Clinical trials: Surgical Adhesions
Ileus, Post-Operative Adhesions
A Study to Evaluate LB1148 for Return of Gastrointestinal Function and Adhesions in Subjects Undergoing Bowel Resection
The purpose of this study is to establish preliminary evidence of the efficacy, safety, and tolerability of LB1148 for the treatment of post-operative ileus and intra-abdominal adhesions in subjects undergoing elective bowel…
- Trial name
- PROFILE (NCT02836470)
- Testing
- LB1148
- Where
- 28 sites in United States
- Volunteers
- 112 people
- Sponsor
- Palisade Bio
Endometriosis of the Cul-de-sac, Chocolate Cyst of Ovary
Peritoneal Cavity Conditioning Decreases Pain, Inflammation and Adhesions
Full conditioning of the peritoneal cavity during laparoscopic surgery will decrease post-operative pain, inflammation and adhesion formation.
- Conditions
- Endometriosis of the Cul-de-sac, Chocolate Cyst of Ovary, Fibroid/Myoma (Uterus/Cervix)
- Trial name
- NCT01344486
- Testing
- full conditioning, standard pneumoperitoneum
- Where
- Belgium
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- University Hospital, Gasthuisberg
Open Abdomen
An Adhesion Reduction Plan in the Management of the Surgical Open Abdomen
The purpose of this study is to determine whether an adhesion reduction plan, consisting of early adhesion prevention and application of a bioresorbable membrane is effective in reducing the severity of adhesions and the…
- Trial name
- NCT01010464
- Testing
- Adhesion Reduction Plan
- Where
- United States
- Sponsor
- University of Maryland, Baltimore
Intrauterine Adhesion
PREvention of Intrauterine Adhesion After Hysteroscopic Surgery With Novel deGradable Film
Intrauterine adhesions (IUA) are the major long-term complication of intrauterine procedures and are associated with pelvic pain, menstrual disorders, obstetrical complication and infertility.
- Trial name
- PREG1 (NCT04381728)
- Testing
- Womed Leaf
- Where
- 6 sites in Belgium, France and 1 more
- Volunteers
- 23 people
- Sponsor
- Womed
Intervertebral Disc Disorder, Thoracic Intervertebral Disc Disorders
Spine Surgery for Adhesions in Patients Evaluated for Efficacy and Safety of MedicurtainⓇ (Pivotal Study)
This study was designed to evaluate the efficacy and safety of Medicurtain®, an antiadhesion barrier in patients who underwent In Situ Decompression for single level and unilateral herniated lumbar intervertebral disc.
- Conditions
- Intervertebral Disc Disorder, Thoracic Intervertebral Disc Disorders, Thoracolumbar Intervertebral Disc Disorders, Lumbosacral Intervertebral Disc Disorders
- Trial name
- NCT04688281
- Testing
- Medicurtain®, GUARDIX-SG®
- Where
- South Korea
- Volunteers
- 87 people
- Sponsor
- Shin Poong Pharmaceutical Co. Ltd.
Thumb Joint Stiffness
Electrical Stimulation to Recover Greater Range of Motion After Surgery
Background One of the potentially debilitative complications of operative repair and subsequent immobilization is stiffness that appears secondary to inflammation and adhesions.
- Trial name
- NCT01082432
- Testing
- electrically induced muscle activation
- Where
- France
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Université Joseph Fourier
Focal Vitreomacular Adhesion
Safety and Efficacy Study of Microplasmin in for Non-Surgical Treatment of Focal Vitreomacular Adhesion
This study will evaluate the safety and efficacy of Microplasmin administered as an intravitreal injection, in subjects with focal vitreomacular adhesion.
- Trial name
- MIVI-8 (NCT01055535)
- Testing
- Microplasmin
- Where
- Belgium
- Volunteers
- 17 people
- Sponsor
- ThromboGenics
Impacted Mandibular Third Molar, Postoperative Wound Healing
Soft Tissue Healing and Bacterial Load With Triclosan-Coated Sutures After Impacted Mandibular Third Molar Surgery
The goal of this clinical trial is to learn if triclosan-coated absorbable stitches (polyglactin 910 sutures coated with triclosan, an antibacterial agent) help soft tissue heal better and have fewer bacteria stuck to the…
- Trial name
- NCT07386366
- Testing
- Triclosan-coated Polyglactin 910 suture, Non-coated polyglactin 910 suture
- Where
- Vietnam
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University of Medicine and Pharmacy at Ho Chi Minh City
Uterine Fibroids, Fertility Disorders
Efficacity Assessment of PREVADH® in Adhesion Prevention in Gynaecologic Surgery
The purpose of this study was to evaluate clinically the efficacy of the PREVADH® Film in the prevention of adhesions in gynaecologic surgery, and to assess post-operative complications related to adhesions and pregnancy rate…
- Trial name
- NCT01388907
- Testing
- Ringer lactate solution, Prevadh film
- Where
- 11 sites in France
- Volunteers
- 61 people
- Sponsor
- Medtronic - MITG
Post-surgery Adhesion Formation
Safety Study Investigating Local Tolerability and Pharmacokinetics of PXL01 in Healthy Volunteers
The main purpose of this study is to determine whether three different single doses of PXL01 are safe and well tolerated by healthy volunteers. The pharmacokinetic properties of PXL01 (same doses) will also be investigated.
