Clinical trials: Surgical Resection
Non-small Cell Lung Cancer, Renal Cell Carcinoma
Pre-Incisional Ketorolac for Patients Undergoing Surgery for Non-Small Cell Lung Cancer and Renal Cell Carcinoma
This is a pilot study of biomarker evaluation and safety of pre-incisional ketorolac for patients undergoing surgical resection for non-small cell lung cancer and renal cell carcinoma.
- Trial name
- NCT04495894
- Testing
- Preoperative Ketorolac
- Where
- 4 sites in United States
- Volunteers
- 68 people
- Sponsor
- Emory University
Stage III Colon Cancer
Maintenance Tegafur-uracil Versus Observation Following Adjuvant Oxaliplatin-based Regimen in Patients With Stage III Colon Cancer After Radical Resection
Primary Objective: To compare 3-year disease free survival (DFS) of tegafur-uracil following adjuvant oxaliplatin-based regimen to observation following adjuvant oxaliplatin-based regimen in patients with stage III colon cancer…
- Trial name
- NCT02836977
- Testing
- tegafur-uracil
- Where
- Taiwan
- Volunteers
- 400 people
- Sponsor
- Kaohsiung Medical University Chung-Ho Memorial Hospital
Rectal Cancer, Colon Cancer
Perfusion Assessment in Laparoscopic Left Anterior Resection
The purpose of this study is to demonstrate that NIR fluorescence angiography using the PINPOINT Endoscopic Fluorescence Imaging System ("PINPOINT System" or "PINPOINT") can assess viability of colon tissue during laparoscopic…
- Conditions
- Rectal Cancer, Colon Cancer, Crohn's Disease, Polyp
- Trial name
- PILLAR II (NCT01560377)
- Testing
- PINPOINT Endoscopic Fluorescence Imaging System
- Where
- 11 sites in United States
- Volunteers
- 147 people
- Sponsor
- Novadaq Technologies ULC, now a part of Stryker
Endometriosis, Endometriosis Rectum
Clinical Impact of Ultrasound Diagnosis in Bowel Endometriosis
This retrospective single-centre study evaluates how accurately preoperative ultrasound detects bowel involvement in women with deep endometriosis, using surgical findings as the reference.
- Conditions
- Endometriosis, Endometriosis Rectum, Endometriosis Pelvic, Endometriosis Colon
- Trial name
- NCT07900698
- Testing
- preoperative transvaginal ultrasound
- Where
- Belgium
- Volunteers
- 100 people
- Sponsor
- Erasme University Hospital
Locally Advanced Non-Small Cell Lung Cancer, Chemoradiotherapy
Upfront Resection of Locally Advanced NSCLC Followed by Chemoradiotherapy
For patients with irresectable locally advanced non-small cell lung cancer (NSCLC) (e.g. multilevel or bulky N2 disease or presence of N3 lymph node metastases), current guidelines recommend treatment with chemoradiotherapy (CRT)…
- Conditions
- Locally Advanced Non-Small Cell Lung Cancer, Chemoradiotherapy, Cavitation Lung, Surgery
- Trial name
- UPLAN-I (NCT05620199)
- Testing
- Upfront resection
- Volunteers
- 20 people
- Sponsor
- The Netherlands Cancer Institute
Polyp of Large Intestine
Microwave Coagulation Using CROMA Electrosurgical System
This is a single centre, prospective, non-randomised pivotal clinical investigation to be undertaken at St Mark's Hospital, Harrow, UK.
- Trial name
- NCT02372552
- Testing
- CROMA
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- Creo Medical Limited
Colon Cancer Liver Metastasis, Multiple Pulmonary Nodules
Combined Liver and Right Lung Resection for Colorectal Metastases by Means of J-shaped Thoracophrenolaparotomy
The purpose of this study is to determine whether J-shaped thoracophrenolaparotomy is effective in the surgical treatment of simultaneous liver and right lung metastases from colorectal cancer
- Trial name
- NCT02090816
- Testing
- Surgery of liver and lung
- Where
- Italy
- Volunteers
- 10 people
- Sponsor
- University of Milan
Rectal Cancer
Observation Versus Surgical Resection in Patients With Rectal Cancer Who Achieved Complete Clinical Response After Neoadjuvant Chemoradiotherapy
With the possibility of pathological complete response in surgical specimens, some authors have proposed non-operative management of the patient group, when re-staged after neoadjuvant treatment, have complete clinical response.
- Trial name
- NCT02052921
- Testing
- Rectal resection, Observation
- Where
- Brazil
- Volunteers
- 13 people
- Sponsor
- Instituto do Cancer do Estado de São Paulo
Gastric Cancer
Laparoscopic Versus Open Resection of Cancer Stomach
The aim of surgical procedures for resection of cancer stomach is to resection of the tumor mass with safety margin and its drainage lymph nodes (lymphadenectomy).
- Trial name
- NCT02789826
- Testing
- Laparoscopic gastrectomy, Open gastrectomy
- Where
- Egypt
- Volunteers
- 73 people
- Sponsor
- Assiut University
Benign Prostatic Hyperplasia, Post-Op Complication
Artery Embolization vs Operation of Benign Prostate Hyperplasia
Aim of the study is to compare prostate artery embolization (PAE) to the established surgical treatment for patient acceptance, morbidity, complications, and the functional outcomes.
