Clinical trials: Surgical Procedures, Elective
Arthroplasty, Replacement, Knee, Venous Thrombosis
A Study of BIBR 1048 in Prevention of Venous Thromboembolism in Patients With TKR Surgery.
The goal of this study is to evaluate the comparative efficacy and safety of three different doses ( 110 mg, 150 mg, 220 mg) of BIBR 1048 (Dabigatran etexilate) orally, compared to placebo, in prevention of venous thromboembolism…
- Trial name
- NCT00246025
- Testing
- Dabigatran etexilate
- Where
- 38 sites in Japan
- Volunteers
- 512 people
- Sponsor
- Boehringer Ingelheim
Pregnancy, Obesity
Investigation of Continuous Versus Interrupted Subcutaneous Fat Closure in Reducing Surgical Site Infection
This research aims to clarify the best way to perform subcutaneous tissue closure in overweight and obese patients undergoing caesarean section to reduce the occurrence of surgical site infections.
- Trial name
- NCT05856968
- Testing
- continuous subcutaneous tissue closure, Interrupted subcutaneous tissue closure
- Volunteers
- 266 people, healthy volunteers welcome
- Sponsor
- The University of The West Indies
Delirium, Postoperative Cognitive Deficit (POCD)
Neuroprotection With Dexmedetomidine in Patients Undergoing Elective Cardiac or Abdominal Surgery (Neuprodex)
The drug Dexmedetomidine will be investigated in 72 patients (men and women) undergoing elective cardiac or abdominal surgery. The study medication will be administered perioperatively by intravenous infusion continuously (at the…
- Trial name
- NCT02096068
- Testing
- Dexmedetomidine (Dexdor®), 0.9% Sodium Chloride
- Where
- Germany
- Volunteers
- 78 people
- Sponsor
- Claudia Spies
Wound
Study of DERMABOND ProPen in Closure of Colectomy Wounds
2-octylcyanoacrylate (2-OCA) has been used extensively in clinical practice in trauma, plastic surgery, orthopaedic surgery, emergency medicine and paediatrics.
- Trial name
- NCT00978133
- Testing
- Dermabond ProPen (2-octylcyanoacrylate), Skin closure with skin staples
- Where
- Singapore
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- Singapore General Hospital
Laparoscopic Cholecystectomy, Postoperative Quality of Recovery
Effect of Preoperative Melatonin on Quality of Recovery After Elective Laparoscopic Cholecystectomy
Laparoscopic cholecystectomy is one of the most commonly performed abdominal surgical procedures worldwide. Although the widespread implementation of Enhanced Recovery after Surgery (ERAS) protocols has improved perioperative…
- Conditions
- Laparoscopic Cholecystectomy, Postoperative Quality of Recovery, Preoperative Anxiety, Postoperative Sleep Quality
- Trial name
- MEL-REC (NCT07553143)
- Testing
- Melatonin (N-acetyl-5-methoxytryptamine)
- Where
- Bangladesh
- Volunteers
- 84 people
- Sponsor
- Armed Forces Medical Institute Bangladesh
Reversing Vecuronium-Induced Neuromuscular Blockade in Patients Undergoing General Anesthesia Surgery, Reversing Rocuronium-Induced Neuromuscular Blockade in Patients Undergoing General Anesthesia Surgery
A Dose-Finding Study of Amogammadex Sodium for Reversing Vecuronium and Rocuronium-Induced Neuromuscular Blockade
Background context: Amogammadex sodium has completed Phase I-III clinical studies in China for reversal of rocuronium-induced blockade. No clinical studies have yet been conducted for vecuronium-induced blockade.
- Trial name
- NCT07595393
- Testing
- Rocuronium (0.6mg/kg), vecuronium bromide (0.1mg/kg)
- Volunteers
- 64 people
- Sponsor
- Amckaus PTY LTD.
Preoperative, Gastric
Preoperative Residual Gastric Volume
The goal of this observational study is to assess the preoperative gastric residual volume in adult patients undergoing elective surgery.
- Conditions
- Preoperative, Gastric, Residual Volume
- Trial name
- NCT07031414
- Where
- Turkey (Türkiye)
- Volunteers
- 400 people
- Sponsor
- Izmir City Hospital
Perioperative Hyperglycaemia, Insulin Therapy
Fully Closed-Loop Insulin Delivery in Abdominal Surgery (CLAB)
The purpose of the study is to assess the efficacy, safety and usability of perioperative fully-automated closed-loop insulin delivery versus standard insulin therapy in patients with diabetes other than type 1 diabetes…
- Conditions
- Perioperative Hyperglycaemia, Insulin Therapy, Elective Surgery, Closed-Loop Glucose Control
- Trial name
- CLAB (NCT05392452)
- Testing
- CamAPS HX, Standard insulin therapy
- Where
- 2 sites in Switzerland
- Volunteers
- 38 people
- Sponsor
- Lia Bally
Coronary Artery Disease, Left Ventricular Systolic Dysfunction
Preoperative Gastric Ultrasound and Left Ventricular Function in Coronary Artery Bypass Surgery
This study aims to investigate whether reduced heart function is associated with differences in stomach contents before elective coronary artery bypass graft (CABG) surgery.
