Clinical trials: Surgery for Colorectal Cancer.
Locally Advanced Colorectal Cancer, Colorectal Adenocarcinoma
Serplulimab Plus Decitabine and CAPOX Before Surgery for Locally Advanced Colorectal Cancer
Title:A Single-Arm, Single-Center, Phase II Exploratory Study of Serplulimab Combined with Decitabine plus CAPOX as Neoadjuvant Therapy for Locally Advanced Colorectal Cancer Background:Colorectal cancer is one of the most common…
- Trial name
- NCT07691632
- Testing
- Serplulimab + Decitabine + CAPOX (Oxaliplatin + Capecitabine)
- Where
- China
- Volunteers
- 35 people
- Sponsor
- Tianjin Medical University Cancer Institute and Hospital
Pancreatic Cancer, Esophageal Cancer
Perioperative Geriatrics Intervention for Older Cancer Patients Undergoing Surgical Resection
The purpose of this research study is to addresses the challenge of managing the unique perioperative needs of older cancer patients undergoing surgical resection.
- Conditions
- Pancreatic Cancer, Esophageal Cancer, Gastric Cancer, Rectal Cancer
- Trial name
- NCT02810652
- Testing
- Usual Care, Perioperative Geriatrics Intervention
- Where
- United States
- Volunteers
- 160 people
- Sponsor
- Massachusetts General Hospital
Colorectal Neoplasms, Diverticulitis
Neomycin and Metronidazole Hydrochloride With or Without Polyethylene Glycol in Reducing Infection in Patients Undergoing Elective Colorectal Surgery
This randomized clinical trial studies how well neomycin and metronidazole hydrochloride with or without polyethylene glycol work in reducing infection in patients undergoing elective colorectal surgery.
- Conditions
- Colorectal Neoplasms, Diverticulitis, Inflammatory Bowel Diseases, Surgical Site Infection
- Trial name
- NCT03042091
- Testing
- Polyethylene Glycol, Neomycin, Metronidazole Hydrochloride
- Where
- United States
- Volunteers
- 224 people
- Sponsor
- Thomas Jefferson University
Adenocarcinoma of the Colon, Stage III Colon Cancer
Comparison of Combination Chemotherapy Regimens With or Without Cetuximab in Treating Patients Who Have Undergone Surgery For Stage III Colon Cancer
This randomized phase III trial was originally designed to compare three different combination chemotherapy regimens to see how well they work.
- Trial name
- NCT00079274
- Testing
- irinotecan hydrochloride, oxaliplatin, leucovorin calcium
- Where
- 894 sites in United States, Canada and 1 more
- Volunteers
- 3,397 people
- Sponsor
- National Cancer Institute (NCI)
Colorectal Cancer, Incisional Hernia
Comparing Polypropylene Mesh and "Small Bites" Technique in Emergency Colorectal Surgery's Midline Laparotomy Closure. Study for Incisional Hernia Prevention.
The 2023 World Journal of Emergency Surgery guidelines couldn't provide a recommendation for emergency abdominal wall closure due to insufficient consensus (>80% required).
- Conditions
- Colorectal Cancer, Incisional Hernia, Wound Infection
- Trial name
- BITEME (NCT06220058)
- Testing
- Closure of the midline laparotomy using the "small bites" technique, Closure of the midline laparotomy using the "small bites" technique with an absorbable PP mesh
- Where
- Spain
- Volunteers
- 148 people
- Sponsor
- Fernandez Zamora
Colon Cancer
Definition of Surgical Technique of Lymphadenectomy and Complete Mesocolon Excision for Radical Right Colectomy: a Delphi Consensus
A Delphi consensus to define surgical steps of lymphadenectomy and complete mesocolic excision for radical right colectomy
- Trial name
- NCT05544474
- Testing
- Delphi questionnaire
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- University of Rome Tor Vergata
Rectal Cancer
ctDNA-Based Adjuvant Chemotherapy for High-Risk Rectal Cancer
The goal of this clinical trial is to investigate whether adjuvant chemotherapy can prevent disease recurrence in patients with high-risk rectal cancer who have detectable ctDNA after surgery.
- Trial name
- REACT (NCT07188025)
- Testing
- Adjuvant chemotherapy
- Where
- 25 sites in Netherlands
- Volunteers
- 103 people
- Sponsor
- Erasmus Medical Center
Literacy, Bowel Symptoms
Effectiveness of Experiential Learning on Dietary Fiber Literacy
Acute symptom onset is the most common problem in colorectal cancer surgery, and it is also the source of the most painful impact on patients' lives.
- Trial name
- NCT04642417
- Testing
- dietary fiber literacy, routine care
- Where
- Taiwan
- Volunteers
- 66 people
- Sponsor
- National Taiwan University Hospital
Colorectal Cancer Metastatic
Quality of Life After Cytoreductive Surgery and Intraperitoneal Chemotherapy
Cytoreductive surgery with intraperitoneal chemotherapy is one of the most important treatments for patients with colorectal cancer and peritoneal metastasis.
- Trial name
- NCT03503071
- Testing
- Cytoreductive surgery and intraperitoneal chemotherapy
- Where
- South Korea
- Sponsor
- Kyungpook National University Hospital
Colorectal Cancer
Multivisceral Radical Resection for Surgical T4b Colorectal Cancer: Propensity Score-matched Study Comparing the the Laparoscopic and Open Approaches
This study attempts to compare safety and long-term oncological outcomes between laparoscopic surgery and open surgery in the treatment of clinical T4b Colorectal cancer.
