Clinical trials: Surgery for Colorectal Cancer.
Colonic Neoplasms, Diverticulosis, Colonic
Biodegradable Stenting Anastomoses Versus Double-layer Hand Sutures for Reconstruction in Intestinal Anastomosis
Intestinal anastomosis plays an important role in various general surgeries, but the complications such as anastomotic leakage,stenosis and hemorrhage cannot been avoided.
- Conditions
- Colonic Neoplasms, Diverticulosis, Colonic, Crohn Disease
- Trial name
- NCT02752360
- Testing
- Biodegradable Stenting Anastomoses, Double-layer Hand Sutures
- Where
- China
- Volunteers
- 288 people
- Sponsor
- Beijing Friendship Hospital
Minimal Residual Disease, Immunoscore
Neoadjuvant CAPEOX Versus Upfront Surgery for Locally Advanced Colon Cancer With Elevated CEA: A Single-Center, Open-Label, Randomized Controlled Trial
The goal of this interventional clinical trial is to compare the efficacy of neoadjuvant chemotherapy versus upfront surgery in adults aged 18-70 years with stage II (high-risk)-III, non-MSI-H colon adenocarcinoma and elevated…
- Conditions
- Minimal Residual Disease, Immunoscore, Neoadjuvant Chemotherapy, Colon Cancer (Stage II &Amp; III)
- Trial name
- NCT07413146
- Testing
- ctDNA-Based Molecular Residual Disease (MRD) Monitoring and Immunoscore Assessment, Neoadjuvant Chemotherapy, Adjuvant chemotherapy
- Volunteers
- 100 people
- Sponsor
- Sun Yat-sen University
Colorectal Cancer, Leakage Testing
Efficacy and Safety of Colorectal Anastomotic Leak Testing
To evaluate the effectiveness of the gastroscopy, air, and methylene blue (GAM) leak testing in reducing the incidence of postoperative anastomotic complications, especially anastomotic leakage, in patients with colorectal…
- Conditions
- Colorectal Cancer, Leakage Testing, Colorectal Surgery, Complications
- Trial name
- NCT06865638
- Testing
- Intraoperative leak testing
- Where
- China
- Volunteers
- 264 people
- Sponsor
- Nanchong Central Hospital
Rectal Cancer
Reasons for Non-reversal of Temporary Stomas After Surgeries of Mid-low Rectal Cancer （NORESTO Study）
The goal of this observational study is to learn about in mid-low rectal patients who received temporary ostomies after surgery of the primary tumors.
- Trial name
- NCT06194708
- Where
- China
- Volunteers
- 235 people
- Sponsor
- Peking Union Medical College Hospital
Rectal Neoplasms
Selection of Surgical Technique in Rectal Cancer
Currently, there is no prediction scale available to identify patients with rectal neoplasms as technically complex in the middle and lower thirds; that is, those who are at high risk of affected circumferential margins and low…
- Trial name
- TECARE (NCT06442215)
- Testing
- Data collection
- Where
- Spain
- Volunteers
- 333 people
- Sponsor
- Institut d'Investigació Biomèdica de Girona Dr. Josep Trueta
Colon or Upper Rectum Adenocarcinoma
Investigate the Efficacy of Chemotherapy in Patients With Positive ctDNA After Surgery and Adjuvant Chemotherapy for a Stage III Colorectal Cancer
Phase III multicentric, open-label, randomized study The main objective is to assess the efficacy on time to disease recurrence (TTR) of treating minimal residual disease diagnosed by the presence of ctDNA after full treatment…
- Trial name
- CIRCULATE PAC (NCT06197425)
- Testing
- "FOLFIRI" cures, Trifluridine cures, BIOLOGICAL ASSESSMENT
- Where
- France
- Volunteers
- 1,660 people
- Sponsor
- Centre Hospitalier Universitaire Dijon
Colon Cancer
Effect of Perioperative Intravenous Infusion of Lidocaine on the Postoperative Course and the Immune Response in Patients Undergoing Surgery for Colon Cancer - the PILDI Study
There are very few data in the literature on changes in inflammatory markers when lidocaine is administered perioperatively in patients with colorectal cancer.
