Clinical trials: Surgical Anastomosis
Surgery--Complications
Clinical Study on the Safety of Double and a Half Layered Esophagojejunal Anastomosis in Curative Gastrectomy
Surgical resection remain the main means for gastric cancer. With the improvement of surgical techniques and concepts, the incidence of postoperative complications gradually decreased, but esophagojejunostomy complications occur…
- Trial name
- NCT05282563
- Testing
- double and a half layered esophagojejunal anastomosis
- Where
- China
- Volunteers
- 21 people
- Sponsor
- Henan Cancer Hospital
Rectal Cancer
SIS-Reinforced vs. Conventional Anastomosis for Mid-to-Low Rectal Cancer: A Multicenter RCT on Anastomotic Leak
The goal of this clinical trial is to learn whether using a reinforcing material called SIS (small intestinal submucosa) during bowel connection after rectal cancer surgery can help prevent anastomotic leakage-a serious…
- Trial name
- NCT07209787
- Testing
- SIS-reinforced anastomosis
- Where
- China
- Volunteers
- 966 people
- Sponsor
- Beijing Chao Yang Hospital
Colorectal Surgery, Enhanced Recovery
CRP Point-of-care Testing Trajectory, a Predictive Factor for Anastomotic Leak in Elective Colorectal Surgery
In colorectal surgery, one of the most feared complications is anastomotic leak (AL). To limit the consequences of AL, it must be diagnosed as early as possible, before it becomes symptomatic.
- Conditions
- Colorectal Surgery, Enhanced Recovery, CRP Point-of-care Testing Trajectory, Post-operative Complication
- Trial name
- CRP (NCT07464600)
- Testing
- blood sample, Blood taken from a fingertip, Abdomino-pelvic CT scan
- Where
- France
- Volunteers
- 500 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Mesenteric Vascular Disease, Colorectal Surgery
Anastomotic Leakage Prevention by Endovascular Stenting of the Superior Mesenteric Artery
Rationale: Anastomotic leakage (AL) is a severe complication of colon surgery, with an incidence of 2.7-11.9%. It is associated with long-term increased mortality, reduced quality of life, and high healthcare costs due to…
- Conditions
- Mesenteric Vascular Disease, Colorectal Surgery, Preventive Intervention
- Trial name
- ALPrES²MA (NCT07486570)
- Testing
- Percutaneous transluminal angiopasty and endovascular stenting of the superior mesenteric artery, Colon surgery, Mono antiplatelet therapy with Ascal 80mg daily
- Where
- 18 sites in Netherlands
- Volunteers
- 360 people
- Sponsor
- Medisch Spectrum Twente
Rectal Cancer Patients
Preoperative Nasal Intestinal Obstruction Catheter Mediated Terminal Ileum Fecal Diversion Versus Intraoperative Protective Ileostomy for Preventing Anastomotic Leakage After Mid Low Rectal Cancer Surgery: A Non Inferiority, Prospective, Multicenter Randomized Controlled Trial
We are currently conducting a multicenter randomized controlled clinical trial entitled *Preoperative Nasal Placement of Bowel Obstruction Catheter for Terminal Ileum Fecal Diversion versus Intraoperative Protective Ileostomy in…
- Trial name
- NCT07821437
- Testing
- Preoperative oral placement of bowel obstruction catheter
- Volunteers
- 500 people
- Sponsor
- First Affiliated Hospital of Wenzhou Medical University
Lymphedema, Lymphedema Arm
Reduction of Arm Volume and Improvement in Lymphedema Via Surgery
This clinical trial aims to evaluate the effectiveness of lymphatic microsurgical treatments in reducing limb volume in female patients with breast cancer-related lymphedema (BCRL).
