Clinical trials: Surgery, Cardiovascular
Peripheral Vascular Disease
Lower Extremity Regional Anesthesia and Infrainguinal Bypass Grafting
In this investigation, the investigators will attempt to demonstrate that patients who have received nerve blocks (regional anesthesia) prior to open surgical vascular bypass of the lower extremities (infrainguinal bypass…
- Trial name
- NCT01803165
- Testing
- Single shot femoral and sciatic nerve block
- Sponsor
- University of Nebraska
Valvular Heart Surgery
Prediction of Fluid Responsiveness in Atrial Fibrillation Patients Who Underwent Valvular Heart Surgery: Peep-induced Increase in Central Venous Pressure vs. Passive Leg Raising
Dynamic indices of preload depending on the heart-lung interaction require sinus rhythm and cannot be applied to patients with atrial fibrillation.
- Trial name
- NCT02224378
- Testing
- peep induced CVP, passive leg raising(PLR)
- Where
- South Korea
- Volunteers
- 44 people
- Sponsor
- Yonsei University
Atrial Fibrillation, Acute Kidney Injury
Autonomic State, Cardiovascular Control and Outcomes in Coronary Surgery
Characterization of the perioperative autonomic nervous system state, cardiovascular and cerebrovascular control and microcirculation in order to predict postoperative atrial fibrillation and acute kidney injury in patients…
- Trial name
- NCT03169608
- Where
- Italy
- Volunteers
- 200 people
- Sponsor
- IRCCS Policlinico S. Donato
Arthroplasty, Replacement, Knee
A Study to Evaluate the Safety and Efficacy of YM150 in Patients With Knee Replacement Surgery
To evaluate the safety and efficacy of twice daily dosing and once daily dosing of YM150 in subjects undergoing primary elective knee replacement surgery
- Trial name
- PEARL (NCT00595426)
- Testing
- YM150, Warfarin
- Where
- 54 sites in United States, Canada
- Volunteers
- 685 people
- Sponsor
- Astellas Pharma Inc
Heart Diseases, Hypertension, Pulmonary
Study of the Efficacy and Safety of Tezosentan in Patients With Pre-operative Pulmonary Hypertension, Due to Left Heart Disease, Undergoing Open Heart Surgery
Endothelin-1 is a powerful substance that may be involved in causing hemodynamic instability (problems related to unstable blood pressure) during and after open heart surgery.
- Trial name
- NCT00458276
- Testing
- tezosentan
- Where
- 33 sites in United States, Austria and 12 more
- Volunteers
- 274 people
- Sponsor
- Idorsia Pharmaceuticals Ltd.
Congenital Heart Disease
Evaluation of Coagulation Testing in Patients Undergoing Cardiac Surgery
Neonates, children with single ventricle congenital heart disease, and those undergoing multiple complex cardiac surgeries are at high risk of increased perioperative blood loss, and blood product transfusions.
- Trial name
- NCT02410473
- Testing
- Discarded blood samples, Discarded Urine Sample
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Boston Children's Hospital
Mitral Valve Regurgitation, Mitral Valve Insufficiency
HighLife™ Transcatheter Mitral Valve Replacement System Study
Multicenter feasibility study of the HighLife™ TMVR system.
- Trial name
- NCT02974881
- Testing
- Transcatheter Mitral Valve Replacement
- Where
- 10 sites in France, Germany
- Volunteers
- 5 people
- Sponsor
- HighLife SAS
Cardiac Surgery, Surgery--Complications
Connected Electronic Wrist Strap for Patient Follow-up After Cardiac Surgery
After cardiac surgery, patients' follow-up after discharge is a major public health issue. Since the main complications occur mostly during the first extra-hospital month, a follow-up period becomes necessary as the average…
- Conditions
- Cardiac Surgery, Surgery--Complications, Cardiac Disease, Physical Disability
- Trial name
- BECSuP (NCT03113565)
- Testing
- Count daily number of footsteps.
- Where
- France
- Volunteers
- 137 people
- Sponsor
- CMC Ambroise Paré
Abdominal Aortic Aneurysm
Evaluation of the Impact of Prehabilitation on Recovery Following Open Surgery for Abdominal Aortic Aneurysm
This is a pilot, prospective, randomized control trial that aim to provide a first estimation of the 3-month post-operative variation in the functional recovery of patients who benefited from an outpatient pre-habilitation…
- Trial name
- EPOP-AORTA (NCT05375292)
- Testing
- PREHABILITATION
- Where
- France
- Volunteers
- 60 people
- Sponsor
- University Hospital, Toulouse
Ischemic Heart Disease
Oral Glutamine in Cardiopulmonary Bypass
Introduction: Glutamine (GLN) is the most abundant free amino acid in the body. It modulates immune cell function and is an important energy substrate for most cells (especially for enterocytes and lymphocytes) in critical…
- Trial name
- NCT02491931
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Instituto Mexicano del Seguro Social
Hypertension, Cardiac Disease
A Pilot Study to Assess the Accuracy of Blood Pressure Assessment by the Omron HeartGuide Smartwatch
The accuracy of devices like the recent FDA-clearance of the Omron HeartGuide™ Blood Pressure sensor in robust clinical settings remain in question and thus form the underpinning of this research study.
