Clinical trials: Surgical Oncology
Rectal Cancer, Adenocarcinoma
Prospective Randomized Study of SILS Versus CLS for Rectal Cancer
Background: Single-port laparoscopic surgery is emerging as a method to improve morbidity and cosmetic benefits of conventional laparoscopic surgery and minimize the surgical trauma.
- Trial name
- NCT01579721
- Testing
- Single Incision Laparoscopic Surgery
- Where
- Denmark
- Volunteers
- 40 people
- Sponsor
- Hvidovre University Hospital
Brain Tumor, Surgery
Confocal Laser Endomicroscopy for Brain Tumors
The prognosis of glioblastoma patients highly depends on resection extent. Various strategies have been introduced to overcome the dilemma of intraoperative tumor identification.
- Conditions
- Brain Tumor, Surgery, Convivo System, Laser Endomicroscopy
- Trial name
- CONVIVO (NCT04280952)
- Testing
- CONVIVO
- Where
- Switzerland
- Volunteers
- 174 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
NSCLC
Combination of Cisplatin, Docetaxel and Bevacizumab in Patients With Non-small Cell Lung Carcinoma (NSCLC)
Despite recent advances in the treatment of NSCLC overall survival within these patients remains dismal and there is yet an unmet medical need for additional treatment options.
- Trial name
- NCT01368848
- Testing
- Bevacizumab, Cisplatin, Docetaxel
- Where
- 3 sites in Austria
- Volunteers
- 7 people
- Sponsor
- Arbeitsgemeinschaft medikamentoese Tumortherapie
Colon Rectal Cancer, Surgical Site Infection
Surveillance and Implementation of a Bundle of Care to Reduce Surgical Site Infection in Colorectal Surgery (CCR-VINCat)
The Nosocomial Infection Surveillance Program in Catalonia (VINCat) monitors surgical site infection (SSI) in elective colorectal surgery since 2007 in 55 public and private acute care hospitals.
- Trial name
- CCR-VINCat (NCT04496635)
- Testing
- Implementation of a bundle of care
- Where
- Spain
- Volunteers
- 60,000 people
- Sponsor
- Hospital de Granollers
Colorectal Cancer
Effect of Intravenous Lidocaine on the Tolerability of Early Oral Feeding After Laparoscopic Colorectal Surgery
The purpose of this study is to determine whether intravenous lidocaine increase the tolerability of early oral feeding after laparoscopic colorectal surgery in patients with colorectal cancer. Degree of nausea/vomiting.
- Trial name
- NCT01346917
- Testing
- Lidocaine, Normal saline
- Where
- South Korea
- Volunteers
- 77 people
- Sponsor
- Kangbuk Samsung Hospital
Bowel Dysfunction, Bladder Dysfunction
Incidence of The Bowel, Bladder, and Sexual Dysfunction Following Surgery for Colorectal Malignancy
Colorectal cancer is the second most common cancer by the site in Europe and the third most common cancer in the USA with high morbidity and mortality.
- Conditions
- Bowel Dysfunction, Bladder Dysfunction, Sexual Dysfunction, Colorectal Surgery
- Trial name
- NCT04134104
- Testing
- Surgery for Colorectal malignant diseases either LAR or APR
- Volunteers
- 38 people
- Sponsor
- National Academy of Medical Sciences, Nepal
Predictive Cancer Model, Lung Cancer
CT-based Radiomic Algorithm for Assisting Surgery Decision and Predicting Immunotherapy Response of NSCLC
The purpose of this study was to investigate whether the combined radiomic model based on radiomic features extracted from focus and perifocal area (5mm) can effectively improve prediction performance of distinguishing…
- Conditions
- Predictive Cancer Model, Lung Cancer, Preinvasive Adenocarcinoma
- Trial name
- TOP-RLC (NCT04452058)
- Testing
- Radiomic Algorithm
- Where
- 3 sites in China
- Volunteers
- 500 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Postoperative Pain, Postoperative Nausea and Vomiting
Surgical Site Infiltration of Exparel vs TAP Block With Exparel in Patients Undergoing Laparotomy Via Midline Incision
This is a randomized-controlled prospective study to be conducted at Danbury Hospital and Norwalk Hospital to compare postoperative opioid consumption and pain scores of patients with suspected or known gynecologic malignancies…
- Conditions
- Postoperative Pain, Postoperative Nausea and Vomiting, Opioid Use
- Trial name
- NCT03870685
- Testing
- TAP Block, Surgical Site Infiltration, Exparel
- Where
- United States
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- Danbury Hospital
Glioma, Glioblastoma (GBM)
Pilot IntraOperative Neuronal Electrophysiology in Tumor rElatEd suRgery
INTRODUCTION AND RATIONALE Aggressive brain tumors like glioma have the ability to infiltrate the surrounding healthy brain tissue, disrupting normal neuronal activities and leading to impaired motor and cognitive functions, as…
- Conditions
- Glioma, Glioblastoma (GBM), Brain Tumor-Glioma, Brain Metastasis
- Trial name
- PIONEER (NCT06617208)
- Testing
- Neuropixel probe recording
- Where
- Netherlands
- Volunteers
- 20 people
- Sponsor
- Erasmus Medical Center
Long-term Effects of Cancer Treatment
A Long-term Survival Analysis of Different Surgical Method in Early Hepatocellular Carcinoma
The investigators established three prospective cohorts of patients with BCLC stage 0-A HCC, based on different surgical approaches (open, laparoscopic and robotic).
- Trial name
- NCT05117047
- Testing
- liver resection
- Where
- China
- Volunteers
- 369 people
- Sponsor
- Chen Xiaoping
Sarcoma
Sorafenib, Epirubicin, Ifosfamide, and Radiation Therapy Followed By Surgery in Treating Patients With High-Risk Stage II or Stage III Soft Tissue Sarcoma
RATIONALE: Sorafenib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth and by blocking blood flow to the tumor.
- Trial name
- NCT00822848
- Testing
- epirubicin hydrochloride, ifosfamide, sorafenib tosylate
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- OHSU Knight Cancer Institute
Glioma, High-Grade Glioma (HGG)
Feasibility Assessment of a Medical Device for Tumour Cell Retention and Radiotherapy Sensitization in Patients With Suspected High-grade Glioma
This is a prospective, multicenter, single-arm, pilot clinical investigation, aimed at evaluating the safety and preliminary efficacy of the GlioHook implant in patients with high-grade glioma undergoing surgical resection…
- Conditions
- Glioma, High-Grade Glioma (HGG), Surgical Resection
- Trial name
- CT-GlioHook (NCT07725640)
- Testing
- GlioHook device
- Where
- 3 sites in Spain
- Volunteers
- 15 people
- Sponsor
- Batea Oncology
Esophageal Cancer, Surgery
Prehabilitation for Esophageal Resection Surgery
Consenting patients scheduled for esophageal resection surgery will be randomized to receive standard nutrition counseling (including nutritional supplements as needed) or standard nutrition counseling and exercise 4 weeks before…
- Trial name
- NCT01666158
- Testing
- Exercise
- Where
- Canada
- Volunteers
- 68 people
- Sponsor
- Franco Carli
Lung Adenocarcinoma, Lung Adenocarcinoma, Mixed Subtype
Veliparib With or Without Radiation Therapy, Carboplatin, and Paclitaxel in Patients With Stage III Non-small Cell Lung Cancer That Cannot Be Removed by Surgery
