Clinical trials: Surgical Condition
Pain, Postoperative, Respiratory Depression
Effect of Postoperative Girdle Following Abdominal Surgery on Pulmonary Function, Mobilisation and Postoperative Pain
There is a considerable lack of knowledge in everyday surgical practice concerning treatment with a corset after laparotomy, in surgery for incisional hernia or as conservative treatment.
- Trial name
- NCT01517217
- Testing
- No girdle, Girdle
- Where
- Sweden
- Volunteers
- 50 people
- Sponsor
- Karolinska Institutet
Pressure Ulcer
Fluid Immersion Simulation (FIS) System Versus Air Fluidized Bed (AFB) System for Pressure Ulcers
The primary objective is to compare the efficacy of the FIS on closure rate to the AFB after 2 weeks of operative debridement and closure.
- Trial name
- NCT03522714
- Testing
- Fluid Immersion Simulation System, Air Fluidized Bed System
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Northwestern University
Rectal Cancer
Rectal Preserving Treatment for Early Rectal Cancer. A Multi-centred Randomised Trial of Radical Surgery Versus Adjuvant Chemoradiotherapy After Local Excision for Early Rectal Cancers
Current therapy for early colorectal cancer is radical Total Mesorectal Excision (TME). Colorectal surgical resections are accompanied with high morbidity of up to 33% and 90 days mortality of up to 9% in the fragile elderly…
- Trial name
- TESAR (NCT02371304)
- Testing
- Adjuvant chemoradiotherapy, Additional TME surgery, capecitabine
- Where
- Netherlands
- Volunteers
- 302 people
- Sponsor
- Amsterdam UMC, location VUmc
Postoperative Residual Curarization
Postoperative Residual Paralysis After Cardiac Surgery
The main objective of this study is to describe the incidence of postoperative residual paralysis (mean train-of-four <90%) when weaning from the ventilator in patients admitted to the Intensive Care Unit (ICU) after elective…
- Trial name
- NCT03291184
- Testing
- peripheral neuromuscular monitor
- Where
- Belgium
- Volunteers
- 93 people
- Sponsor
- Onze Lieve Vrouw Hospital
Breast Cancer, Breast Neoplasms
Different Volumes of Erector Spinae Plane Block for Breast Surgery
Postoperative pain is an important issue in female patients underwent breast surgery. Postoperative effective pain treatment provides early mobilization and shorter hospital stay.
- Conditions
- Breast Cancer, Breast Neoplasms, Breast Diseases
- Trial name
- NCT05232084
- Testing
- Bupivacaine + Fentanyl
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Medipol University
Pain, Postoperative, Postoperative Nausea and Vomiting
Single Port Versus Four Ports Laparoscopic Cholecystectomy and Early Postoperative Pain
This is a trial to evaluate if single port laparoscopic cholecystectomy causes less pain than conventional laparoscopic cholecystectomy.
- Conditions
- Pain, Postoperative, Postoperative Nausea and Vomiting, Postoperative Complications
- Trial name
- UMBI-CHOL (NCT01268748)
- Testing
- Conventional laparoscopic procedure, Experimental laparoscopic procedure
- Where
- 3 sites in Denmark
- Volunteers
- 120 people
- Sponsor
- Bispebjerg Hospital
Tourniquet Pain
Ketamine Reduces Tourniquet Pain In Patients Undergoing Lower Limb Surgery Under Spinal Anaesthesia
A prospective, double blind, randomised controlled trial to evaluate the effect of ketamine in reducing tourniquet pain for patients undergoing lower limb surgery under spinal anaesthesia.
- Trial name
- NCT03357055
- Testing
- Ketamine, Normal saline
- Volunteers
- 60 people
- Sponsor
- Dr Foo Li Lian
Neuromuscular Blockade
Neuromuscular Blockade Improves Surgical Conditions
This study is designed to test the clinical hypothesis that a neuromuscular block improves surgical conditions, operation time, and post-operative pain.
- Trial name
- NISCO (NCT00895778)
- Testing
- Neuromuscular blockade with rocuronium and reversal with sugammadex
- Where
- Germany
- Volunteers
- 57 people
- Sponsor
- Technical University of Munich
Molar, Fourth, Extracting Own Teeth
Effects of the Application of a Hyper-oxygenated Gel After Oral Surgery
The goal of this clinical trial is to evaluate whether the topical application of Novox® Drop on surgical wounds after the extraction of lower third molars can have a clinical advantage.
- Conditions
- Molar, Fourth, Extracting Own Teeth, Edema Face, Pain
- Trial name
- NCT06458478
- Testing
- Hyper-oxygenated gel, glycerin based gel
- Where
- Italy
- Volunteers
- 72 people
- Sponsor
- Azienda Ospedaliera di Perugia
Periodontal Diseases
Addition of Dehydrated Human Amnion-Chorion Membrane During Scaling and Root Planing
Hypothesis: There will be an additional reduction of pocket depth and gain of clinical attachment when dehydrated human amnion-chorion membrane (dHACM) is placed into the periodontal disease defect after mechanical scaling and…
- Trial name
- NCT03836378
- Testing
- BioXclude™
- Where
- United States
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Hemorrhoids, Surgery
Impact of Moderate to Severe Pain in the Post-intervention Monitoring Room After Hemorrhoidectomy on the Length of Stay in the Outpatient Surgery Unit
The target rate for outpatient surgery has been set by the Ministry of Health at 70% for 2020. To achieve this objective, this requires increasing the panel of eligible outpatient procedures to more mutilating surgeries and…
- Trial name
- HEM_DOULEUR (NCT04567485)
- Where
- France
- Volunteers
- 446 people
- Sponsor
- Fondation Hôpital Saint-Joseph
Obesity, Diabetes
Semaglutide 2.4 mg in Patients With Poor Weight-loss
A double-blinded, randomised, placebo-controlled trial of semaglutide 3.0 mg/ml in patients with poor weight-loss following bariatric surgery.
