Clinical trials: Surgery for Colorectal Cancer.
Colorectal Adenocarcinoma, Colorectal Surgery
Trends and Outcomes in Laparoscopic Versus Open Surgery for Rectal Cancer
Retrospective cohort study used to analyze trends in minimally invasive versus open surgery in colorectal surgery, over time, in outcome in the laparoscopic, robotic and open surgery groups in patients receiving colorectal…
- Trial name
- NSQIPc (NCT03683446)
- Testing
- Laparoscopic rectal surgery, Open rectal surgery
- Volunteers
- 31,795 people
- Sponsor
- Catherine H. Davis, MD
Colonic Carcinoma, Laparoscopic Right Hemicolectomy
Standardizing Right Hemicolectomy for Colon Cancer
A surgical intervention might be highly variable amongst surgeons and centers. This variability has a potential relevance concerning clinical outcomes.
- Conditions
- Colonic Carcinoma, Laparoscopic Right Hemicolectomy, Standardisation, Training
- Trial name
- Right (NCT04889456)
- Testing
- Implementation standardised laparoscopic right hemicolectomy with proctoring, Implementation standardised laparoscopic right hemicolectomy without proctoring
- Where
- Netherlands
- Volunteers
- 930 people, healthy volunteers welcome
- Sponsor
- Amsterdam UMC, location VUmc
Rectal Cancer
Capecitabine, Irinotecan Hydrochloride, Cetuximab, and Radiation Therapy in Treating Patients Undergoing Surgery for Locally Advanced Rectal Cancer
RATIONALE: Drugs used in chemotherapy, such as capecitabine and irinotecan hydrochloride, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing.
- Trial name
- EXCITE (NCT00972881)
- Testing
- cetuximab, capecitabine, irinotecan hydrochloride
- Where
- 5 sites in United Kingdom
- Volunteers
- 82 people
- Sponsor
- University College, London
Rectal Cancer, Organ Preservation
Treatment Strategy for Rectal Cancer Patients With Complete Clinical Response
This was a propensity-score matched observational analysis, comparing the oncological outcome of surgical resection vs watch and wait apporach for rectal cancer patients with a cCR.
- Trial name
- NCT03846726
- Testing
- standard TME surgery
- Where
- China
- Volunteers
- 513 people
- Sponsor
- Yuan-hong Gao
Rectal Neoplasms, Robotic Surgery
Robotic Transanal Specimen Extraction Surgery Versus Robotic Transabdominal Incision Specimen Extraction Surgery for Patients With Rectal Cancer: A Multicenter Randomized Controlled Trial
This prospective, multicenter, randomized, open-label study aims to evaluate the perioperative safety and feasibility of specimen extraction through anus regarding robotic radical excision of rectal cancer.
- Conditions
- Rectal Neoplasms, Robotic Surgery, Natural Orifice Specimen Extraction Surgery
- Trial name
- NCT05468944
- Testing
- Transanal specimen extraction robotic surgery, Transabdominal specimen extraction robotic surgery
- Where
- 12 sites in China
- Volunteers
- 556 people
- Sponsor
- Taiyuan Li
Colonic Neoplasms, Laparoscopy
ERAS in Laparoscopic Surgery for Colorectal Cancer: Risk Factors for Delayed Recovery
Although there is evidence for reducing complication rate and improving recovery after the implementation of Enhanced Recovery After Surgery (ERAS) protocols into colorectal surgery, most published papers include patients…
- Conditions
- Colonic Neoplasms, Laparoscopy, Perioperative Care
- Trial name
- NCT02527967
- Where
- Poland
- Volunteers
- 143 people
- Sponsor
- Jagiellonian University
Colorectal Cancer, Anastomotic Leak
Quantitative ICG Fluorescence Angiography in Colorectal Surgery
Fluorescence angiography with indocyanine green (ICG-FA) has gained increased popularity in colorectal surgery to check perfusion to the newly-formed anastomotic area and decrease the rate of postoperative anastomotic leakage.
- Trial name
- QUANTICO (NCT05153954)
- Testing
- Quantitative Indocyanine Green Fluorescence Angiography
- Where
- 2 sites in Denmark
- Volunteers
- 114 people
- Sponsor
- Zealand University Hospital
Adenocarcinoma of the Rectum
Can we Save the Rectum by Watchful Waiting or TransAnal Surgery Following (Chemo)Radiotherapy Versus Total Mesorectal Excision for Early REctal Cancer?
Bowel cancer is the second most common tumour with 41 000 new cases diagnosed annually in the UK, 447 000 across Europe and 1.36 million worldwide; of which one third are located in the rectum.
- Trial name
- STAR-TREC (NCT02945566)
- Testing
- Standard TME surgery, Long course concurrent chemoradiation with capecitabine and radiotherapy, Short course radiotherapy
- Where
- 5 sites in Belgium, Denmark and 3 more
- Volunteers
- 380 people
- Sponsor
- University of Birmingham
Colon Carcinoma
Neoadjuvant Immune Checkpoint Inhibition and Novel IO Combinations in Early-stage Colon Cancer
In this exploratory study, patients with stage 1-3 adenocarcinoma of the colon with no signs of distant metastases will be treated with short-term immunotherapy + novel IO combinations (i.e.
- Trial name
- NICHE (NCT03026140)
- Testing
- Nivolumab, Ipilimumab, Celecoxib 200mg
- Where
- 6 sites in Netherlands
- Volunteers
- 353 people
- Sponsor
- The Netherlands Cancer Institute
Colorectal Cancer, Surgery
Randomized Controlled Trial for Retractor SPONGE Evaluation in Laparoscopic Colorectal Surgery
To achieve an adequate visual working field during laparoscopic colorectal surgery without disturbance of the small intestine, patients are positioned in Trendelenburg position.
