Clinical trials: Surgery for Colorectal Cancer.
Rectal Adenocarcinoma, Stage IIA Rectal Cancer AJCC v8
FOLFOX, Botensilimab, and Balstilimab for the Treatment of Localized Rectal Cancer Before Surgery
This phase II trial tests how well fluorouracil, oxaliplatin and leucovorin calcium (folinic acid) (FOLFOX) with botensilimab and balstilimab given before surgery (neoadjuvant) works in treating patients with rectal…
- Conditions
- Rectal Adenocarcinoma, Stage IIA Rectal Cancer AJCC v8, Stage III Rectal Cancer AJCC v8
- Trial name
- NCT06780787
- Testing
- Balstilimab, Biospecimen Collection, Botensilimab
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- City of Hope Medical Center
Colorectal Cancer
Surgery With or Without Chemotherapy and Radiation Therapy in TreatingPatients With Stage I Rectal Cancer
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Radiation therapy uses high-energy x-rays to damage tumor cells.
- Trial name
- NCT00023751
- Testing
- fluorouracil, leucovorin calcium, conventional surgery
- Where
- 180 sites in United States, Canada and 1 more
- Volunteers
- 320 people
- Sponsor
- Alliance for Clinical Trials in Oncology
Cancer, Appendiceal, ColoRectal Cancer
Comparing Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy (CRS-HIPEC) Using Mitomycin-C Versus Melphalan for Colorectal Peritoneal Carcinomatosis
The purpose of this trial is to compare the morbidity and mortality of CRS-HIPEC using mitomycin-C versus melphalan for colorectal peritoneal carcinomatosis.
- Trial name
- NCT03073694
- Testing
- Mitomycin c, Melphalan
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Kansas Medical Center
Colorectal Cancer, Rectal Cancer
A Study of Botensilimab and Balstilimab for Colorectal Cancer With ctDNA+ After Surgery and Chemotherapy
The researchers are doing this study to find out whether the combination of botensilimab and balstilimab (BOT/BAL), followed by balstilimab alone, is an effective treatment for people with microsatellite stable (MSS) colorectal…
- Trial name
- NCT07227636
- Testing
- Botensilimab, Balstilimab
- Where
- 7 sites in United States
- Volunteers
- 284 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Colorectal Cancer, Enhanced Recovery After Surgery
CHASE : aCcelerated 23-Hour erAS Care for Colorectal Surgery
Rationale: Throughout the years, there has been a rapid change in the perioperative protocols and procedures surrounding colorectal surgery.
- Trial name
- CHASE (NCT04461275)
- Testing
- ERAS 2.0
- Where
- Netherlands
- Volunteers
- 41 people
- Sponsor
- Zuyderland Medisch Centrum
Colo-rectal Cancer, Colonic Neoplasms Malignant
The Use of Indocyanine Green Near-infrared Fluorescence for Bowel Perfusion Quantitative Assessment in Order to Prevent Anastomotic Leakage in Colorectal Surgery
Anastomotic leakage (AL) is a serious complication after surgery for colon cancer, leading to a significant increase in mortality.Intraoperative fluorescence imaging using indocyanine green has proven to be a feasible and…
- Trial name
- ICG-NIRF (NCT06845306)
- Testing
- ICG-guided bowel perfusion assessment, Conventional Bowel Anastomosis group
- Where
- Russia
- Volunteers
- 1,268 people
- Sponsor
- Vadim Kuznetsov
Long-term Oncologic Outcome of MILS in Patients With CRLM and Prognostic Indicators
Minimally Invasive Liver Surgery for Metastases From Colorectal Cancer: Oncologic Outcome and Prognostic Factors
Only few reports exist on long-term survival after minimally invasive liver surgery (MILS for colorectal liver metastases. No data are available assessing prognostic factors in the era of current modern treatment strategies.
- Trial name
- NCT01356706
- Where
- Belgium
- Volunteers
- 274 people
- Sponsor
- University Hospital, Gasthuisberg
Colorectal Cancer, Metastatic Cancer
Monoclonal Antibody Therapy in Treating Patients With Colorectal Cancer
RATIONALE: Monoclonal antibodies can locate tumor cells and either kill them or deliver tumor-killing substances to them without harming normal cells.
- Trial name
- NCT00005616
- Testing
- conventional surgery, neoadjuvant therapy, radionuclide imaging
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Colon Cancer, Rectal Cancer
Trial Comparing Transversus Abdominis Plane Block Versus Epidural Anesthesia for Pain Management in Colorectal Surgery
The primary outcome for this study is the Numeric Pain Score (NPS) for elective patients undergoing elective colorectal surgery that have been randomized to transversus abdominis plane block or epidural anesthesia for the…
- Conditions
- Colon Cancer, Rectal Cancer, Colonic Diverticulosis
- Trial name
- TAP (NCT02591407)
- Testing
- TAP Block, Continuous Epidural Analgesia
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Trinity Health Michigan
Rectal Cancer
A Prospective Feasibility Study for TAMIS
Most recently, the Transanal Minimally Invasive Surgery (TAMIS) approach combined with single-port technology has allowed that pelvic surgery can be laparoendocopically performed from both its abdominal and perineal…
- Trial name
- TAMIS (NCT02626728)
- Testing
- laparoscopic assisted transanal surgery (TAMIS)
- Where
- Denmark
- Volunteers
- 25 people
- Sponsor
- Hvidovre University Hospital
Rectal Tumors, Tumor of Sigmoid Colon
Effect of Dexmedetomidine on Lung Protection in Elderly Patients Undergoing Laparoscopic Surgery for Colorectal Cancer
The primary change in aging lung tissue among older people is atrophy, leading to a significant decline in ventilatory function.