- Trial name
- PILDI (NCT06923787)
- Testing
- Lidocaine
- Where
- 2 sites in Slovenia
- Volunteers
- 100 people
- Sponsor
- Institute of Oncology Ljubljana
Laparoscopic Colectomy, Cancer Colon
Laparoscopic Colectomies In Management of Colonic Cancers
The aim of this study is to compare the Surgical outcomes after laparoscopic intracorporeal versus extracorporeal anastomosis for right and left hemicolectomies in management of colonic cancers .
- Conditions
- Laparoscopic Colectomy, Cancer Colon, Intracorporeal Anastomosis
- Trial name
- NCT04972994
- Testing
- laparoscopic intracorporeal versus extracorporeal anastomosis for right and left hemicolectomies
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Sohag University
Colon Neoplasms
A Novel Technique of HALS With CME and CVL for RCC
The purpose of this study is to determine the short and long outcomes of the novel technique of hand-assisted laparoscopic right hemicolectomy with complete mesocolic excision and central vascular ligation for right colon cancer.
- Trial name
- NCT02625272
- Testing
- Group A
- Where
- China
- Volunteers
- 60 people
- Sponsor
- West China Hospital
Colorectal Cancer, Endoscopic Tattoo of Suspected Colon Cancer
Confirming the Accuracy of Endoscopic Marking Using a New Marker, a Novel Luminomarker, in Lesion Marking Before Colorectal Cancer Surgery.
Early-stage lesions are difficult to identify intraoperatively during colorectal cancer surgery. Therefore, preoperative lesion marking using a colonoscopic approach is crucial to confirm the location and extent of resection…
- Conditions
- Colorectal Cancer, Endoscopic Tattoo of Suspected Colon Cancer, Indocyanine Green (ICG)
- Trial name
- Tattooing (NCT07380867)
- Testing
- LuminoMark inj. 0.2mL
- Where
- South Korea
- Volunteers
- 30 people
- Sponsor
- Seoul St. Mary's Hospital
Rectal Tumour
Transanal Endoscopic Microsurgery (TEM) After Radiochemotherapy for Rectal Cancer
In the Netherlands approximately 2300 new patients are diagnosed with rectal cancer each year. Standard treatment for patients with a T2 or T3 rectal cancer consists of preoperative short course of radiotherapy followed by…
- Trial name
- CARTS (NCT01273051)
- Testing
- Capecitabine, radiotherapy, TME resection
- Where
- 13 sites in Netherlands
- Volunteers
- 55 people
- Sponsor
- Radboud University Medical Center
Colorectal Cancer
Effect of Intravenous Lidocaine on the Tolerability of Early Oral Feeding After Laparoscopic Colorectal Surgery
The purpose of this study is to determine whether intravenous lidocaine increase the tolerability of early oral feeding after laparoscopic colorectal surgery in patients with colorectal cancer. Degree of nausea/vomiting.
- Trial name
- NCT01346917
- Testing
- Lidocaine, Normal saline
- Where
- South Korea
- Volunteers
- 77 people
- Sponsor
- Kangbuk Samsung Hospital
Pleural Metastases, Breast Cancer
Heated Chemotherapy for Cancers That Have Spread to the Chest Cavity
Cancers that have spread to the inner lining of the chest are classified as Stage IV and bear a poor prognosis. Surgery is rarely an option, with palliative chemotherapy and/or radiation therapy the only treatment options.
