Clinical trials: Surgical Patients
Complications Wounds, Negative Pressure Wound Therapy
Incisional Negative Pressure Wound Therapy in High Risk Patients Undergoing Panniculectomy: A Prospective Randomized Controlled Trial
Incisional negative pressure therapy (INPWT) has previously been shown in certain patient populations to decrease wound healing complications, decrease the rate of hematomas and seromas, as well as have better scar quality.
- Conditions
- Complications Wounds, Negative Pressure Wound Therapy, Wound Healing Delayed, Incisional
- Trial name
- NCT03010137
- Testing
- Incisional Negative Pressure Wound Therapy, Standard Closure with Skin Glue, PICO (Smith&Nephew)
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of California, Davis
Overactive Bladder
Over Active Bladder Patients Having Sling Surgery
The purpose of this study is to determine whether treatment with anti-muscarinic medications following sub-urethral sling procedures improves overall subjective and objective outcomes in women with mixed incontinence with primary…
- Trial name
- NCT00852696
- Testing
- Solifenacin
- Where
- United States
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- Cleveland Clinic Florida
Post-operative Pain, Gynecological Surgery
Acupuncture for Post-Operative Pain Control for Patients Undergoing Gynecological Surgery
This study investigates the role of acupuncture in controlling post-operative pain in patients who have undergone gynecological surgery.
- Conditions
- Post-operative Pain, Gynecological Surgery, Acupuncture
- Trial name
- NCT02855567
- Testing
- Acupuncture needles
- Where
- United States
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Icahn School of Medicine at Mount Sinai
Postoperative Cognitive Dysfunction
The Influence of Postoperative Analgesia on Systemic Inflammatory Response and POCD After Femoral Fractures Surgery
The purpose of this study is to determine whether epidural levobupivacaine applied for the purpose of post-operative analgesia compared to systemic analgesia with morphine leads to better pain control, stronger suppression of the…
- Trial name
- NCT02848599
- Testing
- morphine, levobupivacaine
- Where
- Croatia
- Volunteers
- 86 people, healthy volunteers welcome
- Sponsor
- Osijek University Hospital
Chlorhexidine Gluconate Cloths, Infection; Cesarean Section
STRIPES Study: Study To Reduce Infection Post cEsarean Section
The objective of this study is to determine if the use of chlorhexidine gluconate cloths prior to cesarean section reduce the rate of infectious morbidity (i.e. surgical site infections, endometritis).
- Conditions
- Chlorhexidine Gluconate Cloths, Infection; Cesarean Section, Infectious Morbidity, Surgical Site Infections
- Trial name
- NCT02402907
- Testing
- 2% chlorhexidine gluconate (CHG) cloth
- Where
- United States
- Volunteers
- 1,356 people, healthy volunteers welcome
- Sponsor
- Icahn School of Medicine at Mount Sinai
NASH - Nonalcoholic Steatohepatitis; NAFLD - Nonalcoholic Fatty Liver Disease
Biomarkers of Liver Pathology in Patients With Presumed Non-Alcoholic Steatohepatitis Following Bariatric Surgery
The purpose of this study is to evaluate imaging and other biomarkers of non-alcoholic fatty liver disease before and after bariatric surgery.
- Trial name
- BARI (NCT03294850)
- Testing
- Bariatric surgery, HepQuant SHUNT Dual Cholate Liver Diagnostic Kit
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- AdventHealth Translational Research Institute
Scar, Skin Scarring
Scar Appearance After Postoperative Hydrocolloid Dressing Versus Standard Petrolatum Ointment
Patients will be randomized either to receive standard daily dressing or hydrocolloid dressing using a randomization generator. After closing the wound with the sutures,the scar will be covered by a hydrocolloid dressing, which…
- Conditions
- Scar, Skin Scarring, Skin Cancer, Wound Heal
- Trial name
- NCT05618912
- Testing
- Hydrocolloid dressing, Petrolatum jelly dressing
- Where
- United States
- Volunteers
- 146 people, healthy volunteers welcome
- Sponsor
- Indiana University
Gastric Bypass, Parathyroid Hormone
Trial Of Paricalcitol and Cholecalciferol(Vitamin D3) in the Treatment Of Secondary Hyperparathyroidism in Patients After ROUX-EN-Y Gastric Bypass Surgery
Evaluate the efficacy of paricalcitol, cholecalciferol, and placebo in the reduction of parathyroid hormone in patients after Roux-en-Y gastric bypass surgery (RYGB).
- Trial name
- ExtenD (NCT01138475)
- Testing
- Paricalcitol, Cholecalciferol
- Where
- United States
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- Kerstyn C. Zalesin, M.D.
Vitreoretinopathy, Coats' Disease
DEXTENZA in Pediatric Patients Following Retinal Surgery or Laser Treatment Under Anesthesia
The Tender Study is a prospective, open-label, single-center, randomized, investigator-initiated clinical study seeks to investigate the safety and efficacy of the DEXTENZA insert in pediatric patients following retinal surgery…
- Conditions
- Vitreoretinopathy, Coats' Disease, Exudative Retinopathy, Lattice Degeneration
- Trial name
- NCT05620901
- Testing
- Dextenza 0.4Mg Ophthalmic Insert, Pred Forte
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Lejla Vajzovic, MD, FASRS
ACL, ACL Injury
Acupuncture ACL (Anterior Cruciate Ligament)
Acupuncture research in regards to PONV has been fairly well established, however, studies about perioperative pain control and acupuncture are a little more murky.
