Clinical trials: Surgical Procedures, Elective
Coronary Artery Disease, Valvular Heart Disease
PRehabilitiation in Elective Frail and Elderly Cardiac Surgery PaTients
Older and more frail adults are more often being referred for cardiac surgery. These patients are often in suboptimal health, and may be physically frail, malnourished, and have other conditions, such as diabetes, that complicate…
- Trial name
- PREFECT (NCT03399162)
- Testing
- PREHAB Workshop, PREHAB Exercise Program
- Where
- Canada
- Sponsor
- Ottawa Heart Institute Research Corporation
Myocardial Ischemia, Critical Illness
Bright Light Exposure in Surgical Patients
1. Elucidate the influence of intense light therapy pretreatment in patients undergoing cardiac surgery. We hypothesize that intense light exposure is associated with the peripheral stabilization of Per2 in human buccal swabs and…
- Conditions
- Myocardial Ischemia, Critical Illness, Endothelial Dysfunction
- Trial name
- NCT03822949
- Testing
- Day Light, ICU Intense Light
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- University of Colorado, Denver
Obesity, Elective Surgery
Development of PK/PD Model for Individualized Propofol Dosing
The U.S. National Health and Nutrition Examination Survey of 1994 indicated that 59% of American men and 49% of women have body mass indexes (BMIs) over 25.
- Trial name
- NCT00948597
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Plasma Volume Replacement, Surgery of the Pancreatic Head
Plasma Volume Replacement (PVR) Therapy With Colloid and Crystalloid Solutions
The purpose of this study is to investigate the efficacy of target controlled fluid therapy with a hyper-oncotic balanced HES solution compared to an iso-oncotic HES solution in patients undergoing elective surgery of the…
- Trial name
- NCT01117649
- Testing
- HES 10%, HES 6%, balanced electrolyte solution
- Where
- 3 sites in Germany
- Volunteers
- 63 people
- Sponsor
- B. Braun Melsungen AG
Patients Scheduled for Elective Lower Extremity Surgery, Ages 18-80
Parasacral Ischial Plane Block in Lower Extremity Surgery
The parasacral ischial plane block is a novel fascial plane approach targeting the sacral plexus. This technique is technically less challenging and eliminates the requirement for direct visualization of the sacral plexus.
- Conditions
- Patients Scheduled for Elective Lower Extremity Surgery, Ages 18-80, ASA I-III, Patients Operated on Under Regional Anesthesia
- Trial name
- NCT07594197
- Testing
- Parasacral Ischial Plan Block, Sacral plexus block
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Bursa Yuksek Ihtisas Training and Research Hospital
Ambulatory Surgical Procedures, Anxiety Disorders
Educational Video and Peri-operative Anxiety
Preoperative anxiety is a common problem with an impact on surgical outcome, anaesthetic drug dosage and patient's satisfaction. An important component of preoperative anxiety is due to concerns related to anaesthesia.
- Trial name
- NCT03581097
- Testing
- Video Group
- Where
- Switzerland
- Volunteers
- 93 people
- Sponsor
- University Hospital, Geneva
Type 2 Diabetes Mellitus, Elective Abdominal Surgery
Preoperative Carbohydrate Loading in Diabetic Patients Undergoing Elective Abdominal Surgery
This study evaluates the effect of preoperative carbohydrate loading on early postoperative recovery in patients with type 2 diabetes mellitus undergoing elective abdominal surgery.
- Conditions
- Type 2 Diabetes Mellitus, Elective Abdominal Surgery, Gastric Emptying, Postoperative Recovery
- Trial name
- CARB-DM (NCT07451015)
- Testing
- Standard Preoperative Fasting With Water, Preoperative Oral Carbohydrate Loading
- Where
- Egypt
- Volunteers
- 120 people
- Sponsor
- Tanta University
To Compare Lung Transplant Outcomes Between Study Patients and Standard Patients Who Have Already Undergone Lung Transplantation by Conventional Procedures, Lung Transplant
Planned Semi-Elective Lung Tx Study
When suitable donor lungs become available for a consented recipient, and the donor cross clamp time occurs between 6pm and 4am, the transplant procedure (anesthesia starting time) will be allowed to be moved to a 6am start or…
- Trial name
- NCT04601818
- Testing
- Experimental: Preserving of Donor Lungs
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- University of Florida
Elective Cesarean Section, Postoperative Recovery
Enhanced Recovery After Surgery (ERAS) Protocol in Elective Cesarean Sections
This study evaluates the effect of the Enhanced Recovery After Surgery (ERAS) protocol on early postoperative recovery in women undergoing elective cesarean section.
- Conditions
- Elective Cesarean Section, Postoperative Recovery, Enhanced Recovery After Surgery (ERAS)
- Trial name
- ERAS-CS (NCT07104890)
- Testing
- Enhanced Recovery After Surgery (ERAS) Protocol, which includes early oral intake, early mobilization, opioid-sparing multimodal analgesia, prophylactic antiemetics, early urinary catheter removal, an
- Where
- Turkey (Türkiye)
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Havva Betül Bacak
Aneurysm Cerebral
Perioperative Risk in Patients on Chronic Aspirin Undergoing Craniotomy
This study is looking at how taking aspirin regularly affects bleeding during and after brain surgery. Specifically, it focuses on patients who are having elective surgery to clip a brain aneurysm.