- Conditions
- Pleural Metastases, Breast Cancer, Colon Cancer, Ovarian Cancer
- Trial name
- NCT01163552
- Testing
- Surgical debulking and Intrathoracic Hyperthermic Chemotherapy
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- St. Luke's-Roosevelt Hospital Center
Colorectal Cancer (Diagnosis)
Effects of a WhatsApp-assisted Prehabilitation for Patient Undergoing Elective Colorectal Cancer Surgery
The goals of this study is to evaluate the feasibility and the effects of a WhatsApp-assisted prehabilitation for colorectal cancer patients undergoing elective surgery.
- Trial name
- NCT07376668
- Testing
- Intervention, Standard care
- Where
- Hong Kong
- Volunteers
- 100 people
- Sponsor
- Tseung Kwan O Hospital, Hong Kong
Rectal Cancer
Proximally Extended Resection for Rectal Cancer After Neoadjuvant Chemoradiotherapy
Neoadjuvant chemoradiotherapy has been recommended as the standard preoperative treatment for locally advanced rectal cancer. However, preoperative radiotherapy increases the risk of bowel dysfunction after sphincter-preserving…
- Trial name
- PERN (NCT02649647)
- Testing
- Conventional resection, Proximally extended resection
- Where
- China
- Volunteers
- 240 people
- Sponsor
- Sixth Affiliated Hospital, Sun Yat-sen University
Metastatic Colorectal Cancer
A Study With Neoadjuvant mFOLFOX7 Plus Cetuximab to Determine the Surgical Conversion Rate for Unresectable Colorectal Cancer With Metastases Confined to the Liver
FC-6 is a Phase II, multi-center clinical trial for patients with unresectable, wild-type K-RAS, colorectal cancer with metastases confined to the liver.
- Trial name
- NCT00803647
- Testing
- cetuximab, 5-FU, oxaliplatin
- Where
- 23 sites in United States
- Volunteers
- 20 people
- Sponsor
- NSABP Foundation Inc
Colorectal Cancer, Quality of Life
Follow-up After Surgery for Colorectal Cancer
The currently developed implementation study aims to evaluate if a patient-led home-based follow-up approach is successful, improves quality of life, reduces anxiety and lessens fear of cancer recurrence during the years after…
- Trial name
- FUTURE-primary (NCT05656326)
- Where
- Netherlands
- Volunteers
- 200 people
- Sponsor
- Erasmus Medical Center
Colorectal Cancer, Esophageal Cancer
Clinical Trial Protocol for Evaluating the Efficacy and Safety of Thoracoabdominal Endoscopic Surgery System in Remote Laparoscopic Surgery for Urology, General Surgery, Gynecology and Thoracic Surgery
Evaluation of the Efficacy and Safety of the Thoracoabdominal Endoscopic Surgery System Produced by Shenzhen Cornerstone Robotics Technology Co., Ltd.
- Conditions
- Colorectal Cancer, Esophageal Cancer, Hepatectomy, Radical Hysterectomy
- Trial name
- NCT07382635
- Testing
- Robot-assisted surgery
- Volunteers
- 98 people
- Sponsor
- Cornerstone Robotics
Solid Organ Cancers
GL-ONC1 Administered Intravenously Prior to Surgery to Patients With Solid Organ Cancers
The purpose of this study is to evaluate the safety of the investigational product GL-ONC1. GL-ONC1, a vaccinia virus, has been genetically modified for use as a potential anti-cancer drug to destroy cancer cells.
- Trial name
- NCT02714374
- Testing
- GL-ONC1
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Andrew Lowy
Colorectal Cancer
Adjuvant Chemotherapy Combined With Huaier Granule for Treating High-risk Stage II, Stage III Colorectal Cancer
A randomized, paralleled control clinical study investigating Huaier Granule for prevention of recurrence and metastasis of colorectal cancer after radical surgery, to evaluate the efficacy and safety.
- Trial name
- NCT02785146
- Testing
- Huaier Granule, Oxaliplatin, Calcium folinate
- Where
- China
- Volunteers
- 230 people
- Sponsor
- Sixth Affiliated Hospital, Sun Yat-sen University