Clinical trials: Surgical Condition
Pain, Postoperative
Efficacy of Fascia Iliaca Block Versus Intraoperative Nerve Infiltration During Anterior Hip Replacement Surgery
Surgical trauma causes nerve sensitization leading to amplification and prolongation of postoperative pain. In experimental studies, pre-injury neural blockade using local anesthetics has been shown to reduce post-injury…
- Trial name
- NCT01693900
- Testing
- Pre-operative Ultrasound FICB Group, Intra-operative FICB Group
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Randy Fayne, DO
Thyroidectomy, Thyroid Diseases
Preoperative Single-dose Steroid Application for the Treatment of Nausea and Vomiting After Thyroid Surgery
The study is to compare the postoperative recovery, as determined by postoperative nausea and vomiting (PONV) after preoperative application of single-dose dexamethasone versus saline in patients undergoing partial or total…
- Trial name
- tPONV (NCT01189292)
- Testing
- Dexamethasone, NaCl 0.9%
- Where
- Switzerland
- Volunteers
- 152 people
- Sponsor
- Cantonal Hospital of St. Gallen
Ambulatory Surgery, Coughing
Effect of Fentanyl on Coughing and Recovery After Anesthesia With an LMA Laryngeal Mask Airway)for Airway Management
The purpose of this research is to evaluate the effectiveness of fentanyl for reducing coughing during the perioperative period (i.e., insertion of an LMA [Laryngeal Mask Airway] device, maintenance period during surgery, and…
- Trial name
- LMA (NCT01368809)
- Testing
- Saline, Fentanyl
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Cedars-Sinai Medical Center
Pain, Postoperative, Postoperative Nausea and Vomiting
A Comparison of Tumescence in Breast Reduction Surgery
The investigators' main hypothesis is that in breast reduction surgery, the use of tumescent solution containing both dilute lidocaine and epinephrine will lead to better control of postoperative pain, nausea, vomiting, shorter…
- Trial name
- NCT01602692
- Testing
- Tumescent solution with dilute lidocaine and epinephrine, Tumescent Solution with dilute epinephrine
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Urinary Incontinence
Mixed Incontinence: Medical Or Surgical Approach?
The purpose of this study is to compare treatment outcomes for patients with mixed urinary incontinence (MUI) for whom therapy is initiated with surgery to those for whom therapy is initiated with non-surgical treatment.
- Trial name
- MIMOSA (NCT00803270)
- Testing
- Non-Surgical Intervention, Surgical
- Where
- 10 sites in United States
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Carelon Research
Muscle Loss
Enhanced Bioscaffold for Volumetric Muscle Loss
This is a prospective, single center study conducted at the University of Pittsburgh designed to test the applicability and utility of XenMatrix™ AB Surgical Graft in the restoration of function in the setting of volumetric…
- Trial name
- MTEC-VML (NCT04051242)
- Testing
- XenMatrix™ AB Surgical Graft
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- J. Peter Rubin, MD
Spinal Injuries, Adhesions
DuraGen Plus® Adhesion Barrier for Use in Spinal Surgery
To evaluate the safety and effectiveness of DuraGen Plus® Adhesion Barrier Matrix as an adhesion barrier in spinal surgery to reduce the extent of peridural fibrosis formation and radicular pain in comparison to a control group…
- Trial name
- NCT00387829
- Testing
- DuraGen Plus Adhesion Barrier Matrix
- Where
- 36 sites in United States
- Volunteers
- 347 people
- Sponsor
- Integra LifeSciences Corporation
Breast Neoplasm, Lesion
Radiofrequency Identification Technology in Locating Non-palpable Breast Lesions in Patients Undergoing Surgery
This pilot clinical trial studies radiofrequency technology in locating non-palpable breast lesions in patients undergoing surgery.
- Trial name
- NCT03202472
- Testing
- Implanted Medical Device, Mammography, Questionnaire Administration
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Jonsson Comprehensive Cancer Center
Ileus, Gastrointestinal Dysfunction
Alvimopan as a Rescue Treatment of Postoperative Ileus
This study aims to evaluate the cost effectiveness of Alvimopan as rescue therapy in patients undergoing colorectal or small bowel resection who develop POI, and its safety and effectiveness in reducing LOS and POI duration.
- Trial name
- NCT04405037
- Testing
- Alvimopan
- Where
- United States
- Volunteers
- 65 people
- Sponsor
- Scott Steele
Constipation, Impaction, and Bowel Obstruction, Unspecified Adult Solid Tumor, Protocol Specific
S1316, Surgery or Non-Surgical Management in Treating Patients With Intra-Abdominal Cancer and Bowel Obstruction
This partially randomized clinical trial studies surgery or non-surgical management in treating patients with intra-abdominal cancer and bowel obstruction.
