Clinical trials: Surgery, Cardiovascular
Tachycardia, Hypertension
A Comparison of the Perioperative Hemodynamic Effects of Remifentanil and Esmolol in Intracranial Surgery
It was hypothesized that the use of esmolol as an alternative to remifentanil with sevoflurane inhalation anesthesia during intracranial surgery, could provide better hemodynamic conditions and cause lesser side effects in the…
- Conditions
- Tachycardia, Hypertension, Myocardial Ischemia
- Trial name
- NCT01628562
- Testing
- Esmolol, Remifentanil
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Diskapi Teaching and Research Hospital
Endocarditis, Neurologic Complication
Impact of Early Cardiac Surgery in Severe Left Endocarditis With Neurological Complications: a Retrospective Study
Surgical delay in severe endocardits, with neurological complications, is still debated. Early surgery, if indicated, permits to avoid new embolic events, or to fix valvular damages, but can create or increase a cerebral…
- Trial name
- ICE-COCA (NCT04387513)
- Testing
- Cardiac surgery
- Volunteers
- 192 people
- Sponsor
- Gros, Alexandre, M.D.
Morbid Obesity, Type2diabetes
Comorbidities Resolution After MGB Surgery and Change in Body Composition
This observational study aims to learn about the correlation between the improving comorbidities associated with obesity after MGB (Mini-Gastric Bypass) surgery and changes in body composition in morbidly obese patients.
- Conditions
- Morbid Obesity, Type2diabetes, Sleep Apnea, Hypothyroidism
- Trial name
- MOGAMBO (NCT06015620)
- Testing
- Mini gastric bypass surgery
- Where
- India
- Volunteers
- 35 people
- Sponsor
- All India Institute of Medical Sciences, Bhubaneswar
Ischemic Optic Neuropathy
Safety and Efficacy of Using SightSaver Visual Evoked Potential (VEP) for VEP Monitoring in Prone Spine Surgery
Post-operative visual loss (POVL) following non-ocular surgical procedures is an infrequent but severe complication. Little is understood about this complication, but most cases seem to result from loss of blood flow to the optic…
- Trial name
- SightSaver (NCT02643615)
- Testing
- VEP under TIVA, VEP under balanced anesth., Propofol
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Ohio State University
Mitral Regurgitation
TEER for Severe DMR of Low to Intermediate Surgery Risk
To investigate the efficacy and safety of transcatheter mitral valve edge-to-edge repair (TEER) for severe degenerative mitral regurgitation (DMR) patients of low to intermediate surgery risk.
- Trial name
- NCT06162780
- Testing
- ultrasonic cardiography (UCG), TEER
- Where
- China
- Volunteers
- 160 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Hemodynamic Instability, Cardiovascular Complication
Evaluation of Cardiac Functions in Deep Trendelenburg Position
Robotic-assisted laparoscopic prostatectomy (RALP) is a surgical method with good short-term results and accepted as the gold standard because of its minimal invasiveness.
- Trial name
- NCT05685979
- Testing
- Robotic-assisted laparoscopic prostatectomy in deep Trendelenburg position.
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Acibadem University
Surgical Procedure, Non-cardiac, Cardiovascular Disease Patients
Perioperative Ischemia Versus Perioperative Bleeding During Non-cardiac Surgery in Cardiac Patients
The aim of the study is to analyze the present use of antithrombotic therapy on a large cohort of consecutive cardiacs undergoing non-cardiac surgery.
- Conditions
- Surgical Procedure, Non-cardiac, Cardiovascular Disease Patients, Perioperative Period
- Trial name
- PRAGUE-14 (NCT01897220)
- Where
- 2 sites in Czechia
- Volunteers
- 1,200 people
- Sponsor
- Charles University, Czech Republic
Hypotension, Hemodynamic Instability
Perioperative Hypotension in Gynaecologic Oncologic Surgery: HPI-ClearSight Versus Arterial Waveform Analysis
Background Intraoperative hypotension is associated with increased morbidity and mortality. The Hypotension Prediction Index (HPI) is an advancement of the arterial waveform analysis to predict intraoperative hypotension minutes…
- Conditions
- Hypotension, Hemodynamic Instability, Gynecologic Cancer
- Trial name
- NCT05354661
- Testing
- Hypotension Prediction Index
- Where
- Italy
- Volunteers
- 68 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Venous Thromboembolism
Evaluation of AVE5026 as Compared to Enoxaparin for the Prevention of Thromboembolism in Patients Undergoing Hip Fracture Surgery
The primary objective was to compare the efficacy of once daily [q.d] subcutaneous [s.c.] injections of Semuloparin sodium (AVE5026) with q.d. s.c.
- Trial name
- SAVE-HIP2 (NCT00721760)
- Testing
- Enoxaparin sodium, Semuloparin sodium
- Where
- 25 sites in United States, Argentina and 23 more
- Volunteers
- 1,003 people
- Sponsor
- Sanofi
Surgery, Stroke
Neuralert Stroke Monitor Trial
The Neuralert monitoring system, a non-invasive device worn on each wrist, is designed to provide continuous monitoring and expedited recognition of stroke by identifying asymmetry in the extremities, facilitating patient…
- Trial name
- NCT07362303
- Testing
- Neuralert Monitor
- Where
- United States
- Volunteers
- 1,200 people
- Sponsor
- Neuralert Technologies LLC
Peripheral Arterial Disease
Assessment of Bypass Surgery and Balloon Angioplasty Effects in Peripheral Arterial Disease Using Contrast Ultrasound
Contrast ultrasound perfusion imaging (CUPI) is a novel tool for the assessment of muscle perfusion deficits in peripheral arterial disease (PAD).
