Clinical trials: Surgical Oncology
Pancreatic Cancer
Standardization of Surgery on the Pancreatic Cancer
This study was designed to test the hypothesis that more extensive nodal and soft-tissue clearance in patients with adenocarcinoma of the head of the pancreas would improve survival without an increase in morbidity and mortality.
- Trial name
- NCT00679913
- Testing
- Standard pancreatoduodenectomy, Extended pancreatoduodenectomy
- Where
- South Korea
- Volunteers
- 244 people
- Sponsor
- Seoul National University Hospital
Prostate Cancer
Surgery With or Without Docetaxel and Leuprolide or Goserelin in Treating Patients With High-Risk Localized Prostate Cancer
RATIONALE: Drugs used in chemotherapy, such as docetaxel, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing.
- Trial name
- NCT00430183
- Testing
- docetaxel, LHRH agonist, surgery
- Where
- 226 sites in United States, Canada
- Volunteers
- 788 people
- Sponsor
- Alliance for Clinical Trials in Oncology
Glioblastoma
PH Sensitive MRI Based Resections of Glioblastoma
Current standard of care therapy and all FDA approved adjuvant therapy for glioblastoma continue to provide less than 12 months of progression free survival (PFS) and less than 24 months of overall survival (OS).
- Trial name
- NCT06176066
- Testing
- CEST PH MRI based resection of glioblastoma
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- University of California, Los Angeles
Breast Cancer, Surgery
Unnecessary Mastectomy Due to False Size Prediction by Preoperative Imaging Studies in Breast Cancer
The surgical method for breast cancer is determined according to the size and location of the remaining lesions after prior chemotherapy.
- Conditions
- Breast Cancer, Surgery, IMAGE, Chemotherapy Effect
- Trial name
- PUMP (NCT04689529)
- Testing
- Preoperative imaging study
- Where
- South Korea
- Volunteers
- 360 people
- Sponsor
- Seoul National University Hospital
Breast Cancer
Metformin Hydrochloride in Treating Women With Stage I or Stage II Breast Cancer That Can Be Removed By Surgery
RATIONALE: Metformin hydrochloride may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. PURPOSE: This phase I trial is studying how well metformin hydrochloride works in treating women with…
- Trial name
- NCT00984490
- Testing
- metformin hydrochloride, laboratory biomarker analysis
- Where
- 3 sites in United States
- Volunteers
- 5 people
- Sponsor
- Vanderbilt-Ingram Cancer Center
Metastatic Melanoma, Mucosal Melanoma
Nab-Paclitaxel and Bevacizumab or Ipilimumab as First-Line Therapy in Treating Patients With Stage IV Melanoma That Cannot Be Removed by Surgery
This randomized phase II trial studies how well nab-paclitaxel and bevacizumab or ipilimumab works as first-line therapy in treating patients with stage IV melanoma that cannot be removed by surgery.
- Conditions
- Metastatic Melanoma, Mucosal Melanoma, Stage IV Cutaneous Melanoma AJCC v6 and v7, Stage IV Uveal Melanoma AJCC v7
- Trial name
- NCT02158520
- Testing
- Bevacizumab, Ipilimumab, Laboratory Biomarker Analysis
- Where
- 13 sites in United States
- Volunteers
- 24 people
- Sponsor
- Academic and Community Cancer Research United
Urinary Bladder Neoplasms, Muscle-Invasive Bladder Cancer
A Study to Compare Chemotherapy Alone Versus Chemotherapy Plus Nivolumab or Nivolumab and BMS-986205, Followed by Continued Therapy After Surgery With Nivolumab or Nivolumab and BMS-986205 in Participants With Muscle Invasive Bladder Cancer
The purpose of this study is to compare nivolumab plus neoadjuvant gemcitabine/cisplatin (GC) chemotherapy, followed by post-surgery continuation of immuno-oncology (IO) therapy, with neoadjuvant GC chemotherapy alone in adult…
- Trial name
- NCT03661320
- Testing
- Nivolumab, Gemcitabine, Cisplatin
- Where
- 172 sites in United States, Argentina and 26 more
- Volunteers
- 855 people
- Sponsor
- Bristol-Myers Squibb
Axillary Web Syndrome
Effectiveness of Physical Therapy on Axillary Web Syndrome After Breast Cancer Surgery
Objective: To determine the effectiveness of physical therapy on the axillary web syndrome in improving pain, reducing swelling and increasing mobility of the shoulder. Design: randomized single-blinded controlled trial.
