Clinical trials: Surgical
Obesity
Microenvironment of Adipose Tissue in Endocannabinoid System
The purpose of this study is examine the relationship between adipose tissue inflammation and activation of the endocannabinoid system before and after Roux-en-Y gastric bypass surgery.
- Trial name
- NCT00978289
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Vanderbilt University
Delirium, Postoperative Cognitive Deficit (POCD)
Neuroprotection With Dexmedetomidine in Patients Undergoing Elective Cardiac or Abdominal Surgery (Neuprodex)
The drug Dexmedetomidine will be investigated in 72 patients (men and women) undergoing elective cardiac or abdominal surgery. The study medication will be administered perioperatively by intravenous infusion continuously (at the…
- Trial name
- NCT02096068
- Testing
- Dexmedetomidine (Dexdor®), 0.9% Sodium Chloride
- Where
- Germany
- Volunteers
- 78 people
- Sponsor
- Claudia Spies
Urologic Surgery
Does Laryngoscopic Tecnique Facilitate cLMA Insertion?
it is compared that laryngeal mask insertion with standard technique and laryngoscopic technique
- Trial name
- cLMA (NCT02000791)
- Testing
- Comparison of fibreoptic view
- Where
- Turkey (Türkiye)
- Volunteers
- 180 people
- Sponsor
- Diskapi Yildirim Beyazit Education and Research Hospital
Perioperative Period
Treatment of Supraventricular Tachycardia in Patients With Non-cardiac Surgery by Dexmedetomidine
Supraventricular tachycardia (SVT) is a common arrhythmia in the perioperative period, which is associated with adverse stimulus such as cardiovascular risk factors, emotional tension, hypoxia, CO2 accumulation, hypokalemia…
- Trial name
- NCT04284150
- Testing
- Dexmedetomidine; Midazolam;
- Volunteers
- 60 people
- Sponsor
- Lianyungang Hospital Affiliated Bengbu Medical College
Intubation; Difficult, Intubation Complication
McGrath Series 5 Videolaryngoscope for Double-lumen Tube Intubation
1. Double-lumen tube intubation is difficult, compared with single lume tube. 2. McGrath Series 5 videolaryngoscope hase been used in difficult airway management, both in anesthetized and awake patients. 3.
- Trial name
- NCT01984970
- Testing
- videolaryngoscope
- Where
- China
- Volunteers
- 43 people
- Sponsor
- Huazhong University of Science and Technology
Periodontitis, Diabetes Mellitus, Type 2
Effect of Periodontal Treatment on Adipokine Levels
The present study aimed to determine the effect of non-surgical periodontal treatment (NSPT) on serum and salivary adipokine and interleukin-1β levels in periodontitis patients with or without type 2 Diabetes Mellitus (T2DM).
- Trial name
- NCT06225154
- Testing
- Non-surgical periodontal treatment
- Where
- 2 sites in Finland, Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Marmara University
Bladder Cancer, Drug/Agent Toxicity by Tissue/Organ
Gemcitabine, Cisplatin, and Amifostine Following Surgery in Treating Patients With Locally Advanced Bladder Cancer
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Chemoprotective drugs, such as amifostine, may protect normal cells from the side effects of chemotherapy.
- Trial name
- NCT00006105
- Testing
- amifostine trihydrate, cisplatin, gemcitabine hydrochloride
- Where
- United States
- Volunteers
- 37 people
- Sponsor
- University of Chicago
Non-cardiac Surgery
European Surgical Outcomes Study
The European Surgical Outcomes Study (EuSOS) is a multi-centre, international cohort study of peri-operative care and clinical outcomes for patients undergoing non-cardiac surgery.
- Trial name
- EuSOS (NCT01203605)
- Where
- 28 sites in Belgium, Croatia and 26 more
- Volunteers
- 46,985 people
- Sponsor
- Queen Mary University of London
Invasive Bladder Cancer
Testing the Utilization of a Mobile Health App for Patients Undergoing Cystectomy Surgery for Bladder Cancer
This is a pilot study that involves human subjects undergoing cystectomy surgery for bladder cancer, testing the utilization of a mobile health app that promotes postoperative patient engagement, along with provider monitoring…
- Trial name
- NCT03862105
- Testing
- Mobile Health app tool - Twistle
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Glaucoma, Blindness, Acquired
Laminar Drainage Implant: Safety of a Novel Surgical Treatment for Refractory Glaucoma.
Purpose: To assess the feasibility of a surgical technique and present the preliminary safety results of a new glaucoma device devoid of a tube in painful blind eyes.
- Conditions
- Glaucoma, Blindness, Acquired, End-Stage Glaucoma, Glaucoma Traumatic
- Trial name
- NCT03166566
- Testing
- Laminar drainage implant surgery.
- Volunteers
- 15 people
- Sponsor
- Federal University of Minas Gerais
Anesthesia, Thyroid
Analgesic Efficacy of an Intermediate CPB in Neck Surgeries.
