Clinical trials: Surgery With General Anesthesia
General Anesthesia
Efficacy and Safety of HSK3486 Compared to Propofol for Adults Undergoing Elective Surgery With General Anesthesia
To demonstrate HSK3486 0.4/0.2 mg/kg (0.4 mg/kg intravenous [IV] slow injection over 30 [±5] seconds for the first dose, an additional 0.2 mg/kg if needed) is non-inferior to propofol 2.0/1.0 mg/kg (2.0 mg/kg IV slow injection…
- Trial name
- NCT05478174
- Testing
- HSK3486, Propofol
- Where
- 23 sites in United States
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Haisco-USA Pharmaceuticals, Inc.
Anesthesia, Local, Ophthalmopathy
Comparison Between Peribulbar And Sub-tenon Blocks on Oculocardiac Reflex (OCR) During Pediatric Strabismus Surgery
The aim of this study is to compare between peribulbar block and subtenon block as an adjunct to general anesthesia in children undergoing strabismus surgery on oculocardiac reflex (OCR), post-operative analgesia and…
- Conditions
- Anesthesia, Local, Ophthalmopathy, Strabismus, Pediatric ALL
- Trial name
- NCT06293586
- Testing
- peribulbar block, sub-tenon block, Paracetamol
- Where
- Egypt
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Cairo University
Lumbar Disc Herniation, Lumbar Disc Disease
GA + ESP vs. SA + ESP in Lumbar Decompression Surgeries
The purpose of this study is to determine the optimal anesthetic routine for lumbar decompression surgery. General Anesthesia is the standard of care in spine surgery.
- Conditions
- Lumbar Disc Herniation, Lumbar Disc Disease, Lumbar Radiculopathy
- Trial name
- NCT05444751
- Testing
- General anesthetic, SA + ESP
- Where
- United States
- Volunteers
- 142 people, healthy volunteers welcome
- Sponsor
- Hospital for Special Surgery, New York
Sepsis, Glucocorticoid
Clinical Characteristics and Risk Factors for In-Hospital Mortality in Surgical Patients With Abdominal Sepsis
A retrospective study of sepsis patients with abdominal infections who underwent abdominal surgery was conducted in an attempt to reveal the epidemiological characteristics of sepsis after abdominal surgery, risk factors, and to…
- Trial name
- NCT06756750
- Where
- China
- Volunteers
- 476 people
- Sponsor
- Chinese PLA General Hospital
Postoperative Pain, Breast Cancer
Comparison of Erector Spinae Plane Block With Serratus Anterior Plane Block for Breast Surgery
Breast cancer is by far the world's most common cancer among women and the most common cause of female death from cancer worldwide. It's worldwide incidence is 43.4 in 100.000 while in Egypt is 48.8 in 100.000.
- Trial name
- NCT03579524
- Testing
- Erector Spinae Plane Block, Serratus Anterior Plane Block
- Where
- Egypt
- Volunteers
- 62 people
- Sponsor
- Fayoum University Hospital
Delirium, Postoperative, Anesthesia
Depth of Anesthesia on Postoperative Delirium and Cognitive After Surgery
The goal of this clinical trial (Balanced-2 study) is to compare light to deep general anesthesia using widely available brain monitors, to see if 'light' anesthesia could reduce rates of delirium, cognitive decline, and…
- Conditions
- Delirium, Postoperative, Anesthesia, Surgery-Complications, Cognition Disorder
- Trial name
- Balanced-2 (NCT06268080)
- Testing
- Depth of anesthesia titration using pEEG
- Where
- 3 sites in New Zealand
- Volunteers
- 2,766 people
- Sponsor
- Auckland City Hospital
Hypothermia
National Epidemiologic Survey on the Incidence of Perioperative Hypothermia
Study Objective: to project the incidence of perioperative hypothermia in patients with elective surgery under general anesthesia in China to determine the risk factors associated with perioperative hypothermia.
- Trial name
- NCT02211703
- Where
- China
- Volunteers
- 2,208 people
- Sponsor
- Jie YI
Brain Neoplasms, Surgery
Cerebral Blood Perfusion Changes After General Anesthesia for Craniotomy
Few studies look into cerebral blood flow (CBF) changes during emergence from general anesthesia for craniotomy. The purpose of this study is to demonstrate CBF changes during emergence from general anesthesia for craniotomy…
- Conditions
- Brain Neoplasms, Surgery, Hyperemia
- Trial name
- NCT01642147
- Testing
- Transcranial Doppler (TCD), jugular venous bulb catheterization, Tumor removal surgery under general anesthesia
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Huashan Hospital
Vitreoretinal Surgeries, Postoperative Nausea and Vomiting
Paracetamol and Metamizole With SPI-guided Anaesthesia for VRS
The aim of this randomized trial is to assess the efficacy of preemptive analgesia using paracetamol or metamizole or both of them under SPI-guided anaesthesia for vitreoretinal surgery (VRS), presence of PONV (postoperative…
- Conditions
- Vitreoretinal Surgeries, Postoperative Nausea and Vomiting, Postoperative Pain
- Trial name
- P&MSPIVRS (NCT03389243)
- Testing
- Metamizol, paracetamol, paracetamol and metamizole
- Where
- Poland
- Volunteers
- 165 people
- Sponsor
- Medical University of Silesia
Surgery With General Anesthesia
Validation of the Effect of Propofol and Opiates Closed-loop Administration Device During Anesthesia and Sedation
Sleeping medication and analgesia are standard administered during anesthesia. Sleeping medication, Propofol (Diprivan, AstraZeneca), and analgesia, Remifentanil (GlaxoSmithKline), are most frequently used In the University…
- Trial name
- NCT00764855
- Testing
- Automatic administration of propofol and opiates during routine clinical practice
- Where
- Belgium
- Volunteers
- 180 people
- Sponsor
- University Hospital, Ghent
Surgery With General Anesthesia
Diagnosis and Its Procedural Pattern Among Patients Who Underwent Surgery at Aloha Medical Mission in Dhankuta, 2018
This was a retrospective, cross-sectional study of the Aloha medical mission in 2018, which involved analyzing recorded data on the sociodemographic profiles of patients, diseases, and surgical procedures.
