Clinical trials: Surgical Procedures, Elective
Pancreatectomy, Hepatic Resection
Safety and Performance of a Synthetic Tissue Sealant in Reducing Fluid Leakage in Hepatobiliary and Pancreatic Surgery
Polyganics BV (Groningen, The Netherlands), in close collaboration with University Hospital-Eppendorf (UKE) Hamburg, has developed the Sealing Device for use in hepato-pancreato-bilary (HPB) surgery to reduce leakage of fluids…
- Trial name
- SHIELDS (NCT04024956)
- Testing
- Sealing Device
- Where
- 2 sites in Germany
- Volunteers
- 80 people
- Sponsor
- Polyganics BV
Postoperative Delirium
Optimized Anesthesia to Reduce Incidence of Postoperative Delirium
The purpose of this study is to compare the difference of incidence of postoperative delirium between patients received general anesthesia guided by Bispectral index (BIS) and patients received general anesthesia using standard…
- Trial name
- NCT02133430
- Testing
- Bispectral index, as measured by a BIS processor
- Where
- Thailand
- Volunteers
- 140 people
- Sponsor
- Chiang Mai University
Laryngeal Masks Comparison
Laryseal Pro LMA Versus Ambu Aura Gain LMA in Elective Ophthalmological Surgeries
Tracheal intubation is considered the gold standard for protecting the airway. As the supraglottic airway devices (SADs) could be inserted without laryngoscopy, so that SADs with different designs and safety issues could be used…
- Trial name
- NCT06140667
- Testing
- LarysealTM Pro, Ambu Aura Gain
- Where
- Egypt
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Cairo University
Venous Thromboembolism
BIBR 1048 in the Prevention of Venous Thromboembolism in Patients Undergoing Primary Elective Total Hip Replacement Surgery
To determine the therapeutic window of BIBR 1048 in order to select doses for further studies in the development plan. Twice daily regimen will be tested for most dose levels and once daily administration will also be evaluated…
- Trial name
- NCT02170701
- Testing
- BIBR 1048
- Volunteers
- 289 people
- Sponsor
- Boehringer Ingelheim
Diverticular Disease of Left Side of Colon
Quality of Life (QOL) After Elective Sigmoidectomy for Diverticular Diseases (DIVERTI)
Acute diverticulitis of the left colon is among the most common abdominal disorders. To date, both conservative therapy in uncomplicated stages and emergency surgery in perforated disease with peritonitis are consensual.
- Trial name
- DIVERTI-QDV (NCT04730765)
- Testing
- left elective colectomy (Surgical Experimental Group), antibiotic therapy (medical Control Group)
- Volunteers
- 220 people
- Sponsor
- University Hospital, Caen
Brain Tumor, Surgery
Does Perioperative Intravenous Magnesium Affect Postoperative Quality of Recovery in Craniotomy Surgery Patients?
Perioperative pain management for craniotomy patients may be challenging because the commonly used agents such as opioids, gabapentin, and dexmedetomidine also cause sedation, which can confound the neurological exam and can lead…
- Trial name
- NCT05049707
- Testing
- IV magnesium sulfate
- Volunteers
- 110 people
- Sponsor
- Thomas Jefferson University
Venous Thromboembolism
A Trial to Learn How Well REGN7508 Works for Preventing Blood Clots After a Knee Replacement in Adult Participants
This study is researching an experimental drug called REGN7508 (called "study drug"). The study is focused on adults undergoing elective, unilateral (one side) total knee replacement (TKR) surgery.
- Trial name
- ROXI-VTE II (NCT06454630)
- Testing
- REGN7508, Enoxaparin
- Where
- 14 sites in Bulgaria, Hungary and 3 more
- Volunteers
- 179 people
- Sponsor
- Regeneron Pharmaceuticals
Respiration and the Airways With Laryngeal Masks
Blind Tracheal Intubation Through Supraglottic Airway Devices
Tracheal intubation is considered the gold standard for protecting the airway. As the supraglottic airway devices (SADs) could be inserted without laryngoscopy, so that SADs with different designs and safety issues could be used…
- Trial name
- NCT05624073
- Testing
- Air-QTM Blocker, LarySealTM Pro
- Where
- 2 sites in Egypt
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Cairo University
Remote Ischaemic Preconditioning, Contrast Induced Nephropathy
Use of Remote Ischaemic Preconditioning in the Prevention of Contrast Induced Nephropathy
With an increasingly ageing population the incidence of peripheral arterial disease (PAD) is rising. With approximately one quarter of all PAD patients ultimately progressing to Critical Limb Ischaemia (CLI), increased demands…
- Trial name
- NCT02516072
- Testing
- RIPC
- Where
- Singapore
- Volunteers
- 40 people
- Sponsor
- Changi General Hospital
Respiratory Morbidity
Effect of Single Dose Antenatal Betamethasone on Neonatal Respiratory Morbidity After Elective Cesarean
Patients undergoing elective C-section will be randomized into two groups. The first group will receive one dose of Betamethasone at least 24 hours before scheduled C-section. The second group will receive placebo.
