Clinical trials: Supratentorial Neoplasms
Pituitary Neoplasms, Adenoma
Dopamine Agonist Treatment of Non-functioning Pituitary Adenomas
Due to lack of hormone overproduction in non-functioning pituitary adenomas (NFPAs), only the symptomatic adenomas or large adenomas with proven growth and risk for symptoms in near future will undergo pituitary surgery.
- Trial name
- NCT02288962
- Testing
- cabergoline
- Where
- 3 sites in Norway, Sweden
- Volunteers
- 60 people
- Sponsor
- St. Olavs Hospital
Grade I Meningioma, Grade II Meningioma
Hypofractionated Proton Therapy for Benign Intracranial Brain Tumors, the HiPPI Study
This phase II trial studies how well hypofractionated proton or photon radiation therapy works in treating patients with brain tumors.
- Conditions
- Grade I Meningioma, Grade II Meningioma, Grade III Meningioma, Intracranial Neoplasm
- Trial name
- HiPPI (NCT04278118)
- Testing
- Hypofractionated Radiation Therapy, Photon Beam Radiation Therapy, Proton Beam Radiation Therapy
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- Emory University
Brain and Central Nervous System Tumors, Childhood Germ Cell Tumor
Dasatinib, Ifosfamide, Carboplatin, and Etoposide in Treating Young Patients With Metastatic or Recurrent Malignant Solid Tumors
RATIONALE: Dasatinib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Drugs in chemotherapy, such as ifosfamide, carboplatin, and etoposide, work in different ways to stop the growth of…
- Conditions
- Brain and Central Nervous System Tumors, Childhood Germ Cell Tumor, Extragonadal Germ Cell Tumor, Kidney Cancer
- Trial name
- NCT00788125
- Testing
- carboplatin, dasatinib, etoposide phosphate
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- City of Hope Medical Center
Pituitary Adenoma
Heart Rate Variability (HRV) in Pituitary Adenoma
Several studies have been reported that heart rate is known to be associated with prognosis in chronic diseases and acute diseases.
- Trial name
- NCT03164148
- Testing
- T-REX TRI00A
- Where
- South Korea
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Seoul St. Mary's Hospital
Adult Brain Tumor
Light Sedation or Intubated General Anesthesia in Patients With Brain Cancer Undergoing Craniotomy
This randomized clinical trial studies light sedation compared with intubated general anesthesia (a loss of feeling and a complete loss of awareness that feels like a very deep sleep) in reducing complications and length of…
- Trial name
- NCT02193568
- Testing
- Arm I (light sedation), Arm II (intubated general anesthesia)
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Ohio State University Comprehensive Cancer Center
Brain Tumor, Central Nervous System Tumors
Cyproheptadine and Megestrol in Preventing Weight Loss in Children With Cachexia Caused By Cancer or Cancer Treatment
RATIONALE: Cyproheptadine and megestrol may improve appetite and help prevent weight loss in children with cancer. PURPOSE: This phase II trial is studying how well cyproheptadine and megestrol work in improving appetite and…
- Conditions
- Brain Tumor, Central Nervous System Tumors, Cachexia, Leukemia
- Trial name
- NCT00066248
- Testing
- cyproheptadine hydrochloride, megestrol acetate
- Where
- 43 sites in United States, Canada and 1 more
- Volunteers
- 70 people
- Sponsor
- University of South Florida
Pituitary Tumor
Differential Study of Invasive Pituitary Adenomas in the Sellar and Cavernous Sinus Regions
This study involves collecting paired tumor samples from intrasellar and cavernous sinus regions of 20 invasive pituitary tumor patients, preserving them at -80°C for quality multi-omics analysis.
- Trial name
- NCT06705036
- Testing
- surgery
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Shanghai Zhongshan Hospital
Cushing's Disease, Hypercortisolism
Osilodrostat Therapy and 11C-methionine PET to Improve Corticotroph Adenoma Detection
Cushing's disease is a rare condition where the body produces too much of a hormone called cortisol. Cortisol helps with metabolism, the immune system, and managing stress.
- Conditions
- Cushing's Disease, Hypercortisolism, Pituitary Adenoma, Pituitary ACTH Secreting Adenoma
- Trial name
- OPTIMAL (NCT06701838)
- Testing
- 11C-Methionine PET/CT
- Volunteers
- 15 people
- Sponsor
- Imperial College London
Adrenal Insufficiency, Pituitary Neoplasm
Evaluation of Patients With Endocrine-Related Conditions
This study will evaluate patients with a variety of endocrine disorders in order to 1) learn more about conditions that affect the endocrine glands (glands that secrete hormones) and 2) to train physicians in endocrinology.
- Conditions
- Adrenal Insufficiency, Pituitary Neoplasm, Obesity
- Trial name
- NCT00005664
- Where
- United States
- Volunteers
- 1,588 people
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Glioblastoma Multiforme, Primary Brain Tumor
Temozolomide Plus Bevacizumab in Supratentorial Glioblastoma in 70 Years and Older Patients With an Impaired Functional Status
The optimal treatment of glioblastoma multiforme (GBM) in patients aged ≥70 years with a Karnofsky performance status (KPS) <70 is unestablished.