- Conditions
- Benign Prostatic Hyperplasia, Post-Op Complication, Embolization Therapeutic, Transurethral Resection of Prostate Syndrome
- Trial name
- NORTAPE (NCT04084938)
- Testing
- Prostate operation or prostate artery embolization
- Where
- Norway
- Volunteers
- 140 people
- Sponsor
- Oslo University Hospital
Submucosal Tumor of Intestine
Endomina as an Aid for Endoscopic Full Thickness Resection
The concept of natural orifice transluminal endoscopic surgery (NOTES) (1) has evolved to endoscopic full thickness resection (EFTR).
- Trial name
- EFTR (NCT03608540)
- Testing
- Endomina
- Where
- Belgium
- Volunteers
- 4 people
- Sponsor
- Erasme University Hospital
Glioblastoma, Glioblastoma, IDH-wildtype
The RESBIOP-study: Resection Versus Biopsy in High-grade Glioma Patients (ENCRAM 2202)
There are no guidelines or prospective studies defining the optimal surgical treatment for gliomas of older patients (≥70 years) or those with limited functioning performance at presentation (KPS ≤70).
- Conditions
- Glioblastoma, Glioblastoma, IDH-wildtype, Glioblastoma Multiforme, Glioblastoma Multiforme, Adult
- Trial name
- RESBIOP (NCT06146725)
- Testing
- Tumor resection, Tumor biopsy
- Where
- 8 sites in United States, Belgium and 3 more
- Volunteers
- 564 people
- Sponsor
- Jasper Gerritsen
Low Anterior Resection Syndrome
Effect of Treatment of Low Anterior Resection Syndrome After Rectal Cancer Surgery
A randomized controlled trial (RCT) in patients who underwent sphincter preserving surgery due to rectal cancer. The study will analyze the effect of Transanal irrigation (TAI) and medication that can help control of the bowel…
- Trial name
- NCT03215017
- Testing
- Transanal irrigation, Medication
- Where
- 3 sites in Sweden
- Volunteers
- 45 people
- Sponsor
- Mirna Abraham-Nordling
Uterine Leiomyomas, Endometrial Polyps
Symphion® System In-Office Study
The purpose of this study is to determine the safety and feasibility of using the Symphion system in an office setting.
- Trial name
- NCT02520414
- Testing
- Symphion® Bipolar Hysteroscopic Tissue Resection System
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Minerva Surgical, Inc.
Endometriosis, Deep Endometriosis
The Association Between Deep Endometriosis and the Occurrence of Colorectal Carcinoma
The goal of this study is to identify the molecular or genetic mechanisms that may predispose patients with bowel endometriosis to an increased risk of colorectal carcinoma.
- Conditions
- Endometriosis, Deep Endometriosis, Bowel Endometriosis, Colorectal Carcinoma
- Trial name
- NCT07386431
- Volunteers
- 30 people
- Sponsor
- University Medical Centre Ljubljana
Intestinal Disease
Neuromuscular Blockade Comparison for GI-2 Recovery After Bowel Resection
The purpose of this research study is to see the outcome of Sugammadex versus Neostigmine with Glycopyrrolate in colorectal surgery as it relates to its effects on post-surgical time (in hours) to first bowel movement and…
- Trial name
- NCT06112353
- Testing
- Neostigmine Injectable Solution, Sugammadex injection
- Where
- United States
- Volunteers
- 132 people
- Sponsor
- University of California, Irvine
Pain
A Study to Evaluate the Efficacy and Safety of HR18042 Tablets for Postoperative Analgesia After Impacted Teeth Removal Surgery.
This is a multicenter, randomized, double-blind, dose finding, parallel controlled with active drug and placebo, phase II clinical trial, and the purpose of the study is to evaluate the efficacy and safety of HR18042 tablets for…
- Trial name
- NCT05470075
- Testing
- HR18042 tablets, Tramadol hydrochloride SR Tablets
- Where
- China
- Volunteers
- 110 people
- Sponsor
- Jiangsu HengRui Medicine Co., Ltd.
Epiretinal Membrane
Randomized Trial Comparing Epiretinal Membrane Surgery With and Without Internal Limiting Membrane Removal
Macular epiretinal membrane (ERM) is a semitranslucent, avascular, fibrocellular membrane on the inner surface along the internal limiting membrane (ILM) of the retina.
- Trial name
- NCT01532765
- Testing
- Pars plana vitrectomy and epiretinal membrane peel, ILM peel assisted by ICG, CE-IOL
- Where
- 3 sites in Canada
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Sunnybrook Health Sciences Centre
Resectable Pancreatic Cancer, Adjuvant Chemoradiotherapy
Adjuvant Chemoradiation Following Radical Resection of Pancreatic Ductal Adenocarcinoma, a Prospective Cohort Study
This is a prospective observation cohort study to evaluate efficacy of different types of adjuvant therapy strategies, including chemoradiotherapy, chemotherapy alone, or no adjuvant treatment, for pancreatic ductal…
- Conditions
- Resectable Pancreatic Cancer, Adjuvant Chemoradiotherapy, Surgery
- Trial name
- NCT04737551
- Testing
- Follow-up only, Adjuvant chemotherapy, Adjuvant chemoradiotherapy
- Where
- China
- Volunteers
- 400 people
- Sponsor
- Shanghai Zhongshan Hospital
Sentinel Lymph Node, Early Gastric Cancer
Feasibility Study of Sentinel Navigation Surgery After Non-curative Endoscopic Resection
Purpose: To prove the feasibility of sentinel node navigation surgery (SNNS) in early gastric cancer patients with the risk of lymph node metastasis after endoscopic resection and preparation of multicenter phase 3 trial of…
- Trial name
- SENORITA2 (NCT03123042)
- Testing
- Sentinel basin dissection
- Where
- 9 sites in South Korea
- Volunteers
- 243 people
- Sponsor
- National Cancer Center, Korea
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