- Conditions
- Rectal Tumors, Tumor of Sigmoid Colon, Lung Injury, Surgery, Laparoscopic
- Trial name
- Dex (NCT07385898)
- Testing
- Dexmedetomidine, Normal saline
- Where
- China
- Volunteers
- 64 people
- Sponsor
- The Second Affiliated Hospital of Chongqing Medical University
Colorectal Cancer
GM-CSF and Combination Chemotherapy in Treating Patients Who Are Undergoing Surgery for Stage II or Stage III Colon Cancer
RATIONALE: Colony-stimulating factors, such as GM-CSF, may increase the number of immune cells found in bone marrow or peripheral blood and may help the immune system recover from the side effects of chemotherapy or kill tumor…
- Trial name
- NCT00262808
- Testing
- sargramostim, fluorouracil, leucovorin calcium
- Where
- 2 sites in United States
- Volunteers
- 50 people
- Sponsor
- University of Rochester
Laparoscopic Surgery, Colorectal Cancer
Laparoscopic Approach for Emergency Colon Resection
This is a randomized, controlled, parallel, multicenter trial to compare post-operative complications and long-term results between open and laparoscopic technique in emergency colorectal surgery.
- Conditions
- Laparoscopic Surgery, Colorectal Cancer, Colorectal Disorders, Emergencies
- Trial name
- NCT05005117
- Testing
- Laparoscopic operation, Open operation
- Where
- Finland
- Volunteers
- 192 people
- Sponsor
- Joint Authority for Päijät-Häme Social and Health Care
Rectal Cancer
Prognostic Factors Affecting Recurrence and Disease-Free Survival After Surgical Resection for Cancer Rectum
Tumor recurrence after curative surgical resection for rectal cancer is a serious complication that greatly affects the overall morbidity and the outcome.
- Trial name
- NCT06096493
- Testing
- curative surgery for cancer rectum
- Where
- Egypt
- Volunteers
- 200 people
- Sponsor
- South Valley University
Colorectal Cancer
Does Administration of Antibiotics in Patients Undergoing Surgery for Colorectal Cancer Result in Less Complications and Better Prognosis?
The primary objectives of this randomized clinical trial are to evaluate if perioperative SDD can reduce clinical anastomotic leakage rate and its septic consequences as well as other infectious complications.
- Trial name
- SELECT (NCT01740947)
- Testing
- Selective decontamination of the digestive tract (SDD) (colistin sulfate, tobramycin, amphotericin B)
- Where
- 5 sites in Netherlands
- Volunteers
- 485 people
- Sponsor
- H. Jaap Bonjer, PhD
Colon Cancer
Follow-up After Surgery for Colon Cancer. General Practice vs. Surgical-based Follow-up?
The purpose of this study is to clarify cost effectiveness and quality of life issues among colon cancer patients followed up in a hospital setting or by their GP's.Statement of study hypothesis:Postoperative follow up of colon…
- Trial name
- ONKOLINK (NCT00572143)
- Testing
- ca coli follow-up by GP
- Where
- Norway
- Volunteers
- 180 people
- Sponsor
- University Hospital of North Norway
Circulating Tumor Cells, CTC
CTCs and Novel Target Bio-marker Analysis for Prediction and Monitoring of Metastasis/Recurrence in Post-surgery Colorectal Cancer Patients Using MiSelect R Rare Cell System
Despite the growing public awareness and recent progress in multimodality therapy to the colorectal cancer (CRC), CRC still ranks high on the list of the most common and deadly cancers in Taiwan.
- Trial name
- NCT03013868
- Where
- Taiwan
- Volunteers
- 200 people
- Sponsor
- MiCareo Taiwan Co., Ltd.
Rectal Cancer
Application of Left Colic Artery Preservation, Anastomotic Reinforcing Sutures and Transanal Tube in Robotic Low Anterior Resection
The purpose of this study is to evaluate the results of combined application of left colic artery preservation, anastomotic reinforcing sutures and postoperative transanal tube placement in robotic Low Anterior Resection for…
- Trial name
- NCT03609710
- Testing
- Transanal tube placement, Left colic artery preservation, Anastomotic reinforcing sutures
- Where
- China
- Volunteers
- 500 people
- Sponsor
- Fudan University
Colorectal Liver Metastases, Colorectal Neoplasms
Multimodal Survival Prediction Model for Colorectal Liver Metastases Post-Operation
The purpose of this study is to construct and validate a multimodal survival prediction model by integrating 3D radiomics features derived from preoperative magnetic resonance imaging (MRI) with systemic clinical baseline…
- Conditions
- Colorectal Liver Metastases, Colorectal Neoplasms, Liver Neoplasms
- Trial name
- NCT07830576
- Testing
- Multimodal Predictive Evaluation
- Where
- China
- Volunteers
- 205 people
- Sponsor
- Anhui Provincial Hospital
Colorectal Neoplasms
Person-Centred Information and Communication for Patients Undergoing Colo-Rectal Surgery - the PINCORE Project
An overarching aim is to create prerequisites for person-centred information and communication. The specific aim is to evaluate if an intervention with a written information and communication support tool and person-centred…
- Trial name
- PINCORE (NCT03587818)
- Testing
- person-centred communication
- Volunteers
- 488 people
- Sponsor
- Göteborg University