Clinical trials: Surgery, Cardiovascular
Moyamoya Disease, Magnetic Resonance Imaging
Predicative Value of Multimodal MRI in Moyamoya Disease
Moyamoya disease (MMD) is a nonatherosclerotic cerebrovascular abnormality, characterized by a progressive stenosis or occlusion of the intracranial internal carotid arteries (ICAs) and their proximal branches, with subsequent…
- Trial name
- NCT03785171
- Testing
- surgical revascularization
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Chinese PLA General Hospital
Hyperbilirubinemia, Hepatic Impairment
The Investigation of the Causes of Hepatic Dysfunction in the Postoperative Period During Open-heart Surgeries
In a prospective observational study during the six-month duration, coronary artery bypass graft surgery (CABG) and valve repair surgery (mitral, mitral, and aortic valve and/or tricuspid valve) patients were investigated for…
- Conditions
- Hyperbilirubinemia, Hepatic Impairment, Surgery, Cardiac Disease
- Trial name
- NCT04271098
- Testing
- Open-Heart Surgery for nine months duration, Relation between possible risk factors and hyperbilirubinemia, Follow-up period
- Volunteers
- 340 people
- Sponsor
- Kartal Kosuyolu Yuksek Ihtisas Education and Research Hospital
Ascending Aorta Aneurism, Aortic Insufficiency
Extravalvular Procedure for Surgical Treatment of Ascending Aorta Aneurism
The investigators expect that the using of prothesis with sinuses has more benefits for long term competence and condition of aortic valve than the using of straight prothesis.
- Trial name
- EPSTAAA (NCT01456975)
- Testing
- Aortic valve reimplantation using Valsalva prosthesis
- Where
- Russia
- Volunteers
- 60 people
- Sponsor
- Meshalkin Research Institute of Pathology of Circulation
Coronary Artery Disease
Etomidate Versus Propofol in CABG Surgery
The objective of this single-blinded randomized controlled interventional clinical trial is to learn about the efficacy and long-term safety of etomidate compared to propofol as an anesthesia induction agent in patients…
- Trial name
- ETOPRO (NCT06068764)
- Testing
- Etomidate, Propofol
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- Hartford Hospital
Aortic Diseases, Aortic Dissection
Proximal Aortopathy in Scotland - Epidemiology and Surgical Outcomes
The aorta is the principal arterial vessel arising from the left heart that transfers blood to the body. Certain genetic and familial disease processes are known to weaken the aortic wall resulting in dilation and potential…
- Conditions
- Aortic Diseases, Aortic Dissection, Aortic Aneurysm, Thoracic, Aortic Ectasia
- Trial name
- NCT05389865
- Testing
- Surgery on the proximal aorta (aortic root +/- ascending aorta), Patients diagnosed with thoracic aortopathy but not operated upon
- Where
- United Kingdom
- Volunteers
- 1,662 people
- Sponsor
- Golden Jubilee National Hospital
Venous Thromboembolism
Prevention of Venous Thromboembolism in Subjects Undergoing Hip Fracture Surgery or Surgery in the Lower Extremities
The study objective is to evaluate the efficacy and safety of oral YM150 for prevention of venous thromboembolism in subjects undergoing hip fracture surgery or surgery in the lower extremities.
- Trial name
- NCT00937911
- Testing
- YM150
- Where
- 8 sites in Japan
- Volunteers
- 101 people
- Sponsor
- Astellas Pharma Inc
Postoperative Pain
Efficacy of Parasternal Blocks in Cardiovascular Surgery Patients Undergoing Median Sternotomy
Acute and chronic pain after cardiac surgery is a common problem that negatively affects quality of life. Postoperative pain after cardiac surgery is most intense in the first two days and decreases in the following period.
- Trial name
- NCT06387095
- Testing
- 1. no block, 2. superficial parasternal block, 3. deep parasternal block
- Where
- Turkey (Türkiye)
- Volunteers
- 300 people
- Sponsor
- Kartal Kosuyolu Yuksek Ihtisas Education and Research Hospital
Brain Tumor, Cerebrovascular Disorders
The Neuroprotective Effects of Dexmedetomidine During Brain Surgery
Dexmedetomidine (DEX) is a Alpha-2 specific agonist, is a common ICU sedation medication. In brain tumor resection craniotomy, it is proven to be effective in improving postoperative hypertension and tachycardia, mitigates…
- Trial name
- NCT02878707
- Testing
- Dexmedetomidine
- Where
- Taiwan
- Volunteers
- 160 people
- Sponsor
- National Taiwan University Hospital
Varicose Veins
RCT - Does Treating Incompetent Perforators Reduce Recurrence?
The aim of this randomised case-controlled trial is to investigate whether ablation of incompetent perforating vein in addition to ablation of truncal vein reduces the rate of recurrent varicose veins post-treatment compared with…
- Trial name
- NCT01949207
- Testing
- EVLA, phlebectomies, TRansluminal Occlusion of Perforators (TRLOP)
- Where
- United Kingdom
- Volunteers
- 190 people
- Sponsor
- The Whiteley Clinic
Chronic Subdural Hematoma, Surgical Procedures, Operative
A National Study Examining the Most Effective Drainage Method After Burr Hole Evacuation of Chronic Subdural Hematoma
Chronic subdural hematoma (CSDH) is a common disease. The main treatment is neurosurgical evacuation and subsequent hematoma drainage.