- Conditions
- Obesity, Diabetes, Metabolic Syndrome
- Trial name
- BARI-STEP (NCT05073835)
- Testing
- Semaglutide 3 mg
- Where
- United Kingdom
- Volunteers
- 70 people
- Sponsor
- University College, London
Colon Cancer
Oral Versus Parenteral Nutrition Support to Improve Protein Balance in Colorectal Surgical Patients
A prospective, randomized controlled study, using stable isotope methodology, is proposed to determine whether an oral nutrition support regimen, containing pressurized whey protein and glucose, is more effective at normalizing…
- Trial name
- NCT01222208
- Testing
- Oral Nutrition with dextrose and pressurized whey protein, Peripheral Parenteral Nutrition
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Pelvic Organ Prolapse
Evaluation of the Results of Laparoscopic Sacrohysteropexy and Sacrocolpopexy Surgeries Performed Without Mesh in the Surgical Treatment of Pelvic Organ Prolapse
Evaluation of the anatomical and functional results of laparoscopic sacrohysteropexy and sacrocolpopexy surgeries performed without using mesh in the surgical treatment of pelvic organ prolapse
- Trial name
- NCT06176521
- Testing
- Laparoscopic Sacrohysteropexy and Sacrocolpopexy Surgeries Performed Without Mesh
- Where
- Turkey (Türkiye)
- Volunteers
- 35 people
- Sponsor
- Gaziosmanpasa Research and Education Hospital
Perioperative Myocardial Injury, Autonomic Dysfunction
LANdiolol to Avoid TAchycardia in Patients at Risk for Cardiovascular Events Undergoing Major Non-cardiac Surgery
Limiting perioperative tachycardia (aiming for a heart rate <90 beats per minute throughout the perioperative period) using the ultra-short acting beta-blocker landiolol in patients with cardiovascular risk factors undergoing…
- Conditions
- Perioperative Myocardial Injury, Autonomic Dysfunction, Cardiovascular (CV) Risk, Major Surgery
- Trial name
- LANTA-P (NCT07168421)
- Testing
- Landiolol
- Where
- Switzerland
- Volunteers
- 114 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Dental Crowding, Gingival Recession
Evaluating the Clinical Efficacy of Collagen Scaffold (Ossix VOLUMAX) With Piezo-Surgical Decortication in Enhancing Orthodontic Treatment Outcomes: A Randomized Controlled Trial
Recent advances in orthodontic treatment have explored various materials to enhance treatment efficacy, particularly focusing on collagen scaffolds.
- Conditions
- Dental Crowding, Gingival Recession, Thin Phenotype
- Trial name
- NCT07097714
- Testing
- Piezocision with ribose cross-linked collagen matrix (Ossix® Volumax), control
- Where
- Russia
- Volunteers
- 70 people
- Sponsor
- NMSI DENTMASTER
Myocardial Injury, Myocardial Ischemia
PeRiOperaTivE CardioproTection With Ivabradine in Non-cardiac Surgery
Perioperative myocardial injury (PMI) after non-cardiac surgery (NCS), i.e. the elevation of postoperative troponin, occurs in nearly 20% of patients older than 45 years undergoing NCS and is independently and strongly associated…
- Trial name
- PROTECTIN (NCT04436016)
- Testing
- Ivabradine
- Where
- Switzerland
- Volunteers
- 78 people
- Sponsor
- University Hospital, Geneva
Pain
Evaluation of Post-PACU Pain Management in Pediatric Surgery
This study aims to assess the differences in overall pain severity, pain management, and satisfaction during recovery period between two groups of children who either receive or do not receive additional education related to…
- Trial name
- NCT02352116
- Testing
- Additional face-to-face education, Standard of care management
- Where
- United States
- Volunteers
- 900 people, healthy volunteers welcome
- Sponsor
- Columbia University
Myoma;Uterus, Surgery
Myomectomy Operation and Fundus Incision, Energy Modalities and Methods of Extraction
Myomectomy operation due to myoma uteri is an operation that can cause serious blood loss. For some anatomical reasons, fundal myomas were removed, while a group of investigators recommended the initiation of a longitudinal…
- Trial name
- NCT03901404
- Testing
- Myomectomy Operation
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Kanuni Sultan Suleyman Training and Research Hospital
Knee Injuries
Femoral/Sciatic Block for Knee Surgery
Knee arthroplasty has a high potential for postoperative pain. This study compares analgesia and postoperative bleeding from intrathecal morphine with the continuous femoral and a single-shot sciatic nerve blockades.
- Trial name
- NCT02882152
- Testing
- femoral nerve blockade, morphine
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo General Hospital