- Conditions
- Hypertension, Cardiac Disease, Surgery
- Trial name
- NCT03986281
- Testing
- Omron Wearable Device, Standard Arterial Line
- Where
- United States
- Volunteers
- 56 people
- Sponsor
- The Cleveland Clinic
Gynecologic Neoplasms, Venous Thromboembolism
Thromboprophylaxis After Surgery for Gynecologic Malignancy in China
Venous thromboembolism (VTE) is an important cause of post-operative morbidity and mortality in women undergoing surgery for gynecologic malignancies.
- Conditions
- Gynecologic Neoplasms, Venous Thromboembolism, Low Molecular Weight Heparin, Argatroban
- Trial name
- NCT02935530
- Testing
- s-LMWH, LMWH, Argatroban
- Where
- China
- Volunteers
- 315 people
- Sponsor
- Huazhong University of Science and Technology
Colorectal Surgery, VTE (Venous Thromboembolism)
A Multicenter, Open-Label, Non-Inferiority Randomized Controlled Trial of Postoperative VTE Prevention in Chinese Patients After Colorectal Cancer Surgery
research objective 1. Optimize VTE prevention management after CRC surgery. 2. Improve the prevention and treatment level of VTE in current perioperative patients. 3. Reduce the social burden of VTE related diseases.
- Trial name
- NCT06583330
- Testing
- Low Molecular Weight Heparin (dalteparin)
- Volunteers
- 1,448 people
- Sponsor
- Beijing Friendship Hospital
Arteriovenous Fistula, Isometric Exercise
The Effect of Intelligent Exercise on Vascular Function, Grip Strength and Adherence in Patients With AVF After Surgery
Isometric exercise can effectively promote the vascular function of arteriovenous fistula and increase hand grip strength, but patients needs to perform isometric exercises patiently.
- Trial name
- NCT05686200
- Testing
- Forearm isometric exercise intervention program
- Where
- Taiwan
- Volunteers
- 52 people
- Sponsor
- National Taipei University of Nursing and Health Sciences
Haemorrhoid
Traditional Ferguson Hemorrhoidectomy vs Stapled Hemorrhoidopexy
This study aimed to compare the short- and long-term outcomes of stapled hemorrhoidopexy (the procedure for prolapsed hemorrhoids, PPH) with anoplasty versus traditional Ferguson method for the treatment of patients with grade…
- Trial name
- NCT05959577
- Testing
- Stapled hemorrhoidopexy with anoplasty, Ferguson hemorrhoidectomy
- Where
- Taiwan
- Volunteers
- 200 people
- Sponsor
- National Taiwan University Hospital
Stroke, Transient Ischemic Attack
The "COSMOS"-Study (Copeptin in Osmoregulation and Stress Assessment)
Sodium imbalance is common and an adverse prognostic factor in hospitalized patients. However, identifying the causes of sodium imbalance is challenging in clinical practice.
- Trial name
- NCT00390962
- Where
- Switzerland
- Volunteers
- 469 people
- Sponsor
- University Hospital, Basel, Switzerland
Hip Fractures, Pain, Postoperative
PENG Block vs FNB + ONB in Patients Undergoing Hip Fracture Surgery With Contraindications to Neuraxial Anesthesia
The aim of the study is to demonstrate the efficacy of PENG block as the main anesthetic technique to manage perioperative analgesia for hip fracture surgery compared to femoral and obturator nerve block in patients with…
- Conditions
- Hip Fractures, Pain, Postoperative, Coagulopathy, Comorbidities and Coexisting Conditions
- Trial name
- PENG/FNB+ONB (NCT06457880)
- Testing
- PENG BLOCK, Femoral Nerve Block, Obturator Nerve Block
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- Campus Bio-Medico University
Other Diseases of Veins and Lymphatics
ACCUvein Measure Before ULtrasound as A facilitataTION Tool for Venous Marking
Ultrasound marking of saphenous veins before varicose vein surgery or for saphenectomy for vascular or coronary artery bypass grafting is a long, tedious, low-grading examination, generating overconsumption of many consumables…
- Trial name
- ACCUMULATION (NCT03538080)
- Testing
- ACCUVEIN plus ultrasound, Ultrasound only
- Where
- France
- Volunteers
- 50 people
- Sponsor
- University Hospital, Angers
Ventricular Septal Defect
Immune Heterogeneity Before and After Cardiopulmonary Bypass in Children
The goal of this observational study is to learn about functional heterogeneity of immune cells before and after cardiopulmonary bypass (CPB) in children with congenital heart disease (CHD).
- Trial name
- NCT06214182
- Where
- China
- Volunteers
- 3 people
- Sponsor
- The Children's Hospital of Zhejiang University School of Medicine
Intraoperative Hypotension, Cerebral Ischemia
Effect of Leg Elevation on Prevention of Intraoperative Hypotension During Beach Chair Position
The aim of this study is to evaluate the effect of leg elevation on the prevention of intraoperative hypotension during shoulder surgery in the Beach-chair position.
- Conditions
- Intraoperative Hypotension, Cerebral Ischemia, Shoulder Disease
- Trial name
- NCT03393559
- Testing
- leg elevation
- Where
- South Korea
- Volunteers
- 50 people
- Sponsor
- Seoul National University Hospital
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