Clinical trials: Surgery-first
Induced Abortion, Abortion Techniques
Mifepristone Versus Misoprostol for Cervical Preparation Prior to Surgical Abortion Between 11 to 15 Weeks
Surgical abortion in the late first trimester and early second trimester is usually performed with the aid of a cervical preparing agent, which helps to open up the uterine cervix for the procedure.
- Conditions
- Induced Abortion, Abortion Techniques, Mifepristone, Misoprostol
- Trial name
- MIMI11-15 (NCT01636063)
- Testing
- Mifepristone, Misoprostol
- Where
- United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Boston University
Colonic Neoplasms, Rectal Neoplasms
NITI CAR27 (ColonRing) Compression Anastomosis in Colorectal Surgery
After resection of diseased segments of the large intestine, the continuity of the intestine has to be restored. This can be done by suturing or with so called stapling devices.
- Conditions
- Colonic Neoplasms, Rectal Neoplasms, Diverticulitis, Inflammatory Bowel Diseases
- Trial name
- NCT01056913
- Testing
- Compression Anastomosis Device, follow-up colonoscopy
- Volunteers
- 62 people
- Sponsor
- St John of God Hospital, Vienna
Epithelium, Corneal
Comparison of the Effect of 4th Generation Fluoroquinolones, Gatifloxacin and Moxifloxacin, on Epithelial Healing Following Photorefractive Keratectomy (PRK), A Substudy of: Initial Evaluation of Excimer Laser Keratorefractive Surgery in U.S. Army Personnel (WU # 2335-99)
The purpose of this study is a prospective,double-blinded, randomized trial to compare the rate of healing following PRK after the use of two commercially available 4th generation fluoroquinolones, moxifloxacin and gatifloxacin.
- Trial name
- NCT00414011
- Testing
- Moxifloxacin, Gatifloxacin
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Walter Reed Army Medical Center
Pancreatic Cancer
SBRT Plus Pembrolizumab and Trametinib for Pancreatic Cancer
Hypothesis: Survival benefits could be found in SBRT Plus Pembrolizumab and Trametinib compared with SBRT plus gemcitabine.
- Trial name
- NCT02704156
- Testing
- Cyberknife plus Pembrolizumab and Trametinib, Cyberknife plus Gemcitabine
- Where
- China
- Volunteers
- 170 people
- Sponsor
- Changhai Hospital
Jaw, Edentulous, Partially
Clinical Study Comparing Submerged Versus Trans-mucosal Healing of P.004 Implants in the Anterior Mandible and Maxilla
The purpose of this study is To demonstrate that there is no difference in change in bone level around P.004 implants between 1st stage surgery and 6 months post surgery when transmucosal implant placement is compared to…
- Trial name
- NCT00906425
- Testing
- Straumann Bone Level Implant
- Where
- 11 sites in United States, Australia and 5 more
- Volunteers
- 145 people
- Sponsor
- Institut Straumann AG
Stage IV Pancreatic Cancer
S0727 Gemcitabine Hydrochloride and Erlotinib Hydrochloride With or Without Monoclonal Antibody Therapy in Treating Patients With Metastatic Pancreatic Cancer That Cannot Be Removed By Surgery
This randomized phase I/II trial is studying the side effects and best dose of monoclonal antibody therapy when given together with gemcitabine hydrochloride and erlotinib hydrochloride and to see how well they work compared with…
- Trial name
- NCT00617708
- Testing
- cixutumumab, erlotinib hydrochloride, gemcitabine hydrochloride
- Where
- 146 sites in United States
- Volunteers
- 134 people
- Sponsor
- National Cancer Institute (NCI)
Surgery, Anesthesia, Endotracheal
The Videolaryngoscopy in Small Infants
Complications related to infant (≤ 1 year) airway management are under-appreciated because of few rigorous and targeted studies.
- Trial name
- VISI (NCT03396432)
- Testing
- Video Laryngoscopy for ET placement, Direct Laryngoscopy for ET Placement
- Where
- 5 sites in United States, Australia
- Volunteers
- 566 people
- Sponsor
- Children's Hospital of Philadelphia
Blood Loss
Blood Loss at the Time of First Trimester Surgical Abortion in Anticoagulated Women
The primary objective of this study is to compare blood loss resulting from surgical termination of pregnancy up to 12 weeks gestation between women who are anticoagulated to therapeutic levels and those who are not…
- Trial name
- NCT00614432
- Where
- 2 sites in United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Hawaii
Pancreatic Carcinoma Non-resectable, Stage IV Pancreatic Cancer
Study to Evaluate Bi-weekly Dosing of Gemcitabine Plus Nab-Paclitaxel to Treat Metastatic Pancreatic Cancer
To determine whether the occurrence of adverse events can be decreased by moving to a bi-weekly schedule of gemcitabine plus nab-Pacitaxel for the treatment of unresectable/metastatic pancreatic cancer.
