Clinical trials: Surgery, Cardiovascular
Hypotension, Hypertension
Oliceridine Versus Sufentanil for Blood Pressure Control During Anesthesia Induction in Older Women With Hypertension Undergoing Gynecological Laparoscopic Surgery
Blood pressure can fall during the start of general anesthesia, particularly in older patients with high blood pressure. This study compared two medicines, oliceridine and sufentanil, to assess their effects on low blood pressure…
- Trial name
- NCT07871500
- Testing
- Oliceridine, Sufentanil
- Where
- China
- Volunteers
- 134 people
- Sponsor
- Xingguo Xu
Heart Defects, Congenital
Effects of Perioperative Nesiritide or Milrinone Infusion on Recovery From Fontan Surgery
The staged surgical pathway to treat children with single ventricle heart defects culminates with the Fontan operation. In this procedure, systemic venous return is rerouted directly to the pulmonary arteries, which serves to…
- Trial name
- NCT00543309
- Testing
- nesiritide, milrinone
- Where
- United States
- Volunteers
- 106 people
- Sponsor
- John M Costello
Systolic Heart Failure, Peripheral Chemoreceptor Hypersensitivity
Surgical Removal of Carotid Body in Patients With Systolic Heart Failure
The aim of the study is to determine safety, tolerability and feasibility of unilateral and bilateral carotid body excision in patients with systolic heart failure and peripheral chemoreceptor hypersensitivity.
- Trial name
- FIM (NCT01653821)
- Testing
- Carotid body excision
- Where
- Poland
- Volunteers
- 10 people
- Sponsor
- Noblewell
Pericardial Effusion
Surgical Options for Management of Pericardial Effusion
This is a retrospective descriptive study which will be conducted at Sohag university Hospital, Sohag, Egypt at emergency and cardiothoracic department .
- Trial name
- NCT05061914
- Testing
- pericardial effusion drainage
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Sohag University
Aortic Coarctation, Retrospective Studies
Prevalence and Risk Factors for Hypertension and Recoarctation in Patients Operated for Aortic Coarctation
Multicenter Retrospective Study Over a 14-Year Period From 2010 to 2024
- Conditions
- Aortic Coarctation, Retrospective Studies, Cohort Studies, Hypertension
- Trial name
- PRECOHA (NCT07499609)
- Where
- France
- Volunteers
- 901 people
- Sponsor
- Institut Saint Pierre
Cancer (Colon Cancer, Breast Cancer, Lymphoma, Chronic Lymphoma Leukemia, Multiple Myeloma)
Use of Preoperative Postbiotic Supplementation in Colorectal Cancer Surgery
The treatment of colorectal cancer, in the absence of metastases, is primarily based on surgical removal. Colorectal surgery, which involves resecting part of the intestine and restoring intestinal continuity, carries a risk of…
- Trial name
- POSBIO-CRC (NCT07268846)
- Testing
- Postbiotic
- Where
- Brazil
- Volunteers
- 164 people
- Sponsor
- AC Camargo Cancer Center
Coronary Artery Disease, Arteriosclerosis
Associations Between Diabetes, Arterial Stiffness and Fibulin-1 in Patients Undergoing Heart- and Vascular Surgery?
Diabetes Mellitus (DM) is frequently appearing in patients with cardiovascular disease and these patients, as a consequence herby, has a lesser prognosis. DM is often related to increased arterial stiffness and hypertension.
- Conditions
- Coronary Artery Disease, Arteriosclerosis, Carotid Stenosis, Thrombosis
- Trial name
- NCT01106573
- Where
- Denmark
- Volunteers
- 1,400 people
- Sponsor
- Odense University Hospital
Deep Vein Thrombosis, Pulmonary Embolism
Evaluation of Anti-Xa Levels in Surgery Patients Receiving Weight-based Heparin
The purpose of this study is to determine if weight-based heparin infusions at a rate of 10 units/kg/hour are sufficient to maintain a target anti-Xa of 0.1-0.35 IU/mL for VTE prophylaxis in patients undergoing microvascular…
- Conditions
- Deep Vein Thrombosis, Pulmonary Embolism, Venous Thromboembolism
- Trial name
- NCT03516656
- Testing
- Standard heparin dose, Real time heparin dose adjustment
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Utah
Aortic Valve Disease
Use of Transvenous Pacing Wire During Minimally Invasive Port Access Aortic Valve Surgery
The study is being done to determine if the Endovent pulmonary catheter kit, used for port access surgery, can be used as a passageway for a pacing wire.
- Trial name
- NCT01631188
- Testing
- Minimally Invasive Aortic Valve, Minimally Invasive Aortic Valve Surgery, Manipulation in OR surgical technique
- Volunteers
- 100 people
- Sponsor
- Rutgers, The State University of New Jersey
End Stage Renal Disease on Dialysis
Comparing Surgical and Endovascular Arteriovenous Fistula Creation
Patients with end-stage kidney disease (ESKD) who use hemodialysis to filter their blood require vascular access for the dialysis machine; the most common type of vascular access is called an arteriovenous fistula (AVF).