- Trial name
- NCT00424450
- Testing
- lower limb artery bypass surgery, percutaneous angioplasty (PTA)
- Where
- Germany
- Volunteers
- 30 people
- Sponsor
- University Hospital Freiburg
Aortic Valve Stenosis
Clinical Evaluation of Percutaneous Implantation of the Medtronic CoreValve Aortic Valve Prosthesis (18Fr-Study)
The investigation concerns a prospective, multicenter, single arm safety and performance study evaluating the Medtronic CoreValve system.
- Trial name
- NCT01051518
- Testing
- Medtronic CoreValve System
- Where
- 9 sites in Canada, Germany and 2 more
- Volunteers
- 126 people
- Sponsor
- Medtronic Cardiac Rhythm and Heart Failure
Pupil Constriction, Iris Floppiness
Clinical Factors Associated Floppy Iris
This study is planned to investigate the incidence of intraoperative floppy iris and its relationship with pseudoexfoliation, diabetes, hypertension as well as systemic alpha-1 adrenergic blocker use.
- Conditions
- Pupil Constriction, Iris Floppiness, Iris Prolapsus From the Wound
- Trial name
- NCT00472888
- Where
- Turkey (Türkiye)
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Baskent University
Mother-Infant Interaction
Bonding, Self-effıcacy and Vital Signs in Infants Undergoing Cardiovascular Surgery
Congenital heart diseases, the most common type of congenital anomalies, which affect approximately 3% of all live births and are the second most common cause of death in infants, are associated with 7% of all neonatal deaths.
- Trial name
- NCT06158373
- Testing
- infant massage practice, Safe Swaddling, Control
- Where
- Turkey (Türkiye)
- Volunteers
- 36 people
- Sponsor
- Istanbul University - Cerrahpasa
Heparin-Induced Thrombocytopenia, Thrombosis
Generation of Heparin-induced Thrombocytopenia (HIT)-Antibodies Without Prior Heparin Exposure
The purpose of this study is to determine the HIT-antibody generation without prior heparin-exposure in patients undergoing orthopedic surgery.
- Trial name
- NCT01102790
- Where
- Germany
- Volunteers
- 160 people
- Sponsor
- Johann Wolfgang Goethe University Hospital
Intracerebral Hemorrhage, Spontaneous Intracerebral Hemorrhage
Minimally Invasive Surgery for Spontaneous Deep Intracerebral Hemorrhage
This observational cohort study evaluates the real-world effectiveness and safety of minimally invasive surgery (MIS) versus standard medical management in adults with spontaneous deep intracerebral hemorrhage.
- Conditions
- Intracerebral Hemorrhage, Spontaneous Intracerebral Hemorrhage, Basal Ganglia Hemorrhage
- Trial name
- MIS-DEEP ICH (NCT07710313)
- Testing
- Minimally Invasive Surgery (MIS), Standard medical treatment (SMT)
- Volunteers
- 300 people
- Sponsor
- Tam Anh Research Institute
Congenital Heart Disease (CHD)
Mesenchymal Stromal Cells for Infants With Congenital Heart Disease (MedCaP)
The proposed study will be a prospective, open-label, single-center, safety and feasibility phase 1 trial of allogeneic bone marrow-derived mesenchymal stromal cell (BM-MSC) delivery though cardiopulmonary bypass (CPB) using a…
- Trial name
- MedCaP (NCT04236479)
- Testing
- BM-MSC
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- Catherine Bollard
Valve Disease, Heart, Atrial Fibrillation (AF)
Apixaban VS Warfarin in AF Pts First Three Months After Repair or BIO AVR MVR
SAFE-HEART is a single-centre, randomized controlled trial comparing the safety and efficiency of Apixaban versus Warfarin in the early period (3 months) after repair or bioprosthetics of the mitral and aortic valve cardiac…
- Conditions
- Valve Disease, Heart, Atrial Fibrillation (AF), Valve Replacement Surgery, Aortic Valve Surgery
- Trial name
- SAFE-HEART (NCT07434661)
- Testing
- Apixaban, Warfarin
- Where
- Russia
- Volunteers
- 120 people
- Sponsor
- Meshalkin Research Institute of Pathology of Circulation
Pulmonary Hypertension
Sildenafil for Post-capillary Pulmonary Hypertension in Patients Undergoing Cardiac Surgery
Pulmonary hypertension increases the perioperative risk in patients undergoing cardiac surgery for valvular heart diseases, especially in patients with a long life mitral valve disease.
- Trial name
- SiPaHCS (NCT01481350)
- Testing
- sildenafil
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- University of Turin, Italy
Cardiovascular Risk Factor, Frailty
"Pilot Study: Effects of Vibration on Postoperative Early Mobilization of Cardiac Surgery Patients"
The rapid mobilization of cardiac surgery patients within the first 48 postoperative hours in the intensive care unit is common practice and decisive for the outcome, especially in this group (over 65 years).
- Trial name
- CardioVIB (NCT04243213)
- Testing
- Vibration Plate, Tilt at 15°, Standard hospital mobilization
- Where
- Austria
- Volunteers
- 30 people
- Sponsor
- Medical University of Graz
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