- Trial name
- NCT01851174
- Testing
- Gemcitabine, nab-Paclitaxel
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Western Regional Medical Center
Abortion in First Trimester, Pain, Procedural
Ketamine Versus Fentanyl for Surgical Abortions
Ketamine is commonly used for procedural sedation and analgesia. It is widely used for trauma cases in the emergency department and is considered a superior agent in the outpatient setting due to its lack of respiratory and…
- Conditions
- Abortion in First Trimester, Pain, Procedural, Opioid Use
- Trial name
- NCT04871425
- Testing
- Ketamine, Fentanyl
- Where
- United States
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- University of Washington
Parkinson's Disease
DBS Under General Anesthesia: Comparison To The Standard Technique
There is a growing trend in functional neurosurgery toward direct anatomical targeting for deep brain stimulation (DBS). This study describes a method and reports the initial experience placing DBS electrodes under general…
- Trial name
- NCT01997398
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- St. Joseph's Hospital and Medical Center, Phoenix
Colorectal Cancer
Bevacizumab and Combination Chemotherapy as First-Line Therapy in Treating Patients With Metastatic Colorectal Cancer That Cannot Be Removed by Surgery
RATIONALE: Monoclonal antibodies, such as bevacizumab, can block tumor growth in different ways. Some block the ability of tumor cells to grow and spread.
- Trial name
- OMEGA (NCT00467142)
- Testing
- bevacizumab, fluorouracil, irinotecan hydrochloride
- Where
- France
- Volunteers
- 62 people
- Sponsor
- Institut Bergonié
Glaucoma, Open Angle Glaucoma
Long-term Safety and Performance of the ARGOS-SC Suprachoroidal Pressure Sensor System in Patients With Glaucoma Underwent Non-penetrating Glaucoma Surgery
The purpose of this study is to evaluate the long-term safety and performance of the ARGOS-SC system.
- Trial name
- NCT04773106
- Testing
- ARGOS-SC suprachoroidal pressure sensor
- Where
- 5 sites in Germany, Switzerland
- Volunteers
- 22 people
- Sponsor
- Implandata Ophthalmic Products GmbH
Hallux Valgus, Pain
Initial Effects of Kinesiotaping in Non Surgical Treatment of Hallux Valgus
The main aim of this study was to find the initial effects of kinesiotaping on pain and joint alignment used in the conservative treatment of hallux valgus.
- Trial name
- NCT01952691
- Testing
- kinesiotaping
- Volunteers
- 22 people
- Sponsor
- Hacettepe University
Obesity, Morbid, Bariatric Surgery
Adjunct Phentermine + Topiramate After Bariatric Surgery in 12-24 Year Olds
The goal of this pilot study is to establish the feasibility and initial efficacy of the combination of phentermine and topiramate for adolescents and young adults who require additional risk reduction after bariatric surgery.
- Conditions
- Obesity, Morbid, Bariatric Surgery, Adolescent, Young Adult
- Trial name
- NCT04095104
- Testing
- Phentermine, Immediate Release Topiramate
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- University of Colorado, Denver
Clear Cell Renal Cell Carcinoma, Metastatic Clear Cell Renal Cell Carcinoma
Pazopanib Hydrochloride With or Without Ascorbic Acid in Treating Patients With Kidney Cancer That Is Metastatic or Cannot Be Removed by Surgery
This randomized phase II trial studies how well pazopanib hydrochloride with or without ascorbic acid work in treating patients with kidney cancer that has spread to other places in the body (metastatic) or cannot be removed by…
- Conditions
- Clear Cell Renal Cell Carcinoma, Metastatic Clear Cell Renal Cell Carcinoma, Stage III Renal Cell Cancer AJCC v8, Stage IV Renal Cell Cancer AJCC v7
- Trial name
- NCT03334409
- Testing
- Ascorbic Acid, Pazopanib Hydrochloride
- Where
- 5 sites in United States
- Volunteers
- 5 people
- Sponsor
- Academic and Community Cancer Research United
Cervical Adenocarcinoma, Cervical Adenosquamous Carcinoma
Radiation Therapy With or Without Chemotherapy in Patients With Stage I-IIA Cervical Cancer Who Previously Underwent Surgery
This randomized phase III trial studies radiation therapy with chemotherapy to see how well they work compared to radiation therapy alone in treating patients with stage I-IIA cervical cancer who previously underwent surgery.
- Conditions
- Cervical Adenocarcinoma, Cervical Adenosquamous Carcinoma, Cervical Squamous Cell Carcinoma, Not Otherwise Specified, Stage I Cervical Cancer AJCC v6 and v7
- Trial name
- NCT01101451
- Testing
- Cisplatin, External Beam Radiation Therapy, Intensity-Modulated Radiation Therapy
- Where
- 719 sites in United States, Japan and 1 more
- Volunteers
- 340 people
- Sponsor
- GOG Foundation
Postoperative Pain, Adverse Effects
Continuous Interscalene Block Results in Superior Recovery Throughout the First Postoperative Week
The investigators undertook this prospective, randomized trial to compare the recovery profile throughout the first postoperative week in patients receiving continuous (CISB) interscalene brachial plexus block, single injection…
- Trial name
- NCT01881776
- Testing
- ISB
- Where
- United States
- Volunteers
- 71 people, healthy volunteers welcome
- Sponsor
- St. Luke's-Roosevelt Hospital Center
Pain
Lidocaine and Pain Management in First Trimester Abortions
The purpose of this study is to examine the effect of lidocaine (a numbing medication) inside the uterus on patient pain during an early abortion, compared to the paracervical block (lidocaine injected on either side of the…
- Trial name
- NCT00613821
- Testing
- Lidocaine
- Where
- 2 sites in United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Undesired Intrauterine Pregnancy, First Trimester Pregnancy
Trial Comparing Intravenous and Oral Moderate Sedation for First Trimester Surgical Abortions
In the United States, the majority of first-trimester surgical abortions are performed in outpatient clinics that utilize a wide variety of oral and intravenous regimens for pain control.
- Trial name
- NCT01011634
- Testing
- Intravenous moderate sedation versus oral medication
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco