Clinical trials: Surgeries Undergoing General Anesthesia
Anesthesia
Efficacy and Safety of HSK3486 Compared to Propofol in Induction of General Anesthesia in Adults Having Elective Surgery
This is a multicenter, randomized, double-blinded, propofol-controlled, Phase 3 clinical study to evaluate the efficacy and safety of HSK3486 for induction of general anesthesia in adults undergoing elective surgery.
- Trial name
- NCT04711837
- Testing
- HSK3486, Propofol
- Where
- 13 sites in United States
- Volunteers
- 255 people, healthy volunteers welcome
- Sponsor
- Haisco-USA Pharmaceuticals, Inc.
Gallbladder Disease
Effect IV Ibuprofen and Inflammatory Responses
This study is being done because the investigators wish to study ways to improve recovery after surgery. Injury, including surgical injury, causes inflammation.
- Trial name
- NCT01938040
- Testing
- ibuprofen
- Where
- 4 sites in United States
- Volunteers
- 60 people
- Sponsor
- University of Medicine and Dentistry of New Jersey
General Anesthesia
Efficacy and Safety of HSK3486 Compared to Propofol for Adults Undergoing Elective Surgery With General Anesthesia
To demonstrate HSK3486 0.4/0.2 mg/kg (0.4 mg/kg intravenous [IV] slow injection over 30 [±5] seconds for the first dose, an additional 0.2 mg/kg if needed) is non-inferior to propofol 2.0/1.0 mg/kg (2.0 mg/kg IV slow injection…
- Trial name
- NCT05478174
- Testing
- HSK3486, Propofol
- Where
- 23 sites in United States
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Haisco-USA Pharmaceuticals, Inc.
Strabismus
The Effect of Povidone-iodine Ophthalmic Surgical Prep Solution on Respiration in Children Undergoing Strabismus Surgery With General Anesthesia.
Determine whether the application of povidone-iodine ophthalmic solution onto the ocular surface causes a change in respiration in children undergoing strabismus surgery with general anesthesia.
- Trial name
- NCT03349515
- Testing
- Provodine-Iodine Solution, Group B will receive three drops in each eye of ophthalmic balanced salt solution.
- Where
- United States
- Volunteers
- 106 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Anesthesia, General, Neuromuscular Blockade
Comparison of 2.0 mg/kg Sugammadex and Neostigmine at Reappearance of T2 in Chinese and European Subjects (Study 19.4.324)(P05768AM1)(COMPLETED)
The present trial was set up to evaluate the efficacy and safety of 2.0 mg.kg-1 sugammadex compared to neostigmine administered at reappearance of T2 in Chinese and Caucasian subjects for registration purposes in China.
- Trial name
- NCT00825812
- Testing
- Sugammadex, neostigmine
- Volunteers
- 308 people
- Sponsor
- Merck Sharp & Dohme LLC
Post Operative Delirium
Effect of Anesthesia on Post-operative Delirium in Elderly Patients Undergoing Hip Fracture Surgery
The purpose of this study is evaluate postoperative delirium after general anesthesia and regional anesthesia in elderly patients undergoing hip fracture surgery.
- Trial name
- RAGADelirium (NCT02213380)
- Testing
- method of anesthesia
- Where
- 13 sites in China
- Volunteers
- 950 people
- Sponsor
- Wenzhou Medical University
Lung Function, Bariatric Surgery
Pre-op Use of Incentive Spirometry in Obese Patients
The purpose of this study is to evaluate the use of preoperative incentive spirometry (IS) as an aid to improve postoperative lung function.
- Trial name
- IS (NCT01004146)
- Testing
- Incentive Spirometry
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center, Houston
Anesthesia, General, Neuromuscular Blockade
Efficacy and Safety of 4.0 mg/kg Sugammadex at 1-2 PTC in Chinese and European Subjects (Study 19.4.335)(P05775AM1)(COMPLETED)
The present trial is set up to evaluate the efficacy and safety of 4.0 mg.kg-1 sugammadex in Chinese and Caucasian subjects for registration purposes in China.
- Trial name
- NCT00826176
- Testing
- Sugammadex
- Volunteers
- 164 people
- Sponsor
- Merck Sharp & Dohme LLC
Cystoscopes, Baxter Anaesthesia Brand of Desflurane
Comparing Desflurane to Sevoflurane for the Effect on Recovery Time in Patients Undergoing Urological Cystoscope Surgery
This is a single-center, prospective, randomized, double-blind, double-arm trial including 68 subjects scheduled to undergo urological cystoscope surgeries under general anesthesia (GA) with intubation through a laryngeal mask…
- Conditions
- Cystoscopes, Baxter Anaesthesia Brand of Desflurane, Sevoflurane
- Trial name
- NCT01219881
- Testing
- Desflurane, Sevoflurane
- Where
- United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Ohio State University
Surgery, Anesthesia
Intravenous Sedation Versus General Anesthesia in Patients Undergoing Minor Gynecologic Surgery
The use of deep sedation may improve the quality of recovery of patients undergoing minor gynecologic procedures. These patients may also have shorter hospital stays and potentially lower healthcare costs.
- Conditions
- Surgery, Anesthesia, Pain
- Trial name
- NCT01890707
- Testing
- General Anesthesia, Deep Sedation
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- Northwestern University
Osteoarthritis
General or Regional Anesthesia for Hip Surgery
The purpose of this study is to determine whether general anaesthesia or regional anaesthesia is best for patients undergoing Total Hip Arthroplasty.