- Conditions
- ACL, ACL Injury, Anterior Cruciate Ligament Injury, Anterior Cruciate Ligament Rupture
- Trial name
- NCT03711734
- Testing
- Acupuncture + Standard of Care
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Hospital for Special Surgery, New York
Catheter-Associated Urinary Tract Infection
Prevention of Catheter-Associated Urinary Tract Infection in Incontinence and Reconstructive Pelvic Surgery Patients
The study will assess the risk of catheter associated urinary tract infection in women undergoing incontinence or reconstructive pelvic surgery. Women will be given an antibiotic or placebo at the time of catheter removal.
- Trial name
- PRECAUTION (NCT01108757)
- Testing
- Bactrim
- Where
- United States
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- The Cleveland Clinic
Postoperative Pain, Adverse Effects
Continuous Interscalene Block Results in Superior Recovery Throughout the First Postoperative Week
The investigators undertook this prospective, randomized trial to compare the recovery profile throughout the first postoperative week in patients receiving continuous (CISB) interscalene brachial plexus block, single injection…
- Trial name
- NCT01881776
- Testing
- ISB
- Where
- United States
- Volunteers
- 71 people, healthy volunteers welcome
- Sponsor
- St. Luke's-Roosevelt Hospital Center
Osseointegration Failure of Dental Implant
Immediate Loading and Fully Guided Surgery: Single Implants
To evaluate the overall treatment outcome of single implants installed with the assistance of fully guided-surgery, submitted to immediate loading with restorations fabricated with the help of intraoral scanning, during a 1-year…
- Trial name
- NCT04061694
- Testing
- Immediate loading, fully guided surgery and 3D printed restoration, Immediate loading
- Where
- Sweden
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Folktandvården Skåne AB
Chronic Low Back Pain
Intra-operative Ketamine Infusions in Opioid-dependent Patients With Chronic Lower Back Pain
Noxious stimuli occurring intraoperatively and postoperatively generate central sensitization, decreasing pain thresholds and ultimately increasing analgesic requirements.
- Trial name
- NCT00899600
- Testing
- Ketamine, Normal saline
- Where
- United States
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- Dartmouth-Hitchcock Medical Center
Pain, Acute
Programmed Intermittent Bolus Dosing Versus Continuous Epidural Infusion for Epidural Analgesia in Abdominal Surgery.
Epidurals are an effective means for providing neuraxial anesthesia and analgesia. Prior studies in labor epidurals have demonstrated that a programmed intermittent bolus application of local anesthesia can improve pain control…
- Trial name
- NCT03307174
- Testing
- Bupivacaine, Fentanyl
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Surgery
A Pilot Trial to Determine the Effective N-acetylcysteine Dose for Opioid Reduction for Spine Surgery.
Determine the optimal dose of IV N-acetylcysteine (NAC) to produce opioid reduction following spine surgery and estimate the difference in opioid consumption between placebo and the selected optimal dose.
- Trial name
- NCT04562597
- Testing
- Dose Response Curve N-acetylcysteine 50 mg/kg, Dose Response Curve N-acetylcysteine 100 mg/kg, Dose Response Curve N-acetylcysteine 150 mg/kg
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Postoperative Nausea and Vomiting
Aprepitant for PONV Prophylaxis in Outpatient Plastic Surgery
Hypothesis: Aprepitant plus ondansetron is more effective than ondansetron plus placebo for prevention of postoperative emesis in patients at moderate-to-high risk for PONV for up to 48 hours after surgery.
- Trial name
- NCT00659945
- Testing
- Aprepitant plus Ondansetron
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Postoperative Nausea and Vomiting
Prevention of Postoperative Nausea and Vomiting (PONV) in Surgical Patients
This study will compare two different drug regimens (oral dronabinol versus intravenous ondanseteron) for the prevention of post-operative nausea and vomiting (PONV).
- Trial name
- PONV (NCT00757822)
- Testing
- Dronabinol, Ondansetron
- Where
- United States
- Volunteers
- 216 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Chronic Peridontitis Patients, Chronic Gingivitis
Effect of Non-surgical Periodontal Therapy on Gingival Crevicular Fluid Interleukin-21 Levels
Human IL-21 is present in gingival crevicular fluid in periodontal health, gingivitis and chronic periodontitis. A significant increase in the concentration of IL-21 in gingival crevicular fluid is observed with an increase in…
- Conditions
- Chronic Peridontitis Patients, Chronic Gingivitis, Healthy
- Trial name
- NCT02861937
- Testing
- non surgical periodontal therapy
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Krishnadevaraya College of Dental Sciences & Hospital
Surgical Abortion, Patient Satisfaction
Effects of Aromatherapy on Patient Satisfaction With Surgical Abortion at Less Than 10 Weeks Gestation
The investigators propose a single-site, double-blinded, placebo-controlled clinical trial of lavender aromatherapy versus placebo for patient satisfaction in adult women having a surgical abortion before 10 weeks and 0 days…
- Conditions
- Surgical Abortion, Patient Satisfaction, Anesthesia, Pain
- Trial name
- NCT04969900
- Testing
- Lavender oil.
- Where
- United States
- Volunteers
- 144 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver