Clinical trials: Surgery, Cardiovascular
Postoperative Delirium (POD), Cerebral Small Vessel Diseases
Prospective Randomized Controlled Trial of VR Cognitive Training in Reducing Postoperative Delirium in Elderly Patients With Cerebral Small Vessel Disease Undergoing Non-Cardiac Surgery
This clinical study investigates whether virtual reality (VR)-based cognitive training can help prevent postoperative delirium (POD) in elderly non-cardiac patients with pre-existing cerebral small vessel disease (CSVD).
- Trial name
- NCT06999668
- Testing
- Virtual reality cognitive function training, Virtual scene intervention
- Where
- 2 sites in China
- Volunteers
- 416 people
- Sponsor
- Peking University Third Hospital
Coronary Artery Disease
Transepicardial With Transseptal Autologous CD 133+ Bone Marrow Cell Implantation in Patient Following CABG Surgery
Heart Failure has several etiologies and one of them is coronary artery disease. Coronary artery bypass grafting (CABG) is one of revascularizations method which has been used for decades in coronary artery disease theraphy.
- Trial name
- NCT02870933
- Testing
- Transepicardial with Transseptal CD 133+ Implantation
- Where
- Indonesia
- Volunteers
- 30 people
- Sponsor
- National Cardiovascular Center Harapan Kita Hospital Indonesia
Systemic Inflammatory Response Syndrome, Infections
AOrtic Surgery: Systemic Inflammatory Response Versus Sepsis
The goal of the prospective observational study is to evaluate the immunological background of inflammatory response often seen after open thoracic aortic surgery.
- Conditions
- Systemic Inflammatory Response Syndrome, Infections, Thoracic Aortic Aneurysm, Aortic Diseases
- Trial name
- AOSIS (NCT06028789)
- Testing
- Blood sample test, Thoracic Aortic Surgery
- Where
- Czechia
- Volunteers
- 60 people
- Sponsor
- University Hospital Hradec Kralove
Anaemia
Oral and Intravenous Iron in Patients Postoperative Cardiovascular Surgery Under Extracorporeal Circulation
Anaemia is a common postoperative problem of cardiovascular surgery after cardiopulmonary bypass (CPB). Because of this the need for hemoderived blood transfusions is high.
- Trial name
- NCT01078818
- Testing
- IV trivalent saccharose hydroxide ferrous, Oral ferrous fumarate
- Where
- Spain
- Volunteers
- 159 people
- Sponsor
- Fundación Canaria Rafael Clavijo para la Investigación Biomédica
Myelopathy, Compressive, Hypertension
Decompressive Cervical Surgery and Hypertension
There is a relationship between CSM and hypertension, probably a cause/effect relationship, and investigators term this type of hypertension "cervicogenic hypertension".
- Trial name
- NCT02016768
- Testing
- decompressive cervical surgery
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Peking University First Hospital
Coronary Artery Disease
Clinical Trial of Kryptonite for Prevention of Sternal Complications in High Risk Patients Undergoing Cardiac Surgery
Kryptonite is a non-toxic biologic polymer, that has previously been used in orthopedic surgery. The objective of our study is to demonstrate the benefits of Kryptonite in cardiac surgery patients at high risk for sternal wound…
- Trial name
- Kryptonite (NCT01368991)
- Testing
- Kryptonite, Conventional closure
- Where
- Canada
- Volunteers
- 48 people
- Sponsor
- Cardiology Research UBC
Cardiovascular Disease, Healthcare Associated Infectious Disease
Optimizing Prevention of Healthcare-Acquired Infections After Cardiac Surgery (HAI)_2
The investigators will conduct qualitative interviews of hospital personnel regarding HAI prevention practices, and use coded data from these interviews to assist in developing standardized practices.
- Conditions
- Cardiovascular Disease, Healthcare Associated Infectious Disease, Sternal Superficial Wound Infection, Deep Sternal Infection
- Trial name
- NCT02073760
- Testing
- There is no intervention. The investigators are interviewing cardiac surgery staff with knowledge of infection prevention.
- Where
- United States
- Volunteers
- 79 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Liver Cancer, Surgery
Study of Liver Resection With Versus Without Hepatic Inflow Occlusion for the HBV-related HCC
The study aims to compare the perioperative and long-term outcomes of liver resection for HBV-related HCC with versus without hepatic inflow occlusion.
- Trial name
- OHx-NOHx (NCT02563158)
- Testing
- non-occlusion technique
- Where
- China
- Volunteers
- 114 people
- Sponsor
- Chinese PLA General Hospital
Valve Heart Disease, Coronary Artery Disease
Construction of a Prospective Cohort Database for the Perioperative Period of Cardiac Surgery
Cardiovascular disease (CVD) is the leading cause of global morbidity and mortality, with its prevalence increasing significantly from 1990 to 2019.
- Conditions
- Valve Heart Disease, Coronary Artery Disease, Coronary Heart Disease, Aortic Diseases
- Trial name
- NCT07662317
- Testing
- Cardiac surgey
- Where
- China
- Volunteers
- 10,000 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Cardiovascular Diseases, Cardiovascular Complication
Colchicine in Patients at Cardiac Risk Undergoing Major Non-Cardiac Surgery
Perioperative myocardial injury and major adverse cardiovascular events (MACE) are common causes of morbidity and mortality in patients at increased cardiovascular risk undergoing non-cardiac surgery.
