIS 2.0 - Tobacco Use Behavioral Support and Intervention System
Background: Tobacco smoking and vaping remains public health concern, with many adults continuing to experience difficulties accessing appropriate support for smoking cessation in Switzerland and Türkiye.
- Conditions
- Tobacco Use Disorder, Nicotine Dependence, Vaping, Smoking Tobacco
- Trial name
- TUBSIS_2_0 (NCT07568483)
- Testing
- TUBSIS 2.0
- Where
- Switzerland
- Volunteers
- 406 people
- Sponsor
- University of Zurich
Dysphagia, Non-Small Cell Lung Cancer
Study to Evaluate Palifermin in the Reduction of Dysphagia in Patients With Locally Advanced Non-Small Cell Lung Cancer (NSCLC)
The purpose of this study is to determine if palifermin will reduce the incidence of dysphagia in patients receiving concurrent chemoradiotherapy followed by consolidation chemotherapy for treatment of unresectable stage III…
- Conditions
- Dysphagia, Non-Small Cell Lung Cancer, Lung Cancer
- Trial name
- NCT00094861
- Testing
- Palifermin, Radiotherapy, Paclitaxel
- Volunteers
- 100 people
- Sponsor
- Swedish Orphan Biovitrum
Leukemia, Myeloid, Acute
An Efficacy and Safety Study of Oral Azacitidine (CC-486) as Maintenance Therapy in Chinese Participants With Acute Myeloid Leukemia in Complete Remission
The purpose of this study is to evaluate the efficacy and safety of Oral Azacitidine (CC-486) in Chinese participants with acute myeloid leukemia in complete remission.
- Trial name
- NCT05413018
- Testing
- CC-486
- Where
- 34 sites in China
- Volunteers
- 34 people
- Sponsor
- Bristol-Myers Squibb
HIV/AIDS, Adolescent Behavior
Youth Power Action Feasibility Study of Online Support Group Intervention Among Adolescents Living With HIV in Nigeria
This study will examine the feasibility and acceptability of an intervention designed to improve retention in HIV care services and improve anti-retroviral therapy (ART) adherence among adolescents ages 15-19 years living with…
- Conditions
- HIV/AIDS, Adolescent Behavior, Medication Adherence, Health Behavior
- Trial name
- NCT03076996
- Testing
- Online support group
- Where
- Nigeria
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- FHI 360
Care Burden, Care Giving Burden
Caring for the Carer
The purpose of the present study is to investigate the acceptability and feasibility of implementing a novel, Cognitive Behavioral Therapy (CBT) intervention to caregivers and supporters of individuals who have experienced…
- Conditions
- Care Burden, Care Giving Burden, Caregiver Burnout, Caregiver Wellbeing
- Trial name
- CFC (NCT07167641)
- Testing
- Cognitive Behavioral Therapy for Caregivers
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Prostate Cancer Patients
AI Chatbot for Prostate Radiation Therapy Patient Education
This study will evaluate whether an artificial intelligence chatbot can help patients better understand radiation therapy for localized prostate cancer.
- Trial name
- NCT07719062
- Testing
- AI Educational Chatbot
- Volunteers
- 50 people
- Sponsor
- Brigham and Women's Hospital
Heart Failure With Reduced Ejection Fraction (HFrEF), Sacubitril/Valsartan
Evaluating Dashboard-Integrated Pharmacist-Led Education on Improving Sacubitril/Valsartan Adherence in Heart Failure (PharmD ASSIST HFrEF)
The goal of this pragmatic clinical trial is to evaluate whether pharmacist-led education, integrated with interactive visualization dashboards, can enhance medication adherence in patients with heart failure who are prescribed…
- Conditions
- Heart Failure With Reduced Ejection Fraction (HFrEF), Sacubitril/Valsartan, Medication Adherence
- Trial name
- NCT06900803
- Testing
- interactive visualization dashboard (the Enhancing Sacubitril/valsartan Adherence from Initiation to Continuation [ESAIC] dashboard)
- Volunteers
- 200 people
- Sponsor
- National Taiwan University Hospital
Cancer
Examining Early Palliative Care in Newly Diagnosed Cancer Patients
To understand the impact of initiation of palliative care in this low-resource setting, and whether palliative care is a cost-reducing intervention that will improve patient-reported outcomes and quality of life.
- Trial name
- NCT03712436
- Testing
- Palliative care, Standard oncological care
- Where
- Ethiopia
- Volunteers
- 98 people
- Sponsor
- Yale University
Gout
Gout Self-Monitoring Aiming to Reach Target
This study evaluates whether a supported self-management approach to gout is able to achieve target levels of serum urate, and better control of gout flares.
- Trial name
- Gout-SMART (NCT03274063)
- Testing
- Supported self-management, Usual care
- Where
- United Kingdom
- Volunteers
- 60 people
- Sponsor
- University of Edinburgh
Hepatocellular Carcinoma
A Study of Ramucirumab (IMC-1121B) Drug Product (DP) and Best Supportive Care (BSC) Versus Placebo and BSC as 2nd-Line Treatment in Participants With Hepatocellular Carcinoma After 1st-Line Therapy With Sorafenib
This is a Phase 3 multicenter, randomized study evaluating the safety and efficacy of ramucirumab DP plus BSC as a double-blind, placebo-controlled (placebo plus BSC) comparison.
- Trial name
- REACH (NCT01140347)
- Testing
- Ramucirumab DP (IMC-1121B), BSC
- Where
- 146 sites in United States, Australia and 25 more
- Volunteers
- 565 people
- Sponsor
- Eli Lilly and Company
HIV Antiretroviral Therapy (ART) Adherence
Optimizing Care Delivery to Support Reengagement in PLWH Returning to HIV Care After Treatment Lapses in Zambia
1.0 Introduction The scale-up of human immunodeficiency virus (HIV) treatment services has expanded rapidly in Zambia, facilitated by evolution of the HIV response from centralized services to decentralized care and now towards…
- Trial name
- Reengagement (NCT06803316)
- Where
- Zambia
- Volunteers
- 658 people
- Sponsor
- Centre for Infectious Disease Research in Zambia
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