- Conditions
- Coronary Artery Disease, Left Ventricular Systolic Dysfunction, Gastric Contents
- Trial name
- NCT07898215
- Testing
- Gastric Ultrasonography
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Adiyaman University
Tracheal Intubation, Elective Surgery, Tracheal Diamater Measurement
Ultrasound Measurement of Skin-to-Epiglottis Distance for Prediction of Difficult Airway in Adult Patients
This prospective observational study aims to evaluate the predictive value of ultrasound-measured skin to epiglottis distance for difficult airway in adult patients undergoing elective or emergency procedures requiring airway…
- Conditions
- Tracheal Intubation, Elective Surgery, Tracheal Diamater Measurement, Ultrasound Evaluation of Airway
- Trial name
- NCT07609147
- Where
- Turkey (Türkiye)
- Volunteers
- 300 people
- Sponsor
- Hacettepe University
Surgical Procedures, Elective, Nurse Based Care Management
Effects of White and Pink Noise Applied Before and During Colonoscopy on Pain and Anxiety
In recent years, there has been an increase in the use of endoscopic procedures due to the increase in diseases. Colonoscopy is widely used in the screening and diagnosis of many diseases, especially colorectal cancer.
- Trial name
- Colonoscopy (NCT07034638)
- Testing
- WNG, PNG
- Where
- Turkey (Türkiye)
- Volunteers
- 135 people, healthy volunteers welcome
- Sponsor
- Akdeniz University
Obesity, Pregnancy
A Trial of the Use of Ultrasound to Aid the Insertion of Combined Spinal Epidural Anaesthesia
The study will establish whether the use of ultrasound scanning with a purpose built probe will aid the insertion of the needles for epidural and spinal anaesthesia for obese women undergoing elective caesarean section The study…
- Trial name
- NCT00166699
- Testing
- ultrasound
- Where
- 5 sites in United Kingdom
- Volunteers
- 42 people
- Sponsor
- NHS Greater Glasgow and Clyde
Head-and-neck Cancer, Carcinoma of Unknown Primary
Elective Mucosal Irradiation in Head-and-Neck Cancer of Unknown Primary
The optimal treatment of HNCUP remains controversial and lacks evidence from prospective randomized trials. The management of these patients relies primarily on surgery and radiotherapy.
- Trial name
- NCT02764216
- Testing
- Elective mucosal irradiaton
- Where
- 2 sites in China
- Volunteers
- 48 people
- Sponsor
- Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University
Effect of Drugs
Dexmedetomidine Adjuvant to General Anesthesia of Abdominal Hysterectomy
To assess the effect of perioperative Dexmedetomidine infusion on Interleukin 6 and cortisol level in patients undergoing general anesthesia for total abdominal hysterectomy
- Trial name
- NCT03600506
- Testing
- Dexmedetomidine
- Volunteers
- 52 people
- Sponsor
- Suez Canal University
Postoperative Ileus, Laparoscopic Colectomy Without Stoma Formation
Does Caffeine Reduce Postoperative Bowel Paralysis After Elective Colectomy?
Postoperative bowel paralysis is common after abdominal operations, including colectomy. As a result, hospitalization may be prolonged leading to increased cost.
- Conditions
- Postoperative Ileus, Laparoscopic Colectomy Without Stoma Formation, Colorectal Neoplasm, Diverticulitis
- Trial name
- CaCo (NCT02510911)
- Testing
- Caffeine (100 mg), Caffeine (200 mg), corn starch (250 mg approx.)
- Where
- 2 sites in Switzerland
- Volunteers
- 60 people
- Sponsor
- Thomas Steffen
Colorectal Disorders
Does a Central Venous Line Reduce Perioperative Fluid Administration?
'Hypothesis-generating' study to assess whether the presence of a central venous line significantly affects the volumes of fluid infused perioperatively in major elective colorectal surgery
- Trial name
- NCT03985111
- Testing
- Central Venous Catheter
- Where
- United Kingdom
- Volunteers
- 40 people
- Sponsor
- Barts & The London NHS Trust
Acute Pain, Total Hip Arthroplasty
Auricular Acupuncture for Analgesia During Total Hip Arthroplasty
The aim is to investigate whether auricular acupuncture is superior to sham acupuncture in relief of acute pain and in reduction of analgesics in patients during total hip arthroplasty
- Trial name
- NCT00334165
- Testing
- Auricular acupuncture (procedure)
- Where
- 2 sites in Germany
- Volunteers
- 360 people
- Sponsor
- University Medicine Greifswald
Stroke, Acute Coronary Syndrome
Factors Associated With Perioperative Outcomes in Non-emergency Surgery
This epidemiological study investigates the association of recent stroke, acute coronary syndrome or pneumonia and adverse perioperative outcomes following elective non-cardiac and cardiac surgery using routinely collected UK…
- Conditions
- Stroke, Acute Coronary Syndrome, Pneumonia
- Trial name
- NCT02455492
- Testing
- stroke or myocardial infarction or pneumonia
- Volunteers
- 266,436 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Post Operative Wound Infection, Suture
No Closure vs Interrupted vs Continuous Subcutaneous Closure: Operative Time and Wound Outcomes
The goal of this clinical trial is to research whether different methods of suturing during elective cesarean delivery affect surgery time and early wound healing.
- Conditions
- Post Operative Wound Infection, Suture, Suture Techniques, Ceserean Section
- Trial name
- NCT07451275
- Testing
- Suture technique, Interrupted closure (3 sutures), Suture technique, Continuous non-locking closure
- Where
- Turkey (Türkiye)
- Volunteers
- 300 people
- Sponsor
- Yuzuncu Yil University
Cannulation, Sevoflurane Induction
Determination of Optimum Time for Intravenous Cannulation in Children With Dexmedetomidine Premedication
Inhalational induction with sevoflurane, nitrous oxide, and oxygen is accepted as a safe technique to avoid any movement during intravenous cannulation in children.
- Conditions
- Cannulation, Sevoflurane Induction, Dexmedetomidine
- Trial name
- NCT05139212
- Testing
- Optimum time for intravenous cannulation in children premedicated with dexmedetomidine
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Karaman Training and Research Hospital
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