- Trial name
- NCT01733472
- Testing
- GA-arm, remifentanil, RA-arm
- Where
- Sweden
- Volunteers
- 120 people
- Sponsor
- Region Skane
Hernia Abdominal Wall
Remifentanil in Deep vs Moderate Neuromuscular Blocks During Surgical Pleth Index-guided Anesthesia for Laparoscopic Herniorrhaphy
The primary purpose of this study is to compare the remifentanil requirements in deep versus moderate neuromuscular blocks during the surgical pleth index -guided anesthesia in patients undergoing laparoscopic herniorrhaphy.
- Trial name
- NCT04022733
- Testing
- Moderate neuromuscular block, Deep neuromuscular block
- Where
- South Korea
- Volunteers
- 134 people
- Sponsor
- Ajou University School of Medicine
Postoperative Delirium, Hemodynamic Instability
Perioperative Multimodal General AnesTHesia Focusing on Specific CNS Targets in Patients Undergoing carDiac surgERies
In the PATHFINDER 2 trial, the study investigators will test the intraoperative EEG-guided multimodal general anesthesia (MMGA) management strategy in combination with a postoperative protocolized analgesic approach to: 1.
- Conditions
- Postoperative Delirium, Hemodynamic Instability, Pain, Neurocognitive Dysfunction
- Trial name
- PATHFINDERII (NCT05279898)
- Testing
- EEG Monitoring, Ropivacaine, Ketamine
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- Beth Israel Deaconess Medical Center
Post-Operative Nausea and Vomiting
A Study of Kytril (Granisetron) in the Prevention of Post-Operative Nausea and Vomiting (PONV) in Pediatric Subjects Undergoing Tonsillectomy or Adenotonsillectomy
This 2 arm study will evaluate the efficacy and safety of a single intravenous injection of Kytril in preventing postoperative nausea and vomiting (PONV) in children.
- Trial name
- NCT00231478
- Testing
- granisetron
- Where
- 11 sites in United States
- Volunteers
- 171 people
- Sponsor
- Hoffmann-La Roche
Surgeries Undergoing General Anesthesia
Study: Study to Compare Video Miller Device to Direct Laryngoscopy
The purpose of this study is to compare: the standard pediatric intubation instrument (Miller blade) used as direct laryngoscopy during tracheal intubation to the VideoMiller device (the standard pediatric blade with a camera…
- Trial name
- NCT01371032
- Testing
- VideoMiller, Direct Laryngoscopy
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- Cedars-Sinai Medical Center
Anesthesia, General
Using the SEDLine for the Titration of Sevoflurane in Elderly Patients Recovery Using the SEDLine TM for the Titration of Sevoflurane in Elderly Patients Undergoing Non-Cardiac Surgery After Beta-Adrenergic Blockade
Asses the effect of the use of Patient State Index (PSI) monitoring on difference in emergence profiles in the elderly (age >65 yrs) population to develop a cost-benefit profile.
- Trial name
- NCT00938782
- Testing
- Sedline
- Where
- 2 sites in United States
- Volunteers
- 67 people
- Sponsor
- Stanford University
Arrhythmia, Cardiac, Kidney Cancer
Cardiac Arrhythmias in Patients Undergoing Kidney Cancer Surgery Depending on the Anaesthesia Method
This study evaluates the incidence of cardiac arrhythmias during the perioperative period in patients undergoing open kidney cancer surgery in the lateral position.
- Conditions
- Arrhythmia, Cardiac, Kidney Cancer, Surgery, Anesthesia, Local
- Trial name
- NCT02988219
- Testing
- Bupivacaine-fentanyl, Holter ECG monitor, Open kidney cancer surgery
- Where
- Poland
- Volunteers
- 50 people
- Sponsor
- Medical University of Warsaw
Postoperative Nausea and Vomiting
Effectiveness of Triple Therapy With Palonosetron for PON Prophylaxis
Postoperative nausea and vomiting (PONV) is a displeasing experience that distresses surgical patients during the first 24 hours after a surgical procedure.
- Trial name
- NCT02635828
- Testing
- Palonosetron 0.075 mg IV, Dexamethasone 10 mg IV, Promethazine 25 mg IV
- Volunteers
- 40 people
- Sponsor
- Ohio State University
Surgery
Comparison of Vital HEAT (vH2) Temperature Management System to Upper-body Forced-air Warming
The primary objective of this study is to determine if the intraoperative distal esophageal (core) temperature with vitalHEAT warming is non-inferior to upper-body forced-air warming in patients undergoing open colectomy under…
- Trial name
- NCT00815191
- Testing
- a forced-air warming cover, vital HEAT (vH2) Temperature Management System
- Where
- United States
- Volunteers
- 73 people
- Sponsor
- The Cleveland Clinic
General Anesthesia
Safety and Efficacy of HSK3486 Compared to Propofol for Induction of General Anesthesia in Adults With Elective Surgery
To demonstrate HSK3486 0.4/0.2 mg/kg (0.4 mg/kg intravenous [IV] slow injection over 30 [±5] seconds for the first dose, an additional 0.2 mg/kg if needed) is non-inferior to Propofol 2.0/1.0 mg/kg (2.0 mg/kg IV slow injection…
- Trial name
- NCT05486416
- Testing
- HSK3486, Propofol
- Where
- 28 sites in United States, Poland and 1 more
- Volunteers
- 465 people, healthy volunteers welcome
- Sponsor
- Haisco-USA Pharmaceuticals, Inc.