Clinical trials: Surgery, Cardiovascular
Cardiac Disease
Pilot Study of the Feasibility of Multicenter NIRS Data Collection and Interventions for Desaturation in Cardiac Surgery
Using the 9 centers (Appendix B) involved with the planned multicenter NIRS comparative effectiveness trial the specific aims of this study are: 1.
- Trial name
- NCT01765504
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Johns Hopkins University
Hepatocellular Carcinoma, Portal Vein Thrombosis
Prognostic Value Related to the Presence of Thrombosis or Portal Vein Invasion in Patients With Hepatocellular Carcinoma Submitted to Surgery
A retrospective study based on analysis of medical records of patients with hepatocellular carcinoma treated at the Hospital Sírio-Libanês (Sao Paulo-Brazil) between 2001 and 2011 with diagnosis confirmed by imaging or…
- Conditions
- Hepatocellular Carcinoma, Portal Vein Thrombosis, Hepatic Portal Vein Tumor Invasion
- Trial name
- HSL2012-06 (NCT01690715)
- Where
- Brazil
- Volunteers
- 50 people
- Sponsor
- Hospital Sirio-Libanes
Coagulopathy
Quantra vs TEG for Congenital Cardiac Surgery - a Pilot Validation Study
Congenital heart surgery on cardio-pulmonary bypass (CPB) is associated with impacted coagulation quality and increased bleeding after separation of CPB.
- Trial name
- NCT05295693
- Testing
- Correlation of the Quantra with the TEG
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Stanford University
Cardiovascular Diseases, Dysphagia
Clinical Markers of Dysphagia in Cardiac Surgical Patients
Although dysphagia is a known complication of cardiac surgery, risk factors and sensitive bedside clinical markers of dysphagia have not yet been identified.
- Trial name
- NCT05304416
- Testing
- Fiberoptic Endoscopic Evaluation of Swallowing, Simultaneous FEES and Videofluoroscopy instrumental swallowing exam, Videofluoroscopy instrumental swallowing exam (VFSS)
- Where
- 2 sites in United States
- Volunteers
- 347 people
- Sponsor
- University of Florida
Carotid Artery Disease
CHOICE: Carotid Stenting For High Surgical-Risk Patients
The purposes of this study is to 1) Provide additional information that the commercially available Abbott Vascular Carotid Stent Systems and Embolic Protection Systems can be used successfully by a wide range of physicians under…
- Trial name
- NCT00406055
- Testing
- RX ACCULINK , RX ACCUNET , XACT , EMBOSHIELD and EMBOSHIELD Nav6
- Where
- United States
- Volunteers
- 18,855 people
- Sponsor
- Abbott Medical Devices
Cardiac Disease
The Effects of Neurophysiological Facilitation Techniques After Coronary Artery Bypass Graft Surgery
The aim of the study is to investigate the effects of neurophysiological facilitation techniques, applied in addition to Phase I cardiac rehabilitation in the early postoperative period after coronary artery bypass graft (CABG)…
- Trial name
- NCT06640699
- Testing
- exercise
- Volunteers
- 36 people
- Sponsor
- Istanbul University - Cerrahpasa
Vascular Disease, Surgery
Clinical Trial of a Silver Eluting Dressing System
This prospective, multi-institutional randomized clinical trial of a silver ion eluting dressing material compared to standard dry gauze for closed skin incisions after open surgical revascularizations for peripheral vascular…
- Trial name
- SILVER (NCT01229358)
- Testing
- Surgical dressing
- Where
- 3 sites in United States
- Volunteers
- 500 people
- Sponsor
- Brigham and Women's Hospital
Postoperative Complications, Heart Failure
Association Between Portal Flow Pulsatility and Right Ventricular Dysfunction in the Postoperative Period of Cardiac Surgery
Right ventricular dysfunction (RVD) after cardiac surgery is associated with ischemia and myocardial injury. While echocardiographic measures like Tricuspid Annular Plane Systolic Excursion (TAPSE) are frequently used to assess…
- Trial name
- LIFESAVE (NCT06777355)
- Testing
- Transthoracic and Transesophageal echography within 24 hours post cardiac surgery
- Where
- France
- Volunteers
- 32 people
- Sponsor
- CMC Ambroise Paré
Obesity, Morbid, Diabetes Mellitus, Type 2
Different Limb Lengths in Gastric Bypass Surgery
Obesity and type 2 diabetes mellitus (T2DM) are reaching epidemic proportions in the developed world. In morbidly obese patients only surgical treatment (bariatric operations) leads to a sustained weight loss and relief of…
- Conditions
- Obesity, Morbid, Diabetes Mellitus, Type 2, Hypertension, Dyslipidemias
- Trial name
- SLIM (NCT04219787)
- Testing
- Long BPL LRYGB, Short BPL LRYGB
- Where
- Switzerland
- Volunteers
- 800 people
- Sponsor
- Clarunis - Universitäres Bauchzentrum Basel
Varicose Veins
Treatment of Great Saphenous Vein Varicosities
Venous insufficiency at lower extremities may result in clinical problems from cosmetic issues to ulcerations. When the frequency of venous insufficiency and its related problems are considered besides their diversity, it is…
- Trial name
- NCT05655416
- Testing
- Endovenous chemical ablation with Trendelenburg's operation (eCAT)
- Where
- Egypt
- Volunteers
- 55 people
- Sponsor
- Al-Azhar University
Vasoplegic Syndrome, Vasoplegia
Analysis of miRNAs Expression in Vasoplegic Syndrome After On-pump Coronary Artery Bypass Surgery
This study looks for a correlation between microRNAs (miRNAs) and vasoplegic syndrome after on-pump coronary artery bypass surgery.
- Conditions
- Vasoplegic Syndrome, Vasoplegia, Surgery-Complications, Surgery
- Trial name
- PREVENT (NCT05354193)
- Testing
- vasoplegic syndrome
- Where
- Brazil
- Volunteers
- 320 people
- Sponsor
- University of Sao Paulo General Hospital
Coronary Artery Disease, Anesthesia
Xenon in Off-pump Coronary Artery Bypass Graft Surgery
Purpose of this study is to test whether xenon application during off-pump-coronary artery bypass (OPCAB)-surgery is safe and feasible.
- Trial name
- NCT01757106
- Testing
- Xenon, sevoflurane
- Where
- Belgium
- Volunteers
- 42 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Type A Aortic Dissection, Complication of Surgical Procedure
Safety and Efficacy of XJ-Procedure in Patients With Acute Type A Aortic Dissection Surgery
This is a national, multicenter, open-label, randomized, controlled, endpoint-blinded clinical trial of patients diagnosed with ATAAD and undergoing "Sun's procedure" coordinated by the First Affiliated Hospital of Xi'an Jiaotong…
- Conditions
- Type A Aortic Dissection, Complication of Surgical Procedure, Aortic Diseases
- Trial name
- ADVANCED-XJ-Ⅱ (NCT06199401)
- Testing
- Vascular Grafts Eversion and Built-in Technique(XJ-Procedure)
- Where
- China
- Volunteers
- 680 people
- Sponsor
- First Affiliated Hospital Xi'an Jiaotong University
Hypotension
Effect of EEG-guided General Anesthesia on Cumulative Dose of Norepinephrine
Intraoperative hypotension is common in patients having non-cardiac surgery under general anesthesia and is associated with major postoperative complications including myocardial injury, AKI, and death.
- Trial name
- NCT05293288
- Testing
- EEG-guided general anesthesia
- Where
- Germany
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Rheumatic Valve Disease, Atrial Fibrillation
Efficiency of Radiofrequency Ablation for Surgical Treatment of Chronic Atrial Fibrillation With Rheumatic Valve Disease
The purpose of this study is to determine whether concomitant radiofrequency Maze procedure for surgical treatment of chronic atrial fibrillation with rheumatic valve disease could provide better sinus rhythm control, improved…
- Trial name
- NCT01013688
- Testing
- Cardioblate® Surgical Ablation System
- Where
- China
- Volunteers
- 150 people
- Sponsor
- China National Center for Cardiovascular Diseases
Deep Vein Thrombosis, Total Hip Prosthesis
Generation of Thrombin and Prediction of Deep Vein Thrombosis Post Prosthetic Orthopedic Surgery of the Lower Limbs
The numerical ratio between the value of the thrombin generation test performed without soluble thrombomodulin and the value of the thrombin generation test performed in the presence of soluble thrombomodulin, performed…
- Conditions
- Deep Vein Thrombosis, Total Hip Prosthesis, Knee Prosthesis
- Trial name
- GT-PT (NCT03634124)
- Testing
- Blood test, Doppler ultrasound
- Where
- France
- Volunteers
- 146 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Coronary Artery Bypass Graft Triple Vessel, Hypotension
The Efficacy and Safety of Ramosetron in Patients Undergoing Off Pump Coronary Artery Bypass Surgery
The purpose of this study is to assess the effects of ramosetron on corrected QT interval in patients undergoing off pump coronary artery bypass surgery.
- Trial name
- NCT02139241
- Testing
- Ramosetron, Normal saline
- Where
- South Korea
- Volunteers
- 114 people
- Sponsor
- Seoul National University Hospital
Aortic Arch Replacement, Hemi Arch Replacement
Neurologic Injury Following Aortic Arch Replacement
Investigators are seeking to learn how well different cooling temperatures along with different blood flow pathways to the brain reduce the risk of injury to the brain in participants planning to undergo elective aortic arch and…
- Trial name
- NCT02750423
- Testing
- DHCA+RCP, MHCA + SACP
- Where
- 2 sites in United States
- Volunteers
- 20 people
- Sponsor
- Emory University
Vascular Diseases
Clinical Frailty Scale Validation in Patients Scheduled for Vascular Surgery
Major vascular operations put the body under stress. We are trying to find out if the general health of a patient and the stress resulting from surgery can lead to the development of complications after surgery as well as…
- Trial name
- NCT03403673
- Testing
- Frailty assessment tools
- Where
- United Kingdom
- Volunteers
- 100 people
- Sponsor
- South Tees Hospitals NHS Foundation Trust
Coronary Artery Disease, Valvular Disease
Evaluation of the Brain Natriuretic Peptide as a Predictor of Morbidity and Mortality in Cardiac Surgery
Objective: The purpose of the present study is to assess if perioperative variation of Brain Natriuretic Peptide (BNP) levels is a predictor of mortality and morbidity after cardiac surgery.Material and Methods: 500 consecutive…
- Trial name
- NCT00699673
- Where
- France
- Volunteers
- 500 people
- Sponsor
- University Hospital, Strasbourg, France
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