Clinical trials: Surgery, Cardiovascular
Coronary Artery Disease, Atrial Fibrillation (AF)
Cardiovascular Innovation & Research Institute 's NEXUS Registry, the Whole is Greater Than the Parts.
Information gathered from the patients via a disease specific questionnaire will be married to data from the National Cardiovascular Data Registry (NCDR®).
- Trial name
- NCT03428048
- Testing
- Hybrid procedure, Endocardial ablations, left atrial appendage occlusion
- Where
- United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Cardiovascular Innovation and Research Institute
Right Ventricular Dysfunction, Stroke Volume Index
Relationship Between Strain and Stroke Volume in Cardiac Surgery
Patients undergoing coronary artery bypass grafting up tp 30% will develop postoperative right ventricle dysfunction. Its imperative for the physician to fully understand the severity of this complication in order to perform an…
- Conditions
- Right Ventricular Dysfunction, Stroke Volume Index, Longitudinal Heart Strain
- Trial name
- NCT04694378
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Tufts Medical Center
Atrial Fibrillation
Effectiveness of Pulmonary Vein Isolation in Prevention of Atrial Fibrillation Following Heart Bypass Surgery
Atrial fibrillation (AF) is an irregular heart rhythm that occurs in 30% to 40% of patients following heart surgery. This irregular heart rhythm, although often self-limiting, can be cause for concern.
- Trial name
- NCT00338715
- Testing
- PVI with Medtronic's Cardioblate BP2 radiofrequency catheter
- Where
- Canada
- Volunteers
- 193 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Subaortic Stenosis, Congenital Heart Disease
The Fate of Aortic Valve After SAS Surgery in Children
Aortic valve regurgitation (AR) is a common complication following surgery for subaortic stenosis (SAS), yet the long-term outcomes and risk factors for postoperative significant AR (SAR) remain poorly understood.
- Conditions
- Subaortic Stenosis, Congenital Heart Disease, Aortic Regurgitation
- Trial name
- NCT06751368
- Where
- China
- Volunteers
- 232 people
- Sponsor
- Chinese Academy of Medical Sciences, Fuwai Hospital
Deep Venous Thrombosis
Study Comparing Desirudin With Heparin to Prevent Vein Clots After Heart and Lung Surgery
A blood clot in the veins, also known as deep venous thrombosis (DVT), is one of the most common complications after surgery. This may result in death if a clot breaks off and travel to the lungs; this is referred to as pulmonary…
- Trial name
- NCT00329433
- Testing
- Desirudin (Iprivask™), Heparin
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Washington University School of Medicine
Atrial Fibrillation
Remote Ischemic Conditioning and Atrial Fibrillation After Coronary Artery Bypass Grafting (CABG)
Recent studies indicate that remote ischemic conditioning can protect the heart and other organs during cardiac surgery. The investigators aim to investigate whether such a stimulus can reduce the incidence of atrial fibrillation…
- Trial name
- RICO (NCT01107184)
- Testing
- Remote ischemic conditioning
- Where
- Netherlands
- Volunteers
- 191 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Coronary Artery Disease
Clinical Outcomes of Patients Undergoing CABG Surgery With VEST Supported Venous Grafts
This is a prospective, investigator-initiated, multi-center, open label and post-market registry, enrolling patients with atherosclerotic coronary artery disease, scheduled for CABG with at least one SVG bypass.
- Trial name
- NCT04761068
- Testing
- VEST
- Where
- 13 sites in Austria, Germany and 3 more
- Volunteers
- 1,000 people
- Sponsor
- Cardiocentro Ticino
Reconstructive Surgical Procedures, Plastic Surgery
Leica Microsystems Sponsored Study to Collect and Confirm Clinical Data on the Performance of the GLOW800 Device When Used in Accordance With Its Intended Use.
This post-market clinical follow-up (PMCF) study aims to confirm the safety and performance of the GLOW800 surgical microscope accessory when used in conjunction with the ARveo8x surgical microscope.
- Conditions
- Reconstructive Surgical Procedures, Plastic Surgery, Vascular Surgical Procedure, Cerebrovascular Disorder
- Trial name
- IMED-GLOW800 (NCT07164040)
- Testing
- The GLOW800, a non-contact, non-invasive device, allows the surgical microscope ARveo 8 and ARveo 8X to produce excitation light and resolve fluorescence emission from the fluorescent agent ICG
- Where
- 3 sites in Portugal, Spain and 1 more
- Volunteers
- 31 people
- Sponsor
- Leica Microsystems (Schweiz) AG
Hypotension
Norepinephrine and Phenylephrine, Which Better for Elderly?
this is a prospective, double-blinded and single-center study. this study is based on the Stroke volume variation fluid guided therapy, to compare the effects of norepinephrine and phenylephrine in treating perioperative…
- Trial name
- NCT04067817
- Testing
- norepinephrine, Phenylephrine
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- The Second Affiliated Hospital of Dalian Medical University
Hemodynamic Instability, Blood Pressure, Low
Hemodynamic OptimizaTion in Sitting POsition Surgery Trial
Intraoperative hypotension (MAP <65 mmHg) in patients undergoing general anesthesia is a notable risk factor for the development of post-operative complications including acute kidney injury (AKI), myocardial injury, stroke and…
- Conditions
- Hemodynamic Instability, Blood Pressure, Low, Orthopedic Disorder
- Trial name
- HOTSPOT (NCT05143632)
- Testing
- ClearSight
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Myocardial Injury After Non-Cardiac Surgery, Ischemia Reperfusion Injury
Differential Impact of Pringle and Portal Vein Occlusion on Myocardial Injury After Non-Cardiac Surgeries.
