Clinical trials: Surgery (Major Vascular)
Left-Sided Heart Failure, Right-Sided Heart Failure
Echocardiography as Risk-Assessment for Major Adverse Cardiac Events in Major Vascular Surgery Patients
Patient with coronary artery disease (CAD), heart failure and abnormal heart function undergoing major vascular surgery have a high associated high morbidity and mortality with myocardial infarction accounting for 33-50% of…
- Conditions
- Left-Sided Heart Failure, Right-Sided Heart Failure, Heart Valve Diseases
- Trial name
- NCT04836702
- Volunteers
- 813 people
- Sponsor
- University of Virginia
Critically Ill Patients, Cardiac Surgery
Impact Of Antioxidant Micronutrients On Intensive Care Unit (ICU) Outcome
Critically ill patients are generally exposed to an increased oxidative stress, which is proportional to the severity of their condition.
- Conditions
- Critically Ill Patients, Cardiac Surgery, Trauma, Subarachnoid Hemorrhage
- Trial name
- Etude-AOX (NCT00515736)
- Testing
- Selenium (Se), Zinc (Zn), Vitamin C, Vitamin B1, Vitamin E
- Where
- Switzerland
- Volunteers
- 200 people
- Sponsor
- Centre Hospitalier Universitaire Vaudois
Airway Complication of Anesthesia
Prevalence of Major Vessels Underlying the Potential Incision Site for Emergency Front of Neck Airway Access in Adult Surgical Patients With Impalpable Neck Anatomy
Patients undergoing general anesthesia require assistance with their breathing and with the delivery of oxygen to their lungs. To achieve this, an anesthesiologist inserts a type of plastic breathing tube into the airway via the…
- Trial name
- NCT06637319
- Testing
- Ultrasound
- Where
- Canada
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Mount Sinai Hospital, Canada
Coronary Artery Disease, Left Ventricular Cardiac Dysfunction
Clinical Outcome of Coronary Artery Bypass Graft Surgery Versus Percutaneous Coronary Intervention in Patients With Severe Left Ventricular Disfunction (CROWN)
The objective of this study is to evaluate the best treatment strategy in patients with critical coronary artery disease and severe left ventricular dysfunction.
- Trial name
- CROWN (NCT07817524)
- Where
- Italy
- Volunteers
- 300 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Ischemia Reperfusion Injury
The Effect of Remote Ischemic Preconditioning in Patients Undergoing Major Liver Surgery
The project has been designed to determine whether a brief period of leg ischemia will reduce the I/R injury sustained by the liver during liver surgery and liver transplantation.
- Trial name
- NCT00796588
- Testing
- remote preconditioning
- Where
- United Kingdom
- Volunteers
- 48 people
- Sponsor
- Royal Free Hampstead NHS Trust
Coagulation; Intravascular, Fluid Electrolyte Disorders
Effect of Human Plasma Protein Transfusion With and Without Crystalloids During Major Liver Resection Surgeries
Evaluation of acid-base and electrolyte changes after administration of commonly used colloid solutions (plasma protein fraction contains 5% albumin), and crystalloids (saline 0.9% and lactated ringers solutions) is the primary…
- Trial name
- NCT05033704
- Testing
- 5% human plasma protein fraction (PPF)
- Where
- Qatar
- Volunteers
- 48 people
- Sponsor
- Hamad Medical Corporation
Hypotension
PeRsonalized Blood prEssure Management on Postoperative Complications and Mortality in hIgh-risk Patients Undergoing Major Non-cardiac Surgery
High-risk populations, particularly elderly individuals and patients with cardiovascular comorbidities, exhibit markedly elevated incidences of postoperative myocardial injury (MINS), acute kidney injury (AKI), and mortality.
- Trial name
- PREMIUM (NCT06952387)
- Testing
- Personalized blood pressure management, Routine blood pressure management
- Where
- 7 sites in China
- Volunteers
- 1,624 people
- Sponsor
- Nanfang Hospital, Southern Medical University
Major Non-cardiac Surgeries
A Trial of a Hospital Policy of Tranexamic Acid Use to Reduce Transfusion in Major Non-cardiac Surgery
A Phase IV trial of a hospital policy of Tranexamic acid to reduce transfusion in major non-cardiac surgery.
- Trial name
- TRACTION (NCT04803747)
- Testing
- Tranexamic acid (TXA)
- Where
- 10 sites in Canada
- Volunteers
- 8,421 people
- Sponsor
- University of Manitoba
Arteriovenous Malformations
Prospective Evaluation of the Efficacy of Sirolimus (Rapamune®) in the Treatment of Severe Arteriovenous Malformations
The aim of the study is to evaluate the efficacy and safety of sirolimus (oral form), to decrease the volume and symptoms due to superficial arteriovenous malformations (AVM).
- Trial name
- MAV-RAPA (NCT02042326)
- Testing
- Sirolimus
- Where
- 13 sites in Belgium, France
- Volunteers
- 50 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Severe and Symptomatic Aortic Stenosis, Undergoing TAVI
Vascular Complications and Bleeding After Transfemoral TAVI
Since the first implantation by Cribier, transcatheter aortic valve implantation (TAVI) revolutionized the management of severe symptomatic aortic stenosis.