- Trial name
- PTaws (NCT02224261)
- Testing
- Physical Therapy protocol, Control
- Where
- Spain
- Volunteers
- 90 people
- Sponsor
- University of Alcala
Cervical Cancer, Locally Advanced Cervical Cancer
Neoadjuvant Chemoimmunotherapy Versus Concurrent Chemoradiotherapy for LACC
It is a prospective, open-label, randomized, controlled phase II/III clinical trial in which patients with PD-L1-positive FIGO stage IB3, IIA2 and IIB（tumors >4 cm in diameter）will be enrolled and randomly divided into the…
- Conditions
- Cervical Cancer, Locally Advanced Cervical Cancer, Concurrent Chemoradiotherapy, Neoadjuvant Chemoimmunotherapy
- Trial name
- NCT06288373
- Testing
- Camrelizumab, Cisplatin, Nab paclitaxel
- Where
- 12 sites in China
- Volunteers
- 440 people
- Sponsor
- Tongji Hospital
Prostate Cancer, Gynecologic Cancer
Implementation of a Multimodal Prehabilitation Program in Robotic Oncological Surgery
Current literature on prehabilitation is broad and heterogenous. Ploussard et al initiated a multimodal one-day prehabilitation program in patients before robotic radical prostatectomy involving urology nurses, anaesthetic…
- Trial name
- NCT05671094
- Testing
- Prehabilitation
- Where
- Belgium
- Volunteers
- 21 people
- Sponsor
- Jessa Hospital
Recurrence, Survival Rate
Impact of Perioperative Hyperoxia on Cancer Recurrence and Mortality After Elective Colorectal Cancer Surgery
The goal of this observational study is to evaluate whether perioperative hyperoxia (FiO₂ > 0.8), compared to conventional oxygen therapy (FiO₂ < 0.4), is associated with increased cancer recurrence and mortality in patients…
- Conditions
- Recurrence, Survival Rate, Mortality, Colorectal Surgery
- Trial name
- OncO2 (NCT06989346)
- Where
- Spain
- Volunteers
- 403 people
- Sponsor
- Parc de Salut Mar
Non-small Cell Lung Cancer, Thoracic Surgery
Robotic Lobectomy vs. Thoracoscopic Lobectomy for Early Stage Lung Cancer: RCT
During video-assisted thoracoscopic lobectomy (VATS), the surgeon inserts a small camera attached to a thoracoscope that puts the image onto a video screen.
