Clinical trials: Surgical Oncology
Breast Cancer, Weight Changes
Weight Control Programs in Women Who Have Undergone Surgery for Early Stage Breast Cancer
RATIONALE: Measuring changes in body weight and body composition in women with early-stage breast cancer may help doctors plan the best weight control program and improve patients' quality of life.
- Trial name
- NCT00869466
- Testing
- behavioral dietary intervention, exercise intervention, counseling intervention
- Where
- 5 sites in United Kingdom
- Volunteers
- 409 people
- Sponsor
- Wythenshawe Hospital
Lung Injury, Acute, Thoracotomy
Prevention of Lung Edema After Thoracic Surgery
Background : Acute lung injury (ALI) occasionally occurs after pulmonary resection and carries a bad prognosis with a high mortality rate ranging from 20 to 100%. Objectives : 1.
- Conditions
- Lung Injury, Acute, Thoracotomy, Anesthesia, Intensive Care, Surgical
- Trial name
- NCT00498251
- Testing
- inhalation of salbutamol (5 mg), ipratropium
- Where
- Switzerland
- Volunteers
- 30 people
- Sponsor
- University Hospital, Geneva
Breast Cancer, Seroma
EvaLuating negAtive pressUre Wound theRapy in brEast coNserving Surgery
Negative pressure wound therapy (NPWT) could improve surgical outcomes and reduce complications like SSI, wound dehiscence and seroma in closed surgical wounds.
- Conditions
- Breast Cancer, Seroma, Wound Complication
- Trial name
- LAUREN (NCT05509829)
- Testing
- Negative pressure wound therapy
- Where
- Netherlands
- Volunteers
- 300 people
- Sponsor
- Zuyderland Medisch Centrum
Lymphedema of Face, Secondary Lymphedema
Complete Decongestive Therapy on Head and Neck Lymphedema
This will be a prospective, randomized controlled study of ~60 adult patients who have undergone a laryngectomy, neck dissection, maxillectomy or mandibulectomy surgical procedure for the treatment of head and neck cancer at Our…
- Trial name
- NCT04045860
- Testing
- Complete Decongestive Therapy, Observation
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- Our Lady of the Lake Hospital
Rectal Cancer Surgery
Comparison of Different Surgical Approaches in Female Rectal Cancer.
Mid-to-low rectal cancer exhibits an extremely high incidence rate in China. Currently, the primary treatment approach for mid-to-low rectal cancer remains surgical intervention, with total mesorectal excision (TME) being the…
- Trial name
- NCT07189780
- Testing
- Surgical approach
- Volunteers
- 200 people
- Sponsor
- First Affiliated Hospital of Wenzhou Medical University
Soft Tissue Sarcoma
Prehabilitation Soft-Tissue Sarcoma of Lower Limb
This study is about preparing people with cancerous tumours, soft-tissue sarcoma (STS), in the leg to recover more quickly from surgery.
- Trial name
- NCT04518488
- Testing
- Exercises, Informational Support Group (Control group)
- Volunteers
- 30 people
- Sponsor
- McGill University
Adenoid Cystic Carcinoma, Sinonasal Carcinoma
SPARE-1st: Surgery Alone vs Surgery Plus Postoperative Radiotherapy for Sinonasal Adenoid Cystic Carcinoma
Background: Sinonasal adenoid cystic carcinoma (ACC) is a rare type of cancer that starts in the nasal cavity or sinuses. Although surgery can remove the tumor, doctors often recommend radiation therapy after surgery to reduce…
- Trial name
- SPARE-1st (NCT07563088)
- Testing
- Postoperative Radiotherapy, Observation
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Eye & ENT Hospital of Fudan University
Gastric Adenocarcinoma
SOX Regimen as Neoadjuvant Chemotherapy for AJCC Stage II-III Gastric Cancer
This is a randomized, multicenter, controlled trial to prove efficacy of S-1 and Oxaliplatin as Neoadjuvant Chemotherapy for Advanced Gastric Cancer Patients who undergo D2 gastrectomy.
- Trial name
- RESONANCE (NCT01583361)
- Testing
- Oxaliplatin+S-1, Adjuvant Oxaliplatin/S-1（SOX）
- Where
- China
- Volunteers
- 772 people
- Sponsor
- Lin Chen
Oropharyngeal Cancer, Palate Free Flap Reconstruction
Functional Results of Soft Palate Free Flap Reconstruction
The oropharynx is a complex anatomical structure necessary for nasal breathing, swallowing and phonation. The removal of oropharyngeal cancers can lead to sequelae, particularly in the case of resections affecting the soft…
- Trial name
- RECaVoLL (NCT03890783)
- Testing
- Evaluation of phonation quality, Evaluation of swallowing quality, global quality of life questionnaire
- Where
- France
- Volunteers
- 29 people
- Sponsor
- Hospices Civils de Lyon
Breast Cancer
Study on the Efficacy and Safety of "Body-Tuning, Voice-Tuning, Mind-Tuning" Three-Dimensional Integrated Art Therapy in Regulating the Physical-Mental-Social Status of Young and Middle-Aged Breast Cancer Patients After Surgery
To evaluate the improvement effect of the "Body-Tuning, Voice-Tuning, Mind-Tuning" three-dimensional integrated art therapy on insomnia and physical-mental-social status in breast cancer patients aged ≤45 years, and to explore…
- Trial name
- ArtRehab (NCT07815262)
- Testing
- ArtRehab
- Where
- China
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Keda Yu
Ependymoma
A Trial of Surgery and Fractionated Re-Irradiation for Recurrent Ependymoma
The primary purpose of this study is to investigate whether surgery and re-irradiation will help treat ependymoma that has come back after initial treatment.
- Trial name
- NCT02125786
- Testing
- Irradiation, Surgery, ^1^8F-Fluorodeoxyglucose
- Where
- United States
- Volunteers
- 68 people
- Sponsor
- St. Jude Children's Research Hospital
Esophageal Squamous Cell Carcinoma (ESCC)
Phase II Study of Induction Chemoimmunotherapy Followed by Radiotherapy and Organ Preservation in Resectable ESCC
This multicenter, prospective Phase II study investigates a response-adapted organ-preservation strategy in patients with resectable esophageal squamous cell carcinoma (ESCC).
- Trial name
- SCOPE (NCT07711470)
- Testing
- Sugemalimab and Chemotherapy, Nab-paclitaxel, Cisplatin
- Where
- China
- Volunteers
- 140 people
- Sponsor
- Cancer Institute and Hospital, Chinese Academy of Medical Sciences
Breast Cancer and Rehabilitation
Effect of Preoperative Rehabilitation Exercise on Improving Postoperative Lymphedema, Quality of Life and Care Needs in Patients With Breast Cancer Surgery
Breast cancer is one of the most common cancers among women worldwide, with surgery being a primary treatment. However, surgical tumor resection combined with lymph node dissection often leads to upper extremity lymphedema as a…
- Trial name
- NCT07743294
- Testing
- Preoperative Upper Limb Rehabilitation Exercise, Standard Nursing Care and Education
- Where
- 2 sites in Taiwan
- Volunteers
- 105 people
- Sponsor
- National Taiwan University Hospital
Abdominal Cancer
A Seven-day Preoperative Exercise Training Program in People With Abdominal Cancer
Background: Preoperative exercise training programs of long duration, that delay surgical resection of tumors, may not be feasible in the treatment of malignant disease.
- Trial name
- NCT04114422
- Testing
- Seven-day preoperative exercise training program
- Where
- Brazil
- Sponsor
- Universidade Cidade de Sao Paulo
Intermediate-to-High Risk Differentiated Thyroid Cancer
Desiccated Thyroid Extract Combined With Levothyroxine for TSH Suppression Therapy in DTC
The global incidence of Differentiated Thyroid Cancer (DTC) is rising. While surgery followed by TSH suppression is the standard of care, achieving target TSH levels with levothyroxine (L-T4) monotherapy remains challenging, with…
- Trial name
- DELTA (NCT07239674)
- Testing
- desiccated thyroid extract (DTE)+levothyroxine (L-T4)
- Volunteers
- 646 people
- Sponsor
- West China Hospital
Lung Cancer
A Study to Evaluate Pegsitacianine, an Intraoperative Fluorescence Imaging Agent for the Detection of Lung Malignancies
This Phase 2 study is an open-label, single-arm trial where each patient is his/her own "intrapatient" control. All patients will receive a single dose of pegsitacianine prior to standard of care surgery.
- Trial name
- NCT05048082
- Testing
- pegsitacianine, Tumor resection surgery
- Where
- 2 sites in United States
- Volunteers
- 24 people
- Sponsor
- OncoNano Medicine, Inc.
Pancreatic Cancer
Fatigue and Pancreas and Bile Duct Cancer Study
The purpose of this pilot study is to determine the effects of a walking program on fatigue, physical functioning and QOL in patients with pancreatic and periampullary cancers who have had surgery or are undergoing adjuvant…
- Trial name
- NCT00902759
- Testing
- Walking Program
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University
Lung Adenocarcinoma, Stage IA1 Lung Cancer American Joint Committee on Cancer (AJCC) v8
Testing the Safety of Dapagliflozin Prior to Surgery for the Treatment of Patients With Stage IA Lung Adenocarcinoma
This early phase I trial tests the safety and side effects of dapagliflozin given prior to surgery in patients with stage IA lung adenocarcinoma.
- Conditions
- Lung Adenocarcinoma, Stage IA1 Lung Cancer American Joint Committee on Cancer (AJCC) v8, Stage IA2 Lung Cancer AJCC v8, Stage IA3 Lung Cancer AJCC v8
- Trial name
- NCT07235280
- Testing
- Biospecimen Collection, Computed Tomography Assisted Biopsy, Dapagliflozin Propanediol
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- Jonsson Comprehensive Cancer Center
Lung Neoplasms, Non-Small Cell Lung Cancer, Postoperative Complications
Smartphone-based Remote Symptom Monitoring to Improve Postoperative Rehabilitation Exercise Adherence After Video-assisted Thoracic Surgery (VATS) for Lung Cancer
Brief Summary: This randomized controlled trial aims to evaluate whether active remote symptom monitoring and management via a smartphone app utilizing electronic patient-reported outcomes (ePRO) can improve adherence to…
- Conditions
- Lung Neoplasms, Non-Small Cell Lung Cancer, Postoperative Complications, Patient Reported Outcome Measures, Telerehabilitation
- Trial name
- NCT05990946
- Testing
- ePRO based Remote Symptom Management provide by a mobile phone app
- Where
- China
- Volunteers
- 736 people
- Sponsor
- Zhongshan People's Hospital, Guangdong, China
Neuroblastoma
Combination Chemotherapy or Observation Following Surgery in Treating Infants With Neuroblastoma
RATIONALE: Sometimes neuroblastoma will regress without treatment, but sometimes additional treatment may be necessary. Giving more than one chemotherapy drug after surgery to remove the tumor may kill more tumor cells.
- Trial name
- NCT00002803
- Testing
- cyclophosphamide, doxorubicin hydrochloride, vincristine sulfate
- Where
- Germany
- Volunteers
- 44 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
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