Clinical trials: Surgery Complications
Pain, Post-operative
Evaluation of N1539 Following Major Surgery
The primary objective of this study is to evaluate the safety and tolerability of N1539 in a variety of post-surgical conditions.
- Trial name
- NCT02720692
- Testing
- N1539
- Where
- 32 sites in United States, Australia and 2 more
- Volunteers
- 722 people
- Sponsor
- Baudax Bio
Degenerative Lumbar Disease
Minimal Access Surgical Technique (MAST) in Obese Patients in Degenerative Lumbar Disease
The study concerns a retrospective analysis of all subjects operated as of 1st Jan 2008 using Minimal Access Surgical Technique (MAST).
- Trial name
- NCT01195584
- Where
- Austria
- Volunteers
- 72 people
- Sponsor
- General Hospital Amstetten
Pulmonary Disease
High Flow vs Conventional Oxygen in Head and Neck Surgery
Patients undergoing major head and neck surgery are at risk for postoperative pulmonary complications. The goal of this randomized clinical trial is to evaluate the effectiveness of high flow heated humidified oxygen at…
- Trial name
- NCT05362526
- Testing
- High flow humidification, Conventional cool mist aerosol humidification
- Where
- United States
- Volunteers
- 56 people
- Sponsor
- University of Florida
Major Surgery
Intravenous Oliceridine and Opioid-related Complications
The investigator will evaluate the side effects of oliceridine.
- Trial name
- NCT04979247
- Testing
- Oliceridine
- Where
- 3 sites in United States
- Volunteers
- 204 people
- Sponsor
- The Cleveland Clinic
Surgical Wound Infections
Prevention of Neurosurgical Wound Infections
The goal of this study is to determine whether injecting the antibiotic vancomycin directly into surgical wounds can decrease the rate of infection following implantation of neurosurgical devices.
- Trial name
- POWI (NCT00915967)
- Testing
- Vancomycin
- Where
- United States
- Volunteers
- 214 people
- Sponsor
- Oregon Health and Science University
Postoperative Hemorrhage
U.S. Study of Fibrocaps in Surgical Hemostasis
The purpose of this study was to characterize the safety and hemostatic activity of topical Fibrocaps in surgical patients when control of mild to moderate bleeding by standard surgical techniques was ineffective and/or…
- Trial name
- NCT01256164
- Testing
- Fibrocaps (fibrin sealant), Gelfoam
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- Mallinckrodt
Post-operative Pain, Colon Cancer
The Effect of Exparel on Post Operative Pain and Narcotic Use After Colon Surgery
The purpose of the study is to evaluate the effect of Exparel on pain control and patient outcome after colon resection. The investigators will evaluate the clinical course of the patients who receive exparel as compared to the…
- Conditions
- Post-operative Pain, Colon Cancer, Diverticulitis
- Trial name
- NCT02052557
- Testing
- Bupivacaine, Bupivacaine liposome suspension
- Where
- United States
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Des Moines University
Laminectomy, Post-laminectomy Syndrome
Spinal Cord Stimulation in Patients With Post-Laminectomy Syndrome in Testing Phase
Traditionally, pain relief through spinal cord stimulation has been associated with the appearance of paresthesia in the affected area.
- Conditions
- Laminectomy, Post-laminectomy Syndrome, Spinal Cord Syndrome, Failed Back Surgery Syndrome
- Trial name
- NCT03702010
- Testing
- spinal cord stimulation conventional, spinal cord stimulation experimental
- Where
- 2 sites in Spain
- Volunteers
- 27 people
- Sponsor
- Fundación Instituto de Estudios de Ciencias de la Salud de Castilla y León
Surgical Site Infection
Checklist to Prevent MRSA Surgical Site Infections
The goals of this project are 1) to assess the effectiveness and cost-effectiveness of the checklist to prevent MRSA SSIs among Veterans undergoing TJA or cardiac surgery, and 2) to assess barriers and facilitators to checklist…
- Trial name
- NCT02216227
- Testing
- Mupirocin, Chlorhexidine gluconate, Cefazolin
- Where
- 11 sites in United States
- Volunteers
- 23,005 people
- Sponsor
- VA Office of Research and Development
Coronary Artery Disease, Pain, Postoperative
Parasternal Nerve Block in Cardiac Patients
Exparel is a new local analgesic (numbing medication) that is intended to be longer acting than currently available local analgesics.
- Trial name
- NCT01826851
- Testing
- Exparel
- Where
- United States
- Volunteers
- 79 people
- Sponsor
- Peter A Knight
Uterine Diseases
Hysterectomy by Transabdominal Laparoscopy or NOTES
Objective: To randomly compare hysterectomy by vaginal Natural Orifice Transluminal Endoscopic Surgery (vNOTES) versus laparoscopy uterus in women with benign gynecological pathology.
- Trial name
- HALON (NCT02631837)
- Testing
- vNOTES hysterectomy, LSC hysterectomy
- Where
- Belgium
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Imelda Hospital, Bonheiden
Bleeding, Blood Loss, Surgical
PCC vs. FFP for Post Cardiopulmonary Bypass Coagulopathy and Bleeding
This will be the first prospective randomized controlled clinical trial directly comparing Prothrombin Complex Concentrate (PCC) Compared to Fresh Frozen Plasma (FFP) for post cardiopulmonary bypass microvascular bleeding and…
- Conditions
- Bleeding, Blood Loss, Surgical, Cardiovascular Surgical Procedures, Prothrombin Complex Concentrates
- Trial name
- NCT02557672
- Testing
- Prothrombin complex concentrate (Human), Fresh frozen plasma (FFP)
- Where
- United States
- Volunteers
- 106 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Video Assisted Thoracoscopic Surgery, Pain, Postoperative
Comparison of Three Different Pain Blocks for Subjects Undergoing VATS (Video Assisted Thoracoscopic Surgery) Procedure.