This phase I/II partially randomized trial studies the side effects and best dose of veliparib when given together with radiation therapy, carboplatin, and paclitaxel and to see how well it works in treating patients with stage…
- Conditions
- Lung Adenocarcinoma, Lung Adenocarcinoma, Mixed Subtype, Lung Large Cell Carcinoma, Lung Squamous Cell Carcinoma
- Trial name
- NCT01386385
- Testing
- 3-Dimensional Conformal Radiation Therapy, Carboplatin, Laboratory Biomarker Analysis
- Where
- 232 sites in United States
- Volunteers
- 53 people
- Sponsor
- National Cancer Institute (NCI)
Uterine Cervical Neoplasms
4 Versus 6 Courses of Adjuvant Chemotherapy in LACC Patients Previously Treated With NACT Plus Radical Surgery
The investigators primary outcome was to evaluate the effectiveness in term of Overall Survival (OS) and disease free interval (DFI) of two different platinum-based chemotherapic regimen (3 and 6 cycles) for treatment of Locally…
- Trial name
- NCT02365935
- Testing
- Group A adjuvant chemotherapy, Group B adjuvant chemotherapy, Cisplatin
- Where
- Italy
- Volunteers
- 215 people
- Sponsor
- Campus Bio-Medico University
Abdominal Cancer, Blood Pressure
The Effect of Patient Position Changes on Advanced Cardiac Indices in Cancer Surgery
Esophageal Doppler Monitoring (Deltex CardioQ Esophageal Doppler Monitor, ODM) is used to manage patients' fluid therapy by non-invasively measuring continuous cardiac output with an esophageal probe.
- Conditions
- Abdominal Cancer, Blood Pressure, Cardiac Indices
- Trial name
- NCT06293391
- Testing
- cardiac indices in supine and trendelenburg position
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Dr Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital
Colorectal Cancer
Effect of Stent Placement on Short Term Survival of Left Sided Obstructive Colorectal Cancers
The aim of this observational study is to determine effect of stent placement on survival results in first three years in a patient who applied to the emergency department with obstruction due to colorectal cancer.
- Trial name
- NCT06437691
- Testing
- Self-Expandable Metallic Stent Placement
- Volunteers
- 65 people
- Sponsor
- Yasir Musa Kesgin, MD
Cavernous Malformation, Cerebral, Cavernous Angioma
Quantitative Susceptibility Biomarker and Brain Structural Property for Cerebral Cavernous Malformation Related Epilepsy
Cerebral cavernous malformation (CCM)-related epilepsy (CRE) impairs the quality of life in patients with CCM. Patients could not always achieve seizure freedom after surgical resection of the lesion, suggesting an inadequate…
- Conditions
- Cavernous Malformation, Cerebral, Cavernous Angioma, Cavernous Hemangioma, Cavernous Hemangioma of Brain
- Trial name
- CRESS (NCT04076449)
- Where
- 2 sites in China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- yuanli Zhao
Squamous Cell Carcinoma of Oropharynx, HPV Positive Cancer
ctHPVDNA in HPV Positive Squamous Cell Carcinoma of the Oropharynx
This study is a prospective phase II trial, designed to assess the efficacy and feasibility of adjuvant treatment deintensification guided by ctHPVDNA levels for patients with HPV+OPSCC who undergo transoral surgery and neck…
- Conditions
- Squamous Cell Carcinoma of Oropharynx, HPV Positive Cancer, Throat Cancer, Tonsil Cancer
- Trial name
- NCT06915038
- Testing
- NavDx, Adjuvant Radiation 30 Gray, Adjuvant Radiation 40 Gray
- Where
- 2 sites in United States
- Volunteers
- 120 people
- Sponsor
- Indiana University
Non Small Cell Lung Cancer
Trial Exploring Combined Neoadjuvant Therapy With Pembrolizumab/Lenvatinib + Adjuvant Pembrolizumab in Pat. With NSCLC
The primary aim of this single arm, phase II study is to determine the efficacy of the combination therapy Pembrolizumab/Lenvatinib regarding the rate of major pathological response (MPR-Rate).
- Trial name
- INNWOP1 (NCT04875585)
- Testing
- neoadjuvant therapy with Pembrolizumab/Lenvatinib, Surgery, Adjuvant Treatment Phase
- Where
- Austria
- Volunteers
- 33 people
- Sponsor
- Medical University Innsbruck
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