Clinical trials: Surgical Procedure
Laparoscopy
RollOut -Pre-Rolled TachoSil in Laparoscopic Utilisation. A Non-Interventional Study
The purpose of this study is to describe ease of use and satisfaction with application of the pre-rolled TachoSil in laparoscopic procedures within approved therapeutic indication as per Summary of Product Characteristics (SmPC).
- Trial name
- NCT02685007
- Testing
- Tachosil
- Where
- 8 sites in Austria
- Volunteers
- 131 people
- Sponsor
- Takeda
Skin Flora Contamination
Study of the Combination of a Cyanoacrylate and Surgical Solutions in Reducing Skin Flora Contamination
The purpose of this study is to determine if there is a qualitative reduction in microbial skin flora post-surgery compared to pre-surgery when a cyanoacrylate based microbial sealant is used in combination with a surgical skin…
- Trial name
- NCT00467857
- Testing
- InteguSeal* skin sealant and standard surgical preparation, Standard preoperative skin preparation
- Where
- 5 sites in United States, Brazil and 3 more
- Volunteers
- 293 people
- Sponsor
- Kimberly-Clark Corporation
Pain, Postoperative, Dental Pain
A Study of Acetaminophen for Post Surgical Dental Pain
To assess the safety, tolerability, analgesic, efficacy and pharmacokinetics of high dose acetaminophen relative to placebo and low dose acetaminophen relative to placebo over a 24 hour period in patient experiencing moderate to…
- Trial name
- NCT04018612
- Testing
- Acetaminophen
- Where
- United States
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Nevakar, Inc.
Acute Pain, Post Operative Pain
Study of MR-107A-02 in the Treatment of Post Surgical Dental Pain.
MR-107A-02 is being studied to investigate its efficacy, safety and dose-response after dental surgery.
- Conditions
- Acute Pain, Post Operative Pain, Pain
- Trial name
- NCT05317312
- Testing
- MR-107A-02
- Where
- United States
- Volunteers
- 111 people
- Sponsor
- Mylan Specialty, LP
Surgical Port Site Hernia
The neoClose Abdominal Closure vs Carter-Thomason Trial
The purpose of this study is to compare the neoClose abdominal closure to the standard Carter-Thomason closure in a bariatric surgery gastric bypass population.
- Trial name
- NCT02589171
- Testing
- Neo Close Abdominal Closure, Carter Thomason Device
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- The University of Texas Health Science Center, Houston
Postoperative Nausea and Vomiting
Prevention of Postoperative Nausea and Vomiting (PONV) in Surgical Patients
This study will compare two different drug regimens (oral dronabinol versus intravenous ondanseteron) for the prevention of post-operative nausea and vomiting (PONV).
- Trial name
- PONV (NCT00757822)
- Testing
- Dronabinol, Ondansetron
- Where
- United States
- Volunteers
- 216 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Post Operative Surgical Site Infection
Local Antibiotic Therapy to Reduce Infection After Operative Treatment of Fractures at High Risk of Infection: A Multicenter Randomized, Controlled Trial (VANCO)
The Vancomycin Study is a multi-center, prospective randomized controlled trial that will compare the proportion of deep surgical site infections within 6 months in patients treated with local Vancomycin powder compared to those…
- Trial name
- VANCO (NCT02227446)
- Testing
- Vancomycin antibiotic powder
- Where
- United States
- Volunteers
- 1,036 people
- Sponsor
- Major Extremity Trauma Research Consortium
Coronary Artery Bypass, Cardiac Surgical Procedures
Thiamine as an Adjunctive Therapy in Cardiac Surgery
The main purpose of this pilot study is to test the effects of thiamine (vitamin B1) administration before and after major cardiac surgery. Half of patients will receive thiamine and the other half will receive placebo.
- Trial name
- NCT02322892
- Testing
- Thiamine, Normal saline solution
- Where
- United States
- Volunteers
- 64 people
- Sponsor
- Beth Israel Deaconess Medical Center
Juvenile; Scoliosis, Scoliosis Idiopathic
Digital Health Psychosocial Intervention for Adolescent Spine Surgery Preparation and Recovery
This is a randomized controlled trial to test effectiveness of the SurgeryPal intervention vs. education control to improve acute and chronic pain and health outcomes in youth undergoing major musculoskeletal surgery.
- Conditions
- Juvenile; Scoliosis, Scoliosis Idiopathic, Scoliosis; Adolescence, Scoliosis;Congenital
- Trial name
- SurgeryPal (NCT04637802)
- Testing
- CBT (SurgeryPal), Education
- Where
- United States
- Volunteers
- 433 people
- Sponsor
- Seattle Children's Hospital
Colorectal Surgery
Prospective, Randomized, Parallel-arm Clinical Trial of CleanCision or Alexis O in Elective Colorectal Surgery
Surgical site infection (SSI) remains a problem in colorectal surgery. Strategies to reduce the incidence of SSI following colorectal surgery are important to improve overall patient outcomes, reduce healthcare-associated costs…
- Trial name
- NCT03816995
- Testing
- CleanCision Wound Retraction and Protection System, Alexis O Wound Protector
- Where
- United States
- Volunteers
- 702 people
- Sponsor
- Scott Steele
Wound Healing and Prevention
Performance, Safety and Efficacy of NPWT Device
Smith \& Nephew are assessing a new investigational single use NPWT system.
