Clinical trials: Surgery, Cardiovascular
Ischemia Reperfusion Injury, Aortic Aneurysm
Microcirculation and Anesthesia in Vascular Surgery
Ischemia/reperfusion injury following aortic cross-clamping for vascular surgery leads to systemic hemodynamic and microcirculatory perturbances. The use of different anesthetic regimens may have an impact on tissue perfusion.
- Conditions
- Ischemia Reperfusion Injury, Aortic Aneurysm, Anesthesia
- Trial name
- NCT03510793
- Testing
- balanced anesthesia, Total intravenous anesthesia
- Volunteers
- 40 people
- Sponsor
- Università Politecnica delle Marche
Congenital Heart Disease, Cardiopulmonary Bypass
Influence of Lung Volume Optimization Maneuver on Cardiac Output and Lung Compliance in Ventilated Children With Congenital Heart Disease Undergoing Surgical Repair
The aim of this randomized interventional multi-center clinical trial is to determine whether a standardized lung volume optimization maneuver (LVOM), including PEEP titration, improves outcomes in children undergoing…
- Conditions
- Congenital Heart Disease, Cardiopulmonary Bypass, Mechanical Ventilation, Peep Titration in Lung Protective Ventilation
- Trial name
- ILOCO-CHD (NCT07486167)
- Testing
- End-expiratory lung volume optimization maneuver with PEEP titration, Standard Care (in control arm)
- Where
- Germany
- Volunteers
- 80 people
- Sponsor
- Charite University, Berlin, Germany
Infarction
Hemicraniectomy for Malignant Middle Cerebral Artery Infarction (HeMMI)
A single-centered, randomized, controlled clinical trial comparing standardized medical care alone with standardized medical care and decompressive hemicraniectomy to determine the effectiveness of decompressive surgery more…
- Trial name
- HeMMI (NCT02002234)
- Testing
- Hemicraniotomy, Standard medical treatment
- Where
- Philippines
- Volunteers
- 29 people
- Sponsor
- University of the Philippines
Coronary Disease, Atrial Fibrillation
Carvedilol Versus Metoprolol for the Prevention of Atrial Fibrillation After Off-Pump Coronary Bypass Surgery
Postoperative new-onset atrial fibrillation (AF) is the most common complication stemming from coronary artery bypass graft surgery, and is associated with increased early and late mortality risk.
- Trial name
- NCT00198614
- Testing
- Carvedilol versus Metoprolol
- Where
- Japan
- Volunteers
- 650 people
- Sponsor
- Ministry of Health, Labour and Welfare, Japan
Infection, Surgical Site
Use of Real-time Fluorescence Imaging in Diabetic Foot Ulcers: the Impact of Colonization
The study evaluates the efficacy of fluorescence-guided de-colonization in patients with non-infected diabetic foot ulcers. The efficacy will also be compared between those who used artificial dermis and split-thickness skin…
- Trial name
- NCT05873049
- Testing
- MolecuLight
- Where
- Taiwan
- Volunteers
- 210 people
- Sponsor
- Taipei Medical University Shuang Ho Hospital
Acute Type A Aortic Dissection
Three-Vessel Versus Unilateral Antegrade Cerebral Perfusion in Emergency Total Arch Replacement for Acute Type A Aortic Dissection
This single-centre retrospective observational cohort study describes the technical feasibility of direct three-vessel antegrade cerebral perfusion, designated modified antegrade cerebral perfusion (MACP), during emergency total…
- Trial name
- MACP (NCT07043777)
- Testing
- Direct Three-Vessel Antegrade Cerebral Perfusion (MACP), Unilateral Right Axillary Antegrade Cerebral Perfusion (uACP)
- Where
- Taiwan
- Volunteers
- 201 people
- Sponsor
- China Medical University Hospital
Deep Venous Thrombosis
Radial, Sequential Compression Device Deep Venous Thrombosis Detection Study
The purpose of this study is to evaluate the effectiveness of a new leg compression device in preventing post-surgical deep vein thrombosis (blood clot) that can occur after major and complex spine surgery.
- Trial name
- NCT04232501
- Testing
- Cirvo Compression device
- Where
- United States
- Sponsor
- Stanford University
Bleeding, Thrombosis
Bridging Therapy in Patients at High Risk for Stent Thrombosis Undergoing Surgery
Patients who have undergone placement of coronary stents require dual antiplatelet therapy with Plavix and aspirin to prevent the serious complication of in-stent thrombosis.
- Trial name
- NCT00653601
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Cedars-Sinai Medical Center
Ischemia; Cerebrovascular, Cognitive Impairment
LA Improves the Prognosis of Patients With ICVD After Surgery
Ischemic cerebrovascular disease will cause serious harm to the life and safety of patients, and the treatment prognosis is poor.
- Trial name
- NCT05656209
- Testing
- Lactobacillus acidophilus
- Volunteers
- 236 people
- Sponsor
- Huaqiu Zhang
Heart Failure
Inhaled Nitric Oxide and Inhaled Prostacyclin After Cardiac Surgery for Heart Transplant or LVAD Placement
Research study evaluating the individual and combined effects of inhaled nitric oxide (iNO) and inhaled prostacyclin (iPGI2), on the function of the right heart after surgery for either heart transplant or for left ventricular…
- Trial name
- NCT01717209
- Testing
- Nitric Oxide, Prostacyclin
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Stanford University
Obesity, Pregnancy Related
Combined Spinal Epidural Anesthesia in Obese Patients Undergoing Cesarean Surgery
This study investigated the maternal and fetal effects during performance of CSEA in the left lateral decubitus and sitting positions in obese pregnant women undergoing elective cesarean section.