- Trial name
- ATAG (NCT02898012)
- Testing
- Temozolomide, Bevacizumab
- Where
- France
- Volunteers
- 70 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Untreated Childhood Anaplastic Astrocytoma, Untreated Childhood Anaplastic Oligodendroglioma
Gefitinib and Radiation Therapy in Treating Children With Newly Diagnosed Gliomas
Biological therapies such as gefitinib may interfere with the growth of the tumor cells and may make the tumor cells more sensitive to radiation therapy.
- Conditions
- Untreated Childhood Anaplastic Astrocytoma, Untreated Childhood Anaplastic Oligodendroglioma, Untreated Childhood Brain Stem Glioma, Untreated Childhood Giant Cell Glioblastoma
- Trial name
- NCT00042991
- Testing
- gefitinib, radiation therapy, pharmacological study
- Where
- United States
- Volunteers
- 69 people
- Sponsor
- National Cancer Institute (NCI)
Pituitary Adenoma
Comparison of Postoperative Recovery of Sevoflurane and Propofol After Transsphenoidal Surgery
Currently, total intravenous anesthesia (TIVA) and inhaled anesthesia are both commonly used for transsphenoidal pituitary adenoma resection.
- Trial name
- NCT05822817
- Testing
- sevoflurane, propofol
- Where
- China
- Volunteers
- 252 people
- Sponsor
- Peking Union Medical College Hospital
Brain and Central Nervous System Tumors
Carmustine in Treating Adults With Recurrent Supratentorial Low-Grade Glioma
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. PURPOSE: Phase II trial to study the effectiveness of carmustine in treating adults with recurrent…
- Trial name
- NCT00003467
- Testing
- carmustine, polifeprosan 20 with carmustine implant, surgical procedure
- Where
- United States
- Volunteers
- 68 people
- Sponsor
- Duke University
Pituitary Adenoma
A Pilot Study of 5-Aminolevulinic Acid (5-ALA) to Enhance Visualization of Pituitary Adenomas
5-Aminolevulinic Acid (5-ALA) was approved by the FDA as an intraoperative optical imaging agent in patients with suspected high-grade gliomas (HGGs) in 2017.
- Trial name
- NCT04390802
- Testing
- 5-aminolevulinic acid
- Volunteers
- 40 people
- Sponsor
- Massachusetts General Hospital
Supratentorial Brain Tumor Surgery
Cerebral Oxygenation and Metabolism After Reversal Of Rocuronium: Comparison Between Sugammadex Versus Neostigmine
Cholinesterase inhibitors such as Neostigmine and Edrophonium have been used to reverse neuromuscular blockade after surgery. However, these drugs have a relatively slow onset and have adverse effects associated with stimulation…
- Trial name
- NCT02944175
- Testing
- Sugammadex, Neostigmine
- Volunteers
- 40 people
- Sponsor
- Mansoura University
Brain and Central Nervous System Tumors
Combination Chemotherapy Plus Radiation Therapy in Treating Adult Patients With Brain Cancer
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Radiation therapy uses high-energy x-rays to damage tumor cells.
- Trial name
- NCT00003309
- Testing
- filgrastim, cisplatin, cyclophosphamide
- Where
- 14 sites in United States
- Volunteers
- 33 people
- Sponsor
- Eastern Cooperative Oncology Group
Supratentorial Neoplasms, Brain Tumor, Primary
Comparison of Stroke Volume Variation-guided Normovolemic and Restrictive Fluid Management During Craniotomy: a Randomized Controlled Trial
Fluid management during neurosurgery presents a special clinical agenda. Volume overload can have detrimental effects on intracranial pressure by increasing either cerebral blood volume or hydrostatically driven cerebral edema…
- Conditions
- Supratentorial Neoplasms, Brain Tumor, Primary, Craniotomy
- Trial name
- NCT02113358
- Testing
- Intravenous colloid bolus with Voluven
- Where
- Taiwan
- Volunteers
- 80 people
- Sponsor
- National Taiwan University Hospital
Pituitary Disease
China Pituitary Disease Registry (CAPASITY)
Epidemiologic studies have revealed a tremendous increase in the prevalence of pituitary disease and related mortality worldwide.
- Trial name
- NCT04713293
- Where
- China
- Volunteers
- 2,000 people
- Sponsor
- Shanghai Jiao Tong University School of Medicine
Brain and Central Nervous System Tumors, Chemotherapeutic Agent Toxicity
Changes in Semen or Sperm Caused by Temozolomide in Patients With Newly Diagnosed, Progressive, or Recurrent Primary Malignant Brain Tumors
RATIONALE: Learning whether temozolomide changes semen or sperm in patients with brain tumors may help doctors learn about the long-term effects of treatment and plan the best treatment.
- Conditions
- Brain and Central Nervous System Tumors, Chemotherapeutic Agent Toxicity, Infertility
- Trial name
- NCT00499798
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Wake Forest University Health Sciences
Brain Tumor, Recurrent
Photodynamic Therapy (PDT) for Recurrent Pediatric Brain Tumors
The goal of this proposal is to evaluate a new Photodynamic Therapy (PDT) modification which could revolutionize the treatment of brain tumors in children and adults.
- Trial name
- NCT01682746
- Testing
- Photofrin (porfimer sodium) & photodynamic therapy.
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Harry T Whelan, MD