Clinical trials: Surgery, Cardiovascular
Aortic Valve Stenosis, Remimazolam
Comparison of Hemodynamic Stability During Anesthesia Using Remimazolam and Sevoflurane in Minimally Invasive AVR
Anesthetic agents can cause hypotension, and be especially dangerous in patients with severe aortic stenosis, which can lead to even circulatory collapse. Remimazolam is known for its hemodynamic stability compared to propofol.
- Trial name
- NCT05864625
- Testing
- Remimazolam besylate, Propofol/ Sevoflurane
- Where
- South Korea
- Volunteers
- 64 people
- Sponsor
- Pusan National University Yangsan Hospital
Hypotension
Intraopertive Hypotension and Postoperative Cardiovascular Complications Among Chinese Elderly Patients Undergoing Oncardiac Surgery : a Retrospective Cohort Study
To explore the relationship of intraoperative hypotension and perioperative cardiovascular complications in elderly noncardiac surgical patients
- Trial name
- NCT06017206
- Volunteers
- 35,262 people
- Sponsor
- Hao Li
Atrial Fibrillation
Effectiveness of Pulmonary Vein Isolation in Prevention of Atrial Fibrillation Following Heart Bypass Surgery
Atrial fibrillation (AF) is an irregular heart rhythm that occurs in 30% to 40% of patients following heart surgery. This irregular heart rhythm, although often self-limiting, can be cause for concern.
- Trial name
- NCT00338715
- Testing
- PVI with Medtronic's Cardioblate BP2 radiofrequency catheter
- Where
- Canada
- Volunteers
- 193 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Hypotension Drug-Induced
A Prospective Study of Vasopressor on Cerebral Oxygenation During General Anesthesia
The purpose of this study is to investigate whether norepinephrine(N), phenylephrine(P) or ephedrine(E) have different effect on cerebral oxygenation in abdominal surgery with propofol or sevoflurane.
- Trial name
- NCT06334549
- Testing
- Ephedrine-P, Phenylephrine-P, Norepinephrine-P
- Where
- China
- Volunteers
- 180 people
- Sponsor
- Dalian Municipal Central Hospital
Hormone Therapy Induced Morphologic Change, Surgical Menopause
Hormone Therapy on Serum Ischemia Modified Albumin in Menopausal Women
Women suffer from cardiovascular diseases 10 years later than men, therefore female sex has been considered as a 'protective factor'.
- Trial name
- NCT04424108
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Karadeniz Technical University
Flap Monitoring, Inflammation
Effect of Dexmedetomidine on Microsurgery Reconstruction in Cancer Patient
This double-blinded randomized controlled trial aims to investigate the effect of intraoperative dexmedetomidine administration on early flap viability and microvascular integrity in cancer patients undergoing elective…
- Conditions
- Flap Monitoring, Inflammation, Thrombosis, Oxidative Stress
- Trial name
- DEXFLAP (NCT06993740)
- Testing
- NaCl 0,9%, Dexmedetomidine
- Where
- Indonesia
- Volunteers
- 60 people
- Sponsor
- Dharmais National Cancer Center Hospital
Inflammation, Aortic Valve Stenosis
Is Monocyte/HDL Ratio a Predictor of Mortality in Aortic Valve Surgery
In this study, the investigators aimed to determine whether the preoperative Monocyte/HDL ratio would be a predictor of postoperative mortality and morbidity in patients who underwent aortic valve replacement due to aortic…
- Conditions
- Inflammation, Aortic Valve Stenosis, HDL
- Trial name
- NCT05641584
- Testing
- retrospective data review study
- Where
- Turkey (Türkiye)
- Volunteers
- 1 people
- Sponsor
- Bakirkoy Dr. Sadi Konuk Research and Training Hospital
Aortic Dissection
Percutaneous Plug-based Femoral Arteriotomy Closure Device Use in Surgery for Acute Type A Aortic Disection
A single-center prospective study. Patients undergoing surgery for acute type A aortic dissection with femoral arterial cannulation between 2017 and 2022 at the Karolinska University Hospital in Stockholm, Sweden are eligible.
- Trial name
- NCT05482555
- Testing
- Percutaneous arteriotomy closed using a plug-based arteriotomy closure device, Surgical cut-down and arterial puncture under direct vision
- Where
- Sweden
- Volunteers
- 171 people
- Sponsor
- Karolinska University Hospital
Anesthesia, Hypotension
Anesthetic Advantages of Dexmedetomidine for Hypotensive Anesthesia
The aim of this study was to evaluate the positive anesthetic properties such as reduce intraoperative analgesic requirement, time to extubation and recovery, and early postoperative pain of dexmedetomidine used as a hypotensive…
- Trial name
- NCT02083055
- Testing
- Dexmedetomidine, Nitroglycerin
- Where
- Thailand
- Volunteers
- 40 people
- Sponsor
- Mahidol University
Mediastinitis, Coronary Artery Disease
Physiotherapy Exercises in Patients With Sternal Instability After Cardiovascular Surgery
Sternal instability caused by mediastinitis is one of the most feared complications for cardiac surgery team for generating large commitments and functional damages to patients.