- Trial name
- SPONGE (NCT02574013)
- Testing
- Endoractor®
- Where
- Netherlands
- Volunteers
- 188 people
- Sponsor
- St. Antonius Hospital
Patient Satisfaction, Quality of Life
Patient Experiences Following Urinary Diversion as Part of Surgery for Advanced and Recurrent Rectal Cancer
The outcomes of patients who undergo radical surgery for locally advanced and recurrent rectal cancer have improved vastly, but there is a lack of emphasis on the quality-of-life outcomes of these patients.
- Conditions
- Patient Satisfaction, Quality of Life, Patient Participation
- Trial name
- Pelvex 3 (NCT04715308)
- Testing
- Urinary diversion
- Where
- Ireland
- Volunteers
- 1,200 people
- Sponsor
- St Vincent's University Hospital, Ireland
Colorectal Cancer
Prospective Randomised Trial of Exercise and / or Antioxidants in COlorectal Cancer Patients Undergoing Surgery.
Colorectal cancer is the fourth most common cancer in the UK. Surgical resection is the mainstay of curative therapy. With the screening program enabling early detection, surgery plays an important role in treatment strategies.
- Trial name
- PEACOCS (NCT02264496)
- Testing
- Exercise
- Where
- United Kingdom
- Volunteers
- 24 people
- Sponsor
- Hull University Teaching Hospitals NHS Trust
Colorectal Neoplasms
Using Multimodal Prehabilitation to Improve Outcomes for Frail Patients Undergoing Resection of Colorectal Cancer
The purpose of this study is to determine if a program of physical activity, nutritional supplements and relaxation techniques is effective at decreasing post operative complications in frail colorectal cancer patients undergoing…
- Trial name
- NCT02502760
- Testing
- Physical Exercise Program, Whey Protein Isolate Powder, Relaxation Techniques
- Where
- 2 sites in Canada
- Volunteers
- 120 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Colorectal Neoplasms, Colorectal Surgery
Intraoperative Hyperspectral Imaging for Laparoscopic Surgery
The study aims to evaluate the use of the HyperSnap Surgical System (HSS1) during laparoscopic surgeries, specifically in bowel resections and cholecystectomies.
- Conditions
- Colorectal Neoplasms, Colorectal Surgery, Cholecystitis, Cholecystectomy, Laparoscopic
- Trial name
- LapHSI (NCT06700317)
- Testing
- HSS1
- Volunteers
- 40 people
- Sponsor
- King's College London
Rectal Neoplasms
Transanal Total Mesorectal Excision Versus Laparoscopic TME for Rectal Cancer
To investigates the feasibility, practicability, safety and subjective as well as functional outcome of transanal minimal invasive surgery toal mesentery excision for rectal cancer.
- Trial name
- NCT02252250
- Testing
- conventional laparoscopic total mesentery excision, transanal hybrid-laparoscopic total mesentery excision
- Where
- China
- Volunteers
- 70 people
- Sponsor
- Third Military Medical University
Rectal Cancer
Rectal Surgery Evaluation Trial (RESET)
Total mesorectal excision (TME) is the standard of care for rectal cancer, which can be combined with low anterior resection (LAR) in patients with mid-to-low rectal cancer.
- Trial name
- RESET (NCT03574493)
- Testing
- TME with LAR
- Where
- France
- Volunteers
- 1,098 people
- Sponsor
- Institut du Cancer de Montpellier - Val d'Aurelle
Antibiotic, Bowel Cancer
Mechanical Bowel Preparation With or Without Oral Antibiotics for Colorectal Cancer Surgery
Investigation of the role of adding oral antibiotics to preoperative mechanical bowel preparation before colorectal surgery for cancer.
- Conditions
- Antibiotic, Bowel Cancer, Colorectal Cancer, Surgical Site Infection
- Trial name
- MECCA (NCT03563586)
- Testing
- Bowel Preparation plus antibiotics, Bowel Preparation
- Where
- Greece
- Volunteers
- 210 people
- Sponsor
- National and Kapodistrian University of Athens
Colorectal Neoplasm
A LAparoscopic and TransAnal Total Mesorectal Excision (TME) for Rectal Cancer Trial
All patients planned for an anterior resection due to rectal cancer with a total mesorectal excision are included. This is a feasibility study, thus no randomization will be performed.
- Trial name
- LATA (NCT02324556)
- Where
- 2 sites in Sweden
- Volunteers
- 6 people
- Sponsor
- Sahlgrenska University Hospital
Minimally Invasive Surgical Procedures, Colon Cancer Patients
Pain Evaluation Across Robotic and Laparoscopic Surgery for Colorectal Procedures
Minimally invasive surgery for colorectal conditions, such as laparoscopic or robotic surgery, has been shown to offer benefits over traditional open surgery.
- Trial name
- PEARL (NCT07431892)
- Where
- Spain
- Volunteers
- 80 people
- Sponsor
- Hospital Central de la Defensa Gómez Ulla
Colorectal Carcinoma, Lung Adenocarcinoma
Binimetinib and Palbociclib Before Surgery for the Treatment of Operable KRAS-Positive Lung, Colorectal, or Pancreatic Cancer
This early phase I trial studies the direct effects on cancer cells of the drugs binimetinib and palbociclib, in patients with KRAS-positive lung, colorectal, or pancreatic cancer that can be removed by surgery (operable).
- Conditions
- Colorectal Carcinoma, Lung Adenocarcinoma, Malignant Solid Neoplasm, Pancreatic Carcinoma
- Trial name
- NCT04870034
- Testing
- Binimetinib, Palbociclib, Therapeutic Conventional Surgery
- Where
- United States
- Sponsor
- Roswell Park Cancer Institute