- Trial name
- NCT02270450
- Testing
- therapeutic conventional surgery, gastrointestinal complications management/prevention, quality-of-life assessment
- Where
- 38 sites in United States, Canada and 3 more
- Volunteers
- 221 people
- Sponsor
- SWOG Cancer Research Network
Venous Thromboembolism, Venous Thrombosis
Intermittent Pneumatic Compression in Surgical Patients at Extremely-high Risk for Venous Thromboembolism
The aim of the study is to evaluate efficacy and safety of venous thromboembolism prophylaxis by the combination of graduated compression stockings (GCS), standard doses of low-molecular-weight heparins (LMWH) and sequential…
- Trial name
- IPCSUPER (NCT03044574)
- Testing
- SCD, GCS, LMWH
- Where
- 2 sites in Russia
- Volunteers
- 407 people
- Sponsor
- Pirogov Russian National Research Medical University
Pneumoperitoneum
Moderate vs Deep Neuromuscular Block on Biotrauma During Laparoscopy
The purposes of this study is to investigate the effects of moderate vs. deep neuromuscular block on respiratory mechanics and biotrauma in patients with intraoperative protective lung ventilation for laparoscopy.
- Trial name
- NCT03576118
- Testing
- Deep neuromuscular block, Moderate neuromuscular block
- Where
- South Korea
- Volunteers
- 74 people
- Sponsor
- Ajou University School of Medicine
Lung Cancer
Carboplatin, Gemcitabine, and Thalidomide in Patients Undergoing Surgery for Stage II or III Non-Small Cell Lung Cancer
RATIONALE: Drugs used in chemotherapy, such as carboplatin and gemcitabine, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing.
- Trial name
- NCT00281827
- Testing
- carboplatin, gemcitabine hydrochloride, thalidomide
- Where
- 3 sites in United States
- Volunteers
- 22 people
- Sponsor
- Masonic Cancer Center, University of Minnesota
Of Bypass Graft of the Extremities, Peripheral Arterial Disease
Standard Versus PICO Dressings in Lower-Extremity Bypass Patients
The objective of this study is to compare the effectiveness of standard moist dressings and PICO single-use negative pressure dressings in post-operative lower extremity bypass patients.
- Conditions
- Of Bypass Graft of the Extremities, Peripheral Arterial Disease, Vascular Diseases, Cardiovascular Diseases
- Trial name
- PICO-LEB (NCT02492854)
- Testing
- PICO Single-Use Negative Pressure Dressings, Sterile Gauze Dressings
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Boston Medical Center
Critical Illness
Glycocalyx Damage in Critically Ill Patients
The hypothesis to be tested: GCX damage and its dynamics correlate to various patient related factors and to using organ-supporting measures. There is a correlation between length of organ support and GCX damage.
- Trial name
- NCT03146585
- Testing
- PBR assessment
- Where
- Czechia
- Volunteers
- 40 people
- Sponsor
- University Hospital Hradec Kralove
Pain Control
A Study of Intrathecal Hydromorphone for Pediatric Idiopathic Scoliosis Repair
The purpose of this study is to identify a dose of intrathecal hydromorphone (opioid pain medicine) that optimizes pain control but minimizes side effects historically seen with this class of pain medications.
- Trial name
- NCT05552443
- Testing
- Hydromorphone 2.5 mcg/kg, Hydromorphone 2.75 mcg/kg, Hydromorphone 3 mcg/kg
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- Mayo Clinic
Neoplasms, Pulmonary, Thoracic Diseases
The Need of Fiberoptic Bronchoscopy for Placing an Endobronchial Blocker
The need of fiberoptic bronchoscopy for placing an endobronchial blocker. Endobronchial blockers (EBB) have been presented effective and safe alternative for lung separation in vedio-assisted thoracoscopic (VATS) operations.
- Trial name
- NCT02133235
- Testing
- conventional, auscultation
- Where
- Taiwan
- Volunteers
- 112 people
- Sponsor
- National Taiwan University Hospital
Acute Kidney Injury
Renal Replacement Therapy and In-Hospital Mortality Incidence in Cardiac Surgery Associated Acute Kidney Injury
The goal of this study is to analyse the relation of severe acute kidney injury post cardiac surgery which characterised by the need of renal replacement therapy, with in-hospital postoperative mortality incidence.
- Trial name
- NCT06091982
- Testing
- Renal Replacement Therapy (RRT)
- Where
- Indonesia
- Volunteers
- 1,113 people
- Sponsor
- National Cardiovascular Center Harapan Kita Hospital Indonesia
Cataract, Inflammation
Mapracorat Ophthalmic Suspension, 3% for the Treatment of Ocular Inflammation and Pain Following Cataract Surgery
The objective of this clinical study is to compare the safety and efficacy of mapracorat ophthalmic suspension, 3% with its vehicle for the treatment of postoperative inflammation and pain following cataract surgery.
- Conditions
- Cataract, Inflammation, Surgery
- Trial name
- NCT01591161
- Testing
- Mapracorat
- Where
- United States
- Volunteers
- 369 people
- Sponsor
- Bausch & Lomb Incorporated
Cataract
A Safety and Efficacy Study of a Dexamethasone Drug Delivery System for Postoperative Inflammation and Pain After Cataract Surgery
This is a safety and efficacy study of a Dexamethasone Drug Delivery System for anterior segment inflammation and pain following cataract extraction with lens implantation.
- Trial name
- NCT01605942
- Testing
- Dexamethasone Drug Delivery System
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Allergan
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