Clinical trials: Surgical Resection
Glioblastoma Multiforme, Anaplastic Astrocytoma
Study of a Retroviral Replicating Vector Combined With a Prodrug to Treat Patients Undergoing Surgery for a Recurrent Malignant Brain Tumor
This is a multicenter study evaluating the safety and tolerability of increasing doses of Toca 511, a retroviral replicating vector, injected into the resection cavity of patients with Grade III or Grade IV Gliomas who have…
- Conditions
- Glioblastoma Multiforme, Anaplastic Astrocytoma, Anaplastic Oligodendroglioma, Anaplastic Oligoastrocytoma
- Trial name
- NCT01470794
- Testing
- Toca 511 vector, Toca FC
- Where
- 8 sites in United States
- Volunteers
- 58 people
- Sponsor
- Tocagen Inc.
Liver Dysfunction, Pain
Efficacy of Multimodal Opioid Therapy During Hepatic Resection Surgery
The patient population requiring hepatic resection can demonstrate an unpredictable risk of exhibiting peri-operative coagulopathy resulting either from the pre-operative hepatic pathophysiology or volume of parenchymal…
- Trial name
- RITM-IVM (NCT00553553)
- Testing
- Morphine sulphate, Morphine hydrochloride, remifentanil hydrochloride
- Where
- Ireland
- Volunteers
- 45 people
- Sponsor
- St Vincent's University Hospital, Ireland
Colon Polyps
Prospective Study of Colonoscopic Resection of Large Polyps and Flat Lesions
With this study, the investigators plan to review the performance of colonoscopic resection of large (> 1 cm) and flat lesions in the colon.
- Trial name
- NCT02332772
- Testing
- Data Collection
- Where
- United States
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- M.D. Anderson Cancer Center
Melanoma (Skin)
Vaccine Therapy in Treating Patients With Metastatic Melanoma Who Are Undergoing Surgery for Lymph Node and Tumor Removal
RATIONALE: Vaccines made from a person's white blood cells and melanoma cells may make the body build an immune response and kill the tumor cells.
- Trial name
- NCT00003229
- Testing
- aldesleukin, gp100 antigen, tyrosinase peptide
- Where
- 2 sites in United States
- Sponsor
- Duke University
Melanoma
Allogeneic Gammadelta T Cells Combined With Interferon-α1b or PD-1 Monoclonal Antibody in Stage III-IV Amenable to Surgical Resection Melanoma
The purpose of this study is to evaluate the efficacy and safety of allogeneic γδ T cells combined with recombinant human interferon-α1b (IFN-α1b) or PD-1 monoclonal antibody in neoadjuvant treatment of patients with Stage III-IV…
- Trial name
- NCT06212388
- Testing
- Ex-vivo expanded allogeneic γδ T cells, Recombinant human interferon α1b, Pembrolizumab
- Volunteers
- 10 people
- Sponsor
- Xijing Hospital
Colorectal Cancer Metastatic, Surgical Procedure, Unspecified
Perioperative Outcomes of Simultaneous Colorectal and Liver Resections
The use of a simultaneous resection in patients with synchronous colorectal liver metastases has increased over the past decades.
- Trial name
- SIMULT (NCT05475041)
- Testing
- Major liver resection, Technically major liver resection
- Where
- Italy
- Volunteers
- 766 people
- Sponsor
- Fondazione Poliambulanza Istituto Ospedaliero
Arthroplasty
Mineral Nano Pathology
Hip arthroplasty is a treatment widely used in most inflammatory, traumatic and degenerative conditions of this joint. The longevity of implants may be disappointing in some cases, despite the promising results obtained during in…
- Trial name
- MINAPUIH (NCT03898531)
- Testing
- hip prosthesis removed metal / polyethylene, simple mobility, hip prosthesis removed metal / polyethylene, double mobility, hip prosthesis removed ceramic/ polyethylene, simple mobility
- Where
- 2 sites in France
- Volunteers
- 55 people
- Sponsor
- Hospices Civils de Lyon
Anastomosis, Perfusion
PPG vs. ICG in Gastrointestinal Resections
This randomized controlled trial compares a novel optical technique against the standard of care for assessing tissue perfusion in gastrointestinal surgery.
