Clinical trials: Surgical Resection
Caesarean Scar Defect
Effectiveness of Transvaginal Niche Resection Versus Expectant Management in Patients with Secondary Infertility and a Large Uterine Caesarean Scar Defect
The goal of this clinical trial is to evaluate the efficacy and safety of transvaginal niche resection in improving pregnancy outcomes of a large uterine caesarean scar defect (niche) with secondary infertility.
- Trial name
- TVARES (NCT06599671)
- Testing
- Transvaginal niche resection
- Volunteers
- 100 people
- Sponsor
- International Peace Maternity and Child Health Hospital
Breast Cancer
Surgical Resection With or Without Axillary Lymph Node Dissection in Treating Women With Node-Negative Breast Cancer and Sentinel Lymph Node Micrometastases
RATIONALE: Surgery to remove lymph nodes in the armpit in patients with sentinel lymph node micrometastases may remove cancer cells that have spread from tumors in the breast.
- Trial name
- 23-01 (NCT00072293)
- Testing
- Axillary lymph node dissection, No axillary lymph node dissection
- Where
- 31 sites in Australia, Belgium and 8 more
- Volunteers
- 931 people
- Sponsor
- ETOP IBCSG Partners Foundation
Rectal Neuroendocrine Tumor
Endoscopic Resection for Small Rectal Neuroendocrine Tumors
In previous single center study, both modified cap-assisted endoscopic mucosal resection (mEMR-C) and endoscopic submucosal dissection (ESD) were reported to be effective for the treatment of small rectal neuroendocrine tumors…
- Trial name
- NCT05429216
- Testing
- mEMR-C procedure, ESD procedure
- Volunteers
- 102 people
- Sponsor
- Nanfang Hospital, Southern Medical University
Esophagus Cancer
Radical Resection of Single-hole Inflatable Mediastinal Mirror Synchronization With Laparoscopic Esophageal Carcinoma
This study is evaluating the feasibility and safety of radical resection of single-hole inflatable mediastinal mirror synchronization with laparoscopic esophageal carcinoma, as well as the clinical value of the radical resection…
- Trial name
- NCT03657914
- Testing
- Single-hole inflatable mediastinal mirror
- Where
- 21 sites in China
- Volunteers
- 155 people
- Sponsor
- Qingdong Cao
Laryngeal Neoplasms
Surgical Treatment of Early Stage Glotto-supraglottic Laryngeal Cancer Via Transoral Resection With Robotic Assistance
The main objective of this study is to determine the rate of healthy surgical margins after tumor resection in transoral robot-assisted surgery for glottic and/or supraglottic early stage (T1-T2) laryngeal cancer.
- Trial name
- NCT01257633
- Testing
- Transoral robot-assisted tumor resection using the da Vinci robot
- Where
- 3 sites in France
- Volunteers
- 54 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Colorectal Neoplasms
Phase II Study of Maintenance Capecitabine to Treat Resectable Colorectal Cancer
RATIONALE: Surgical resection and adjuvant therapy has become the main treatment for resectable colorectal cancer. Treatment with current strategies, however,recurrent rate is high for stage IIIC or R0 resected stage IV.
- Trial name
- CAMCO (NCT01880658)
- Testing
- Capecitabine
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Sun Yat-sen University
Squamous Cell Carcinoma of the Head and Neck, Oral Cancer
Fluorescence-guided Surgery Using cRGD-ZW800-1 in Oral Cancer
This is a two-staged clinical trial to investigate the feasibility of intraoperative Fluorescence Imaging (FLI) to adequately assess tumor margins in patients with oral cancer using cRGD-ZW800-1.
- Conditions
- Squamous Cell Carcinoma of the Head and Neck, Oral Cancer, Squamous Cell Carcinoma of the Oral Cavity
- Trial name
- GuidedbyLight (NCT04191460)
- Testing
- cRGD-ZW800-1.
- Where
- Netherlands
- Volunteers
- 31 people
- Sponsor
- Erasmus Medical Center
Adenocarcinoma, Rectal Diseases
Molecular, Pathologic and MRI Investigation of the Prognostic and Redictive Importance of Extramural Venous Invasion in Rectal Cancer (MARVEL) Trial
Extramural venous invasion (EMVI) is the spread of microscopic tumour cells into the veins around the tumour. Rectal cancer treatment has improved greatly over recent years.
- Conditions
- Adenocarcinoma, Rectal Diseases, Colorectal Neoplasms, Adenocarcinoma, Mucinous
- Trial name
- MARVEL (NCT01995942)
- Where
- 19 sites in United Kingdom
- Volunteers
- 246 people
- Sponsor
- Royal Marsden NHS Foundation Trust
Colorectal Cancer, Polyp of Colon
Reducing Neoplasia Recurrence After Endoscopic Resection of Large Colorectal Polyps
Large (≥20mm) colorectal polyps often harbor areas of advanced neoplasia, making them immediate colorectal cancer (CRC) precursors.
- Trial name
- ABLATION (NCT06271941)
- Testing
- Hybrid Argon Plasma Coagulation (h-APC), Snare tip soft coagulation (STSC)
- Where
- Canada
- Volunteers
- 892 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Pain, Postoperative
Efficacy of Sacral Erector Spinae Plane Block (SESPB) on Postoperative Pain and Catheter-related Bladder Discomfort
The goal of this clinical trial is to evaluate the catheter related bladder discomfort in patients who will undergoing TUR-P operation.
