Clinical trials: Surgical Resection
Mechanical Power, Alveolar Recruitment Maneuvers
The Role of Periodic Alveolar Recruitment Maneuvers in Intraoperative Protective Ventilation
The goal of this clinical trial is to compare three open-lung strategies on respiratory function and lung injury in protective ventilation for laparoscopic anterior resection.
- Conditions
- Mechanical Power, Alveolar Recruitment Maneuvers, Protective Ventilation, Postoperative Pulmonary Complications
- Trial name
- REMAIN-2 (NCT05962125)
- Testing
- periodic alveolar recruitment maneuvers, positive end-expiratory pressure
- Where
- China
- Volunteers
- 75 people
- Sponsor
- Sixth Affiliated Hospital, Sun Yat-sen University
Rectal Cancer Stage I
Tumor Local Excision +Postoperative Adjuvant Chemoradiotherapy for T1-2N0M0 Low/Ultra-Low Rectal Cancer
This study is a single-center, single-arm, prospective clinical trial designed to evaluate the efficacy of local excision followed by postoperative chemoradiotherapy in patients with early-stage low/ultra-low rectal cancer.
- Trial name
- NCT06949098
- Testing
- Local Tumor Resection, Radiotherapy, Chemotherapy
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Hebei Medical University Fourth Hospital
Glioblastoma, Glioblastoma Multiforme
The SAFE-Trial: Awake Craniotomy Versus Surgery Under General Anesthesia for Glioblastoma Patients.
The trial is designed as a multicenter randomized controlled study. 246 patients with presumed Glioblastoma Multiforme in eloquent areas on diagnostic MRI will be selected by the neurosurgeons according the eligibility criteria…
- Conditions
- Glioblastoma, Glioblastoma Multiforme, Glioblastoma Multiforme of Brain, Astrocytoma, Grade IV
- Trial name
- SAFE (NCT03861299)
- Testing
- Awake craniotomy, Craniotomy under general anesthesia
- Where
- 5 sites in Belgium, Netherlands
- Volunteers
- 246 people
- Sponsor
- Jasper Gerritsen
Lung Neoplasms, Lung Cancer
Effect of Muscle and Skin Fixation of Thoracic Drainage Tube on Postoperative Pain
Lung cancer is the leading cause of cancer-related death worldwide. Thoracoscopic pulmonary resection is a prevalent management for early stage of lung cancer.
- Conditions
- Lung Neoplasms, Lung Cancer, Pulmonary Neoplasm, Postoperative Pain
- Trial name
- NCT05202249
- Testing
- muscle layer fixation of thoracic drainage tube
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Daping Hospital and the Research Institute of Surgery of the Third Military Medical University
Rectal Cancer
Mucosal Flap Reinforced Colorectal Anastomosis and Trans-Anal Vacuum Drainage: A Feasibility Study
Background: Dehiscence of colorectal anastomosis is a serious complication associated with increased mortality and impaired functional and oncological outcomes.
- Trial name
- Endodrain (NCT04735107)
- Testing
- colorectal anastomosis reinforcement and trans-anal drainage
- Where
- Slovakia
- Volunteers
- 50 people
- Sponsor
- Comenius University
Breast-Conserving Surgery
Regenerative Collagen Scaffold for Breast Volume Restoration After Breast Cancer Excision
This clinical trial evaluates the safety and efficacy of High Purity Type I Collagen scaffold for breast volume restoration following breast-conserving surgery (BCS).