- Conditions
- Obesity, Pregnancy Related, Cesarean Section Complications, Spinal Anaesthetic Poisoning of Undetermined Intent
- Trial name
- NCT04612998
- Testing
- left lateral decubitus position, sitting position, The use of intravenous ephedrine.
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Ataturk University
Frailty Syndrome, Surgery--Complications
Pre-frailty and Rehospitalization in Cardiac Surgery
Background: It has been demonstrated that pre-frailty has more adverse outcomes after cardiac surgery, however, data on prognosis and long-term evolution in pre-frailty patients after cardiac surgery without postoperative…
- Conditions
- Frailty Syndrome, Surgery--Complications, Coronary Artery Disease, Valve Anomalies
- Trial name
- NCT03949439
- Testing
- Elective Cardiac Surgery
- Where
- Brazil
- Volunteers
- 453 people
- Sponsor
- Instituto Dante Pazzanese de Cardiologia
Obesity, Diabetes
Laparoscopic Roux-en-Y Gastric Bypass Versus Laparoscopic Biliopancreatic Diversion (BPD)- Duodenal Switch for Superobesity
The purpose of this study is to compare the outcome in a broad perspective after laparoscopic Roux-en-Y gastric bypass and laparoscopic BPD-duodenal switch in the treatment of superobesity (body mass index [BMI] > 50 kg/m2).
- Conditions
- Obesity, Diabetes, Hypertension
- Trial name
- ASGARD (NCT00327912)
- Testing
- Laparoscopic Biliopancreatic diversion with Duodenal switch, Laparoscopic Roux-en-Y Gastric Bypass
- Where
- 2 sites in Norway, Sweden
- Volunteers
- 60 people
- Sponsor
- Göteborg University
Pain, Postoperative, Surgical Wound
Transversus Thoracis Muscle Plane Block for Sternotomy Pain in Cardiac Surgery
Sternotomy pain is usually significant after cardiac surgery. Analgesic options for sternotomy in cardiac surgery are often limited. Poorly controlled acute pain is an important factor to development of chronic postsurgical pain.
- Conditions
- Pain, Postoperative, Surgical Wound, Cardiac Event
- Trial name
- NCT04596163
- Testing
- Transversus thoracis muscle plane block
- Where
- Hong Kong
- Volunteers
- 86 people
- Sponsor
- Chinese University of Hong Kong
Heart Failure, Acidosis, Lactic
Preoperative Parenteral Thiamine Supplementation in Patients Undergoing Heart Surgery
The objective of this study is to determine whether preoperative parenteral thiamin supplementation does prevent the intra and early postoperative increase of lactate and whether this effect is related to the extent of thiamine…
- Conditions
- Heart Failure, Acidosis, Lactic, Thiamine Deficiency
- Trial name
- NCT01524315
- Testing
- Vitamin B1-ratiopharm
- Where
- Austria
- Volunteers
- 30 people
- Sponsor
- Medical University of Vienna
Intracranial Arteriovenous Malformations
Multimodal Imaging Techniques in Assessing the Surgical Risk for Eloquent Arteriovenous Malformations
Microsurgical resection for eloquent arteriovenous malformations (AVMs) remains challenging. Currently, there are only two grading systems concerning pretreatment assessment of brain AVMs: the Spetzler-Martin grading system…
- Trial name
- MITASREAVM (NCT02868008)
- Testing
- Microsurgical resection of brain AVMs
- Where
- China
- Volunteers
- 400 people
- Sponsor
- Beijing Tiantan Hospital
Aortic Stenosis, Valvular Heart Disease
Severe Aortic Stenosis in Patients Referred for Valve Surgery
Our main hypothesis on the present study is that new parameters such as risk-taking behavior, patients motivation, health related quality of life, new biomarkers and more precise echocardiography measures in addition to…
- Conditions
- Aortic Stenosis, Valvular Heart Disease, Symptomatic Aortic Stenosis
- Trial name
- SAS (NCT01794832)
- Where
- Norway
- Volunteers
- 500 people
- Sponsor
- Oslo University Hospital
Congenital Heart Disease, Neurodevelopment
Improving Neurodevelopment in Adolescents With Congenital Heart Disease
Executive dysfunction can profoundly impact all dimensions of a child's development. Impairments in executive function are a central component of the neurodevelopmental phenotype associated with CHD, and manifest as behavioral…
- Conditions
- Congenital Heart Disease, Neurodevelopment, Executive Function, Working Memory Training
- Trial name
- NCT02759263
- Testing
- Cogmed Working Memory Training
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Boston Children's Hospital
Brain Neoplasms, Surgery
Cerebral Blood Perfusion Changes After General Anesthesia for Craniotomy
Few studies look into cerebral blood flow (CBF) changes during emergence from general anesthesia for craniotomy. The purpose of this study is to demonstrate CBF changes during emergence from general anesthesia for craniotomy…
- Conditions
- Brain Neoplasms, Surgery, Hyperemia
- Trial name
- NCT01642147
- Testing
- Transcranial Doppler (TCD), jugular venous bulb catheterization, Tumor removal surgery under general anesthesia
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Huashan Hospital
Congenital Heart Disease
Remote Preconditioning and Myocardial Protection
Remote ischemic preconditioning (RIPC) of the myocardium by limb ischemia/reperfusion may mitigate cardiac damage, but its interaction with the anesthetic regimen is unknown.
- Trial name
- NCT02877238
- Testing
- Sevoflurane plus remote ischemic preconditioning, Total intravenous anesthesia plus remote ischemic preconditioning
- Where
- Egypt
- Volunteers
- 91 people
- Sponsor
- Assiut University
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