- Trial name
- C-PelvEx-01 (NCT05707598)
- Testing
- Laparoscopic surgery
- Where
- China
- Volunteers
- 638 people
- Sponsor
- Cancer Institute and Hospital, Chinese Academy of Medical Sciences
Rectal Adenocarcinoma
Neo-adjuvant Chemoradiotherapy Using Infusional Gemcitabine Followed by Surgery for Locally Advanced Rectal Cancer
Phase II Study of Neo-adjuvant Chemoradiotherapy using infusional Gemcitabine followed by Surgery for Locally Advanced (T3 and T4 or Node positive) Rectal Adenocarcinoma.
- Trial name
- NCT02919878
- Testing
- Gemcitabine, XRT, capecitabine
- Where
- Saudi Arabia
- Volunteers
- 25 people
- Sponsor
- King Faisal Specialist Hospital & Research Center
Colorectal Cancer
Oxidative Stress Markers in Open and Laparoscopic Colectomy for Cancer
Contribution to the study of oxidative stress markers in laparoscopic vs open colectomy for colorectal cancer
- Trial name
- NCT00928928
- Testing
- Open colectomy, laparoscopic colectomy
- Where
- Greece
- Volunteers
- 40 people
- Sponsor
- G. Hatzikosta General Hospital
Colorectal Cancer
Personalizing Chemotherapy Selection After Surgery for Patients With Stage III Colorectal Cancer Using a Blood Test
CIRCULATE-III is an international, multicenter, open-label, randomized phase III trial designed to use ctDNA as a selection criterion for intensification or de-escalation of adjuvant chemotherapy.
- Trial name
- CIRCULATEIII (NCT07340567)
- Testing
- Capecitabine, Oxaliplatin, Folfirinox
- Where
- 5 sites in France, Sweden
- Volunteers
- 2,450 people
- Sponsor
- UNICANCER
Colorectal Cancer Metastatic, Cancer Metastatic to the Peritoneal Cavity
Severe Neutropenia After HIPEC Using Mitomycin-C
Mitomycin-C (MMC) is the most commonly used chemotherapeutic agent for hyperthermic intraperitoneal chemotherapy (HIPEC) after cytoreductive surgery (CRS) to treat colorectal cancer patients with peritoneal metastases.
- Conditions
- Colorectal Cancer Metastatic, Cancer Metastatic to the Peritoneal Cavity, Appendiceal Neoplasm, Pseudomyxoma Peritonei
- Trial name
- NCT05513183
- Testing
- Intraoperative blood and peritoneal fluid samplings during HIPEC
- Where
- South Korea
- Volunteers
- 74 people
- Sponsor
- Gangnam Severance Hospital
Anastomotic Leakage
The Value of Early Postoperative Colonoscopy in The Early Diagnosis of Anastomotic Leakage After Surgery for Low Colorectal Cancer
The goal of this clinical trial is to learn whether early postoperative colonoscopy is valuable in the early diagnosis of anastomotic leakage after surgery for low colorectal cancer.The main questions it aims to answer are: 1.
- Trial name
- NCT07588386
- Testing
- electronic colonoscopy
- Where
- China
- Volunteers
- 140 people
- Sponsor
- Nanchong Central Hospital
Peritoneal Metastases From Colorectal Cancer
Adjuvant Pressurized Intraperitoneal Aerosol Chemotherapy to Prevent Colorectal Peritoneal Metastases (ProphyPIPAC)
The objective of this clinical trial is to demonstrate the feasibility and safety of pressurized intraperitoneal aerosol chemotherapy (PIPAC) for the prevention of peritoneal metastases after curative-intent surgery for high-risk…
- Trial name
- ProphyPIPAC (NCT06091683)
- Testing
- Pressurized intraperitoneal aerosol chemotherapy (PIPAC)
- Where
- Italy
- Volunteers
- 10 people
- Sponsor
- Fondazione IRCCS Istituto Nazionale dei Tumori, Milano
Colorectal Cancer
Studying Biomarkers in Tumor Tissue and Blood Samples From Patients Undergoing Chemotherapy and Radiation Therapy for Stage II or Stage III Rectal Cancer That Can Be Removed By Surgery
RATIONALE: Studying samples of tumor tissue and blood from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer.
- Trial name
- NCT00960427
- Testing
- systemic chemotherapy, RNA analysis, gene expression analysis
- Sponsor
- Barbara Ann Karmanos Cancer Institute
Colonic Cancer
Abdominal Massage After Colon Surgery for Cancer
Postoperative ileus is a transient gastrointestinal dysmotility following abdominal surgery that leads to bloating, abdominal distention, visceral pain, nausea, vomiting, and delayed passage of flatus and stool.
- Trial name
- MATRAC_Ter (NCT07713472)
- Testing
- ABDOMINAL MASSAGE, Usual physiotherapeutic intervention
- Where
- France
- Volunteers
- 225 people
- Sponsor
- University Hospital, Grenoble
Rectal Carcinoma, Surgery
COLOR III Trial: Transanal vs Laparoscopic TME
Background Surgery for mid and low rectal cancer is associated with relative high rates of incomplete mesorectal excisions and high rates of circumferential resection margin (CRM) involvement resulting in significant number of…
- Trial name
- COLORIII (NCT02736942)
- Testing
- Laparoscopic TME, TaTME
- Where
- Netherlands
- Volunteers
- 1,104 people
- Sponsor
- Amsterdam UMC, location VUmc
Colonic Cancer, Rectal Cancer
Transanal Decompression Tube Versus Stent for Acute Malignant Left-sided Colonic and Rectal Obstruction
The purpose of this study is to compare the clinical outcomes of transanal decompression tube as a bridge to surgery with stent as a bridge to surgery for acute malignant left-sided colonic and rectal obstruction.
- Trial name
- NCT02585271
- Testing
- Transanal decompression tube, Stent
- Where
- China
- Volunteers
- 8 people
- Sponsor
- Xuzhou Central Hospital