Clinical trials: Surgical Resection
Impacted Third Molar Tooth, Adverse Reaction to Other Local Anesthetics
Lower Third Molar Removal With 2% and 4% Articaine
The present clinical trial randomized compared the clinical efficacy of the local anesthetics articaine in two concentrations, 2% and 4%, in association with 1:200,000 adrenaline, for the removal of lower third molars.
- Trial name
- NCT02457325
- Testing
- Surgery with 2%Articaine first, then Surgery with 4% Articaine, Surgery with 4%Articaine first, then Surgery with 2% Articaine
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Hepatocellular Carcinoma
A Phase III Study of AK104 as Adjuvant Therapy in HCC With High Risk of Recurrence After Curative Resection
The efficacy and safety of AK104 as adjuvant therapy in hepatocellular carcinoma of high recurrence risk after curative resection.
- Trial name
- NCT05489289
- Testing
- AK104
- Where
- China
- Volunteers
- 570 people
- Sponsor
- Akeso
Pancreas Cancer, Fistula
Study Assessing the Effect of Transpapillary Pancreas Duct Stent in Resection of the Pancreatic Tail
Randomized study assessing the effect of transpapillary pancreas duct stent in resection of the pancreatic tail.
- Trial name
- NCT00500968
- Testing
- stent, Distal pancreatectomy
- Where
- Sweden
- Volunteers
- 50 people
- Sponsor
- Karolinska Institutet
Advanced Cancers
Fish Oil Versus Statins Versus Placebos in Reducing Atrial Fibrillation in Patients Undergoing Thoracic Surgery for Lung Cancer
The goal of this clinical research study is to learn if Lipitor (atorvastatin) or fish oil supplements can help to control side effects of the heart that are commonly seen after lung surgery (such as irregular heartbeat).
- Trial name
- NCT01259284
- Testing
- Atorvastatin, Fish Oil Supplement
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- M.D. Anderson Cancer Center
Defecatory Disorders After Left Colonic or Rectal Resection
Improvement of Anorectal Function While Preserving of Inferior Mesenteric Artery Performing Left Hemicolectomy for Diverticulosis
The aim of the study is to evaluate the anorectal function after hemicolectomy if we preserve or not the Inferior Mesenteric Artery (IMA).
- Trial name
- IPIMAL (NCT01326052)
- Testing
- Inferior Mesenteric Artery Preservation, Inferior Mesenteric Artery Ligation
- Where
- Italy
- Volunteers
- 150 people
- Sponsor
- University of Roma La Sapienza
Liver Diseases, Adult Disease
The Effect and Safety of the Four Points Transversus Abdominis Plane Block
The anterior abdominal wall from below the xiphoid to infraumbilical area is dominated by the sensory nerves which originate from the anterior rami of the thoracolumbar spinal nerves from T6-L1.
- Trial name
- NCT03598192
- Testing
- TAP, PVB, Ropivacaine
- Where
- Vietnam
- Volunteers
- 30 people
- Sponsor
- Gia Dinh People Hospital
Adenocarcinoma,Stomach, Adenocarcinoma, Esophagogastric Junction
Feasibility Study of Adjuvant Treatment With S-1 in Patients After R0-Resection of Adenocarcinoma of the Stomach and Esophagogastric Junction
Multicenter trial in Germany: Feasibility Study of Adjuvant Treatment with S-1 in Patients after R0-Resection of Adenocarcinoma of the Stomach and Esophagogastric Junction with the aim to show the feasibility and tolerability of…
- Trial name
- S-1 adjuvant (NCT02564367)
- Testing
- S-1
- Where
- Germany
- Volunteers
- 30 people
- Sponsor
- AIO-Studien-gGmbH
Colorectal Cancer, Colorectal Neoplasms
Predicting Local and Distant Recurrence in T1 Colorectal Cancer
Tumor recurrence significantly affects survival rates following the local resection of submucosal colorectal cancers (T1 CRC). Despite this, there are currently no reliable biomarkers established to predict recurrence in T1 CRC.
- Conditions
- Colorectal Cancer, Colorectal Neoplasms, Colorectal Adenocarcinoma, Colorectal Cancer Stage I
- Trial name
- T1CR (NCT06314971)
- Testing
- Tw1CE
- Where
- 3 sites in United States, Japan and 1 more
- Volunteers
- 138 people
- Sponsor
- City of Hope Medical Center
Dissociated Vertical Deviation
Comparative Study Of Combined Recession-Resection And Fenestration of Superior Rectus Muscle for Treatment of Dissociated Vertical Deviation
Dissociated vertical deviation (DVD) is a slow, disconjugate upward drift of the non-fixating eye, usually with abduction and excyclotorsion, that does not obey Hering's law .
- Trial name
- NCT07883681
- Testing
- resection of superior rectus muscle
- Volunteers
- 30 people
- Sponsor
- Assiut University
Gastric Cancer, Duodenal Stump Leak
Incidence of Duodenal Stump Fistula After Gastrectomy for Gastric Cancer. A Randomized Controlled Trial
The goal of this trial is to demonstrate that the use of Tri-Staple Technology for duodenal resection during open gastrectomy for cancer is safer than the use of other conventional methods of resection/closure of the duodenum and…
- Trial name
- DRTST (NCT03277144)
- Testing
- TST-TriStaple(3lines stapler)Technology, other conventional techniques
- Where
- Italy
- Volunteers
- 700 people
- Sponsor
- University of Turin, Italy
Low Anterior Resection Syndrome, Rectal Cancer
Antegrade Intestinal Fluid Reinfusion for Prevention of Low Anterior Resection Syndrome After Low Anterior Resection: a Single-Center, Prospective Randomized Controlled Trial.