- Conditions
- Cardiovascular Diseases, Cardiovascular Complication, Perioperative Complication, Myocardial Injury
- Trial name
- COLCAT (NCT06279000)
- Testing
- Colchicine
- Where
- Switzerland
- Volunteers
- 880 people, healthy volunteers welcome
- Sponsor
- Cantonal Hospital of St. Gallen
Nursing Students, PechaKucha Method
Pecha Kucha-Based ERAS Education in Cardiovascular Surgery: Effects on Nursing Students' Knowledge and Attitudes
Nursing education is rapidly evolving due to changing healthcare needs and Generation Z learning preferences, which favor short, visual, and interactive methods.
- Conditions
- Nursing Students, PechaKucha Method, PechaKucha Presentation, Teaching Methods
- Trial name
- PK-ERAS (NCT07606144)
- Testing
- Educational/Behavioral, Traditional PowerPoint ERAS Education
- Where
- Turkey (Türkiye)
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Lokman Hekim University
Ischemia Reperfusion Injury
Perioperative Evaluation of MMP-9-TIMP-1 System in Vascular Surgery Regarding Ischemic-reperfusion Injury
The MMP-9-TIMP-1 system has been implicated in many physiological and pathophysiological conditions including vascular surgery related ischemic-reperfusion injury.
- Trial name
- NCT03397732
- Testing
- aorto-bifemoral bypass and aorta stentgraft
- Volunteers
- 20 people
- Sponsor
- University of Pecs
Coronary Artery Disease, Systemic Inflammation
MIECC vs Conventional Cardiopulmonary Bypass and Systemic Inflammation in CABG
This prospective observational study evaluates the effects of minimally invasive extracorporeal circulation (MIECC) and conventional cardiopulmonary bypass on systemic inflammatory response in patients undergoing coronary artery…
- Trial name
- MIECC-CABG (NCT07823400)
- Testing
- Minimally Invasive Extracorporeal Circulation, Conventional Cardiopulmonary Bypass
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people
- Sponsor
- Bursa Yuksek Ihtisas Training and Research Hospital
Atrial Fibrillation
Organization in Acute Atrial Fibrillation Post Open Heart Surgery
A form of irregular heart rate called, Atrial Fibrillation (AF) is a major clinical problem. It afflicts about 2 million Americans and is the single largest heart related cause of stroke.
- Trial name
- A-Fib (NCT00614107)
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- State University of New York - Upstate Medical University
Aneurysm Aortic
Evaluation of the Efficacy of Ischemic Preconditioning to Protect Against Acute Kidney Injury After Open Surgery for Juxtarenal Abdominal Aortic Aneurysm
Juxta-renal abdominal aortic aneurysms (AAA) are challenging to treat with standard endovascular techniques (EVAR) due to their proximity to the renal arteries.
- Trial name
- EPAKI (NCT07441564)
- Testing
- patients with aortic clamping with preconditioning, patients with aortic clamping without preconditioning
- Where
- 7 sites in France
- Volunteers
- 206 people
- Sponsor
- University Hospital, Rouen
Mitral Regurgitation, Computed Tomography
Atrial Fibrillation Risk After Miniinvasive Mitral Valve Repair
This retrospective cohort study investigates how CT-derived tissue quality parameters, serving as markers of metabolic status, predict post-operative atrial fibrillation risk in patients undergoing minimally invasive mitral valve…
- Conditions
- Mitral Regurgitation, Computed Tomography, Atrial Fibrillation
- Trial name
- NCT06707506
- Volunteers
- 114 people
- Sponsor
- Nemocnice AGEL Trinec-Podlesi a.s.
Intracerebral Haemorrhage
Efficacy and Safety of NeuroEndoscopic Surgery for Large IntraCerebral Hemorrhage
This is a multicenter, randomized, controlled clinical trial comparing neuroendoscopic hematoma removal to craniotomy in the treatment of large intracerebral hemorrhage.
- Trial name
- NESICH 2 (NCT06894433)
- Testing
- neuroendoscopic surgery, craniotomy
- Where
- 2 sites in China
- Volunteers
- 280 people
- Sponsor
- Southwest Hospital, China
Heart Disease, Mitral Regurgitation
Using Beta Blockers to Treat Mitral Regurgitation
The purpose of this study tests whether beta-blocker will benefit asymptomatic patients with chronic primary mitral regurgitation.
- Conditions
- Heart Disease, Mitral Regurgitation, Heart Valve Disease, Mitral Valve Insufficiency
- Trial name
- REGURG (NCT00700947)
- Testing
- Beta-blocker therapy (TOPROL-XL® )
- Where
- United States
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Hypotension
Haemodynamic Response to General Anaesthesia in Healthy Orthopaedic Patients
Continuous cardiovascular monitoring as part of management of high-risk surgical patients is widely practiced, however its role in low-risk surgical patients is unclear.
- Trial name
- HRespToAS (NCT02834000)
- Testing
- LiDCO rapid™ CNAP monitoring
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Chelsea and Westminster NHS Foundation Trust
Coronary Artery Bypass Graft Surgery, Myocardial Ischemia
A Safety and Efficacy Study to Confirm the Cardioprotective Effects of MC-1 in Patients Undergoing High-Risk CABG
The purpose of this study is to determine the effect of MC-1 on the combined incidence of cardiovascular death and nonfatal myocardial infarction (MI) up to and including 30 days following coronary artery bypass graft (CABG)…
- Conditions
- Coronary Artery Bypass Graft Surgery, Myocardial Ischemia, Reperfusion Injury
- Trial name
- NCT00402506
- Testing
- (MC-1) Pyridoxal 5'-phosphate
- Where
- 2 sites in United States, Canada
- Volunteers
- 3,000 people
- Sponsor
- Medicure
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