- Conditions
- Lymphedema, Lymphedema Arm, Lymphedema of Arm, Lymphedema of Upper Limb
- Trial name
- REFRESH (NCT06606145)
- Testing
- Lymphovenous Anastomosis, Vascularized Lymph Node Transfer, Combined Lymphovenous Anastomosis and Vascularized Lymph Node Transfer
- Where
- Belgium
- Volunteers
- 179 people
- Sponsor
- Universitair Ziekenhuis Brussel
Endoscopic Vacuum Therapy, Anastomotic Leak
Endoscopic Vacuum Therapy for Transmural Defects in the Upper Gastrointestinal Tract
The goal of this observational study is to learn about the best indications and techniques regarding endoscopic vacuum therapy (EVT) in patients with a transmural defect in the upper gastrointestinal (GI) tract (e.g.
- Conditions
- Endoscopic Vacuum Therapy, Anastomotic Leak, Esophageal Perforation, Esophageal Perforation, Traumatic
- Trial name
- NCT05606822
- Testing
- Observational
- Where
- Netherlands
- Volunteers
- 200 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Stoma Reversal Procedure
Clinical Evaluation of Cohera Sylys Surgical Sealant as an Adjunct to Standard Bowel Anastomosis Closure
A first in human study evaluating the safety of Sylys Surgical Sealant in protecting the anastomotic junction created during a stoma reversal procedure.
- Trial name
- NCT02196519
- Testing
- Sylys Surgical Sealant
- Volunteers
- 16 people
- Sponsor
- Cohera Medical, Inc.
Free Tissue Flaps
Effect of Epidural Anesthesia on Blood Flow in Arterial Anastomosis of Free Flap
Comparing the changes of arterial anastomotic blood flow between general anesthesia alone and general anesthesia with epidural anesthesia in patients who undergoing free flap transposition using Duplex ultrasound.
- Trial name
- NCT03330808
- Testing
- Epidural anesthesia
- Where
- South Korea
- Volunteers
- 52 people
- Sponsor
- Asan Medical Center
Lymphoedema of Leg, Lymphedema Arm
Added Value of Reconstructive Lymphatic Surgery to Usual Care in Lymphoedema
The primary objective of this research proposal is to investigate in patients with lymphoedema of the upper limb or lower limb (P) the added value of reconstructive lymphatic surgery (I) to the decongestive lymphatic therapy…
- Conditions
- Lymphoedema of Leg, Lymphedema Arm, Lymphedema
- Trial name
- SurLym (NCT05064176)
- Testing
- Usual care, Reconstructive lymphatic surgery
- Where
- 3 sites in Belgium
- Volunteers
- 180 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Obesity, Type 2 Diabetes Mellitus (T2DM)
Magnetic Duodeno-Ileal Chile Study
The objective of the MagDI Chile Study is to evaluate the feasibility / performance, safety, and initial efficacy of the MagDI System in eligible participants who are indicated for a duodeno-ileal (small bowel) side-to-side…
- Trial name
- NCT06613724
- Testing
- Magnet System, DI Biofragmentable
- Where
- Chile
- Volunteers
- 10 people
- Sponsor
- GT Metabolic Solutions, Inc.
Surgical Bleeding, Aneurysms
CoSeal for Hemostasis of Aortic Anastamoses
Surgery on the aorta can be associated with significant blood loss. Most commonly this is due to bleeding at the site of aortic anastomosis. Surgical bleeding is associated with significant morbidity.
- Conditions
- Surgical Bleeding, Aneurysms, Aortic Dissection
- Trial name
- NCT01653769
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Michael Reardon, MD
Diabetes Mellitus Type 2 in Obese
Efficacy of SASI Bypass for Type-2 Diabetic Obese Patients
the investigator modified the Sanator's operation by performing a loop rather than Roux-en-Y bipartition reconstruction and the investigator are reporting the first clinical results of the outcomes of SASI bypass as a mode of…
- Trial name
- SASI (NCT02680873)
- Testing
- SASI bypass
- Volunteers
- 50 people
- Sponsor
- Mansoura University
Rectum Cancer
End to End Versus Side to End Anastomosis After Anterior Resection of Cancer Rectum
Comparison between end to end and side to end anastomosis after anterior resection of cancer rectum and compare the outcomes of both surgical techniques. The main outcomes were bowel functional outcomes and QoL.