The goal of this clinical trial is to learn if antegrade intestinal fluid reinfusion works to prevent low anterior resection syndrome (LARS) in patients with prophylactic ileal stoma. The main questions it aims to answer are: 1.
- Trial name
- NCT07537998
- Testing
- intestinal fluid infusion, potable water
- Where
- China
- Volunteers
- 160 people
- Sponsor
- Pei-Rong Ding
Non-muscle-invasive Bladder Cancer
OH2 Oncolytic Viral Therapy in Non-Muscle-Invasive Bladder Cancer
This phase Ⅰb/Ⅱ study evaluates the safety and efficacy of OH2 for adjuvant therapy in non-muscle-invasive bladder cancer after first-line prophylactic intravesical instillation therapy.
- Trial name
- NCT05232136
- Testing
- OH2 injection
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Binhui Biopharmaceutical Co., Ltd.
Pancreas Cancer
Adaptive Approach to Neoadjuvant Therapy to Maximize Resection Rates for Pancreatic Adenocarcinoma
The purpose of this study is to determine if neoadjuvant therapy to increases resection rate for pancreatic adenocarcinoma.
- Trial name
- NCT04594772
- Testing
- Folfirinox, Gemcitabine, radiation therapy
- Where
- 2 sites in United States
- Volunteers
- 32 people
- Sponsor
- University of Cincinnati
Pancreatic Diseases
Influence of Hospital Volume on Mortality and Length of Hospital Stay After Pancreatic Resection in Switzerland
The effect of centralisation measures on the operative outcomes after pancreatic resection in Switzerland has not been highlighted yet.
- Trial name
- NCT07022639
- Testing
- Total pancreatectomy, Proximal pancreatectomy, Distal pancreatectomy
- Where
- Switzerland
- Volunteers
- 6,785 people
- Sponsor
- Cantonal Hospital of St. Gallen
Hepatocellular Carcinoma
Radiofrequency Ablation Versus Liver Resection for Elderly Patients With Hepatocellular Carcinoma (HCC) Within the Milan Criteria
Hepatocellular carcinoma (HCC) is a common cancer, and it is the third commonest global cause of cancer-related death. With an increase in life-expectancy of the general population, the number of elderly with HCC is expected to…
- Trial name
- NCT01570075
- Testing
- HR, RFA
- Where
- China
- Volunteers
- 180 people
- Sponsor
- Sun Yat-sen University
Patients Receiving Hepatectomy Under General Anesthesia
Analgesic Effect of Intrathecal Morphine Combined With Low Dose Local Anesthetics on Postoperative Analgesia After Liver Resection
Efficient postoperative pain control plays a vital part in the management of patients after surgery. In particular, major surgeries including hepatectomy cause intense postoperative pain that may result in cardiovascular or…
- Trial name
- NCT05208801
- Testing
- Percutaneous injection, Morphine, Morphine+Bupivacaine
- Where
- South Korea
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Yonsei University
Barrett Syndrome, Barrett's Syndrome
CLE for Assessment of Neoplasia After Mucosal Ablation or Resection of Gastrointestinal Neoplasia
This study focuses on demonstrating the value of probe-based Confocal Laser Endomicroscopy (pCLE) in guiding endoscopic therapeutic procedures in Barrett's Esophagus (BE).
- Conditions
- Barrett Syndrome, Barrett's Syndrome, Barrett's Esophagus, Barrett Esophagus
- Trial name
- CLEAN-MARGIN (NCT01032044)
- Testing
- Standard endoscopic evaluation, pCLE guided evaluation
- Where
- 6 sites in United States, France and 1 more
- Volunteers
- 164 people
- Sponsor
- Mauna Kea Technologies
Rectal Cancer, Surgery
Multicenter Phase II Study of Transanal TME (taTME)
Radical rectal cancer resection, namely total mesorectal excision (TME), is the cornerstone of the treatment of resectable rectal cancer.
- Trial name
- NCT03144765
- Testing
- Transanal Total Mesorectal Excision (taTME)
- Where
- 12 sites in United States, Canada
- Volunteers
- 100 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Benign Vocal Fold Lesions
Effect of PRP Injection on Voice Recovery After Benign Vocal Fold Surgery
The goal of this clinical trial is to evaluate whether platelet-rich plasma (PRP) injections can improve voice outcomes after microlaryngosurgery in patients with benign vocal fold lesions.
- Trial name
- NCT07300800
- Testing
- Platelet-Rich Plasma (PRP) Injection after Microlaryngoscopic Surgery for PRP Group, Conventional Microlaryngoscopic Surgery (Active Comparator)
- Where
- Egypt
- Volunteers
- 64 people
- Sponsor
- Beni-Suef University
Pleural Effusion, Pleural Effusion Malignant
The Effect of Non-Steroidal Anti-Inflammatory Drug Naproxen on Pleural Effusion Formation After Lung Resection
Following a lung resection procedure, patients have their pleural space drained of fluid that accumulates due to the severing of proximal vessels like lymph nodes.
- Trial name
- NCT01612975
- Testing
- Naproxen
- Where
- Canada
- Volunteers
- 7 people
- Sponsor
- McMaster University
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