- Trial name
- NCT02617186
- Testing
- Video-assisted thoracoscopic surgery, Robotic thoracic surgery
- Where
- Canada
- Volunteers
- 446 people
- Sponsor
- St. Joseph's Healthcare Hamilton
Pancreatic Cancer, Liver Cancer
Improving Outcomes in Cancer Patients With a Nutritional and Physical Conditioning Prehabilitation Program
Major surgery is a stressful procedure; good recovery after surgery is important to patients and their doctors. Studies done at the McGill University Health Centre (MUHC) with cancer patients awaiting surgery have shown that…
- Conditions
- Pancreatic Cancer, Liver Cancer, Bile Duct Cancer, Hepatobiliary Cancer
- Trial name
- NCT03475966
- Testing
- Exercise, Nutrition, Relaxation techniques
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Hepatocellular Carcinoma, Liver Cancer
Efficacy and Safety Study of Bevacizumab and Erlotinib to Treat Primary Liver Cancer That Cannot be Removed By Surgery
The primary objective will be to assess progression-free survival (PFS) measured at 16 weeks following initiation of therapy with the combination of Avastin and erlotinib in patients with unresectable hepatocellular carcinoma…
- Trial name
- NCT00242502
- Testing
- Bevacizumab (Avastin), Erlotinib
- Where
- United States
- Volunteers
- 62 people
- Sponsor
- M.D. Anderson Cancer Center
Medullary Thyroid Carcinoma
CTR-FAPI-guided Precision Surgery for Newly Diagnosed MTC
This is a multicenter, randomized, open-label, non-inferiority Phase III clinical trial, aims to compare 68Ga-CTR-FAPI PET-CT-guided surgery to investigator-chosen surgical approaches to evaluate its efficacy in treating newly…
- Trial name
- CAST-MTC (NCT07383246)
- Testing
- 68Ga-CTR-FAPI PET-CT guided surgery, investigator choice of surgery
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Cancer Institute and Hospital, Chinese Academy of Medical Sciences
Breast Cancer, Cognitive/Functional Effects
Doxorubicin and Cyclophosphamide in Treating Older Women With Stage I, Stage II, or Stage III Breast Cancer That Has Been Removed By Surgery
RATIONALE: Drugs used in chemotherapy, such as doxorubicin and cyclophosphamide, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing.
- Conditions
- Breast Cancer, Cognitive/Functional Effects, Depression, Malnutrition
- Trial name
- NCT00424203
- Testing
- AC regimen, cyclophosphamide, doxorubicin hydrochloride
- Where
- 17 sites in France
- Volunteers
- 40 people
- Sponsor
- UNICANCER
Breast Cancer
Non-Invasive Magnetic Resonance Imaging (MRI) and Magnetic Resonance Spectroscopy Techniques (MRS) for Assessing Neoadjuvant Chemotherapy in Locally Advanced Breast Cancer
The goal of this clinical research study is to learn if magnetic resonance imaging (MRI) with magnetic resonance spectroscopy (MRS) can show the effects of pre-surgical chemotherapy in breast cancer patients who are eligible to…
- Trial name
- NCT00490503
- Testing
- Magnetic Resonance Imaging (MRI), Magnetic Resonance Spectroscopy (MRS)
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- M.D. Anderson Cancer Center
Breast Cancer
Capecitabine and Paclitaxel (Albumin-Stabilized Nanoparticle Formulation) in Treating Women Undergoing Surgery for Stage II or Stage III Breast Cancer
RATIONALE: Drugs used in chemotherapy, such as capecitabine and paclitaxel (albumin-stablized nanoparticle formulation, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them…
- Trial name
- NCT00397761
- Testing
- capecitabine, paclitaxel albumin-stabilized nanoparticle formulation, neoadjuvant therapy
- Where
- United States
- Sponsor
- Medstar Health Research Institute
Recurrent Glioblastoma
Pembrolizumab and a Vaccine (ATL-DC) for the Treatment of Surgically Accessible Recurrent Glioblastoma
This phase I trial studies the side effects and how well of pembrolizumab and a vaccine therapy (ATL-DC vaccine) work in treating patients with glioblastoma that has come back (recurrent) and can be removed by surgery (surgically…
- Trial name
- NCT04201873
- Testing
- Dendritic Cell Tumor Cell Lysate Vaccine, Pembrolizumab, Poly ICLC
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- Jonsson Comprehensive Cancer Center
Breast Cancer Female
Efficacy and Safety of Dexmedetomidine Added to Modified Pectoral's Block
The Pecs block (pectoral nerves block) is an easy and reliable superficial block inspired by the infraclavicular block approach and the intercostal abdominis plane blocks .
- Trial name
- pec's (NCT03063073)
- Testing
- Dexmedetomidine Injection [Precedex], Bupivacaine Injection [Marcaine]
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- South Egypt Cancer Institute
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