Clinical trials: Surgical Resection
Liver Diseases
Risk Factors for Major Complications After Liver Resection
The aim of this study is to determine the risk factors for major complications following liver resection in the setting of a general surgery-teaching department in Morocco, North Africa
- Trial name
- NCT03967067
- Testing
- liver resection
- Where
- Morocco
- Volunteers
- 213 people
- Sponsor
- Moroccan Society of Surgery
Brain and Central Nervous System Tumors, Metastatic Cancer
Radiolabeled Monoclonal Antibody Therapy in Treating Patients With Primary or Metastatic Brain Tumors
RATIONALE: Radiolabeled monoclonal antibodies can locate tumor cells and deliver radioactive tumor-killing substances to them without harming normal cells. This may be effective treatment for primary or metastatic brain tumors.
- Conditions
- Brain and Central Nervous System Tumors, Metastatic Cancer, Neuroblastoma
- Trial name
- NCT00003461
- Testing
- surgical procedure, astatine At 211 monoclonal antibody 81C6
- Where
- United States
- Sponsor
- Duke University
Cirrhosis and Chronic Liver Disease
Sugammadex Versus Neostigmine in Patients With Liver Cirrhosis Undergoing Liver Resection
Liver cirrhosis is a progressive disease characterized by loss of functional hepatocytes that substantially affects drug pharmacokinetics.
- Trial name
- NCT02414880
- Testing
- Sugammadex, Neostigmine, Rocuronium
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Cairo University
Crohn's Disease
Impact of Disease Activity and Nutrition Treat on Postoperative Recurrence and Complications After Bowel Resection for Crohn's Disease
The study was aimed to determine whether perioperative nutrition treat and(or)the perioperative disease activity were associated with postoperative recurrence and complications after bowel resection for Crohn's disease.
- Trial name
- NCT01540942
- Testing
- nutrition treat, surgery
- Where
- China
- Volunteers
- 91 people
- Sponsor
- Jinling Hospital, China
Peripheral Vascular Diseases
Plaque Removal Versus Open Bypass Surgery For Critical Limb Ischemia
To compare the outcome of bypass surgery and plaque excision for treatment of critical limb ischemia in the lower limbs
- Trial name
- PROOF (NCT00504088)
- Testing
- Bypass, Silverhawk Plaque Excision
- Where
- 31 sites in United States
- Sponsor
- FoxHollow Technologies
Metachronous Neoplasm, Gastric Cancer
Aberrant DNA Methylation to Predict Metachronous Gastric Neoplasms
The study is a prospective cohort study to investigate whether aberrant DNA methylation can be useful for the prediction of metachronous recurrence after endoscopic resection of gastric neoplasms (dysplasia or cancer).
- Conditions
- Metachronous Neoplasm, Gastric Cancer, Gastric Neoplasm, Aberrant DNA Methylation
- Trial name
- NCT04830618
- Volunteers
- 300 people
- Sponsor
- Seoul National University Hospital
Gastrointestinal Neoplasms
The Use of a OCT Probe in Assessment of Endoscopic and Surgical Resection Specimen of Gastrointestinal Tract
This is a pilot study aiming to investigate the ability of a novel Optical Coherence Tomography (OCT) probe in assessing the different layers of the gastrointestinal tract and the depth of invasion of early neoplasia, utilising…
- Trial name
- NCT04670718
- Testing
- Optical Coherence Tomography Probe
- Where
- Hong Kong
- Volunteers
- 8 people
- Sponsor
- Chinese University of Hong Kong
Stage III Adult Soft Tissue Sarcoma, Recurrent Adult Soft Tissue Sarcoma
Combination Chemotherapy, Radiation Therapy, and Surgery in Treating Patients With Primary or Recurrent Sarcoma
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Radiation therapy uses high-energy x-rays to damage tumor cells.
- Conditions
- Stage III Adult Soft Tissue Sarcoma, Recurrent Adult Soft Tissue Sarcoma, Stage IVA Adult Soft Tissue Sarcoma, Stage IIB Adult Soft Tissue Sarcoma
- Trial name
- NCT00017160
- Testing
- doxorubicin, filgrastim, ifosfamide
- Where
- 235 sites in United States, Canada
- Sponsor
- Radiation Therapy Oncology Group
Gastrointestinal Stromal Tumor
Imatinib Mesylate in Treating Patients With Gastrointestinal Stromal Tumor That Has Been Completely Removed During Surgery
This phase II trial is studying how well imatinib mesylate works in treating patients with gastrointestinal stromal tumor that was completely removed during surgery.
- Trial name
- NCT00025246
- Testing
- imatinib mesylate, laboratory biomarker analysis
- Where
- United States
- Volunteers
- 89 people
- Sponsor
- National Cancer Institute (NCI)
Pancreas Cancer
Preoperative/Neoadjuvant Therapy and Vascular Debranching Followed by Resection for Locally Advanced Pancreatic Cancer
Pancreatic cancer continues to have a poor prognosis. Many patients are diagnosed with advanced disease. In a considerable proportion of these patients, the tumor has contact with or invades into arterial blood vessels supplying…
- Trial name
- PREVADER (NCT04136769)
- Testing
- Visceral Debranching
- Where
- 3 sites in Germany
- Volunteers
- 3 people
- Sponsor
- Ulrich Ronellenfitsch, MD
Newly Diagnosed Glioblastoma Who Underwent at Least Partial Resection of the Tumor Surgically
Potentiation of Chemotherapy in Brain Tumors by Zinc
Glioblastoma (GB) is the most common and aggressive type of primary malignant brain tumor in adults. Despite advances in surgical resection, radiotherapy and chemotherapy, prognosis remains very poor.
- Trial name
- NCT04488783
- Testing
- zinc and ascorbate
- Where
- Israel
- Volunteers
- 30 people
- Sponsor
- Sheba Medical Center
Breast Cancer
Intraoperative Use of ClearEdge Device in Breast Conserving Surgery
Multi center, pivotal prospective, randomized clinical trial The proposed randomized controlled study will evaluate the benefits of adding the ClearEdge imaging device to the Standard of Care (SoC) of margins assessment in breast…
- Trial name
- NCT05456373
- Testing
- ClearEdge device
- Where
- United States
- Volunteers
- 288 people
- Sponsor
- LS BioPath
Carcinoma, Hepatocellular, Liver Dysfunction
Evaluation of Remnant Liver Function Using Primovist-enhanced MRI Before Resection/Ablation of Hepatocellular Carcinoma
The purpose of this study is to determine whether the global and segmental hepatic uptake and excretion of Gd-EOB-DTPA on Gd-EOB-DTPA-enhanced liver MRI correlates with standard liver function test results in the patients with…
- Trial name
- LiFE (NCT01490203)
- Testing
- Gd-EOB-DTPA, MRI
- Where
- 4 sites in South Korea
- Volunteers
- 71 people, healthy volunteers welcome
- Sponsor
- Seoul National University Hospital
Non-small Cell Lung Carcinoma
Efficacy and Safety of Almonertinib Combined With or Without Chemotherapy as an Adjuvant Treatment for Stage II-IIIA Non-small Cell Lung Carcinoma Following Complete Tumour Resection
This is a multicenter, randomized, open label, phase III study.
- Trial name
- APEX (NCT04762459)
- Testing
- Almonertinib, Pemetrexed, Cisplatin
- Where
- 34 sites in China
- Volunteers
- 606 people
- Sponsor
- Chinese Academy of Medical Sciences
Gastric Dysplasia, Gastric Intestinal Metaplasia
Validation of an Artificial Intelligence System Based on Raman Spectroscopy for Diagnosis of Gastric Premalignant Lesions and Early Gastric Cancer
Early detection and treatment of gastric premalignant lesion and early gastric cancer (EGC) have been proposed to improve outcomes of gastric cancer.
- Conditions
- Gastric Dysplasia, Gastric Intestinal Metaplasia, Gastric Cancer
- Trial name
- NCT04869618
- Testing
- Raman spectroscopy based device (SPECTRA IMDx)
- Where
- Singapore
- Volunteers
- 100 people
- Sponsor
- Changi General Hospital
Cholangiocarcinoma, Gall Bladder Carcinoma
Adjuvant Chemotherapy With Gemcitabine and Cisplatin Compared to Standard of Care After Curative Intent Resection of Biliary Tract Cancer
This is a multicenter, prospective, randomized, controlled phase III trial designed to assess the clinical performance of gemcitabine with cisplatin and observation vs.
- Trial name
- ACTICCA-1 (NCT02170090)
- Testing
- Gemcitabine, Cisplatin, Capecitabine
- Where
- 67 sites in Australia, Austria and 6 more
- Volunteers
- 789 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Liver Cancer, Liver Failure
Quantitative MRI and Outcomes of Liver Resection
The present observational study aims to assess the benefit of this quantitative multiparametric magnetic resonance imaging (MRI) in clinical practice, to quantify future liver remnant performance, and to accurately predict the…
- Conditions
- Liver Cancer, Liver Failure, Bile Leak, Liver Metastases
- Trial name
- NCT06181318
- Testing
- Multiparametric MRI scan of the liver
- Volunteers
- 33 people
- Sponsor
- University Hospital Heidelberg
Segmental Long Bone Defects
Comparative Efficacy of the Masquelet Versus Titanium Mesh Cage Techniques for the Treatment of Large Long Bone Defects
The United States Department of Defense (DoD) is funding exciting new research at the University of Texas Medical Branch (UTMB) Department of Orthopaedic Surgery and Rehabilitation that can be a major improvement in the treatment…
- Trial name
- NCT02015390
- Testing
- Autogenous RIA bone grafting, Allogeneic bone grafting
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- The University of Texas Medical Branch, Galveston
Non-small Cell Lung Cancer Stage III
Neoadjuvant Chemo-Immunotherapy and Surgical Resection in Locally Advanced Non-small Cell Lung Cancer With N3 Lymph Node or Other High Risk Features
The goal of this clinical trial is to learn about neoadjuvant cemiplimab with histology-specific chemotherapy followed by resection and adjuvant cemiplimab in stage 3 non-small cell lung cancer (NSCLC) with select N3 lymph node…
- Trial name
- NEO-SURG (NCT06449313)
- Testing
- Cemiplimab-Rwlc
- Where
- 3 sites in United States
- Volunteers
- 21 people
- Sponsor
- Georgetown University
Tissue Injury, Surgery
Is Regional Oxygen Saturation Effective in Predicting Perfusion Parameters and Patient Outcomes in Liver Resection
Sudden hypotension, which may develop during liver resection operations performed under general anesthesia, can affect the patient satisfaction at a high rate by causing complications during and after the operation as a result of…
- Conditions
- Tissue Injury, Surgery, Absorption; Disorder
- Trial name
- NCT05077397
- Testing
- StO2, O3
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Marmara University
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