- Trial name
- NCT04102865
- Testing
- Negative-Pressure Wound Therapy (NPWT)
- Where
- 8 sites in United Kingdom
- Volunteers
- 90 people
- Sponsor
- Smith & Nephew, Inc.
Older Adults, Anxiety
Behavioral Activation and Medication Optimization For Improving Perioperative Mental Health In Older Adults Undergoing Oncologic Surgery
Using a Hybrid Type 1 Effectiveness-Implementation randomized control trial (RCT) design, the investigators will test the effectiveness of a bundled behavioral activation and medication optimization in reducing symptoms of…
- Conditions
- Older Adults, Anxiety, Depression, Major Surgical Resection of a Thoracic Malignancy
- Trial name
- NCT05685511
- Testing
- Behavioral Activation, Medication Optimization, Usual care resources
- Where
- United States
- Volunteers
- 105 people
- Sponsor
- Washington University School of Medicine
Endoscopic Ultrasound
Comparison of Oxygenation Between Nasal PAP vs Nasal During Propofol-based Sedation for EUS
Randomized controlled single site study involves oxygenation, continuous positive airway pressure, and ventilation of subject via nasal mask and oxygenationvia closed facemask.
- Trial name
- SuperNo2VA (NCT04306211)
- Testing
- SuperNO2VA
- Where
- 2 sites in United States
- Volunteers
- 11 people
- Sponsor
- Indiana University
Tracheal Intubation Morbidity
Success of Pediatric Anesthesiologists in Learning to Use Videolaryngoscopes
There are two new instruments on the market that anesthesiologists use when putting a breathing tube into the lungs of patients. The purpose of this study is to see how easily anesthesiologists can learn to use them in children.
- Trial name
- NCT01215422
- Testing
- timed intubation
- Where
- Canada
- Volunteers
- 646 people
- Sponsor
- University of Alberta
Inguinal Hernia
Mastery Learning Inguinal Hernia Repair
Abstract: Minimally invasive techniques are now ubiquitous in the management of surgical disease. Competence in laparoscopy requires specialized training and practice.
- Trial name
- NCT01085500
- Testing
- Mastery Learning TEP Curriculum, Current Practice
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Pain
Drug Interactions Between Morphine and Orally or IV Administered Acetaminophen
Morphine is the opioid used to treat pain after surgery. Acetaminophen (called APAP) can reduce the amount of opioids needed for this. The problem is that morphine slows down digestion. That can delay pain relief from APAP pills.
- Trial name
- NCT02848729
- Testing
- Oral Acetaminophen, IV Acetaminophen, IV Morphine
- Where
- 3 sites in United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Mallinckrodt
Other Surgical Procedures
Ultrasound-guided Axillary Plexus Block - Dose Reduction of Prilocaine
Clinical aim: Does reducing the dose of local anesthetic in ultrasound-guided axillary plexus anesthesia have any effect on the success rate and additional parameters of block quality? Methodology: In this prospective cohort…
- Trial name
- NCT01309360
- Testing
- midazolam, prilocaine 1%
- Volunteers
- 120 people
- Sponsor
- Helios Research Center
Staphylococcal Infections, Surgical Site Infection
Effect of Exeporfinium Chloride (XF-73) Gel on Nasal S.Aureus in Patients at Risk of Post-op Staphylococcal Infection
This study looks at the difference between XF-73 and placebo in reducing the carriage of a bacteria S. aureus in the nose before, during and after heart surgery.
- Trial name
- NCT03915470
- Testing
- XF-73
- Where
- 21 sites in United States, Georgia and 1 more
- Volunteers
- 124 people
- Sponsor
- Destiny Pharma Plc
Gastrointestinal Cancer
Postoperative Chemoradiation or Chemotherapy After Preoperative Chemotherapy for Gastric Cancers
This is an open-label, stratified, two arm design. All patients receive same initial standard preoperative chemotherapy and surgical resection.
- Trial name
- GABLE (NCT03515941)
- Testing
- Oxaliplatin, Capecitabine, Leucovorin
- Where
- 4 sites in United States
- Volunteers
- 6 people
- Sponsor
- Tannaz Armaghany
Intraoperative Bleeding
Adjunctive Application of BioFoam Surgical Matrix in Liver Surgery
This is a prospective, multicenter, randomized, controlled investigation. Subjects in which bleeding from the exposed parenchymal surface is observed intraoperatively following the ligature of vessels visible with the unaided eye…
- Trial name
- BARRIER (NCT01458561)
- Testing
- BioFoam Surgical Matrix, Gelfoam Plus
- Where
- 2 sites in United States
- Volunteers
- 1 people
- Sponsor
- CryoLife, Inc.
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