The purpose of this study is to compare three different pain control methods on subjects who are scheduled to undergo VATS (video-assisted thoracoscopic surgery) procedures.
- Conditions
- Video Assisted Thoracoscopic Surgery, Pain, Postoperative, Pain, Acute
- Trial name
- VATS (NCT03151434)
- Testing
- US Guided Single Shot Paravertebral Block (0.2% ropivicaine infusion), US Guided Paravertebral Catheter (0.2% ropivicaine bolus), Thoracic Epidural (0.125% bupivicaine/hydromorphone)
- Where
- United States
- Volunteers
- 147 people
- Sponsor
- Indiana University
Bladder Cancer, Prostate Cancer
Medtronic Hugo™ Robotic Assisted Surgery (RAS) System in Urologic Surgery (Expand URO)
This study will evaluate the safety and performance of the Medtronic Hugo™ RAS System when used for urologic RAS procedures.
- Conditions
- Bladder Cancer, Prostate Cancer, Kidney Cancer, Pelvic Tumor
- Trial name
- NCT05696444
- Testing
- RAS Prostatectomy, RAS Cystectomy, RAS Nephrectomy
- Where
- 6 sites in United States
- Volunteers
- 144 people
- Sponsor
- Medtronic - MITG
Postoperative Pain, Wisdom Tooth
Protective Analgesia for Postoperative Pain Relief Following Day Case Oral Surgery
The purpose of this study is to investigate whether robust analgesic regime (protective analgesia) can improve postoperative pain experience for patients undergoing lower wisdom teeth extraction under day case general anaesthetic.
- Trial name
- NCT00895843
- Testing
- Brufen retard, ibuprofen, Bupivacaine
- Where
- 2 sites in United Kingdom
- Volunteers
- 122 people, healthy volunteers welcome
- Sponsor
- University of Manchester
Ankle Fractures, Pain, Postoperative
Ropivacaine Versus Bupivacaine as Preemptive Analgesia in Surgical Site in Ankle Fracture Patients
Title: Ropivacaine versus Bupivacaine as Preventive Analgesia in Surgical Incision Site In Patients With Ankle Fracture Background: Ankle fractures are about 10% of the fractures associate to sports and with an incidence of 0.11…
- Conditions
- Ankle Fractures, Pain, Postoperative, Local Infiltration
- Trial name
- NCT02949674
- Testing
- Ropivacaine, Bupivacaine
- Where
- Mexico
- Volunteers
- 93 people, healthy volunteers welcome
- Sponsor
- Instituto Mexicano del Seguro Social
Acute Postoperative Pain, Bunionectomy
Evaluate the Efficacy and Safety of ACP-044 for the Treatment of Acute Postoperative Pain Following Bunionectomy
To evaluate the efficacy of ACP-044 compared with placebo in the treatment of acute postoperative pain
- Trial name
- NCT04855240
- Testing
- ACP-044 Dose A, ACP-044 Dose B
- Where
- 4 sites in United States
- Volunteers
- 239 people
- Sponsor
- ACADIA Pharmaceuticals Inc.
Peritoneal Surface Malignancy, Postoperative Adhesion
SurgiPerito Trial: High-Purity Type-I Collagen for Peritoneal Reconstruction After Cytoreductive Surgery
This dual-centre, randomized controlled trial evaluates the safety and efficacy of high-purity Type-I collagen-based biomaterial, as a peritoneal substitute following peritonectomy in patients undergoing cytoreductive surgery…
- Conditions
- Peritoneal Surface Malignancy, Postoperative Adhesion, Bowel Obstruction, Wound Complications
- Trial name
- NCT07241091
- Testing
- High-Purity Type-I Collagen Scaffold, Standard Peritonectomy Closure
- Where
- 2 sites in India
- Volunteers
- 60 people
- Sponsor
- Adichunchanagiri Institute of Medical Sciences, B G Nagara
Type 2 Diabetes
The Effects of Glycemic Optimization Before Gastric Bypass Surgery
Metabolic surgery such as gastric bypass, gastric banding or sleeve gastrectomy operations can cause rapid and uncontrolled reductions in blood glucose.
- Trial name
- GLUCOSURG2 (NCT01353118)
- Testing
- gastric bypass
- Where
- 2 sites in United Kingdom
- Volunteers
- 41 people
- Sponsor
- Imperial College London
Acute Kidney Injury
Renal Replacement Therapy and In-Hospital Mortality Incidence in Cardiac Surgery Associated Acute Kidney Injury
The goal of this study is to analyse the relation of severe acute kidney injury post cardiac surgery which characterised by the need of renal replacement therapy, with in-hospital postoperative mortality incidence.
- Trial name
- NCT06091982
- Testing
- Renal Replacement Therapy (RRT)
- Where
- Indonesia
- Volunteers
- 1,113 people
- Sponsor
- National Cardiovascular Center Harapan Kita Hospital Indonesia