- Trial name
- NCT05654103
- Testing
- endoAVF, surgAVF
- Where
- 2 sites in United States
- Volunteers
- 90 people
- Sponsor
- University of California, Los Angeles
Renal Failure, Coronary Artery Disease
Prevent Cardiac Surgery Associated AKI Trial
Prevent CSA-AKI (Cardiac Surgery Associated Acute Kidney Injury) trial is a double blinded randomized controlled trial, 242 patients undergoing elective cardiopulmonary bypass surgery (CPB)will either receive a placebo or daily…
- Conditions
- Renal Failure, Coronary Artery Disease, Surgery, Surgery-Complications
- Trial name
- NCT06620523
- Testing
- CoQ10 1200 mg orally with Glutathione 1000 mg orally
- Where
- United States
- Volunteers
- 242 people
- Sponsor
- George Washington University
Coronary Artery Disease, Myocardial Infarction
Outcome After Coronary Artery Bypass Grafting
The E-CABG registry is a multicenter, European registry collecting data on the preoperative characteristics, treatment strategies and outcome of patients undergoing isolated coronary artery bypass grafting (CABG).
- Conditions
- Coronary Artery Disease, Myocardial Infarction, Angina Pectoris
- Trial name
- E-CABG (NCT02319083)
- Testing
- Coronary artery bypass surgery
- Where
- Finland
- Volunteers
- 4,000 people
- Sponsor
- University of Oulu
Coronary Artery Bypass Grafting, Coronary Artery Disease
Radial Artery Assessment in Surgical Coronary Revascularisation
The goal of this observational study is to learn about how screening tests inform the radial artery (RA) suitability for harvesting and coronary bypass grafting in adults with ischaemic heart disease.
- Trial name
- NCT06433960
- Testing
- Modified Allen Test, Pulse-oximetry guided Modified Allen Test, Barbeau Test
- Where
- 2 sites in United Kingdom
- Volunteers
- 77 people
- Sponsor
- Papworth Hospital NHS Foundation Trust
Carotid Artery Disease
Proximal Protection With The Mo.Ma Device During Carotid Stenting
The objective of the ARMOUR study is to evaluate the safety and effectiveness of the Mo.Ma proximal flow blockage cerebral protection device for patients at high surgical risk for carotid endarterectomy who undergo carotid artery…
- Trial name
- ARMOUR (NCT00744523)
- Testing
- Mo.Ma cerebral protection device
- Where
- 2 sites in United States
- Volunteers
- 262 people
- Sponsor
- Medtronic Endovascular
Coronary Artery Disease
Fractional Flow Reserve Versus Angiography for Multivessel Evaluation (FAME) 3 Extended
Coronary artery disease, or narrowing of the blood vessels that provide blood to the heart, is the most common cause of death in the United States and can be treated with either coronary bypass surgery or coronary stent…
- Trial name
- NCT07308860
- Testing
- FFR-guided PCI, CABG
- Where
- United States
- Volunteers
- 1,500 people
- Sponsor
- Stanford University
Obesity, Diabetes
Randomized Clinical Trial; Medical vs Bariatric Surgery for Adolescents (13-16 y) With Severe Obesity
Severe childhood obesity is associated with both immediate and chronic health problems and a severe impact on psychosocial development.
- Conditions
- Obesity, Diabetes, Hypertension, Steatohepatitis
- Trial name
- AMOS2 (NCT02378259)
- Testing
- Laparoscopic Roux-en-Y gastric bypass, Intense conservative treatment
- Where
- 3 sites in Sweden
- Volunteers
- 50 people
- Sponsor
- Göteborg University
Elective Non-cardiac Surgery
Leukocytes and Cardiovascular Perioperative Events-2
The potential use of regulatory T cells as preoperative risk stratification tool is evaluated in order to improve clinical risk stratification and reduce perioperative morbidity and mortality.
- Trial name
- LeukoCAPE-2 (NCT03105427)
- Where
- Germany
- Volunteers
- 233 people
- Sponsor
- University Hospital Heidelberg
Adult Acute Lymphoblastic Leukemia in Remission, Adult B Acute Lymphoblastic Leukemia
Dasatinib in Treating Patients With Solid Tumors or Lymphomas That Are Metastatic or Cannot Be Removed By Surgery
This phase I trial studies the side effects and best dose of dasatinib in treating patients with solid tumors or lymphomas that are metastatic or cannot be removed by surgery.
- Conditions
- Adult Acute Lymphoblastic Leukemia in Remission, Adult B Acute Lymphoblastic Leukemia, Adult Hepatocellular Carcinoma, Adult Nasal Type Extranodal NK/T-Cell Lymphoma
- Trial name
- NCT00608361
- Testing
- Dasatinib, Pharmacological Study
- Where
- 23 sites in United States
- Volunteers
- 80 people
- Sponsor
- National Cancer Institute (NCI)
Heart Valvular Disease, Minimally Invasive Cardiac Surgery
SPSIP Block and Opioid Use After MICS
This prospective, randomized, controlled, single-center clinical study aims to evaluate the effectiveness of the Serratus Posterior Superior Intercostal Plane Block (SPSIPB) in perioperative pain management among patients…
- Conditions
- Heart Valvular Disease, Minimally Invasive Cardiac Surgery, Postoperative Pain Management, Serratus Posterior Superior Intercostal Plane Block
- Trial name
- SPSIPB-MICS (NCT07259824)
- Testing
- Serratus Posterior Superior Intercostal Plane Block (SPSIPB)
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Ankara City Hospital Bilkent
Hyperperfusion Syndrome, Moyamoya Disease
Sevoflurane and Hyperperfusion Syndrome
The aim of the present study is to evaluate the effect of sevoflurane postconditioning on the incidence of postoperative hyperperfusion syndrome following revascularization surgery in moyamoya patients.
- Trial name
- NCT02510586
- Testing
- Sevoflurane
- Volunteers
- 152 people
- Sponsor
- Seoul National University Hospital
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