This study aims to investigate the impact of hepatic ischemia-reperfusion injury (HIRI) on the incidence of myocardial injury after non-cardiac surgery (MINS) and explore the potential underlying mechanisms.
- Trial name
- NCT06895798
- Where
- 2 sites in China
- Volunteers
- 1,286 people
- Sponsor
- Beijing Tsinghua Chang Gung Hospital
Coronary Artery Disease, General Anesthetic Drug Allergy
Xenon Compared to Sevoflurane and Total Intravenous Anaesthesia for Coronary Artery Bypass Graft Surgery
Xenon is a gaseous anaesthetic agent registered in several European countries. It has been administered safely during cardiac surgery in pilot studies.
- Conditions
- Coronary Artery Disease, General Anesthetic Drug Allergy, Coronary Artery Bypass Graft Surgery
- Trial name
- NCT01294163
- Testing
- Xenon, Sevoflurane, Propofol
- Where
- 17 sites in France, Germany and 2 more
- Volunteers
- 509 people
- Sponsor
- Air Liquide Santé International
Deep-Venous Thrombosis, Pulmonary Embolism
Evaluation of Anti-Xa Levels in Surgery Patients Receiving Fixed Dose Heparin
The purpose of this study is to determine if fixed dose heparin infusions at a rate of 500 units/hour are sufficient to maintain a target anti-Xa of 0.1-0.35 IU/mL for venous thromboembolism (VTE) prophylaxis in patients…
- Conditions
- Deep-Venous Thrombosis, Pulmonary Embolism, Venous Thromboembolism
- Trial name
- NCT02970032
- Testing
- Real time heparin dose adjustment, Standard heparin dose
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Utah
Morbid Obesity, Cardiovascular Disease
Omega-3 Fatty Acid Status in Morbid Obesity Before and After Surgical Treatment
The purpose of this study is to determine the concentration of omega-3 fatty acids in plasma, blood and abdominal fat before and after bariatric surgery to provide guidance for future studies.
- Conditions
- Morbid Obesity, Cardiovascular Disease, Fatty Acid Levels
- Trial name
- NCT00558532
- Testing
- Bariatric Surgery
- Where
- United States
- Sponsor
- University of Cincinnati
Pressure Ulcers, Prevention
Study on Pressure Ulcers Prevention With Mepilex® Border Sacrum Dressing in Scheduled Cardiovascular Surgery
The study is a randomised controlled trial of patients admitted for a scheduled cardiac surgery at the Clermont-Ferrand hospital.
- Conditions
- Pressure Ulcers, Prevention, Skin Ulcer, Ulcer
- Trial name
- MEPICARD (NCT03823963)
- Testing
- Mepilex® Border dressing, Standard care
- Where
- France
- Volunteers
- 478 people
- Sponsor
- University Hospital, Clermont-Ferrand
Aortic Aneurysm
Prehabilitation for Aortic Aneurysm Surgery: Proof-of-concept Trial
This is a single-arm, proof-of-concept trial to examine the feasibility, acceptability, and preliminary efficacy of the Ready for Recovery program, a 6-week collaborative care intervention to help prepare individuals for repair…
- Trial name
- NCT06998498
- Testing
- Ready for Recovery
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Massachusetts General Hospital
Aortic Stenosis
TAVI Without On-Site Cardiac Surgery in Poland: A Randomized Multicenter Trial Protocol
Aortic stenosis (AS) represents the most prevalent acquired valvular heart disease in European populations, and transcatheter aortic valve implantation (TAVI) has become the dominant treatment modality for patients with…
- Trial name
- NOSCAR-TAVI (NCT07515768)
- Testing
- transcathter aortic valve implantation
- Volunteers
- 404 people
- Sponsor
- Medical University of Warsaw
Vascular Death, Myocardial Infarction
Vascular Events In Surgery patIents cOhort evaluatioN - Cardiac Surgery
Worldwide over 2 million adults (>30,000 Canadians) undergo heart surgery annually. Although heart surgery provides important survival benefits, it is associated with potential major complications such as death, stroke, and heart…
- Conditions
- Vascular Death, Myocardial Infarction, Stroke, Cardiac Surgery
- Trial name
- NCT01842568
- Where
- 24 sites in United States, Australia and 10 more
- Volunteers
- 15,989 people
- Sponsor
- Population Health Research Institute
Obesity
Autophagy and Inflammasome in Obesity: Effect of Weight Loss and Potential Therapeutic Implications
The main aim of this project is to determine the implication of autophagy and inflammasome in the pathogenesis of obesity and related comorbidities, and to explore in depth the mechanisms associated with the activation of immune…
- Trial name
- NCT05071391
- Testing
- Roux-en-Y gastric bypass
- Where
- Spain
- Volunteers
- 45 people
- Sponsor
- Milagros Rocha Barajas
Acute Renal Failure (ARF)
Venous Congestion and Acute Renal Failure in Cardiac Surgery Postoperative
Acute renal failure (ARF) is a frequent complication in the postoperative cardiac surgery, and is a major risk factor for mortality in this context.
- Trial name
- COVD (NCT03013621)
- Where
- France
- Volunteers
- 30 people
- Sponsor
- University Hospital, Strasbourg, France
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