- Trial name
- NCT07219316
- Testing
- High Purity Type I Collagen Scaffold (Regenerative Matrix)
- Where
- 2 sites in India
- Volunteers
- 40 people
- Sponsor
- Adichunchanagiri Institute of Medical Sciences, B G Nagara
Pancreatic Tumor Patients Who Consecutively Underwent Minimally Invasive or Open Pancreatic Surgery With Venous Reconstruction
Comparison of Prognosis Between Open Pancreatic Surgery With Vein Resection and Reconstruction Versus Minimally Invasive Pancreatic Surgery With Vein Resection and Reconstruction for Pancreatic Cancer
The prognostic differences between open and minimally invasive radical pancreatic surgery combined with venous resection and reconstruction remain controversial, and there is a lack of high-quality evidence-based medical evidence…
- Trial name
- NCT07414004
- Where
- China
- Volunteers
- 2,451 people
- Sponsor
- First Affiliated Hospital Xi'an Jiaotong University
Rectal Cancer, Low Anterior Resection Syndrome
Percutaneous Tibial Nerve Stimulation in the Treatment of Anterior Resection Syndrome After Rectal Cancer Surgery
The study aims to evaluate the efficacy of percutaneous tibial nerve stimulation (PTNS) associated with conservative therapy (arm A) for the treatment of low anterior resection syndrome (LARS) compared with only conservative…
- Trial name
- NCT02177084
- Testing
- PTNS
- Where
- Italy
- Volunteers
- 12 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Total Mesorectal Excision, Laparoscopic
Laparoscopic Extraperitoneal Total Mesorectal Excision (LE-TME): A New Feasible Technical Approach.
The study involves the use of Retroperitoneal plane for TME for rectal anterior resection. Through a pilot prospective study, LR-TME will be assessed as one arm study.
- Trial name
- LE-TME (NCT02455752)
- Testing
- LE-TME
- Where
- Egypt
- Volunteers
- 5 people
- Sponsor
- Mansoura University
Symptomatic Recurrent Diverticular Disease, Benign Adenomatous Sigmoidal Polyp, Requiring Surgery
Randomized Trial Comparing Laparoscopic-assisted Rectosigmoid Resection Versus Laparoscopic Rectosigmoid Resection With Transrectal Specimen Retrieval
Laparoscopic anterior resection is a standardized procedure requiring a small muscle split incision to retrieve the specimen and to fashion the proximal part of the double stapled anastomosis.
- Conditions
- Symptomatic Recurrent Diverticular Disease, Benign Adenomatous Sigmoidal Polyp, Requiring Surgery, Early Non-transmural Sigmoidtumor
- Trial name
- LATA (NCT01033838)
- Testing
- rectosigmoid resection
- Where
- Belgium
- Volunteers
- 1 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Benign Prostatic Hyperplasia
Comparison of TUSP Versus TURP for Treatment of Benign Prostatic Hyperplasia in a Small Prostate Volume
Comparison of transurethral split of the prostate versus transurethral resection of the prostate for treatment of benign prostatic hyperplasia in a small prostate volume: A prospective controlled study
- Trial name
- NCT04912349
- Testing
- TUSP, TURP
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Rectal Cancer
Evaluation of the Learning Curve in Low Anterior Resection for Rectal Resection With the Two Surgical Robots
Central South University in collaboration with Tianjin University developed the first domestically produced Chinese minimally invasive surgical (MIS) robot system which named "Micro Hand S" in 2013.
- Trial name
- NCT04855448
- Testing
- Micro Hand S robot and da Vinci robot, da Vinci robot
- Where
- China
- Volunteers
- 112 people
- Sponsor
- The Third Xiangya Hospital of Central South University
Glioblastoma, Glioblastoma Multiforme
The PALSUR-study: Palliative Care Versus Surgery in High-grade Glioma Patients (ENCRAM 2203)
There is no consensus on the optimal treatment of patients with high-grade glioma, especially when patients have limited functioning performance at presentation (KPS ≤70).
- Conditions
- Glioblastoma, Glioblastoma Multiforme, Glioblastoma, IDH-wildtype, Glioblastoma Multiforme, Adult
- Trial name
- PALSUR (NCT06146738)
- Testing
- Palliative Care, Tumor biopsy, Tumor resection
- Where
- 8 sites in United States, Belgium and 3 more
- Volunteers
- 1,015 people
- Sponsor
- Jasper Gerritsen
Colonic Polyp, Colorectal Adenoma
Clinical Trial Evaluating External Evaluation and Training on the Incomplete Resection (POLIPEVA Study)
Introduction It has been shown that some quality indicators in endoscopy can be improved through educational interventions. There are marked differences in the proportion of incomplete polypectomies among endoscopists.