- Trial name
- NCT00860080
- Testing
- PXL01
- Where
- Sweden
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- PharmaSurgics AB
Periumbilical Adhesions
Ultrasound Visceral Slide Test for Prediction of Periumblical Adhesions Before Gynecologic Laparoscopic Surgery
Ultrasound visceral slide test for prediction of periumbilical adhesions before gynecologic laparoscopic surgery: a prospective cohort study.
- Trial name
- NCT03631888
- Testing
- preoperative abdominal ultrasound examination
- Where
- Israel
- Volunteers
- 80 people
- Sponsor
- Barzilai Medical Center
Intrauterine Adhesions
Efficiency of Amnion Graft to Prevent Intrauterine Adhesions After Hysteroscopic Surgery
The purpose of the study is to evaluate whether human amnion graft reduces the reformation of severe intrauterine adhesions (IUA) following hysteroscopic adhesiolysis.
- Trial name
- NCT02132104
- Testing
- Uterine application of amnion membrane, Foley balloon, Femoston
- Where
- 2 sites in China
- Volunteers
- 208 people, healthy volunteers welcome
- Sponsor
- Capital Medical University
Adhesion, Thyroidectomy
Anti-adhesive Effect and Safety of "Thermo-sensitive Adhesion Barrier (MEDICLORE)"
One of most important complication of thyroid surgery is adhesion. There are many anti-adhesive materials, but none of them showed significant outcomes.
- Trial name
- NCT03293186
- Testing
- MEDICLORE
- Where
- South Korea
- Volunteers
- 90 people
- Sponsor
- Seoul National University Hospital
Nephrectomy, Prostatectomy
HYbrid RObotic Surgery MulTiCentric Study
The purpose of this clinical investigation, HYROS-MTC-I, is to confirm the effectiveness of the combined use of ROB-Bitrack System, its corresponding ElectroSurgical Endoscopic instruments and Non-ElectroSurgical Endoscopic…
- Trial name
- HYROS-MTC-I (NCT06849271)
- Testing
- Radical Nephrectomy (RN), Partial nephrectomy (PN), Radical Prostatectomy (RP)
- Where
- 5 sites in Spain
- Volunteers
- 27 people
- Sponsor
- Rob Surgical Systems S.L.
Prostate Cancer, Postoperative Adhesion
The Effect of Guardix-solution for the Prevention of Postoperative Intestinal Adhesion and Intestinal Obstruction After Laparoscopic Pelvic Cavity Surgery
To assess the anti-adhesive effect of treatment with hyaluronic acid-carboxymethylcellulose following laparoscopic pelvic surgery (radical prostatectomy).
- Trial name
- NCT02773251
- Testing
- hyaluronic acid-carboxymethylcellulose
- Volunteers
- 60 people
- Sponsor
- Bucheon St. Mary's Hospital
Endometriosis, Adhesion
Ovariopexy for Adhesion Prevention After Laparoscopic Removal of Endometriosis of the Pelvic Side Wall or the Ovary
prospective randomized Trial comparing ovariopexy over 2, 4 or 6 days vs Placebo after surgery because of endometriosis of the pelvic side wall or the ovary or both
- Conditions
- Endometriosis, Adhesion, Surgery
- Trial name
- NCT04669756
- Testing
- ovariopexy
- Where
- Germany
- Volunteers
- 409 people
- Sponsor
- University Hospital Muenster
Surgical Adhesions
Prevalence and Severity of Surgical Adhesions Among Women Undergoing Laparoscopic Surgery at Women's Health Hospital
To assess the prevalence of surgical adhesions among women undergoing laparoscopy, and the severity of the adhesions according to proposed classification of intra-abdominal adhesions.
- Trial name
- NCT05703451
- Testing
- laparoscopic surgery
- Where
- 2 sites in Egypt
- Volunteers
- 127 people, healthy volunteers welcome
- Sponsor
- Assiut University
Small Bowel Obstruction, Small Bowel Adhesion
Short and Prolonged Conservative Treatment in Patients With Adhesive Intestinal Obstruction
This study will compare the results of 24 h conservative treatment and N h conservative treatment of adhesive small bowel obstruction (where N = 72 h minus duration of intestinal obstruction).
- Trial name
- NCT05841069
- Testing
- Adhesiolysis, X-ray examination, Conservative treatment
- Where
- 4 sites in Russia
- Volunteers
- 180 people
- Sponsor
- North-Western State Medical University named after I.I.Mechnikov
Endometriosis, Abdominal Adhesions
The Effect of Temporary Ovarian Suspension to the Abdominal Wall During Laparoscopic Endometriosis Surgery for Adhesion Prevention -A Comparative and Prospective Study
Pelvic adhesions, particularly between ovaries and pelvic sidewall, frequently complicate endometriosis surgery. Despite various interventions, no widely accepted solution exists.
- Trial name
- NCT07087756
- Testing
- laparoscopic ovarian suspension
- Where
- Israel
- Volunteers
- 76 people
- Sponsor
- Carmel Medical Center
Anterior Talofibular Ligament Injury
To Evaluate the Effectiveness of the Use of a Novel Crosslinking Hyaluronan Hydrogel on the Prevention of the Adhesion Occurrence After Anterior Talofibular Ligament Repair Surgery
The goal of this clinical trial is to evaluate the effectiveness of the use of a novel crosslinking hyaluronan hydrogel on the prevention of the adhesion occurrence after anterior talofibular ligament repair surgery.
- Trial name
- NCT06826898
- Testing
- DEFEHERE Absorbable Adhesion Barrier
- Where
- Taiwan
- Volunteers
- 50 people
- Sponsor
- Talent Cro Inc.