- Trial name
- SESPB (NCT06127394)
- Testing
- Sacral ESP Block, Pudendal Block
- Where
- Turkey (Türkiye)
- Volunteers
- 54 people
- Sponsor
- Giresun University
Foot Reflexology
Effect of Foot Reflexology on Pain Associated With Mediastinal Chest Drain Removal
Cardiovascular diseases (CVDs) remain the leading cause of death worldwide and significantly affect patient quality of life and socioeconomic status.
- Trial name
- NCT05631522
- Testing
- foot reflexology
- Volunteers
- 80 people
- Sponsor
- Mansoura University
Intrahepatic Cholangiocarcinoma, Peripheral Cholangiocarcinoma
Hepatic Arterial Infusion With Floxuridine and Dexamethasone in Combination With Gemcitabine as Adjuvant Treatment After Resection of Intrahepatic Cholangiocarcinoma
This is a Phase I study, which means we want to find out what effects, good and/or bad, this combination of drugs may have on the patient and the liver cancer at different dose levels.
- Conditions
- Intrahepatic Cholangiocarcinoma, Peripheral Cholangiocarcinoma, Cholangiolar Carcinoma, Cholangiocellular Carcinoma) (ICC)
- Trial name
- NCT01938729
- Testing
- Liver resection and placement of hepatic artery infusion pump, FLOXURIDINE, DEXAMETHASONE
- Where
- 5 sites in United States
- Volunteers
- 8 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Mandibular Resection
A Novel Alloplastic Patient Specific Temporalis Tendon Enthesis
Mandibular reconstruction of segmental defects is an arduous surgical procedure that requires an utmost degree of surgical fidelity.
- Trial name
- NCT06770868
- Testing
- Patient specific reconstruction plate for patients suffering from mandibular segmental defects
- Where
- Egypt
- Volunteers
- 5 people
- Sponsor
- Alexandria University
Rectal Cancer, Defect of Floor of Lesser Pelvis
Collagen Implant (Biological Mesh) Versus GM Flap for Reconstruction of Pelvic Floor After ELAPE in Rectal Cancer
The trial compares two different techniques for reconstruction of the lesser pelvic floor after an extended abdominoperineal excision for locally advanced rectal cancer.
- Trial name
- NEAPE (NCT01347697)
- Testing
- Reconstruction with an acellular porcine dermal collagen implant (biological mesh), Reconstruction with a gluteus maximus myocutaneous flap
- Where
- 8 sites in Finland, Sweden
- Volunteers
- 91 people
- Sponsor
- Umeå University
Rectal Cancer
Economic Analysis of Robotic Rectal Resection in German Health Care System
Analysis of cost effectiveness of robotic rectal resection, either sphincter preserving or abdominoperineal extirpation, in the German diagnosis related groups (DRG) system.
- Trial name
- NCT06113796
- Testing
- Surgery
- Where
- Germany
- Volunteers
- 65 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Aortic Valve Stenosis
Nitinol Circular Blade
The Nitinol Circular Blade (NCB) is indicated for use in patients with symptomatic aortic stenosis requiring aortic valve replacement, who are going to be operated by conventional sternotomy with native valve resection and…
- Trial name
- NCB (NCT03881527)
- Testing
- Aortic valve replacement using a nitinol blade, aortic valve replacement
- Where
- Belgium
- Volunteers
- 40 people
- Sponsor
- Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Lung Cancer
Validation of Rapid On-site Diagnostics in Early Stage Lung Cancer Sampling With a Higher Harmonic Generation Microscope
The aim of this study is to verify a new microscopic technique in diagnosing patients suspected of lung cancer. Patients will undergo navigational bronchoscopy or surgical resection as a part of standard of care.
- Trial name
- VALIDIAG (NCT06007261)
- Where
- Netherlands
- Volunteers
- 250 people
- Sponsor
- Radboud University Medical Center
Cancer Prostate
Assessment of a New Fluorescence Imaging Technique Using Biopsies From Prostate Resection
In this study, we aim to evaluate the feasibility of anti-PSMA labelling to detect post-operative prostatic tissues by two ex vivo fluorescence techniques.
- Trial name
- Bio-Prost (NCT03157856)
- Testing
- Fluorescence assessment
- Where
- 2 sites in France
- Volunteers
- 8 people
- Sponsor
- University Hospital, Grenoble
Gastric Cancer
Annual Hospital Volume and and Short-term Postoperative Outcomes After Gastric Cancer Resection
The effect of centralisation measures on the operative outcomes after gastric cancer resection in Switzerland has not been highlighted yet.
- Trial name
- NCT07072429
- Testing
- Gastric cancer resection
- Where
- Switzerland
- Volunteers
- 3,112 people
- Sponsor
- Cantonal Hospital of St. Gallen
Traumatic Brain Injury
Trauma Molecular Processes
The TRAUMAP study will function as a brain tissue repository for biopsy specimens from patients with traumatic brain injury undergoing brain surgery for contusion removal.
- Trial name
- TRAUMAP (NCT07683169)
- Where
- 2 sites in Italy
- Volunteers
- 500 people
- Sponsor
- Mario Negri Institute for Pharmacological Research
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