This study aims to investigate the analgesic efficacy of Intermediate Cervical Plexus Block combined with GA using two bupivacaine concentrations in patients undergoing neck surgeries (total thyroidectomy or total laryngectomy)
- Conditions
- Anesthesia, Thyroid, Neck, Bupivacaine
- Trial name
- NCT06419556
- Testing
- Cervical Plexus Block
- Where
- Egypt
- Volunteers
- 54 people
- Sponsor
- Cairo University
Gastroesophageal Reflux, Sleeve Gastrectomy
The Use of EndoFlip as a Clinical Tool for the Prediction of Postoperative GERD After Sleeve Gastrectomy
This study aims to determine if preoperative EndoFlip measurement can effectively predict postoperative GERD-related quality of life and lower esophageal acid exposure.
- Conditions
- Gastroesophageal Reflux, Sleeve Gastrectomy, Bariatric Surgery Complication
- Trial name
- NCT05690022
- Testing
- sleeve gastrectomy
- Volunteers
- 100 people
- Sponsor
- Laval University
Incisional Surgical Site Infections
Total Occlusive Ionic Silver-containing Dressing vs Mupirocin Ointment Application vs Conventional Dressing in Elective Colorectal Surgery: Effect on Incisional Surgical Site Infection
The patients were randomized into 3 groups: those patients undergoing a ionic silver-containing dressing (ISD) (Group 1), those undergoing a Mupirocin ointment application (MOA) (Group 2) and those using a conventional dressing…
- Trial name
- NCT02267122
- Testing
- ionic silver-containing dressing, Mupirocin ointment application
- Volunteers
- 147 people
- Sponsor
- Hospital General Universitario Elche
Mitral Valve Regurgitation
Mitral Adjustable Annuloplasty Ring Feasibility and Safety Study
Evaluation of the technical feasibility and safety of the Mitral Adjustable Annuloplasty Ring.
- Trial name
- MAARS (NCT00554151)
- Testing
- Adjustable Annuloplasty Ring
- Where
- 5 sites in Germany, Italy and 1 more
- Volunteers
- 55 people
- Sponsor
- Abbott Medical Devices
Cataract Surgery
Evaluation of the Active Sentry System During Cataract Surgery With the Centurion Phacoemulsifier
Each new generation of phacoemulsification system has aimed to optimize the control of fluidics and the delivery of energy during phacoemulsification.
- Trial name
- SASCA (NCT04732351)
- Where
- France
- Volunteers
- 5,000 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Post-operative Pain, Anesthesia, Local
Evaluation of the Analgesic Benefit of Adding the Blocks of the Intermediate and Medial Femoral Cutaneous Nerves in Addition to the Femoral Triangle Block for Postoperative Analgesia After a Knee Replacement Surgery
Total knee replacement surgery can be associated with a significant postoperative pain burden and an inability to mobilize adequately, which can lead to the failure of the ambulatory course.
- Trial name
- NCT06038851
- Testing
- Para-Sartorial Compartments (PACS) Block, Femoral Triangle Block (FTB), Infiltration between popliteal artery and capsule of the knee (IPACK) block
- Where
- Canada
- Volunteers
- 122 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Breast Cancer
High Five (HiFi) Accelerated Partial Breast Irradiation Study
To establish the role of adjuvant multicatheter interstitial high-dose-rate brachytherapy in doubly accelerated and radiobiologically equivalent irradiation scheme of 5 x 5,4 Gy in 3 days of treatment (High Five, HiFi-APBI)…
- Trial name
- HiFi (NCT05142202)
- Testing
- Breast Irradiation after Breast-Conserving Surgery
- Where
- Poland
- Volunteers
- 147 people
- Sponsor
- The Greater Poland Cancer Centre
Appendicitis (Diagnosis)
Precision Antibiotic Dosing for Appendectomy
This research is studying a drug called cefoxitin already approved by the Food and Drug Administration (FDA) to reduce the risk of infection after surgery to remove an appendix.
- Trial name
- PANDA (NCT06860802)
- Testing
- Cefoxitin
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- University of Michigan
Periodontal Diseases, Peri-implantitis
Implant Surface Decontamination With 2 % Chlorhexidine in Peri-implantitis Treatment
Peri-implantitis is a infectious disease that resides in the mucosa surrounding dental implants and also affects the supporting bone.
- Trial name
- NCT01852253
- Testing
- 2% chlorhexidine, 0.12% chlorhexidine
- Where
- Netherlands
- Volunteers
- 44 people
- Sponsor
- University Medical Center Groningen
Stage II Colon Cancer, Stage III Colon Cancer
Exercise and Colon Cancer
Despite the success of surgery and chemotherapy among people with colon cancer, 30-50% of patients develop recurrent disease. Physical activity has emerged as a potential lifestyle intervention to reduce cancer recurrence and…
- Trial name
- NCT02250053
- Testing
- Exercise
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- Abramson Cancer Center at Penn Medicine