- Trial name
- NCT06311279
- Testing
- Anterior resection of Rectal cancer
- Where
- Egypt
- Volunteers
- 20 people
- Sponsor
- Sohag University
Lymphedema, Lymphoedema
Effect of Lymphovenous Anastomosis on Lower Limb Lymphedema: Pragmatic Randomized Controlled Trial
This multicentre pragmatic randomised controlled trial evaluates lymphovenous anastomosis (LVA) for lower-limb lymphedema (LLL) in Denmark.
- Conditions
- Lymphedema, Lymphoedema, Lymphoedema of Leg, Lymphedema of Leg
- Trial name
- NCT07073586
- Testing
- Lymphovenous Anastomosis, Complete Decongestive Therapy
- Where
- 2 sites in Denmark
- Volunteers
- 66 people
- Sponsor
- Herlev and Gentofte Hospital
Colorectal Anastomosis, Endometrial
Impact of Prior Identification and Education of Patients Requiring a Digestive Stoma for Fecal Diversion
There are many indications for performing a fecal diversion stoma. In both scheduled and emergency situations, and whatever the context (indication or type of fecal diversion stoma), stomal complications can occur early (10-60%)…
- Conditions
- Colorectal Anastomosis, Endometrial, Anastomotic Leak Rectum, Ulcerative Colitis (Disorder)
- Trial name
- RESTODIG (NCT06881303)
- Testing
- preoperative stoma identification and education
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Chronic Dacryocystitis
The Application of Photosensitive Hydrogel in Intranasal Endoscopic Dacryocystorhinostomy
To study the effect of Photosensitive hydrogel used for suture free anastomosis of lacrimal cyst and nasal mucoperiosteal flap in endoscopic nasal dacryocystostomy, and evaluate its adhesion to lacrimal cyst and nasal…
- Trial name
- NCT06551766
- Testing
- Photosensitive hydrogel, 6-0 absorbable stitches
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Eye & ENT Hospital of Fudan University
Anastomosis, Leaking
THE ROLE OF C-REACTIVE PROTEIN (CRP) IN THE EARLY DIAGNOSIS OF ANASTOMOTIC LEAKAGE FOLLOWING PRIMARY REPAIR IN GASTROINTESTINAL SURGERY
Despite advancements in surgical procedures, Anastomotic leakage (AL) remains a common complication following gastrointestinal surgery.
- Trial name
- NCT07763379
- Testing
- c-reactive protein
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Sohag University
Obesity, Type 2 Diabetes
Magnetic Gastro-Ileal or Gastro-Jejunal Diversion Study ("MGI/MGJ Study")
The purpose of this clinical research study is to evaluate the feasibility of the GT Metabolic Solutions Magnet System, GJ Biofragmentable ("MagGJ System") for creation of a side-to-side anastomosis for gastro-ileal or…
- Trial name
- NCT06073457
- Testing
- MagGJ System
- Where
- 4 sites in Canada, Chile and 2 more
- Volunteers
- 35 people
- Sponsor
- GT Metabolic Solutions, Inc.
Rectal Cancer
Side-to-end Anastomosis Versus Colon J Pouch for Reconstruction After Low Anterior Resection for Rectal Cancer (SAVE)
Primary hypothesis: Side-to-end anastomosis is non-inferior to colon J pouch for reconstruction after low anterior resection for rectal cancer in fecal incontinence (Wexner score).
- Trial name
- SAVE (NCT01006577)
- Testing
- side-to-end anastomosis, colon j pouch
- Where
- Germany
- Volunteers
- 306 people
- Sponsor
- Charite University, Berlin, Germany