- Trial name
- ASPRIN (NCT07086183)
- Testing
- Observation
- Where
- 3 sites in United States, Italy and 1 more
- Volunteers
- 100 people
- Sponsor
- Mayo Clinic
Pain
Evaluation of the Safety and Efficacy of EXPAREL When Administered Into the TAP in Subjects Undergoing Cesarean Section
This is a Phase 4, multicenter, open-label study evaluating EXPAREL infiltration into the transversus abdominis plane (TAP) after bupivacaine hydrochloride (HCl) spinal anesthesia in subjects undergoing elective Cesarean section…
- Trial name
- NCT02353754
- Testing
- Intrathecal morphine injection, EXPAREL
- Where
- 5 sites in United States
- Volunteers
- 12 people
- Sponsor
- Pacira Pharmaceuticals, Inc
Airway Complications, Postoperative Sore Throat
Effect of Cuff Pressure Assessment Methods on Postoperative Complications in Breast Surgery
Endotracheal intubation is a standard procedure used to secure the airway during general anesthesia. A key component of the breathing tube is the "cuff," a balloon-like device that is inflated to seal the airway and prevent…
- Conditions
- Airway Complications, Postoperative Sore Throat, Hoarseness, Dysphagia
- Trial name
- NCT07341646
- Testing
- Continuous Cuff Pressure Indicator, Manual Cuff Pressure Manometer, Minimal Occlusive Volume Technique
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people
- Sponsor
- Izmir Katip Celebi University
Colorectal Neoplasms, Diverticulitis
Neomycin and Metronidazole Hydrochloride With or Without Polyethylene Glycol in Reducing Infection in Patients Undergoing Elective Colorectal Surgery
This randomized clinical trial studies how well neomycin and metronidazole hydrochloride with or without polyethylene glycol work in reducing infection in patients undergoing elective colorectal surgery.
- Conditions
- Colorectal Neoplasms, Diverticulitis, Inflammatory Bowel Diseases, Surgical Site Infection
- Trial name
- NCT03042091
- Testing
- Polyethylene Glycol, Neomycin, Metronidazole Hydrochloride
- Where
- United States
- Volunteers
- 224 people
- Sponsor
- Thomas Jefferson University
Dexmedetomidine, Magnesium Sulfate
Dexmedetomidine Versus Magnesium Sulfate as Adjuvants to Intraperitoneal Bupivacaine for Postoperative Analgesia After Elective Laparoscopic Cholecystectomy
This study aimed to assess the efficiency of dexmedetomidine against magnesium sulfate as adjuvants to intraperitoneal bupivacaine for postoperative analgesia in individuals having elective laparoscopic cholecystectomy.
- Conditions
- Dexmedetomidine, Magnesium Sulfate, Adjuvants, Intraperitoneal Bupivacaine
- Trial name
- NCT06879288
- Testing
- Bupivacaine, Dexmedetomidine, Magnesium sulfate
- Where
- Egypt
- Volunteers
- 75 people
- Sponsor
- Tanta University
Elective Non-cardiac Surgery
Leukocytes and Cardiovascular Perioperative Events-2
The potential use of regulatory T cells as preoperative risk stratification tool is evaluated in order to improve clinical risk stratification and reduce perioperative morbidity and mortality.
- Trial name
- LeukoCAPE-2 (NCT03105427)
- Where
- Germany
- Volunteers
- 233 people
- Sponsor
- University Hospital Heidelberg
Laryngeal Masks Comparison
Ventilation With Supraglottic Airway Devices
Airo-Q Self Pressurized airway device with Blocker will be compared with Proseal LMA in anesthetized adult female patients undergoing elective surgeries to discuss the influence of different head and neck positions on the…
- Trial name
- NCT04421261
- Testing
- Air-Q Self Pressurized Airway Device with Blocker, Proseal Laryngeal Mask Airway
- Where
- Egypt
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Reham Ali Abdelhaleem Abdelrahman
Induction of General Anaesthesia
A Phase IIa Study Investigating the Tolerance, Efficacy and Safety of HSK3486
This is a Phase IIa, open-label, propofol-controlled ,dose-escalation, multi-center Study to evaluate the tolerance, efficacy and safety of HSK3486 for induction of general anesthesia in elective surgery patients.This study is…
- Trial name
- NCT03698617
- Testing
- HSK3486, Propofol
- Where
- China
- Volunteers
- 114 people
- Sponsor
- Sichuan Haisco Pharmaceutical Group Co., Ltd
Surgical Site Infection
Comparison of Two Preoperative Antiseptic Solutions Alcohol Based in Abdominal Elective Surgeries
Pragmatic randomized clinical trial comparing Iodine Povacrylex based on alcohol to Chlorhexidine also based on alcohol in efficacy and security to diminish frequency of surgical site infections in major abdominal elective clean…
- Trial name
- NCT03859908
- Testing
- Iodine Povacrylex 7 MG/ML / Isopropyl Alcohol 0.74 ML/ML, Chlorhexidine Gluconate 20 MG/ML / Isopropyl Alcohol 0.7 ML/ML
- Where
- El Salvador
- Volunteers
- 18 people
- Sponsor
- Universidad de El Salvador
Surgical Site Infection
Effect of a Combination of Bundles on Surgical-site Infection After Elective Colorectal Surgery
A prospective randomized clinical trial will be performed. Patients will be randomized in 2 groups. The experimental group will undergo the combined application of intraperitoneal irrigation with clindamycin and gentamicin…
- Trial name
- NCT03081962
- Testing
- Bundle, Standard care
- Where
- Spain
- Volunteers
- 102 people
- Sponsor
- Hospital General Universitario Elche
Elderly, Frail
Effects of Multimodal Prehabilitation on Frail Elderly Patients Undergoing Elective Gastric Cancer Surgery
Research indicates that prehabilitation is effective in optimizing physical status before surgery, although this method may be considered "aggressive" for frail elderly patients.
- Conditions
- Elderly, Frail, Gastric Cancer, Prehabilitation
- Trial name
- NCT06510088
- Testing
- 3-week multimodal prehabilitation program
- Where
- China
- Volunteers
- 112 people
- Sponsor
- Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University
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