Clinical trials: Surgical Resection
Stage III Colon Cancer
Maintenance Tegafur-uracil Versus Observation Following Adjuvant Oxaliplatin-based Regimen in Patients With Stage III Colon Cancer After Radical Resection
Primary Objective: To compare 3-year disease free survival (DFS) of tegafur-uracil following adjuvant oxaliplatin-based regimen to observation following adjuvant oxaliplatin-based regimen in patients with stage III colon cancer…
- Trial name
- NCT02836977
- Testing
- tegafur-uracil
- Where
- Taiwan
- Volunteers
- 400 people
- Sponsor
- Kaohsiung Medical University Chung-Ho Memorial Hospital
Sarcoma
Bone Arches: Performance of Pseudo-scanner Sequences in Segmenting the Extent of the Tumour and in Planning Surgical Resection Using the CT Scan as a Reference
The goal of this exploratory interventional study aims to evaluate the performance of "pseudo-scanner" MRI sequences in delineating the tumor extent within bone sarcomas and its ability to serve as a reference for designing…
- Trial name
- SARCOUPE (NCT06988007)
- Testing
- Whole body MRI
- Where
- 2 sites in Belgium
- Volunteers
- 122 people
- Sponsor
- Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Delayed Bleeding Post EMR, Large Laterally Spreading Lesion in the Colon
Systematic Description of the Post EMR Defect
To date there are no available data on the utility of the endoscopic mucosal resection (EMR) defect in stratifying the risk of immediate or delayed adverse outcomes, particularly clinically significant post EMR bleeding (CSPEB).
- Conditions
- Delayed Bleeding Post EMR, Large Laterally Spreading Lesion in the Colon, Endoscopic Mucosal Resection
- Trial name
- NCT03117400
- Where
- Australia
- Volunteers
- 482 people
- Sponsor
- Western Sydney Local Health District
Dexmedetomidine, Transurethral Resection of Prostate
Intrathecal Versus Intravenous Dexmedetomidine in Prostate Transurethral Resection
This study was conducted to compare the effects of intrathecal versus intravenous dexmedetomidine administration in patients undergoing Transurethral resection of the prostate under spinal anesthesia.
- Conditions
- Dexmedetomidine, Transurethral Resection of Prostate, Analgesia
- Trial name
- NCT05525819
- Testing
- Control group, Intrathecal group, Intravenous group
- Where
- Egypt
- Volunteers
- 75 people
- Sponsor
- Tanta University
Low Rectal Cancer, Rectal Neoplasms
Reinforced Versus Conventional Anastomosis in Laparoscopic Low Rectal Cancer Resection: A Comparative Study
Study Description This prospective, controlled clinical study aims to compare the clinical outcomes of reinforced anastomosis using 8-10 interrupted sutures versus the conventional Dixon procedure in patients undergoing…
- Conditions
- Low Rectal Cancer, Rectal Neoplasms, Colorectal Cancer
- Trial name
- NCT07346534
- Testing
- Reinforced Anastomotic Suturing (8-10 Interrupted Sutures), Conventional Laparoscopic Dixon Procedure
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Shanghai 10th People's Hospital
Brain and Central Nervous System Tumors
Temozolomide During and After Radiation Therapy in Treating Patients Who Have Undergone Previous Surgery and Placement of Gliadel Wafers for Newly Diagnosed Glioblastoma Multiforme
RATIONALE: Drugs used in chemotherapy, such as temozolomide, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing.
- Trial name
- NCT00238277
- Testing
- temozolomide, adjuvant therapy, chemotherapy
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
High Grade Glioma, MGMT-Unmethylated Glioblastoma
DB107-RRV, DB107-FC, and Radiation Therapy With or Without Temozolomide (TMZ) for High Grade Glioma
This is a multicenter, open-label study of DB107-RRV (formerly Toca 511) and DB107-FC (formerly Toca FC) when administered following surgical resection in newly diagnosed High Grade Glioma (HGG) patients.
- Conditions
- High Grade Glioma, MGMT-Unmethylated Glioblastoma, MGMT-Methylated Glioblastoma
- Trial name
- NCT06504381
- Testing
- DB107-RRV, DB107-FC, Radiation Therapy (RT)
- Where
- 5 sites in United States
- Volunteers
- 70 people
- Sponsor
- University of California, San Francisco
Colon Cancer, Frailty
The "SPARCOL" Study
Mortality following elective colorectal cancer surgery range between 2.5-6% and increase for the elderly and frail patient regardless of T-stage.
- Trial name
- NCT05734300
- Testing
- Combined Endoscopic Laparoscopic Surgery (CELS), Standard resection
- Where
- 3 sites in Denmark
- Volunteers
- 48 people
- Sponsor
- Zealand University Hospital
Hepatectomy, Elective Hepatectomy
Interest of PReOPerative Immunonutrition in Liver Surgery for Cancer
To study the efficacy of preoperative immunonutrition in reducing postoperative morbidity after liver resection for cancer.