- Trial name
- Diagnosis and (NCT06969157)
- Testing
- Surgery
- Where
- Nepal
- Volunteers
- 225 people
- Sponsor
- Tribhuvan University Teaching Hospital, Institute Of Medicine.
Intubation
First Attempt Intubation Rate With Airtraq vs Macintosh Direct Laryngoscope
In recent decades, numerous videolaryngoscopes have been introduced to facilitate tracheal intubation. However, it remains unclear whether videolaryngoscope will increase the successful tracheal intubation compared with usual…
- Trial name
- FAIRAiM (NCT03887897)
- Testing
- Tracheal Intubation
- Where
- Hong Kong
- Volunteers
- 1,586 people
- Sponsor
- Chinese University of Hong Kong
Emergence Delirium, Anesthesia
Emergence Delirium、fBFI-ENO Score (Extraversion + Neuroticism - Openness) Based on the Fast Big Five Personality Scale-10、An Adult Patient With ASAI-III Who is Scheduled for Elective Non-cardiac Surgery and is to Undergo General Anesthesia With Tracheal Intubation
The aim of this study is to verify the generalizability of the fBFI-ENO score (extraversion + neuroticism - openness) constructed based on the Rapid Big Five Personality Scale - 10 across different genders, ages, and surgical…
- Trial name
- NCT07775768
- Volunteers
- 880 people
- Sponsor
- Hongjiao Xu
Tissue Perfusion, Lower Extremity Surgery
Comparison of the Effects of General Anesthesia and Spinal Anesthesia on Tissue Perfusion in Patients Undergoing Lower Extremity Surgery
This prospective, single-center observational study compares the effects of general anesthesia and spinal anesthesia on tissue perfusion in patients undergoing lower extremity surgery with tourniquet use.
- Conditions
- Tissue Perfusion, Lower Extremity Surgery, Tourniquet-Induced Ischemia-Reperfusion Injury, General Anesthesia
- Trial name
- Perf-LEX (NCT07474480)
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Prof. Dr. Cemil Tascıoglu Education and Research Hospital Organization
General Anesthesia Induction for Elective Surgery
Carotid Artery Corrected Flow Time as a Predictor of Hypotension After Induction of General Anesthesia in Elderly Patients
The number of elderly patients undergoing elective surgery has been growing in recent years. Elderly patients often have a variety of underlying diseases, including hypertension, coronary heart disease, diabetes…
- Trial name
- NCT05628051
- Testing
- ultrasonographic measurement of carotid artery corrected flow time (FTc)
- Where
- China
- Volunteers
- 177 people
- Sponsor
- Fujian Medical University Union Hospital
Obesity
Comparison of Acceleromyography and Electromyography in Obese Patients Undergoing General Anesthesia
The goal of this prospective observational study is to compare two different methods of monitoring muscle relaxation during anesthesia - acceleromyography (AMG) and electromyography (EMG) - in people with obesity who are having…
- Trial name
- OBAEG (NCT07283354)
- Testing
- Neuromuscular monitoring with electromyography (EMG), Neuromuscular monitoring with acceleromyography (AMG)
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- University of Padova
Anesthesia
Japan Phase 2/3 Clinical Study With BLM-240 (Desflurane)
The purposes of this study are to evaluate the efficacy and safety of desflurane (BLM-240) as an anesthetic agent and to demonstrate the non-inferiority of desflurane to sevoflurane in term of awakening/recovery from anesthesia.
- Trial name
- NCT00762372
- Testing
- desflurane, desflurane/nitrous oxide, sevoflurane/nitrous oxide
- Where
- 15 sites in Japan
- Volunteers
- 216 people
- Sponsor
- Baxter Healthcare Corporation
Anesthesia Brain Monitoring, Ketamine
Effect of Ketamine Infusion on BIS Values
Aim of this trial is to define if Concentration at the effector site (Ce) of Ketamine, during a continuous infusion and calculated with DOMINO model infusion pump are correlated with Bispectral Index BIS values during general…
- Trial name
- NCT05799729
- Testing
- Ketamine
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- University of Padova
Intraoperative Hypotension, Jugular Veins
Internal Jugular Vein Ultrasound and Acute Kidney Injury After Abdominal Surgery
This observational study aims to learn whether changes in the internal jugular vein during anesthesia induction can help predict low blood pressure and kidney injury after surgery. The main questions it aims to answer are: 1.
- Conditions
- Intraoperative Hypotension, Jugular Veins, Hypotension on Induction, General Anesthesia With Propofol
- Trial name
- PRO-JUGULAR (NCT07638306)
- Testing
- Internal Jugular Vein Ultrasound Assesment
- Where
- Romania
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Tîrgu Mureș Emergency Clinical County Hospital, Romania
Pulmonary Embolism
The Clinic Study to Prevent Pulmonary Embolism in Patients With General Anesthesia Operation in Perioperative Period
The purpose of this study is to investigate the prevention of Pulmonary Embolism in Patients who With General Anesthesia Operation in Perioperative Period.
- Trial name
- NCT02460952
- Where
- China
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Beijing Chao Yang Hospital