- Conditions
- Anastomosis, Perfusion, Postoperative Complications, Gastrointestinal Neoplasms
- Trial name
- NCT06222645
- Testing
- ICG fluorescence imaging technology, Imaging Photoplethysmography System
- Where
- 3 sites in China, Russia
- Volunteers
- 200 people
- Sponsor
- Saint Petersburg State University, Russia
Rectum Cancer
Conformal Sphincter-Preservation Operation Versus InterSphincteric Resection on Anal Function in Low Rectal Cancer
In this clinical trial, the investigators compared anal function, genitourinary function, quality of life, perioperative safety, and oncological prognosis after CSPO for patients with low rectal cancer, using ISR as a control, to…
- Trial name
- NCT06567756
- Testing
- CSPO, ISR
- Volunteers
- 84 people
- Sponsor
- Changhai Hospital
Lung Cancer
Lymph Node Removal in Treating Patients With Stage I or Stage II Non-small Cell Lung Cancer
RATIONALE: Surgical removal of all lymph nodes in the chest may kill cancer cells that have spread from tumors in the lung. It is not yet known whether complete removal of all lymph nodes in the chest is more effective than…
- Trial name
- NCT00003831
- Testing
- conventional surgery
- Where
- 74 sites in United States, Australia and 1 more
- Volunteers
- 1,023 people
- Sponsor
- Alliance for Clinical Trials in Oncology
Minimally Invasive Surgical Procedures, VATS
Prolonged Hospital Stay After Thoracoscopic Anatomical Lung Resections
In this study, the reasons for prolonged hospital stay after thoracoscopic (video- or robot-assisted) anatomical lung resections are investigated.
- Conditions
- Minimally Invasive Surgical Procedures, VATS, RATS Surgery, Pulmonary Lobectomy
- Trial name
- PROTRACT (NCT06638645)
- Testing
- VATS/RATS anatomical lung resection
- Where
- 2 sites in Belgium
- Volunteers
- 140 people
- Sponsor
- University Hospital, Ghent
Muscle Invasive Bladder Urothelial Carcinoma, Muscle Invasive Renal Pelvis Urothelial Carcinoma
Testing the Role of DNA Released From Tumor Cells Into the Blood in Guiding the Use of Immunotherapy After Surgical Removal of the Bladder, Kidney, Ureter, and Urethra for Urothelial Cancer Treatment, MODERN Study
This phase II/III trial examines whether patients who have undergone surgical removal of bladder, kidney, ureter or urethra, but require an additional treatment called immunotherapy to help prevent their urinary tract…
- Conditions
- Muscle Invasive Bladder Urothelial Carcinoma, Muscle Invasive Renal Pelvis Urothelial Carcinoma, Muscle Invasive Ureter Urothelial Carcinoma, Muscle Invasive Urethral Urothelial Carcinoma
- Trial name
- NCT05987241
- Testing
- Biospecimen Collection, cfDNA or ctDNA Measurement, Computed Tomography
- Where
- 505 sites in United States, Canada
- Volunteers
- 992 people
- Sponsor
- National Cancer Institute (NCI)
Colorectal Cancer
Celecoxib in Preventing Polyps in Patients Who Have Undergone Surgery for Stage I Colon Cancer
RATIONALE: Chemoprevention therapy is the use of certain drugs to try to prevent the development of cancer. It is not yet known whether celecoxib is effective in preventing polyps in patients with colon cancer.