- Conditions
- Hepatectomy, Elective Hepatectomy, Malignant Tumors
- Trial name
- PROPILS (NCT02041871)
- Testing
- Oral immunonutrition
- Where
- France
- Volunteers
- 399 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Glioma, Recurrent High Grade, Grade 4 Malignant Glioma
A Study of NST-628 in Recurrent Grade 4 Glioma
This is an open-label, single arm, non-randomized, Phase 0 and expansion Phase 1 study of NST-628 in adult patients with recurrent Grade 4 glioma with high phosphorylated extracellular signal-regulated kinase (pERK) expression…
- Trial name
- NCT07784985
- Testing
- NST-628
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Nader Sanai
Pneumothorax
Percussion Device (PD) for Detection of Pneumothorax
This study aims to examine the safety and efficacy of the Percussion Device in detecting a pneumothorax in patients that have undergone thoracic surgery.
- Trial name
- NCT03272815
- Testing
- Percussion Device (PD), Ultrasound (US)
- Where
- Canada
- Volunteers
- 13 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Lung Neoplasms
Multicentric Study VATS Major Introperative Complications
This study investigates the most common major complications that result in unplanned additional surgery in patients undergoing vats anatomical resections. Several high-volume European centres participate.
- Trial name
- NCT02031809
- Where
- 9 sites in Austria, Denmark and 7 more
- Volunteers
- 3,076 people
- Sponsor
- University Hospital, Gasthuisberg
Colon Cancer
Colon Cancer Prognosis After Radical Surgery
1. Radical surgery. It is supposed to improve prognosis of colon cancer. A surrogate measure of achievement of radical surgery is the number of lymph nodes removed with the specimen. 2. Markers.
- Trial name
- NCT00963352
- Where
- 2 sites in Norway
- Volunteers
- 300 people
- Sponsor
- Haraldsplass Deaconess Hospital
Colorectal Adenoma, Intramucinous Adenocarcinoma
Evaluation of the Resection of Adenoma and Colic Adenocarcinoma by EMR Piecemeal or EMR/ESD Hybrid Technique
For tough colic resection, evaluation of our practice for these lesions unresectable in monoblock and evaluation of the contribution of the hybrid technique EMR (mucosectomy dissection) /ESD (submucosal dissection)
- Trial name
- HYBRID ESD (NCT02935049)
- Testing
- Endoscopic resection
- Where
- France
- Volunteers
- 120 people
- Sponsor
- Institut Paoli-Calmettes
Transcervical Resection of Endometrium, Transcervical Resection of Fibroids
Comparing Two Types of Sedation to Gynaecological Patients
The primary endpoint is to investigate the difference in pain between patients who receive deep sedation with spontaneous breathing versus patients who receive general anesthesia.
- Conditions
- Transcervical Resection of Endometrium, Transcervical Resection of Fibroids, Transcervical Resection of Polyp
- Trial name
- NCT01412632
- Testing
- Remifentanil, propofol and citanest
- Where
- Denmark
- Volunteers
- 153 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Benign Prostatic Hyperplasia, Cognitive Functions
Comparative Neurocognitive Outcomes Following Prostate Surgery
This prospective observational cohort study aims to evaluate postoperative cognitive outcomes in patients undergoing surgical treatment for benign prostatic hyperplasia (BPH).
- Trial name
- NCT07468084
- Where
- Turkey (Türkiye)
- Volunteers
- 132 people
- Sponsor
- Cengiz Canakci, MD
Macular Holes
Extent of ILM Removal and Its Impact on Outcomes of MH Surgery
Eligible patients who were scheduled for surgery for idiopathic macular hole (MH) were equally randomized to small extent group or large extent group depending on the extent of internal limiting membrane (ILM) to be removed.
- Trial name
- NCT02010138
- Testing
- small-extent peeling, large-extent peeling
- Where
- South Korea
- Volunteers
- 65 people
- Sponsor
- Samsung Medical Center
Basal Cell Carcinoma, Squamous Cell Carcinoma
Study Assessing the Safety and Performance of Smart Matrix®
Smart Matrix is a sterile, single layer dermal replacement scaffold. The scaffold consists of a porous matrix of cross-linked human fibrin plus alginate that has been designed and optimised to facilitate wound closure and healing…
- Trial name
- NCT03742726
- Testing
- Smart Matrix scaffold
- Where
- 4 sites in United Kingdom
- Volunteers
- 32 people
- Sponsor
- Smart Matrix Limited
Bladder Cancer, Liquid Biopsy
The Guiding Value of Liquid Biopsy Based on Urinary Tumor DNA/RNA in the Second Transurethral Resection of High-risk Non-muscle Invasive Bladder Cancer
High-risk non-muscle-invasive bladder cancer (NMIBC) carries a substantial risk of residual disease after initial transurethral resection of bladder tumor (TURBT).
- Trial name
- NCT07130578
- Testing
- urine tumor DNA/RNA testing
- Where
- 2 sites in China
- Volunteers
- 60 people
- Sponsor
- Tianjin Medical University Second Hospital
Liver Diseases, Liver Neoplasms
Quality of Life After Liver Resection
Patients with malignant diseases are increasingly receiving more extensive hepatic resections, with im-proved preoperative and postoperative care leading to a reduced postoperative morbidity and mortality.
- Trial name
- NCT00681499
- Where
- Switzerland
- Volunteers
- 198 people
- Sponsor
- University of Bern
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