Clinical trials: Supratentorial Brain Tumor
Brain and Central Nervous System Tumors, Lymphoma
Melphalan With BBBD in Treating Patients With Brain Malignancies
RATIONALE: Drugs used in chemotherapy, such as melphalan, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing.
- Conditions
- Brain and Central Nervous System Tumors, Lymphoma, Metastatic Cancer
- Trial name
- NCT00253721
- Testing
- Melphalan
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- OHSU Knight Cancer Institute
Metastatic Cancer, Unspecified Adult Solid Tumor, Protocol Specific
Carmustine Implants in Treating Patients With Brain Metastases
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Giving the drugs in different ways may kill more tumor cells.
- Trial name
- NCT00003878
- Testing
- polifeprosan 20 with carmustine implant, conventional surgery
- Where
- 11 sites in United States
- Sponsor
- New Approaches to Brain Tumor Therapy Consortium
Postoperative Pain, Analgesia
Perioperative Multimodal Analgesia Protocol for Supratentorial Craniotomy
Supratentorial craniotomy is one of the most common neurosurgical procedures, with severe perioperative pain. Inadequate perioperative pain relief has been associated with increased blood pressure and intracranial pressure…
- Conditions
- Postoperative Pain, Analgesia, Supratentorial Brain Tumor
- Trial name
- NCT06406829
- Testing
- Dexmedetomidine, Normal saline, Local analgesic techniques
- Volunteers
- 2,000 people
- Sponsor
- Beijing Tiantan Hospital
Pituitary Neoplasms, Craniopharyngiomas
Effect of Perioperative Glucocorticoid Replacement on Prognosis of Surgical Patients With Sellar Lesions
The purpose of this four-arm randomized controlled study is to determine whether eliminating glucocorticoids (GC) replacement in perioperative period in surgical patients with sellar lesion could result in similar or better…
- Trial name
- NCT02190994
- Testing
- Hydrocortisone, Prednisone
- Where
- China
- Volunteers
- 100 people
- Sponsor
- West China Hospital
Pituitary Adenoma, Craniopharyngioma
Clinical Trial of an Anti-Fog Drainage Device for Endoscopic Endonasal Sellar Region Tumor Surgery
The goal of this clinical trial is to learn if the anti-fog suction device works to keep the surgical view clear during endoscopic nose-to-pituitary operations and whether it lowers the chance of brain-fluid infection.
- Trial name
- NCT07316101
- Testing
- Anti-fog suction device-a 4 Fr multi-channel silicone catheter
- Where
- China
- Volunteers
- 20 people
- Sponsor
- West China Hospital
Pituitary Disease
China Pituitary Disease Registry (CAPASITY)
Epidemiologic studies have revealed a tremendous increase in the prevalence of pituitary disease and related mortality worldwide.
- Trial name
- NCT04713293
- Where
- China
- Volunteers
- 2,000 people
- Sponsor
- Shanghai Jiao Tong University School of Medicine
Pituitary Adenoma
Nasoseptal Double Flap Versus Rescue Flap in Endoscopic Transsphenoidal Pituitary Surgery
This paper investigates the outcomes of two surgical techniques-nasoseptal double flap and nasoseptal rescue flap-used in endoscopic transsphenoidal surgery for pituitary tumors.
- Trial name
- NCT06526481
- Testing
- Endoscopic Transsphenoidal pituitary surgery : Double Nasoseptal Flap Technique, Endoscopic Transsphenoidal pituitary surgery : Rescue Flap Technique
- Where
- Egypt
- Volunteers
- 56 people
- Sponsor
- Mansoura University
Pituitary Tumor
Differential Study of Invasive Pituitary Adenomas in the Sellar and Cavernous Sinus Regions
This study involves collecting paired tumor samples from intrasellar and cavernous sinus regions of 20 invasive pituitary tumor patients, preserving them at -80°C for quality multi-omics analysis.
- Trial name
- NCT06705036
- Testing
- surgery
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Shanghai Zhongshan Hospital
Neoplasms, Pituitary Neoplasms
Intraoperative Imaging of Pituitary Adenomas by OTL
The primary end-point of the study is to determine the specificity and sensitivity of OTL38 in identifying pituitary adenomas when excited by an imaging probe. The investigators intend to enroll 50 patients in this study.
- Trial name
- NCT02629549
- Testing
- OTL38
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- University of Pennsylvania
Recurrent Brain Tumors, Supratentorial PNETs
Therapy Optimization Trial for the Treatment of Relapsed or Refractory Brain Tumors in Children
The purpose of this study is to improve overall survival while maintaining a good quality of life in pediatric patients with refractory or recurrent brain tumors (medulloblastomas, supratentorial PNETs, ependymomas WHO grade II…
- Conditions
- Recurrent Brain Tumors, Supratentorial PNETs, Medulloblastomas, Ependymomas
- Trial name
- HIT-REZ-2005 (NCT00749723)
- Testing
- carboplatin, etoposide, temozolomide
- Where
- 54 sites in Germany
- Volunteers
- 174 people
- Sponsor
- University Hospital, Bonn
Pituitary Tumor, ACTH-producing Pituitary Tumour
Pasireotide LAR Therapy of Silent Corticotroph Pituitary Tumors
This is a phase II, open-label, 12-month pilot study in 10 patients with silent corticotroph pituitary tumors testing the hypotheses that Pasireotide long-acting release (LAR) treatment of patients with silent corticotroph…
- Trial name
- PASSILCORT (NCT02749227)
- Testing
- Pasireotide LAR
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Columbia University
Supratentorial Brain Tumor
Comparison of the Effect of Low and High Fraction of Inspired Oxygen on Postoperative Surgical Field Infection
The purpose of this study is to compare the effect of high 0.8 and low 0.4 *FiO2 ventilation primarily on surgical field infection and secondarily on postoperative pulmonary complications in patients are undergoing supratentorial…
- Trial name
- NCT03454659
- Testing
- Craniotomy
- Volunteers
- 80 people
- Sponsor
- Istanbul University
Pituitary Adenoma Invasive, Nasal Obstruction
Nasal Obstruction Compared by Rhinomanometry and Nasal Inspiratory Peak Flow After Endoscopic Nasal Surgery
The aim of the project is to determine whether nasal inspiratory peak flow is sufficient for preoperative and postoperative measurement of nasal patency compared to rhinomanometry.