- Trial name
- NCT03865043
- Where
- France
- Volunteers
- 300 people
- Sponsor
- University Hospital, Montpellier
Hypertension Arterial, Desaturation
Dexmedetomidine During Carotid Endarterectomy: a Registry on Safety and Satisfaction of Patients and Operators (DexTEA)
From an anesthesiological perspective, carotid endarterectomy (CEA) is an operation that is increasingly being performed with locoregional techniques and sedation.
- Conditions
- Hypertension Arterial, Desaturation, Bradycardia, Surgery (Major Vascular)
- Trial name
- NCT07105527
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- Saint Camillus International University of Health Sciences
Ischemic Heart Disease
By Pass Surgery With Stem Cell Therapy in Chronic Ischemic Cardiopathy
Surgical revascularization has proven its efficacy in term of morbidity and mortality in patients with multivessel coronary disease and poor left ventricular function.
- Trial name
- NCT00690209
- Testing
- Autologous bone marrow derived stem cells myocardial transplantation
- Where
- France
- Volunteers
- 12 people
- Sponsor
- University Hospital, Clermont-Ferrand
Thoracic Surgery, Vascular Injury
Major Vascular Injuries in Elective Thoracic Surgery: A 10-Year Single-Center Experience
This study retrospectively examines major vascular injuries that occurred during elective thoracic surgeries over a 10-year period at a single tertiary care center.
- Conditions
- Thoracic Surgery, Vascular Injury, Intraoperative Complications
- Trial name
- NCT07100509
- Testing
- Major Vascular Injury During Elective Thoracic Surgery
- Volunteers
- 11 people
- Sponsor
- Caner İşevi, MD
Thromboembolism, Arthroplasty, Replacement, Hip
Study to Evaluate the Safety and Efficacy of Pradaxar for the Prevention of Venous Thromboembolism in the Mexican Population Undergoing Elective Total Hip or Knee Replacement Surgery
Open, prospective, uncontrolled, observational cohort study.
- Trial name
- NCT00967447
- Where
- 28 sites in Mexico
- Volunteers
- 2 people
- Sponsor
- Boehringer Ingelheim
Stellate Ganglion Block, Arteriovenous Fistula
Stellate Ganglion Block for Preserving Arteriovenous Fistula in Hemodialysis Patients Undergoing Major Lower Limb Orthopedic Surgery
The aim of this study is to evaluate the role of stellate ganglion blockade (SGB) for preserving arteriovenous fistula in hemodialysis patients undergoing major lower limb orthopedic surgery.
- Conditions
- Stellate Ganglion Block, Arteriovenous Fistula, Hemodialysis, Major Lower Limb Orthopedic Surgery
- Trial name
- NCT06300658
- Testing
- Stellate ganglion block
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Aswan University
Patient Blood Management
Impact of Patient Blood Management (PBM) at the Schulthess Clinic
Aim of this study is to analyze the transfusion requirements of allogenic blood products at the Schulthess Clinic for patients that had major orthopedic or major spine surgery between 2019 and 2024 order to identify patients at…
- Trial name
- PBM (NCT06363214)
- Testing
- Patient blood management
- Volunteers
- 16,000 people
- Sponsor
- Schulthess Klinik
Lumbar Spinal Stenosis, Lumbar Degenerative Disease
Effect of Obesity Phenotype on Intraabdominal Pressure and Bleeding in Major Lumbar Spinal Surgery
Obesity is prevalent among patients with lumbar degenerative disease and is a known risk factor for perioperative complications in spinal surgery.
- Conditions
- Lumbar Spinal Stenosis, Lumbar Degenerative Disease, Obesity, Intraabdominal Hypertension
- Trial name
- OBESPINE (NCT07688265)
- Testing
- Intraabdominal Pressure Measurement via Urinary Bladder Catheter, Total Intravenous Anesthesia (TIVA)
- Volunteers
- 90 people
- Sponsor
- Marmara University Pendik Training and Research Hospital
Hypotension, Postoperative Complications
Biomarkers, Blood Pressure, BIS: Risk Stratification/Management of Patients at Cardiac Risk in Major Noncardiac Surgery
Major adverse cardiovascular events (MACE) are a leading cause of serious complications and death following major noncardiac surgery.
- Conditions
- Hypotension, Postoperative Complications, Acute Coronary Syndrome, Heart Failure
- Trial name
- BBB (NCT02533128)
- Testing
- Liberal blood pressure management, Tight blood pressure management
- Where
- Switzerland
- Volunteers
- 458 people
- Sponsor
- Miodrag Filipovic, Prof. Dr. med.
Venous Thromboembolism
Evaluation of AVE5026 as Compared to Enoxaparin for the Prevention of Venous Thromboembolism in Patients Undergoing Major Abdominal Surgery
The primary objective is to compare the efficacy and safety of once daily (q.d.) subcutaneous (s.c.) injections of Semuloparin sodium (AVE5026) with q.d. s.c.
- Trial name
- SAVE-ABDO (NCT00679588)
- Testing
- Semuloparin Sodium, Enoxaparin sodium
- Where
- 270 sites in United States, Argentina and 37 more
- Volunteers
- 4,413 people
- Sponsor
- Sanofi
Retinal Detachment, Diabetic Retinopathy
Avastin for PDR (Proliferative Diabetic Retinopathy)
The purpose of this study is to determine the effect of anti-VEGF drug (Avastin) adminstration in eyes prior to surgical treatment for Traction retinal detachment (TRD) in patients with Proliferative Diabetic Retinopathy (PDR).
- Trial name
- PDR (NCT01270542)
- Testing
- Avastin (bevacizumab)
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Southern California