Clinical trials: Surgery, Cardiovascular
Aortic Aneurysm, Thoracic
NICardipine Neuroprotection in AortiC Surgery (NICNACS)
Objective The objective of this study is to discover whether an infusion of nicardipine is able to reduce the time taken to achieve electrocerebral silence (ECS) during cardiopulmonary bypass (CPB) for aortic surgery.
- Trial name
- NICNACS (NCT00508118)
- Testing
- Nicardipine, 0.9% saline
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Duke University
Blood Transfusion Complications
Point-of-Care RBC Washing to Prevent Transfusion-Related Pulmonary Complications
This study is designed to determine if point-of-care washing of allogeneic Leukocyte-Reduced Red Blood Cells reduces pulmonary complications when compared to standard-of-care Leukocyte-Reduced Red Blood Cells in a cardiac…
- Trial name
- NCT02094118
- Testing
- Point-of-care washed red blood cell transfusion., Standard of care red blood cell transfusion.
- Where
- 2 sites in United States
- Volunteers
- 171 people
- Sponsor
- Mayo Clinic
Heart Disease
Ancillary Effects of Dexmedetomidine Sedation After Cardiac Surgery
Ancillary Effects of Dexmedetomidine Sedation After Cardiac Surgery
- Trial name
- Decade (NCT02004613)
- Testing
- Dexmedetomidine
- Where
- United States
- Volunteers
- 798 people, healthy volunteers welcome
- Sponsor
- The Cleveland Clinic
Intravitreal Bevacizumab Injection, Pars Plana Vitrectomy
Preoperative Injection of Bevacizumab Prior to Vitreoretinal Surgery in Diabetic Tractional Retinal Detachment
Vitreoretinal surgery for epiretinal proliferation tractional retinal detachment associated with proliferative diabetic retinopathy (PDR) is often complicated by hemorrhage from fibrovascular tissue.
- Conditions
- Intravitreal Bevacizumab Injection, Pars Plana Vitrectomy, Tractional Retinal Detachment, Diabetic Retinopathy
- Trial name
- NCT00548197
- Testing
- Bevacizumab
- Where
- Iran
- Volunteers
- 40 people
- Sponsor
- Iran University of Medical Sciences
Cardiovascular Disease, Coronary Artery Disease
Radial Artery Versus Saphenous Vein Grafts in Coronary Artery Bypass Surgery
VA patients with coronary artery disease and who have agreed to undergo coronary artery bypass graft surgery would be randomized to receive either radial artery or saphenous vein to the study vessel.
- Trial name
- NCT00054847
- Testing
- saphenous vein graft, radial artery graft
- Where
- 11 sites in United States
- Volunteers
- 733 people
- Sponsor
- US Department of Veterans Affairs
Mitral Valve Insufficiency
The Use of Paravertebral Block for Cardiac Surgery
Pain after robotic cardiac surgery is a known problem and is often difficult to manage. Paravertebral nerve blocks are a proven method of pain relief following thoracotomy.
- Trial name
- NCT02180893
- Testing
- Paravertebral Block
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- NYU Langone Health
Coronary Artery Disease
Topical Application of Tranexamic Acid to Reduce Post-operative Bleeding in Coronary Artery Bypass Surgery
The goal of this project is to determine whether the use of tranexamic acid, a clot-promoting drug, applied topically over the heart in coronary artery bypass graft surgery (CABG) will reduce post operative blood loss.
- Trial name
- NCT01519245
- Testing
- Tranexamic Acid, normal saline
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- University of Saskatchewan
Mitral Valve Insufficiency, Heart Failure
Effectiveness of Surgical Mitral Valve Repair Versus Medical Treatment for People With Significant Mitral Regurgitation and Non-ischemic Congestive Heart Failure
Mitral regurgitation (MR), also known as mitral insufficiency, is a condition in which the heart's mitral valve, located between two of the heart's main chambers, does not firmly shut, allowing blood to leak backwards within the…
- Trial name
- SMMART-HF (NCT00608140)
- Testing
- Surgical mitral valvuloplasty with placement of annular ring (SMVR), Optimal medical therapy (OMT)
- Where
- 9 sites in United States, Canada
- Volunteers
- 2 people
- Sponsor
- Duke University
Venous Thrombosis
Comparison of Arixtra vs. Lovenox to Prevent Blood Clots in Medically Ill Patients
A total of 50 patients >40 yrs of age with an expected hospital stay in the Medical Intensive Care or Regional Heart Unit at LVH Muhlenberg of 6 days or longer will be enrolled.