- Trial name
- NCT05921396
- Testing
- Nasal patency - rhinomanometry, Nasal patency - nasal inspiratory peak flow
- Where
- Czechia
- Volunteers
- 30 people
- Sponsor
- University Hospital Ostrava
Brain Tumors, Central Nervous System Tumors
Chemotherapy Plus Peripheral Stem Cell Transplantation in Treating Infants With Malignant Brain or Spinal Cord Tumors
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining chemotherapy with peripheral stem cell transplantation may allow the doctors to give higher doses…
- Conditions
- Brain Tumors, Central Nervous System Tumors, Neuroblastoma, Sarcoma
- Trial name
- NCT00003141
- Testing
- filgrastim, carboplatin, cisplatin
- Where
- 71 sites in United States, Australia and 1 more
- Volunteers
- 94 people
- Sponsor
- Children's Oncology Group
Bone Marrow Suppression, Brain and Central Nervous System Tumors
Acetylcysteine, Mannitol, Combination Chemotherapy, and Sodium Thiosulfate in Treating Children With Malignant Brain Tumors
RATIONALE: Drugs used in chemotherapy, such as cyclophosphamide, etoposide phosphate, and carboplatin, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing.
- Conditions
- Bone Marrow Suppression, Brain and Central Nervous System Tumors, Drug/Agent Toxicity by Tissue/Organ, Long-term Effects Secondary to Cancer Therapy in Children
- Trial name
- NCT00238173
- Testing
- filgrastim, acetylcysteine, carboplatin
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- OHSU Knight Cancer Institute
Brain and Central Nervous System Tumors, Neuroblastoma
Combination Chemotherapy With or Without Radiation Therapy in Treating Children With Brain Tumors
RATIONALE: Drugs used in chemotherapy work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing.
- Trial name
- NCT00281905
- Testing
- carboplatin, cisplatin, cyclophosphamide
- Where
- 21 sites in Ireland, United Kingdom
- Volunteers
- 50 people
- Sponsor
- Children's Cancer and Leukaemia Group
Acromegaly
Efficacy and Safety of Pasireotide Long Acting Release (LAR) Versus Octreotide LAR or Lanreotide Autogel (ATG) in Patients With Inadequately Controlled Acromegaly
This study will evaluate the efficacy and safety of pasireotide LAR 40 and 60 mg versus octreotide LAR or lanreotide ATG in patients with inadequately controlled acromegaly.
- Trial name
- PAOLA (NCT01137682)
- Testing
- Pasireotide, octreotide LAR 30mg, lanreotide ATG 120mg
- Where
- 60 sites in United States, Argentina and 16 more
- Volunteers
- 198 people
- Sponsor
- Novartis Pharmaceuticals
Childhood High-grade Cerebral Astrocytoma, Childhood Oligodendroglioma
Tipifarnib in Treating Young Patients With Recurrent or Progressive High-Grade Glioma, Medulloblastoma, Primitive Neuroectodermal Tumor, or Brain Stem Glioma
This phase II trial is studying how well tipifarnib works in treating young patients with recurrent or progressive high-grade glioma, medulloblastoma, primitive neuroectodermal tumor, or brain stem glioma.
- Conditions
- Childhood High-grade Cerebral Astrocytoma, Childhood Oligodendroglioma, Recurrent Childhood Brain Stem Glioma, Recurrent Childhood Cerebellar Astrocytoma
- Trial name
- NCT00070525
- Testing
- tipifarnib
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- National Cancer Institute (NCI)
Pituitary Tumor
Comparison of Propofol Requirement Between Patients With Pituitary Somatotroph Tumor and With Nonfunctioning Pituitary Tumor in Transsphenoidal Pituitary Surgery Under Total Intravenous Anesthesia
Investigators hypothesized that propofol dose for pituitary somatotroph patients might differ from nonfunctioning pituitary tumor, and investigators will evaluate a target controlled infusion (TCI) effect site concentration (Ce)…
- Trial name
- NCT03465423
- Testing
- Not applicable (measuring subject's effect site concentration of propofol during the induction of general anesthesia)
- Where
- South Korea
- Volunteers
- 62 people
- Sponsor
- Yonsei University
Pituitary Tumor
Nasal Packing Following Endoscopic Endonasal Pituitary Resection
There is considerable controversy about the use of nasal packing following endoscopic endonasal resection of pituitary tumors as a necessary treatment amongst Rhinology-Skull Base Surgeons.
- Trial name
- NCT03677713
- Testing
- No nasal packing., Nasal Packing
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- Ottawa Hospital Research Institute