- Conditions
- Mediastinitis, Coronary Artery Disease, Cardiovascular Infections
- Trial name
- NCT02513576
- Testing
- physiotherapy exercises
- Volunteers
- 30 people
- Sponsor
- Emilia Nozawa, PT PhD
Coronary Artery Disease
Desflurane Versus Propofol Anesthesia for Off-Pump CABG
The purpose of this study is to prove if anesthesia maintained with the inhaled volatile anesthetic desflurane is superior to the intravenously applied propofol anesthesia in off-pump coronary artery bypass grafting (OP-CABG)…
- Trial name
- NCT00528515
- Testing
- Diprivan (propofol), Astra-Zeneca, Suprane (desflurane), Baxter
- Where
- Poland
- Volunteers
- 80 people
- Sponsor
- Medical University of Gdansk
Stroke, Joint Replacement Surgery
SG Healthcare and Assistive Robotics Programme (SHARP) - Proof of Concept Study
Robots are commonly used in many settings to help with transportation needs, reduce human injuries, and assisting clinicians during surgeries.
- Conditions
- Stroke, Joint Replacement Surgery, Acquired Brain Injury, Spinal Cord Injuries
- Trial name
- SHARPCARE (NCT04315389)
- Testing
- (1) Mobile Assistant Balance Robot, (2) Transfer Assistive Cobot
- Where
- Singapore
- Volunteers
- 52 people
- Sponsor
- Tan Tock Seng Hospital
Right Ventricular Dysfunction
Right Ventricular Dysfunction in Cardiac Surgery Patients
To establish the correlation between echocardiographic parameters of the RV, measured with TEE and the right ventricular ejection fraction (thermodilution).
- Trial name
- NCT03183414
- Testing
- echocardiographic measurements
- Where
- Netherlands
- Volunteers
- 15 people
- Sponsor
- Frisius Medisch Centrum
Ischemia-reperfusion Injury.
The Safety of Vardenafil in Patients Undergoing Cardiac Surgery
The purpose of this study is to evaluate the safety of vardenafil in cardiac surgery patients.
- Trial name
- NCT01260285
- Testing
- Vardenafil
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- McGuire Research Institute
Microvascular Rarefaction, Heart Valve Diseases
Evaluation of Systemic Microcirculation of Patients Undergoing Heart Valve Surgery
The study aims to study the systemic microcirculation in adult patients hospitalized at a quaternary public hospital during the preoperative and immediate postoperative periods of heart valve surgery and correlations to their…
- Conditions
- Microvascular Rarefaction, Heart Valve Diseases, Extracorporeal Circulation
- Trial name
- NCT05728047
- Testing
- Evaluation of sublingual microcirculation with side-stream dark field imaging (cytocam)
- Where
- Brazil
- Volunteers
- 31 people
- Sponsor
- National Institute of Cardiology, Laranjeiras, Brazil
Coronary (Artery); Disease, Aortic Valve Stenosis
Preventive Heart Rehabilitation to Prevent Complications in Patients Undergoing Elective Open Heart Surgery
Rationale: Patients undergoing cardiac surgery are at risk of developing perioperative complications and major adverse cardiac events, mainly related to both their preoperative status and type of surgical procedure.
- Conditions
- Coronary (Artery); Disease, Aortic Valve Stenosis, Cardiac Surgery
- Trial name
- Heart-ROCQ (NCT02984449)
- Testing
- Pre+post-operative Cardiac rehabilitation, Postoperative Cardiac rehabilitation
- Where
- Netherlands
- Volunteers
- 350 people
- Sponsor
- University Medical Center Groningen
Cardiovascular Diseases
Groin Complications in Open Vs. Percutaneous Peripheral Cannulation in Minimally Invasive Cardiac Surgery
The aim of this randomized trial is to investigate the groin complications in open vs percutaneous peripheral cannulation for cardiopulmonary bypass in minimally invasive cardiac surgery
- Trial name
- ProGlide-II (NCT05598385)
- Testing
- Open cannulation, Percutaneous cannulation
- Sponsor
- Jessa Hospital
Coronary Artery Disease, Left Ventricular Systolic Dysfunction
Preoperative Gastric Ultrasound and Left Ventricular Function in Coronary Artery Bypass Surgery
This study aims to investigate whether reduced heart function is associated with differences in stomach contents before elective coronary artery bypass graft (CABG) surgery.
- Conditions
- Coronary Artery Disease, Left Ventricular Systolic Dysfunction, Gastric Contents
- Trial name
- NCT07898215
- Testing
- Gastric Ultrasonography
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Adiyaman University
Sternal Injury, Cardiac Surgery
Improving Sternal Healing After Cardiac Surgery: Sternal Wire vs ZIPFIX
The objective of this study is to determine whether sternal reconstruction using the ZIPFIX system compared to standard wire cerclage could improve bone healing, patient function, and decreased postoperative pain.
- Conditions
- Sternal Injury, Cardiac Surgery, Heart Diseases
- Trial name
- Closure (NCT03289104)
- Testing
- Steel Wires, ZipFix Sternal Closure System
- Where
- Canada
- Sponsor
- Ottawa Heart Institute Research Corporation
Bariatric Surgery, Anti-Xa Activity
The OAT Trail: The Obesity Anti-Coagulation Thromboprophylaxis Trial.
Blood clots in the legs or lungs (called venous thromboembolism or VTE) are one of the most serious complications after weight loss surgery.
- Conditions
- Bariatric Surgery, Anti-Xa Activity, VTE (Venous Thromboembolism), Obesity & Overweight
- Trial name
- The OAT-RCT (NCT07559643)
- Testing
- Anti-Xa Activity Monitoring, Tinzaparin (Leo), enoxaparin
- Where
- Ireland
- Volunteers
- 180 people
- Sponsor
- University College Dublin
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