- Trial name
- BRiEF (NCT00521885)
- Testing
- Arixtra (Fondaparinox) 2.5 mg SC Daily, Lovenox 40mg SC Daily
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Lehigh Valley Hospital
Venous Thromboembolism, Venous Thrombosis
Intermittent Pneumatic Compression in Surgical Patients at Extremely-high Risk for Venous Thromboembolism
The aim of the study is to evaluate efficacy and safety of venous thromboembolism prophylaxis by the combination of graduated compression stockings (GCS), standard doses of low-molecular-weight heparins (LMWH) and sequential…
- Trial name
- IPCSUPER (NCT03044574)
- Testing
- SCD, GCS, LMWH
- Where
- 2 sites in Russia
- Volunteers
- 407 people
- Sponsor
- Pirogov Russian National Research Medical University
Leg Ulcer, Diabetic Foot Ulcer
Proof of Concept (Design Validation) in Patient With Hard to Heal Wounds Such as Pressure Ulcer, Diabetic Foot Ulcer and Leg Ulcer, Leia
The purpose of this reseach study is to determine Mölnlycke Health Care´s Leia dressing performance properties is fulfilled and that the dressing is safe when used on wound types such as pressure ulcer, leg ulcer, and diabetic…
- Conditions
- Leg Ulcer, Diabetic Foot Ulcer, Pressure Ulcer
- Trial name
- NCT01966380
- Testing
- Leia
- Where
- Sweden
- Volunteers
- 6 people
- Sponsor
- Molnlycke Health Care AB
Congestive Heart Failure
Feasibility Study of BMAC Enhanced CABG
Patients undergoing CABG will have 60 mL of bone marrow drawn, concentrated in a SmartPRep2 centrifuge and have the concentrated nucleated cells injected into areas of ischemic myocardium
- Trial name
- NCT01074099
- Testing
- BMAC, CABG only
- Where
- 2 sites in United States
- Volunteers
- 5 people
- Sponsor
- Harvest Technologies
Cardiovascular Disease
PeriOperative ISchemic Evaluation-2 Trial
Major surgeries not involving the heart are common, and major heart problems during or after such surgeries represent a large population health problem.
- Trial name
- POISE-2 (NCT01082874)
- Testing
- Active Clonidine, Active ASA
- Where
- 23 sites in United States, Argentina and 21 more
- Volunteers
- 10,010 people
- Sponsor
- Hamilton Health Sciences Corporation
Cardiac Disease
Lidocaine as an Endotracheal Tube (ETT) Cuff Media
Researchers will compare the effects of lidocaine versus air, as a way to fill the breathing tube cuff which is gently inflated to hold in place the trachea (airway) during surgery.
- Trial name
- NCT03343080
- Testing
- 1.8% lidocaine plus 0.76% sodium bicarbonate, Air
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- Mayo Clinic
Aortic Valve Disease, Aortic Stenosis
Perceval Sutureless Implant Versus Standard-Aortic Valve Replacement
Prospective, randomized, stratified non blinded multi-center, international, post market trial assessed in a non-inferiority study. The trial has a flexible sample size that will be determined adaptively.
- Trial name
- PERSIST-AVR (NCT02673697)
- Testing
- Perceval valve, other stented biological valve
- Where
- 47 sites in United States, Austria and 10 more
- Volunteers
- 914 people
- Sponsor
- Corcym S.r.l
Mitral Valve Insufficiency, Coronary Artery Disease
Comparing the Effectiveness of a Mitral Valve Repair Procedure in Combination With Coronary Artery Bypass Grafting (CABG) Versus CABG Alone in People With Moderate Ischemic Mitral Regurgitation
Coronary artery bypass grafting (CABG) is a procedure that people with coronary artery disease (CAD) may undergo to increase blood flow to the heart.
- Trial name
- NCT00806988
- Testing
- Mitral Valve Repair, CABG
- Where
- 27 sites in United States, Canada and 1 more
- Volunteers
- 301 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Hypotension, Kidney Injury
Evaluating Fluid Strategies in Thoracic Surgery Patients Utilizing a Goal Directed Approach
The purpose of this study is to conduct a prospective, randomized, controlled trial comparing a restrictive vs. conservative fluid strategy in thoracic surgery patients.
- Trial name
- NCT02135146
- Testing
- Plasmalyte 3ml/kg/hr group, Plasmalyte 6ml/kg/hr group
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Colorado, Denver
Von Hippel-Lindau Disease
Natural History and Management of Pancreatic Lesions in Von Hippel-Lindau Disease
Von Hippel-Lindau disease (VHL) is an inherited cancer syndrome. Patients are at risk for developing pancreatic cysts and tumors. These tumors are more aggressive in some people than in others.
- Trial name
- NCT00062166
- Where
- United States
- Volunteers
- 340 people
- Sponsor
- National Cancer Institute (NCI)
Coronary Artery Bypass, Myocardial Ischemia
Glutamate for Metabolic Intervention in Coronary Surgery
The main purpose of this study is to determine whether intravenous glutamate infusion given in association with surgery for unstable coronary artery disease can protect the heart from myocardial injury, postoperative heart…
- Conditions
- Coronary Artery Bypass, Myocardial Ischemia, Myocardial Infarction, Coronary Artery Disease
- Trial name
- GLUTAMICS (NCT00489827)
- Testing
- Intravenous infusion of saline, Intravenous glutamate infusion
- Where
- 3 sites in Sweden
- Volunteers
- 865 people
- Sponsor
- University Hospital, Linkoeping
High-risk, Non-cardiovascular Surgeries
Esmolol for Treatment of Perioperative Tachycardia
The purpose of this study is to find out if Esmolol is a safe and effective alternative treatment compared to standard treatment using a long acting beta blocker drug, in controlling abnormal heart rate before, during and…
- Trial name
- NCT01208402
- Testing
- Esmolol
- Where
- 3 sites in United States
- Volunteers
- 76 people
- Sponsor
- Duke University