- Trial name
- NCT04407975
- Testing
- Betamethasone
- Where
- Lebanon
- Volunteers
- 400 people
- Sponsor
- Makassed General Hospital
Arthroplasty, Replacement, Thromboembolism
Pradaxa (Dabigatran Etexilate) 150 mg/q.d. in Patients With Moderate Renal Impairment After Hip or Knee Replacement Surgery
An observational cohort study on safety and efficacy to generate additional data on the benefit/risk profile of the 150 mg dose of Pradaxa in patients with renal impairment
- Trial name
- NCT00847301
- Where
- 53 sites in Austria, France and 5 more
- Volunteers
- 472 people
- Sponsor
- Boehringer Ingelheim
Surgery--Complications, Patient Satisfaction
Optimization of Outpatient Surgery at the CHUM Using the LeoMed Telecare Platform
The main objective of this study is to carry out a medico-economic evaluation of a new platform for outpatient surgical care, by comparing the effectiveness and utility of the deployment of this trajectory on patients and the…
- Conditions
- Surgery--Complications, Patient Satisfaction, Quality of Life
- Trial name
- MEET-OS (NCT04948632)
- Testing
- Complete LeoMed application, Basic LeoMed application
- Where
- Canada
- Volunteers
- 1,000 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Postoperative Pulmonary Complications (PPC)
Geriatric Nutritional Risk Index and ASA Status for Predicting Lung Complications After Major Abdominal Surgery in Older Adults
Postoperative pulmonary complications (PPCs), such as pneumonia, atelectasis, and respiratory failure, are major causes of illness, prolonged hospital stays, and intensive care admissions in older patients undergoing elective…
- Trial name
- NCT07862777
- Where
- Turkey (Türkiye)
- Volunteers
- 170 people
- Sponsor
- Dr Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital
Cognitive Impairment, Postoperative Delirium
Cognitive Impairment Following Elective Spine Surgery
Older people are a rapidly growing proportion of the world's population and their number is expected to increase twofold by 2050.
- Conditions
- Cognitive Impairment, Postoperative Delirium, Spine Fusion
- Trial name
- CONFESS (NCT03486288)
- Where
- Germany
- Volunteers
- 124 people, healthy volunteers welcome
- Sponsor
- University Medicine Greifswald
Patient With Clinically Indicated Invasive Monitoring
ClearSight System CHN Study
The purpose of this clinical trial is to demonstrate that cardiac output (CO) as determined with the Clinical Platform (Model:EV1000A, Software Version:1.9) in a noninvasive manner is comparable to CO as determined by Pulmonary…
- Trial name
- NCT03807622
- Testing
- EV1000NI Clinical Platform: Noninvasive Hemodynamic Monitoring utilizing ClearSight System
- Where
- 3 sites in China
- Volunteers
- 125 people
- Sponsor
- Edwards Lifesciences
Chronic Pain Post-Procedural
Effect of Intrathecal Morphine on Chronic Pain After Elective Caesarean Section
The incidence of chronic post-surgical pain (CPSP) after caesarean section (CS) is reported to be as high as 18%, reflecting it to be a significant clinical problem.
- Trial name
- NCT03451695
- Testing
- Morphine
- Where
- Nepal
- Volunteers
- 290 people
- Sponsor
- B.P. Koirala Institute of Health Sciences
Quality of Life, Surgical Procedure, Unspecified
Assessing Change in Patient-reported Quality of Life After Elective Surgery: an Observational Comparison Study
This study will compare two commonly-used methods for assessing patient-reported quality of life. The first is to assess quality of life before surgery and again after surgery using the same validated scale (ie Veterans Rand 12).
- Trial name
- NCT02771964
- Testing
- Quality of life survey
- Where
- United States
- Volunteers
- 17,850 people
- Sponsor
- Washington University School of Medicine
Primary Hyperparathyroidism
Surgery for Primary Hyperparathyroidism (pHPT) in Patients Older Than 65 Years Compared With Follow-up
General consensus and contemporary guidelines, recommend surgery for primary hyperparathyroidism (pHPT)for all patients below the age of 50, for patients with pronounced hypercalcemia and for patients with organ complications to…
- Trial name
- NCT01087619
- Testing
- Parathyroid surgery
- Where
- Sweden
- Volunteers
- 102 people
- Sponsor
- Region Skane
Cardiac Surgery, Cardiopulmonary Bypass
Sodium Bicarbonate in Cardiac Surgery Study
With over one million operations a year, cardiac surgery with cardiopulmonary bypass is one of the most common major surgical procedures worldwide (1).
- Trial name
- Bic-MC (NCT00672334)
- Testing
- Sodium Bicarbonate, Sodium Chloride
- Where
- 4 sites in Australia, Canada and 2 more
- Volunteers
- 350 people
- Sponsor
- Austin Health
Surgery
Preoperative Carbohydrate Loading in Elective Surgery
Postoperative infectious morbidity remain the most frequent, threatening and costly event after major surgery. Maintenance of postoperative euglycemia might be a key factor to prevent such complications and given the preliminary…
- Trial name
- PROCY (NCT01167387)
- Testing
- PREOP, water
- Where
- Italy
- Volunteers
- 880 people
- Sponsor
- University of Milano Bicocca
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