- Trial name
- NCT00087256
- Testing
- Celecoxib
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- NSABP Foundation Inc
Resectable Hepatocellular Carcinoma With Portal Vein Tumor Thrombus
Preoperative Transarterial Chemoembolization for Resectable HCC With Portal Venous Invasion
Whether preoperative transarterial chemoembolization can prolong survival for the resectable hepatocellular carcinoma remains controversial, particularly in patients with portal vein tumor thrombi.
- Trial name
- NCT01952353
- Testing
- Preoprative TACE, Liver resection plus Thrombectomy
- Where
- China
- Volunteers
- 330 people
- Sponsor
- Sun Yat-sen University
Resection Cavity
Assessment of Neurosensory Function Following Segmental Mandibular Resection.
This study wInclusion criteria for this study will be as follows: Age group: from 15 to 60 years old. Patients with with non malignant mandibular neoplasms indicated for segmental resection.
- Trial name
- NCT03752554
- Testing
- segmental resection
- Where
- Egypt
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Cairo University
Malignant Glioma, Glioma
A Study of Aminolevulinic Acid Used to Enhance Visualization and Surgical Removal of Brain Tumors
In this study subjects will be administered a single oral dose of Aminolevulinic Acid (ALA) prior to surgical resection of their brain tumor.
- Conditions
- Malignant Glioma, Glioma, Glioblastoma, Glioblastoma Multiforme
- Trial name
- NCT01351519
- Testing
- Aminolevulinic Acid
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- MultiCare Health System Research Institute
Breast Cancer, Quality of Life
Factors Influencing Breast Cancer Resection Volumes And Their Impact on Treatment Outcome (FIBRATIO)
The number of breast cancer survivors is constantly growing. Breast conserving surgery (BCS) is equal or superior to mastectomy both regarding survival and quality of life (QoL).
- Conditions
- Breast Cancer, Quality of Life, Patient Satisfaction, Resection Margin
- Trial name
- FIBRATIO (NCT05257577)
- Testing
- Breast conserving surgery
- Where
- 4 sites in Finland
- Volunteers
- 220 people
- Sponsor
- Tampere University Hospital
Colorectal Resection
Impact of Triclosan-coated Suture on Surgical Site Infection After Colorectal Surgery
Despite adequate antimicrobial prophylaxis and perioperative correction of risk factors, surgical site infections (SSI) remain the most frequent complication of colorectal resection (range 10-17%).
- Trial name
- NCT01869257
- Testing
- Triclosan coated suture, regular suture
- Where
- Italy
- Volunteers
- 279 people
- Sponsor
- University of Milano Bicocca
Rectal Cancer, Total Neoadjuvant Treatment
Total Neoadjuvant Therapy and Organ Preservation Versus Surgery for Rectal Cancer.
This study hypothesizes that approximately 50% of rectal cancer patients can preserve their rectum using a watch-and-wait strategy if they achieve a complete or near-complete clinical response to total neoadjuvant therapy (TNT).
- Conditions
- Rectal Cancer, Total Neoadjuvant Treatment, Neoadjuvant Therapy, Radiotherapy
- Trial name
- NCT06758830
- Testing
- Radiation Therapy, Chemoradiotherapy, Consolidation Chemotherapy
- Where
- Lithuania
- Volunteers
- 400 people
- Sponsor
- National Cancer Center Affiliate of Vilnius University Hospital Santaros Klinikos
Postoperative Pain, Lung Cancer
Postoperative Pain Management on Patients Undergoing Lung Tumor Resection
Multimodal analgesia (MMA) is an essential part of Enhanced Recovery After Surgery (ERAS) protocol. The principle of MMA is to manage pain with analgesics of multiple classes acting on distinct target sites through different…
- Conditions
- Postoperative Pain, Lung Cancer, Lung Tumor
- Trial name
- NCT06397807
- Testing
- Dinalbuphine sebacate, Analgesic injectables, Enteral analgesics
- Volunteers
- 400 people
- Sponsor
- China Medical University Hospital
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