- Conditions
- Chronic Subdural Hematoma, Surgical Procedures, Operative, Recurrence, Mortality
- Trial name
- SUPERDURA (NCT06621407)
- Testing
- 24 hours active subperiostal drainage, 24 hours passive subdural drainage
- Where
- 4 sites in Denmark
- Volunteers
- 354 people
- Sponsor
- Aalborg University Hospital
Congenital Disorders
Left Ventricular Aneurysms in Children
Collect data to support "standard of care possibility" of extracardiac repair with closure of intracavitary communication and plication of the aneurysm as probably safest surgical repair for left ventricular aneurysms.
- Trial name
- NCT00268034
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Children's Healthcare of Atlanta
Myocardial Infarction (MI), Perioperative Myocardial Injury
High-Sensitivity Troponin T Kinetics and 30-Day Outcomes After Major Abdominal Surgery (TROP-MAS)
Major abdominal surgery (MAS) carries a high risk of 30-day mortality (>5%). Perioperative myocardial injury (PMI) and myocardial injury after noncardiac surgery (MINS) frequently develop asymptomatically due to surgical…
- Conditions
- Myocardial Infarction (MI), Perioperative Myocardial Injury, Sepsis, Digestive System Surgical Procedures
- Trial name
- TROP-MAS (NCT07850492)
- Testing
- High-sensitivity cardiac troponin T (hs-cTnT) surveillance
- Where
- Vietnam
- Volunteers
- 650 people
- Sponsor
- Bach Mai Hospital
Congenital Heart Disease
The Effect of Dexmedetomidine on Kidney Perfusion in Paediatric Patients
I. Study design: open/ blinded randomized, controlled study. II. Study setting and location: The study will be conducted in Abul Reesh Paediatric Hospital Faculty of Medicine /Cairo University from 2016-2018. III.
- Trial name
- NCT03425734
- Testing
- Dexmedetomidine
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Mai Madkour
Myocardium; Injury, Coronary Artery Disease
Minimal Invasive Imaging of Coronary Artery Disease in Patients With Asymptomatic Myocardial Injury After Major Non-cardiac Surgery.
This is a cross-sectional pilot study to assess coronary artery disease with minimal invasive techniques in patients with asymptomatic troponin elevation after noncardiac surgery.
- Trial name
- AMI-NCS (NCT01960309)
- Testing
- Minimal invasive cardiac imaging
- Where
- Netherlands
- Volunteers
- 70 people
- Sponsor
- UMC Utrecht
Postoperative; Dysfunction Following Cardiac Surgery
Oral Triiodothyronine for Infants Less Than 5 Months & Malnourished Children Undergoing Cardiopulmonary Bypass in Indonesia
Infants and children undergoing cardiac surgery require mechanical support for circulation called cardiopulmonary bypass. The artificial pump ensures that blood flow to the body is maintained during surgical procedure on the…
- Trial name
- I-TRICC (NCT02222532)
- Testing
- Tetronine
- Where
- Indonesia
- Volunteers
- 224 people
- Sponsor
- National Cardiovascular Center Harapan Kita Hospital Indonesia
Cerebral Hypoperfusion, Cerebral Occlusion
Evaluation of Cerebral Blood Flow and Cerebral Oxygenation With Transcranial Doppler and NIRS in Laparoscopic Cholecystectomy Cases
The goal of this clinical trial is to test intracranial blood flow and cerebral oxygenisation changes in patients who have pneumoperitoneum in laparoscopic cholecystectomy procedure.
- Conditions
- Cerebral Hypoperfusion, Cerebral Occlusion, Cholecystitis; Gallstone, Cholecystitis/Cholelithiasis
- Trial name
- NIRS L/C (NCT06036498)
- Testing
- Near Infrared Spectrophotometry Device, Transcranial Doppler Ultrasonography
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Uludag University
Sepsis, Hypotension
Pre-induction Norepinephrine in Septic Patients Undergoing Surgery
This randomized controlled trial aims to evaluate the effect of early pre-induction norepinephrine infusion on perioperative hemodynamic stability in septic patients with SOFA score ≥2 undergoing surgery under general anesthesia.
- Trial name
- NCT07869693
- Testing
- Norepinephrine, Standard Care
- Volunteers
- 90 people
- Sponsor
- Assiut University
Heart Valve Disease
Effect of Remote Ischemic Preconditioning on Acute Kidney Injury in Patients Undergoing Heart Valve Replacement Surgery With Cardiopulmonary Bypass
The purpose of this study is to study the effect of remote ischemic preconditioning on acute kidney injury in patients undergoing heart valve replacement surgery with cardiopulmonary bypass.
- Trial name
- NCT01023152
- Testing
- Automated cuff-inflator
- Volunteers
- 74 people
- Sponsor
- Yonsei University
Hypoplastic Left Heart Syndrome
A Prospective Study of Patients With Hypoplastic Left Heart Syndrome (HLHS) Following Stage II Surgical Palliation
Hypoplastic left heart syndrome (HLHS) is a severe form of congenital heart disease that consists of multiple obstructions to flow through the left heart and aorta, as well as hypoplasia of the left ventricle.
- Trial name
- NCT01708863
- Where
- 3 sites in United States
- Volunteers
- 4 people
- Sponsor
- Timothy J Nelson, MD, PhD
Mitral Valve Regurgitation
Hemodynamic Stress Test in Severe Mitral Regurgitation (HEMI)
The preferred treatment of organic mitral regurgitation (MR) is mitral valve repair. Optimally this should be timed so late that it commensurate with the risk of surgery and before irreversibly damage of the heart and pulmonary…
- Trial name
- HEMI (NCT02961647)
- Testing
- Mitral valve repair
- Where
- Denmark
- Volunteers
- 80 people
- Sponsor
- Odense University Hospital
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