- Conditions
- Colonic Polyp, Colorectal Adenoma, Colorectal Cancer
- Trial name
- POLIPEVA (NCT04636619)
- Testing
- Colonic polypectomy, Online training course
- Where
- Spain
- Volunteers
- 1,920 people
- Sponsor
- Hospital del Rio Hortega
Resectable Esophageal Squamous Cell Carcinoma
Study of Adebrelimab With Chemotherapy, Endoscopy and Sequential Chemoradiotherapy In Inoperable Esophageal Cancer
Evaluating the efficacy and safety of PD-L1 (Programmed Death-L1)antibody combined with endoscopy and radiotherapy for inoperable cT1b-2 (clinical stage tumor 1b-2) esophageal squamous cell carcinoma
- Trial name
- NCT06599775
- Testing
- Adebrelimab injection, Albumin-Bound Paclitaxel, Carboplatin injection
- Volunteers
- 42 people
- Sponsor
- Shanghai Zhongshan Hospital
Bladder Cancer
Longer-term Recurrence Rates in Patients With Bladder Cancer After Hexvix (Cysview)Fluorescence Cystoscopy/TURB
The study is intended to investigate whether the improved initial detection and resection of bladder cancer lesions in patients with non-muscle invasive bladder cancer with Hexvix (Cysview) fluorescence cystoscopy/TURB will lead…
- Trial name
- NCT01166230
- Where
- 24 sites in United States, Austria and 3 more
- Volunteers
- 551 people
- Sponsor
- Photocure
Bone Tumors
Navigation Surgery for Bone and Soft Tissue Tumor
Bone tumor near the articular cartilage is hard to remove sufficiently without damaging adjacent joint. The purpose of this study was to evaluate the feasibility of navigation-assisted surgery for saving joint in bone tumor…
- Trial name
- NCT01179698
- Testing
- Navigation surgery, Navigation system
- Where
- South Korea
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Samsung Medical Center
Duodenal Neoplasm, Gastrointestinal Disease
Side-to-side Duodenojejunostomy After Distal Duodenal Resection (DUORESECT)
Lower partial duodenectomy could be indicated in case of injury, wide neck diverticulum, tumor invasion by other tumors such as retroperitoneal sarcoma and primary tumor of 3rd and 4th portion of the duodenum.
- Conditions
- Duodenal Neoplasm, Gastrointestinal Disease, Surgery--Complications, Survival
- Trial name
- DUORESECT (NCT04151394)
- Testing
- Duodenojejunostomy
- Where
- Spain
- Volunteers
- 13 people
- Sponsor
- Universidad de Extremadura
Wound Infection
Supplemental Oxygen Reduces Surgical Infection
Supplemental perioperative oxygen has been reported to halve or double the risk of surgical wound infection. We tested the hypothesis that supplemental oxygen reduces infection risk following colorectal surgery.
- Trial name
- NCT00235456
- Testing
- Perioperative supplemental oxygen, Standard oxygen
- Where
- Spain
- Volunteers
- 300 people
- Sponsor
- The Cleveland Clinic
Liver Cancer, Hepatocellular Carcinoma
I-FIGS Feasibility Study
Background: Removal of part of the liver (resection) is performed as a treatment for some cancers in the liver. To achieve the best possible outcomes, it is important that the cancer is removed completely (R0 resection) (1).
- Conditions
- Liver Cancer, Hepatocellular Carcinoma, Liver Metastasis Colon Cancer
- Trial name
- I-FIGS (NCT05616039)
- Testing
- Standard Liver Surgery, Indocyanine Fluorescent Image Guided Surgery (I-FIGS)
- Where
- United Kingdom
- Volunteers
- 42 people
- Sponsor
- University Hospital Plymouth NHS Trust
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